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HIST1H4L cDNA ORF clone, Homo sapiens(Human)

Gene Symbol HIST1H4L
Entrez Gene ID 8368
Full Name histone cluster 1 H4 family member l
Synonyms H4.k,H4/k,H4FK
General protein information
Preferred Names

histone cluster 1 H4 family member l

Names

histone H4
H4 histone family, member K
histone 1, H4l
histone cluster 1, H4l

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

6

6p22.1

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Disorder MIM:

602831


mRNA and Protein(s)

mRNA Protein Name
NM_003546.2 NP_003537.1 histone H4



Rattus norvegicus (Norway rat) LOC100912290 XP_003749898.1
Drosophila melanogaster (fruit fly) His4r NP_001262576.1
Xenopus tropicalis (tropical clawed frog) LOC100485962 XP_002944234.1
Homo sapiens (human) HIST1H4L NP_003537.1
Pan troglodytes (chimpanzee) LOC735611 XP_001134995.1
Canis lupus familiaris (dog) LOC488260 XP_005640157.1
Macaca mulatta (rhesus monkey) LOC698354 XP_001087948.1
Mus musculus (house mouse) Hist1h4n NP_783588.1
Bos taurus (cattle) LOC530773 NP_001139343.1
Danio rerio (zebrafish) LOC101882398 XP_005163249.1


Related articles in PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Kipper S, Hamad S, Caly L, Avrahami D, Bacharach E, Jans DA, Gerber D, Bajorek M
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H
Biochemistry54(5)1171-9(2015 Feb)

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.
Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M, Glass KC
FEBS letters588(21)3844-54(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HIST1H4L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H4L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu30263 NM_003546.2
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Homo sapiens histone cluster 1 H4 family member l (HIST1H4L), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30263
Clone ID Related Accession (Same CDS sequence) NM_003546.2
Accession Version NM_003546.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 312bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product histone H4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X83548.1. On Sep 21, 2001 this sequence version replaced NM_003546.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069392.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGTCTGGGC GCGGCAAAGG CGGGAAGGGT CTGGGCAAAG GAGGCGCTAA GCGCCACCGC 
AAAGTTCTGC GCGACAACAT TCAGGGCATC ACCAAGCCCG CCATCCGACG CCTGGCACGG
CGTGGAGGCG TTAAGCGCAT CTCAGGCCTT ATATACGAGG AGACACGCGG AGTTCTTAAA
GTGTTTTTGG AGAATGTAAT CCGCGATGCA GTTACCTACA CGGAGCACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTTTACGCG CTCAAGCGCC AGGGCCGCAC CCTGTATGGC
TTTGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003537.1
CDS2..313
Misc Feature(1)2..310
Misc Feature(2)5..7
Misc Feature(3)5..7
Misc Feature(4)11..13
Misc Feature(5)11..13
Misc Feature(6)17..19
Misc Feature(7)17..19
Misc Feature(8)26..28
Misc Feature(9)26..28
Misc Feature(10)38..40
Misc Feature(11)38..40
Misc Feature(12)50..52
Misc Feature(13)50..52
Misc Feature(14)53..304
Misc Feature(15)62..64
Misc Feature(16)95..97
Misc Feature(17)order(101..103,113..115,125..127,131..133,143..145,152..154,161..166,173..178,185..190,197..202,260..262,272..274)
Misc Feature(18)order(122..124,128..130,134..136)
Misc Feature(19)order(134..139,143..145,221..223,233..238,242..244,248..250,290..292)
Misc Feature(20)143..145
Misc Feature(21)155..157
Misc Feature(22)order(206..208,215..220,227..238,254..259,266..268,275..280)
Misc Feature(23)242..244
Misc Feature(24)266..268
Misc Feature(25)275..277
Misc Feature(26)275..277
Misc Feature(27)290..304
Exon (1)1..364
Translation

Target ORF information:

RefSeq Version NM_003546.2
Organism Homo sapiens(Human)
Definition Homo sapiens histone cluster 1 H4 family member l (HIST1H4L), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003546.2

ORF Insert Sequence:

1
61
121
181
241
301
ATGTCTGGGC GCGGCAAAGG CGGGAAGGGT CTGGGCAAAG GAGGCGCTAA GCGCCACCGC 
AAAGTTCTGC GCGACAACAT TCAGGGCATC ACCAAGCCCG CCATCCGACG CCTGGCACGG
CGTGGAGGCG TTAAGCGCAT CTCAGGCCTT ATATACGAGG AGACACGCGG AGTTCTTAAA
GTGTTTTTGG AGAATGTAAT CCGCGATGCA GTTACCTACA CGGAGCACGC CAAACGCAAG
ACAGTCACAG CCATGGACGT GGTTTACGCG CTCAAGCGCC AGGGCCGCAC CCTGTATGGC
TTTGGCGGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M


book

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kovács IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barabási AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M


book

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)
Kipper S,Hamad S,Caly L,Avrahami D,Bacharach E,Jans DA,Gerber D,Bajorek M


book

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Biochemistry54(5)1171-9(2015 Feb)
Kato D,Osakabe A,Tachiwana H,Tanaka H,Kurumizaka H


book

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.
FEBS letters588(21)3844-54(2014 Nov)
Lubula MY,Eckenroth BE,Carlson S,Poplawski A,Chruszcz M,Glass KC


 
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