H4C5 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | H4C5 |
| Entrez Gene ID | 8367 |
| Full Name | histone cluster 1 H4 family member e |
| Synonyms | H4/j,H4FJ |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_003545.3 | NP_003536.1 | histone H4 |
| NM_003545.4 | NP_003536.1 | histone H4 |
| Pan troglodytes (chimpanzee) | LOC472228 | XP_527602.1 |
| Danio rerio (zebrafish) | LOC564610 | XP_005168857.1 |
| Oryza sativa (rice) | Os03g0119900 | NP_001048783.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101733182 | XP_004917044.1 |
| Drosophila melanogaster (fruit fly) | His4:CG33907 | NP_001027288.1 |
| Arabidopsis thaliana (thale cress) | AT1G07660 | NP_563793.1 |
| Homo sapiens (human) | HIST1H4E | NP_003536.1 |
| Bos taurus (cattle) | LOC517138 | XP_005223857.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012885 | XP_306825.4 |
| Caenorhabditis elegans (roundworm) | his-56 | NP_502139.1 |
Related articles in PubMed
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, C?t? J
Molecular cell62(3)409-421(2016 05)
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Mavrakis KJ, McDonald ER 3rd, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F, Sellers WR
Science (New York, N.Y.)351(6278)1208-13(2016 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following H4C5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H4C5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu30116 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_003545.3 , NM_003545.4 | |
| Accession Version | NM_003545.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-05 | |
| Organism | Homo sapiens(human) | |
| Product | histone H4 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z80787.1. On May 30, 2002 this sequence version replaced NM_003545.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTCTGGTC GCGGCAAAGG CGGAAAGGGA CTGGGTAAAG GAGGCGCTAA GCGTCACCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_003536.1 |
| CDS | 1..312 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_003545.3 |
ORF Insert Sequence:
1 | ATGTCTGGTC GCGGCAAAGG CGGAAAGGGA CTGGGTAAAG GAGGCGCTAA GCGTCACCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu30116 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_003545.3 , NM_003545.4 | |
| Accession Version | NM_003545.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2020-01-04 | |
| Organism | Homo sapiens(human) | |
| Product | histone H4 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031777.5. On Dec 3, 2019 this sequence version replaced NM_003545.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DA880386.1, DA283941.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTCTGGTC GCGGCAAAGG CGGAAAGGGA CTGGGTAAAG GAGGCGCTAA GCGTCACCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_003536.1 |
| CDS | 36..347 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_003545.4 |
ORF Insert Sequence:
1 | ATGTCTGGTC GCGGCAAAGG CGGAAAGGGA CTGGGTAAAG GAGGCGCTAA GCGTCACCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Architecture of the human interactome defines protein communities and disease networks. |
|
The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. |
|
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. |