Gene Symbol | DDI2 |
Entrez Gene ID | 84301 |
Full Name | DNA damage inducible 1 homolog 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » DDI2 cDNA ORF clone
Gene Symbol | DDI2 |
Entrez Gene ID | 84301 |
Full Name | DNA damage inducible 1 homolog 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_032341.5 | NP_115717.3 | protein DDI1 homolog 2 |
NM_032341.4 | NP_115717.3 | protein DDI1 homolog 2 |
DDI2 | XP_001083343.1 | |
Mus musculus (house mouse) | Ddi2 | NP_001017966.1 |
Rattus norvegicus (Norway rat) | Ddi2 | NP_001029321.1 |
Drosophila melanogaster (fruit fly) | rngo | NP_573129.1 |
Oryza sativa (rice) | Os02g0198600 | NP_001046209.1 |
Canis lupus familiaris (dog) | DDI2 | XP_005618021.1 |
Gallus gallus (chicken) | DDI2 | XP_004947602.1 |
Arabidopsis thaliana (thale cress) | AT3G13235 | NP_001189876.1 |
Pan troglodytes (chimpanzee) | DDI2 | XP_001150145.1 |
Danio rerio (zebrafish) | ddi2 | NP_938189.1 |
Xenopus tropicalis (tropical clawed frog) | ddi2 | NP_001029120.1 |
Homo sapiens (human) | DDI2 | NP_115717.3 |
Bos taurus (cattle) | DDI2 | XP_005217265.1 |
Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.
Kottemann MC, Conti BA, Lach FP, Smogorzewska A
Molecular cell69(1)24-35.e5(2018 Jan)
Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation.
Sha Z, Goldberg AL
Current biology : CB26(18)R836-R837(2016 Sep)
The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.
Koizumi S, Irie T, Hirayama S, Sakurai Y, Yashiroda H, Naguro I, Ichijo H, Hamazaki J, Murata S
eLife5(2016 08)
Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.
Siv? M, Svoboda M, Veverka V, Trempe JF, Hofmann K, Ko???ek M, Hexnerov? R, Sedl?k F, Belza J, Brynda J, ??cha P, Hub?lek M, Starkov? J, Flaisigov? I, Konvalinka J, ?a?kov? KG
Scientific reports630443(2016 Jul)
Human and mouse proteases: a comparative genomic approach.
Puente XS, S?nchez LM, Overall CM, L?pez-Ot?n C
Nature reviews. Genetics4(7)544-58(2003 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Here the authors show that the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1.
Title: The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The following DDI2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DDI2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu13844 | |
Clone ID Related Accession (Same CDS sequence) | NM_032341.5 , NM_032341.4 | |
Accession Version | NM_032341.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-05-01 | |
Organism | Homo sapiens(human) | |
Product | protein DDI1 homolog 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK293006.1, BC006011.1, AL598343.1, AK057374.1 and AL121992.24. On Nov 24, 2018 this sequence version replaced NM_032341.4. ##Evidence-Data-START## Transcript exon combination :: AK293006.1, SRR1803612.204530.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000480945.6/ ENSP00000417748.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCTGCTCA CCGTGTACTG TGTGCGGAGG GACCTCTCCG AGGTGACCTT TTCCCTCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_115717.3 |
CDS | 214..1413 |
Translation |
Target ORF information:
Target ORF information:
|
NM_032341.5 |
1 | ATGCTGCTCA CCGTGTACTG TGTGCGGAGG GACCTCTCCG AGGTGACCTT TTCCCTCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13844 | |
Clone ID Related Accession (Same CDS sequence) | NM_032341.5 , NM_032341.4 | |
Accession Version | NM_032341.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-27 | |
Organism | Homo sapiens(human) | |
Product | protein DDI1 homolog 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK293006.1, BC006011.1, AL598343.1 and AK057374.1. On Aug 21, 2010 this sequence version replaced NM_032341.3. ##Evidence-Data-START## Transcript exon combination :: AK293006.1, SRR1660803.203810.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGCTCA CCGTGTACTG TGTGCGGAGG GACCTCTCCG AGGTGACCTT TTCCCTCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_115717.3 |
CDS | 214..1413 |
Translation |
Target ORF information:
Target ORF information:
|
NM_032341.4 |
1 | ATGCTGCTCA CCGTGTACTG TGTGCGGAGG GACCTCTCCG AGGTGACCTT TTCCCTCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. |
Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation. |
The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. |
Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog. |
Human and mouse proteases: a comparative genomic approach. |