SOX14 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | SOX14 |
| Entrez Gene ID | 8403 |
| Full Name | SRY-box 14 |
| Synonyms | SOX28 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_004189.4 | NP_004180.1 | transcription factor SOX-14 |
| NM_004189.3 | NP_004180.1 | transcription factor SOX-14 |
| Bos taurus (cattle) | SOX14 | NP_001157253.1 |
| Rattus norvegicus (Norway rat) | Sox14 | NP_001100320.1 |
| Danio rerio (zebrafish) | sox14 | NP_001032769.1 |
| SOX14 | XP_001114754.1 | |
| Mus musculus (house mouse) | Sox14 | NP_035570.1 |
| Xenopus tropicalis (tropical clawed frog) | sox14 | NP_001093703.1 |
| Homo sapiens (human) | SOX14 | NP_004180.1 |
| Pan troglodytes (chimpanzee) | SOX14 | XP_526317.2 |
| Canis lupus familiaris (dog) | SOX14 | XP_005634531.1 |
| Gallus gallus (chicken) | SOX14 | NP_990092.1 |
Related articles in PubMed
SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors.
Yin H, Qin C, Zhao Y, Du Y, Sheng Z, Wang Q, Song Q, Chen L, Liu C, Xu T
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico19(8)1035-1044(2017 Aug)
SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/?-catenin pathway.
Li F, Wang T, Tang S
International journal of clinical and experimental pathology8(2)1698-704(2015)
Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
Kim HY, Cho S, Yu J, Sung S, Kim H
BMB reports43(8)547-53(2010 Aug)
Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression.
Popovic J, Klajn A, Petrovic I, Stevanovic M
Biochimica et biophysica acta1799(5-6)411-8(2010 May-Jun)
A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
these results demonstrate that SOX14 can promote proliferation and invasion capacity of cervical cancer cells by activating the Wnt/beta-catenin pathway.
Title: SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/?-catenin pathway.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
identified the positive control element and provided the first evidence that FOXA2 is involved in up-regulation of SOX14 expression in HepG2 and U87MG cell lines
Title: Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression.
The following SOX14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu15429 | |
| Clone ID Related Accession (Same CDS sequence) | NM_004189.4 , NM_004189.3 | |
| Accession Version | NM_004189.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-24 | |
| Organism | Homo sapiens(human) | |
| Product | transcription factor SOX-14 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007159.4. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004189.3. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK314127.1, BC106730.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306087.3/ ENSP00000305343.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## | |
1 | ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004180.1 |
| CDS | 471..1193 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_004189.4 |
ORF Insert Sequence:
1 | ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu15429 | |
| Clone ID Related Accession (Same CDS sequence) | NM_004189.4 , NM_004189.3 | |
| Accession Version | NM_004189.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-06-24 | |
| Organism | Homo sapiens(human) | |
| Product | transcription factor SOX-14 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007159.4. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2011 this sequence version replaced NM_004189.2. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. | |
1 | ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004180.1 |
| CDS | 494..1216 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_004189.3 |
ORF Insert Sequence:
1 | ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors. |
|
SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/?-catenin pathway. |
|
Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. |
|
Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. |
|
A census of human transcription factors: function, expression and evolution. |