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SLX4 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SLX4
Entrez Gene ID 84464
Full Name SLX4 structure-specific endonuclease subunit
Synonyms BTBD12,FANCP,MUS312
General protein information
Preferred Names

SLX4 structure-specific endonuclease subunit

Names

structure-specific endonuclease subunit SLX4
BTB/POZ domain-containing protein 12

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

16

16p13.3

Summary This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. [provided by RefSeq, Sep 2016].
Disorder MIM:

613278


mRNA and Protein(s)

mRNA Protein Name
NM_032444.2 NP_115820.2 structure-specific endonuclease subunit SLX4
XM_011522715.2 XP_011521017.1 structure-specific endonuclease subunit SLX4 isoform X1
NM_032444.3 NP_115820.2 structure-specific endonuclease subunit SLX4
XM_017023775.1 XP_016879264.1 structure-specific endonuclease subunit SLX4 isoform X2



Bos taurus (cattle) SLX4 XP_002697931.2
Pan troglodytes (chimpanzee) SLX4 XP_510772.2
Gallus gallus (chicken) SLX4 XP_414962.4
Mus musculus (house mouse) Slx4 NP_803423.2
Rattus norvegicus (Norway rat) Slx4 XP_006245897.1
Canis lupus familiaris (dog) SLX4 XP_005621673.1
Macaca mulatta (rhesus monkey) SLX4 XP_001094220.2
Homo sapiens (human) SLX4 NP_115820.2


Related articles in PubMed

Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation.
Liu Q, Underwood TS, Kung J, Wang M, Lu HM, Paganetti H, Held KD, Hong TS, Efstathiou JA, Willers H
International journal of radiation oncology, biology, physics95(1)78-85(2016 May)

Physical interaction between SLX4 (FANCP) and XPF (FANCQ) proteins and biological consequences of interaction-defective missense mutations.
Hashimoto K, Wada K, Matsumoto K, Moriya M
DNA repair3548-54(2015 Nov)

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.
González-Prieto R, Cuijpers SA, Luijsterburg MS, van Attikum H, Vertegaal AC
EMBO reports16(4)512-9(2015 Apr)

Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.
Ouyang J, Garner E, Hallet A, Nguyen HD, Rickman KA, Gill G, Smogorzewska A, Zou L
Molecular cell57(1)108-22(2015 Jan)

The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.
Guervilly JH, Takedachi A, Naim V, Scaglione S, Chawhan C, Lovera Y, Despras E, Kuraoka I, Kannouche P, Rosselli F, Gaillard PH
Molecular cell57(1)123-37(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that dimeric GEN1 binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81-EME1 resolving enzyme complex. (GEN1 = Holliday junction 5' flap endonuclease; SLX = structure-specific endonuclease subunit; MUS81 = MUS81 endonuclease; EME1 = essential meiotic endonuclease 1) [REVIEW]
Title: Holliday junction-resolving enzymes-structures and mechanisms.

These data also indicate that HIV-1 and HIV-2 Vpr activate the DNA damage response through an SLX4-independent mechanism that remains uncharacterized.
Title: Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment.

SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).
Title: SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).

The functioning of SLX4 is dependent on its dimerization via an oligomerization motif called the BTB domain.
Title: Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex.

Results identified homozygous mutations in FANCA and FANCP/SLX4 genes, both located on chromosome 16, were the affected recessive FA genes in three and one family respectively. Genotyping with short tandem repeat markers and SNP arrays revealed uniparental disomy of the entire mutation-carrying chromosome 16 in all four patients.
Title: Paternal or Maternal Uniparental Disomy of Chromosome 16 Resulting in Homozygosity of a Mutant Allele Causes Fanconi Anemia.

The following SLX4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLX4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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OHu86318 XM_017023775.1
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Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 24-26 $811.30
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OHu18199 NM_032444.3
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Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 25 $951.30
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OHu73552 XM_011522715.2
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Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 25 $951.30
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OHu18199 NM_032444.2 Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 25 $951.30
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu86318
Clone ID Related Accession (Same CDS sequence) XM_017023775.1
Accession Version XM_017023775.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 4683bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product structure-specific endonuclease subunit SLX4 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
ATGAGCTTTT GCAAAAGCCA GAGGCATGAC TGCATTGCAG GGAAGGTGGG CCCGGTTTGT 
GCTAAGTTCC TTTGTCACCT CTGCCCTCCT CCTTCTTGCC CAGCTTATTG GGAGTCACCC
AGGCAGCCTA GGTTCTCTCC AGCCGGAAAC TCCTGTTCAT TTCCTCCAAA CCAAACGAGC
TGCTGCCCGT TGAAAGTGCA GAGTCCCGGG GCGGCTGGTA TAATGTTGAC CATCGGCAGC
CTAAGCTGGG AAGCCCTTCC TTCTGGCCAT GGACAGAGGC ACTGCCGTGG AGCCCTTGCA
GGAGGGAAGG GATCCTTTTC TGCCGGTGTG GCCAGGACCG TCTTCAGTGA TCACAGTAGA
GGTCTGAAAC GGAGAGGACC CACCAGCAAG AAGGAGCCAC GGAAGAGGCG GAAGGTGGAC
GAGGCACCGT CCGAGGACCT GCTGGTGGCC ATGGCTCTGT CCCGGTCGGA GATGGAGCCG
GGTGCGGCTG TACCAGCGCT CAGGCTGGAA AGTGCCTTTT CTGAGAGGAT AAGACCAGAA
GCAGAGAATA AAAGTCGCAA GAAGAAACCC CCGGTATCCC CCCCATTGTT GTTAGTCCAG
GACTCTGAAA CCACAGGCCG ACAGATAGAG GACCGTGTGG CCCTGCTCCT CTCTGAGGAA
GTGGAATTGT CTAGCACGCC ACCACTTCCT GCCAGCAGGA TTTTAAAGGA AGGGTGGGAA
AGAGCGGGCC AGTGTCCTCC TCCACCTGAA CGCAAGCAGA GCTTTCTGTG GGAGGGCAGC
GCACTGACTG GGGCCTGGGC CATGGAGGAC TTCTACACGG CCAGGCTGGT CCCTCCTCTC
GTGCCCCAGC GGCCTGCCCA GGGCCTTATG CAGGAGCCCG TGCCGCCTCT GGTGCCACCT
GAGCACTCAG AGCTGAGCGA GCGAAGGTCA CCCGCTCTCC ACGGCACCCC CACTGCAGGC
TGTGGCTCCA GGGGCCCGTC GCCTTCGGCC AGCCAGAGGG AGCACCAGGC CCTGCAGGAC
CTCGTGGACC TGGCGAGGGA GGGACTGAGC GCCAGCCCGT GGCCCGGCAG TGGGGGCCTG
GCTGGCTCGG AAGGGACTGC AGGGTTGGAC GTGGTGCCCG GCGGCCTTCC TCTGACTGGG
TTTGTGGTGC CATCGCAGGA CAAGCACCCG GACAGGGGCG GCCGCACCTT GCTCTCCCTC
GGGCTGCTGG TTGCTGACTT TGGCGCCATG GTCAATAACC CACACCTGAG TGATGTCCAG
TTTCAGACGG ACAGCGGGGA GGTGCTTTAC GCCCACAAGT TCGTGCTTTA TGCCCGATGC
CCGCTCCTCA TCCAGTATGT GAACAATGAA GGCTTCTCCG CTGTAGAGGA CGGGGTTCTG
ACCCAGCGTG TCCTGCTGGG TGACGTGAGC ACCGAGGCCG CCCGCACGTT CCTGCACTAT
CTCTACACTG CGGACACTGG CCTTCCTCCT GGCCTTAGCT CTGAGCTGAG CTCCCTGGCC
CACAGGTTTG GCGTGAGTGA GCTCGTTCAC CTGTGCGAAC AGGTGCCTAT TGCCACTGAC
TCAGAGGGCA AACCATGGGA GGAGAAGGAA GCAGAGAATT GCGAAAGCAG GGCCGAGAAT
TTCCAGGAAC TCTTGAGGTC AATGTGGGCA GATGAAGAGG AGGAAGCGGA GACTTTGTTG
AAATCCAAGG ACCACGAAGA AGATCAAGAA AACGTGAATG AAGCAGAAAT GGAAGAAATT
TATGAATTTG CAGCTACTCA GCGAAAGCTT CTCCAGGAAG AAAGGGCAGC GGGTGCCGGC
GAGGACGCTG ACTGGCTGGA GGGTGGCAGT CCGGTTTCTG GGCAACTCCT AGCAGGTGTC
CAGGTGCAGA AACAGTGGGA CAAGGTGGAG GAGATGGAGC CGTTGGAGCC AGGAAGAGAT
GAGGCCGCCA CCACCTGGGA GAAGATGGGA CAGTGCGCTC TCCCGCCACC CCAGGGCCAG
CACTCAGGGG CACGGGGAGC AGAGGCCCCT GAGCAGGAGG CGCCAGAGGA GGCGCTTGGC
CATTCCAGCT GCTCCAGCCC TTCCAGGGAC TGCCAGGCAG AGAGAAAAGA AGGCTCTCTT
CCGCACTCAG ATGATGCCGG GGATTACGAA CAGCTCTTCT CATCAACTCA GGGAGAGATC
TCAGAGCCGT CCCAAATAAC AAGTGAGCCC GAGGAACAAA GTGGCGCTGT CAGGGAAAGG
GGGCTGGAGG TTTCTCATCG CCTGGCTCCC TGGCAGGCAT CTCCACCGCA CCCGTGCCGC
TTCCTATTGG GGCCTCCCCA GGGCGGGAGT CCCCGCGGGT CTCATCACAC AAGTGGGTCG
TCCCTGTCAA CACCCCGGTC CCGTGGCGGA ACTTCCCAGG TGGGCTCCCC AACCTTGCTG
TCTCCAGCTG TGCCATCAAA GCAGAAAAGG GACAGGAGCA TCCTCACGCT GTCTAAAGAG
CCAGGGCACC AGAAAGGCAA AGAGCGTCGG TCCGTGCTGG AGTGCAGAAA TAAGGGGGTC
CTGATGTTCC CAGAAAAATC TCCGTCTATT GACCTAACCC AGTCAAATCC TGACCATTCG
AGCTCCAGAT CTCAGAAATC TTCATCCAAA CTGAACGAAG AAGATGAGGT CATCCTCTTA
CTGGACTCGG ATGAGGAGCT GGAGCTAGAA CAAACCAAAA TGAAGTCCAT TTCTAGTGAT
CCTCTGGAAG AAAAGAAAGC TCTAGAAATT AGCCCTAGGT CCTGTGAGCT GTTTTCCATC
ATTGATGTTG ATGCAGATCA GGAACCTTCC CAGAGCCCAC CAAGAAGCGA AGCTGTGCTG
CAGCAGGAGG ATGAGGGGGC GCTGCCGGAG AATCGGGGCT CTTTGGGCAG GAGAGGGGCT
CCCTGGCTGT TCTGTGACCG TGAGAGCAGC CCCAGCGAGG CCAGCACCAC AGACACCTCG
TGGCTGGTGC CCGCCACCCC GCTGGCCAGC AGAAGCCGTG ACTGTTCTTC CCAGACCCAA
ATCAGCAGCC TCAGGAGCGG GCTGGCCGTG CAGGCGGTGA CTCAGCACAC GCCCAGGGCC
TCAGTAGGAA ACAGGGAAGG GAACGAAGTC GCACAGAAGT TTTCTGTCAT CAGGCCCCAG
ACACCACCGC CCCAGACACC GTCCTCATGC CTCACTCCCG TCTCTCCAGG AACTTCTGAC
GGCAGAAGGC AAGGCCACAG AAGCCCTTCC CGTCCCCACC CCGGGGGCCA CCCGCACTCC
TCTCCGCTGG CTCCACATCC CATCTCAGGG GACCGCGCCC ACTTCAGCAG GCGGTTCCTG
AAACACTCGC CGCCTGGGCC AAGCTTCCTG AACCAGACCC CAGCGGGTGA AGTGGTGGAA
GTCGGAGACA GTGACGATGA GCAGGAGGTG GCCTCCCATC AGGCCAACAG AAGCCCCCCA
CTGGACAGTG ACCCCCCAAT TCCAATTGAC GACTGCTGCT GGCACATGGA GCCCCTCTCG
CCAATTCCCA TTGACCACTG GAACCTGGAG CGGACCGGCC CCCTGAGCAC CAGCAGCCCC
AGCCGCAGGA TGAACGAGGC CGCCGACAGC CGTGACTGTC GCTCCCCGGG ACTCCTGGAC
ACCACCCCCA TCCGAGGAAG CTGCACTACC CAGAGGAAAT TGCAAGAGAA GTCCTCGGGC
GCGGGCTCCC TGGGGAATAG CAGGCCGAGC TTTCTGAATT CGGCTCTGTG GGACGTTTGG
GACGGGGAAG AGCAGAGGCC TCCAGAGACC CCTCCTCCGG CCCAGATGCC AAGCGCTGGT
GGAGCTCAGA AGCCCGAAGG GTTAGAGACA CCCAAAGGTG CTAATCGGAA GAAGAACTTG
CCCCCCAAAG TGCCCATAAC GCCGATGCCA CAGTATTCCA TTATGGAGAC GCCGGTGCTG
AAGAAGGAAC TGGATAGGTT TGGAGTCCGC CCTCTGCCTA AACGCCAGAT GGTTCTGAAG
CTGAAGGAGA TATTCCAGTA CACTCACCAG ACCCTGGACT CAGACTCCGA GGACGAGAGC
CAGTCCTCAC AGCCGCTGTT GCAGGCGCCT CACTGCCAGA CCCTCGCCTC CCAGACCTAC
AAGCCTTCAA GGGCAGGGGT CCATGCCCAG CAGGAGGCCA CCACAGGACC TGGGGCCCAT
AGGCCCAAGG GACCTGCTAA GACCAAGGGC CCCCGACATC AAAGGAAGCA TCATGAAAGC
ATCACACCCC CAAGCAGGTC GCCCACCAAG GAGGCACCTC CAGGCCTCAA TGATGACGCC
CAGATCCCAG CCTCTCAAGA ATCCGTGGCC ACCTCTGTGG ATGGCAGTGA CAGCTCCTTG
AGCTCACAGA GTTCTTCCTC CTGTGAGTTT GGAGCGGCAT TTGAGTCTGC AGGTGAAGAG
GAGGGCGAGG GGGAGGTCAG TGCCTCGCAG GCAGCCGTGC AGGCGGCGGA CACAGACGAG
GCGCTGAGGT GCTACATCCG CTCCAAGCCG GCCCTGTACC AGAAGGTGCT GCTGTACCAG
CCCTTTGAGC TGCGGGAGCT GCAGGCAGAG CTGAGGCAGA ACGGCCTCCG TGTGTCCTCG
CGCAGGCTGT TGGACTTCCT GGACACCCAC TGTATCACCT TCACCACTGC CGCCACCCGC
AGGGAGAAGC TCCAGGGCAG GAGGCGGCAG CCTCGGGGCA AGAAGAAGGT GGAGCGGAAC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016879264.1
CDS855..5537
Translation

Target ORF information:

RefSeq Version XM_017023775.1
Organism Homo sapiens(Human)
Definition Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017023775.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
ATGAGCTTTT GCAAAAGCCA GAGGCATGAC TGCATTGCAG GGAAGGTGGG CCCGGTTTGT 
GCTAAGTTCC TTTGTCACCT CTGCCCTCCT CCTTCTTGCC CAGCTTATTG GGAGTCACCC
AGGCAGCCTA GGTTCTCTCC AGCCGGAAAC TCCTGTTCAT TTCCTCCAAA CCAAACGAGC
TGCTGCCCGT TGAAAGTGCA GAGTCCCGGG GCGGCTGGTA TAATGTTGAC CATCGGCAGC
CTAAGCTGGG AAGCCCTTCC TTCTGGCCAT GGACAGAGGC ACTGCCGTGG AGCCCTTGCA
GGAGGGAAGG GATCCTTTTC TGCCGGTGTG GCCAGGACCG TCTTCAGTGA TCACAGTAGA
GGTCTGAAAC GGAGAGGACC CACCAGCAAG AAGGAGCCAC GGAAGAGGCG GAAGGTGGAC
GAGGCACCGT CCGAGGACCT GCTGGTGGCC ATGGCTCTGT CCCGGTCGGA GATGGAGCCG
GGTGCGGCTG TACCAGCGCT CAGGCTGGAA AGTGCCTTTT CTGAGAGGAT AAGACCAGAA
GCAGAGAATA AAAGTCGCAA GAAGAAACCC CCGGTATCCC CCCCATTGTT GTTAGTCCAG
GACTCTGAAA CCACAGGCCG ACAGATAGAG GACCGTGTGG CCCTGCTCCT CTCTGAGGAA
GTGGAATTGT CTAGCACGCC ACCACTTCCT GCCAGCAGGA TTTTAAAGGA AGGGTGGGAA
AGAGCGGGCC AGTGTCCTCC TCCACCTGAA CGCAAGCAGA GCTTTCTGTG GGAGGGCAGC
GCACTGACTG GGGCCTGGGC CATGGAGGAC TTCTACACGG CCAGGCTGGT CCCTCCTCTC
GTGCCCCAGC GGCCTGCCCA GGGCCTTATG CAGGAGCCCG TGCCGCCTCT GGTGCCACCT
GAGCACTCAG AGCTGAGCGA GCGAAGGTCA CCCGCTCTCC ACGGCACCCC CACTGCAGGC
TGTGGCTCCA GGGGCCCGTC GCCTTCGGCC AGCCAGAGGG AGCACCAGGC CCTGCAGGAC
CTCGTGGACC TGGCGAGGGA GGGACTGAGC GCCAGCCCGT GGCCCGGCAG TGGGGGCCTG
GCTGGCTCGG AAGGGACTGC AGGGTTGGAC GTGGTGCCCG GCGGCCTTCC TCTGACTGGG
TTTGTGGTGC CATCGCAGGA CAAGCACCCG GACAGGGGCG GCCGCACCTT GCTCTCCCTC
GGGCTGCTGG TTGCTGACTT TGGCGCCATG GTCAATAACC CACACCTGAG TGATGTCCAG
TTTCAGACGG ACAGCGGGGA GGTGCTTTAC GCCCACAAGT TCGTGCTTTA TGCCCGATGC
CCGCTCCTCA TCCAGTATGT GAACAATGAA GGCTTCTCCG CTGTAGAGGA CGGGGTTCTG
ACCCAGCGTG TCCTGCTGGG TGACGTGAGC ACCGAGGCCG CCCGCACGTT CCTGCACTAT
CTCTACACTG CGGACACTGG CCTTCCTCCT GGCCTTAGCT CTGAGCTGAG CTCCCTGGCC
CACAGGTTTG GCGTGAGTGA GCTCGTTCAC CTGTGCGAAC AGGTGCCTAT TGCCACTGAC
TCAGAGGGCA AACCATGGGA GGAGAAGGAA GCAGAGAATT GCGAAAGCAG GGCCGAGAAT
TTCCAGGAAC TCTTGAGGTC AATGTGGGCA GATGAAGAGG AGGAAGCGGA GACTTTGTTG
AAATCCAAGG ACCACGAAGA AGATCAAGAA AACGTGAATG AAGCAGAAAT GGAAGAAATT
TATGAATTTG CAGCTACTCA GCGAAAGCTT CTCCAGGAAG AAAGGGCAGC GGGTGCCGGC
GAGGACGCTG ACTGGCTGGA GGGTGGCAGT CCGGTTTCTG GGCAACTCCT AGCAGGTGTC
CAGGTGCAGA AACAGTGGGA CAAGGTGGAG GAGATGGAGC CGTTGGAGCC AGGAAGAGAT
GAGGCCGCCA CCACCTGGGA GAAGATGGGA CAGTGCGCTC TCCCGCCACC CCAGGGCCAG
CACTCAGGGG CACGGGGAGC AGAGGCCCCT GAGCAGGAGG CGCCAGAGGA GGCGCTTGGC
CATTCCAGCT GCTCCAGCCC TTCCAGGGAC TGCCAGGCAG AGAGAAAAGA AGGCTCTCTT
CCGCACTCAG ATGATGCCGG GGATTACGAA CAGCTCTTCT CATCAACTCA GGGAGAGATC
TCAGAGCCGT CCCAAATAAC AAGTGAGCCC GAGGAACAAA GTGGCGCTGT CAGGGAAAGG
GGGCTGGAGG TTTCTCATCG CCTGGCTCCC TGGCAGGCAT CTCCACCGCA CCCGTGCCGC
TTCCTATTGG GGCCTCCCCA GGGCGGGAGT CCCCGCGGGT CTCATCACAC AAGTGGGTCG
TCCCTGTCAA CACCCCGGTC CCGTGGCGGA ACTTCCCAGG TGGGCTCCCC AACCTTGCTG
TCTCCAGCTG TGCCATCAAA GCAGAAAAGG GACAGGAGCA TCCTCACGCT GTCTAAAGAG
CCAGGGCACC AGAAAGGCAA AGAGCGTCGG TCCGTGCTGG AGTGCAGAAA TAAGGGGGTC
CTGATGTTCC CAGAAAAATC TCCGTCTATT GACCTAACCC AGTCAAATCC TGACCATTCG
AGCTCCAGAT CTCAGAAATC TTCATCCAAA CTGAACGAAG AAGATGAGGT CATCCTCTTA
CTGGACTCGG ATGAGGAGCT GGAGCTAGAA CAAACCAAAA TGAAGTCCAT TTCTAGTGAT
CCTCTGGAAG AAAAGAAAGC TCTAGAAATT AGCCCTAGGT CCTGTGAGCT GTTTTCCATC
ATTGATGTTG ATGCAGATCA GGAACCTTCC CAGAGCCCAC CAAGAAGCGA AGCTGTGCTG
CAGCAGGAGG ATGAGGGGGC GCTGCCGGAG AATCGGGGCT CTTTGGGCAG GAGAGGGGCT
CCCTGGCTGT TCTGTGACCG TGAGAGCAGC CCCAGCGAGG CCAGCACCAC AGACACCTCG
TGGCTGGTGC CCGCCACCCC GCTGGCCAGC AGAAGCCGTG ACTGTTCTTC CCAGACCCAA
ATCAGCAGCC TCAGGAGCGG GCTGGCCGTG CAGGCGGTGA CTCAGCACAC GCCCAGGGCC
TCAGTAGGAA ACAGGGAAGG GAACGAAGTC GCACAGAAGT TTTCTGTCAT CAGGCCCCAG
ACACCACCGC CCCAGACACC GTCCTCATGC CTCACTCCCG TCTCTCCAGG AACTTCTGAC
GGCAGAAGGC AAGGCCACAG AAGCCCTTCC CGTCCCCACC CCGGGGGCCA CCCGCACTCC
TCTCCGCTGG CTCCACATCC CATCTCAGGG GACCGCGCCC ACTTCAGCAG GCGGTTCCTG
AAACACTCGC CGCCTGGGCC AAGCTTCCTG AACCAGACCC CAGCGGGTGA AGTGGTGGAA
GTCGGAGACA GTGACGATGA GCAGGAGGTG GCCTCCCATC AGGCCAACAG AAGCCCCCCA
CTGGACAGTG ACCCCCCAAT TCCAATTGAC GACTGCTGCT GGCACATGGA GCCCCTCTCG
CCAATTCCCA TTGACCACTG GAACCTGGAG CGGACCGGCC CCCTGAGCAC CAGCAGCCCC
AGCCGCAGGA TGAACGAGGC CGCCGACAGC CGTGACTGTC GCTCCCCGGG ACTCCTGGAC
ACCACCCCCA TCCGAGGAAG CTGCACTACC CAGAGGAAAT TGCAAGAGAA GTCCTCGGGC
GCGGGCTCCC TGGGGAATAG CAGGCCGAGC TTTCTGAATT CGGCTCTGTG GGACGTTTGG
GACGGGGAAG AGCAGAGGCC TCCAGAGACC CCTCCTCCGG CCCAGATGCC AAGCGCTGGT
GGAGCTCAGA AGCCCGAAGG GTTAGAGACA CCCAAAGGTG CTAATCGGAA GAAGAACTTG
CCCCCCAAAG TGCCCATAAC GCCGATGCCA CAGTATTCCA TTATGGAGAC GCCGGTGCTG
AAGAAGGAAC TGGATAGGTT TGGAGTCCGC CCTCTGCCTA AACGCCAGAT GGTTCTGAAG
CTGAAGGAGA TATTCCAGTA CACTCACCAG ACCCTGGACT CAGACTCCGA GGACGAGAGC
CAGTCCTCAC AGCCGCTGTT GCAGGCGCCT CACTGCCAGA CCCTCGCCTC CCAGACCTAC
AAGCCTTCAA GGGCAGGGGT CCATGCCCAG CAGGAGGCCA CCACAGGACC TGGGGCCCAT
AGGCCCAAGG GACCTGCTAA GACCAAGGGC CCCCGACATC AAAGGAAGCA TCATGAAAGC
ATCACACCCC CAAGCAGGTC GCCCACCAAG GAGGCACCTC CAGGCCTCAA TGATGACGCC
CAGATCCCAG CCTCTCAAGA ATCCGTGGCC ACCTCTGTGG ATGGCAGTGA CAGCTCCTTG
AGCTCACAGA GTTCTTCCTC CTGTGAGTTT GGAGCGGCAT TTGAGTCTGC AGGTGAAGAG
GAGGGCGAGG GGGAGGTCAG TGCCTCGCAG GCAGCCGTGC AGGCGGCGGA CACAGACGAG
GCGCTGAGGT GCTACATCCG CTCCAAGCCG GCCCTGTACC AGAAGGTGCT GCTGTACCAG
CCCTTTGAGC TGCGGGAGCT GCAGGCAGAG CTGAGGCAGA ACGGCCTCCG TGTGTCCTCG
CGCAGGCTGT TGGACTTCCT GGACACCCAC TGTATCACCT TCACCACTGC CGCCACCCGC
AGGGAGAAGC TCCAGGGCAG GAGGCGGCAG CCTCGGGGCA AGAAGAAGGT GGAGCGGAAC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18199
Clone ID Related Accession (Same CDS sequence) NM_032444.2 , NM_032444.3
Accession Version NM_032444.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 5505bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product structure-specific endonuclease subunit SLX4
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
ATGAAACTGA GTGTGAATGA GGCTCAGCTA GGCTTCTACT TGGGTTCACT TTCTCATCTG 
TCTGCCTGTC CTGGGATTGA CCCTCGCTCC TCTGAAGACC AGCCTGAAAG CCTTAAAACT
GGTCAGATGA TGGATGAGTC TGATGAGGAC TTTAAAGAAC TCTGCGCTAG CTTTTTCCAA
AGGGTGAAAA AACATGGAAT CAAGGAAGTG TCAGGAGAAA GGAAGACACA AAAGGCTGCC
TCAAACGGCA CTCAGATAAG AAGCAAATTG AAAAGGACCA AACAAACTGC TACCAAGACC
AAAACCCTTC AAGGCCCTGC AGAGAAGAAA CCTCCGTCTG GCAGCCAGGC CCCTAGGACT
AAAAAGCAAA GGGTAACCAA ATGGCAAGCA AGTGAACCGG CCCACTCTGT GAATGGGGAG
GGGGGTGTGC TTGCCTCTGC TCCAGATCCA CCTGTGCTCC GGGAAACAGC ACAAAACACC
CAGACGGGTA ACCAGCAAGA ACCATCGCCA AACCTTTCCA GAGAGAAAAC CAGAGAGAAT
GTGCCCAACA GCGACTCCCA GCCTCCTCCT TCCTGTTTGA CAACAGCAGT GCCAAGTCCC
TCCAAACCCC GCACAGCACA ATTGGTCCTA CAGCGAATGC AGCAGTTCAA GAGAGCAGAC
CCCGAGCGTT TGAGACACGC TTCAGAAGAG TGCTCCCTCG AGGCTGCGCG GGAAGAAAAT
GTCCCAAAGG ATCCTCAAGA GGAGATGATG GCGGGGAATG TGTATGGGCT TGGGCCCCCT
GCCCCAGAGA GCGACGCTGC GGTGGCCTTG ACCCTGCAGC AGGAGTTTGC ACGGGTAGGA
GCATCGGCAC ATGATGATAG CCTGGAGGAA AAGGGTTTGT TCTTCTGCCA GATTTGTCAA
AAGAACCTCT CAGCCATGAA CGTGACCCGA AGGGAACAGC ATGTGAACAG GTGCTTGGAT
GAAGCTGAAA AGACACTAAG ACCTTCTGTG CCTCAGATCC CTGAGTGCCC GATTTGTGGG
AAACCGTTTC TTACCTTAAA GAGCAGAACC AGTCACTTGA AGCAGTGTGC TGTGAAGATG
GAGGTTGGCC CCCAGCTCCT GCTTCAGGCT GTGCGGCTGC AGACAGCACA GCCTGAGGGT
AGCAGCAGCC CACCCATGTT CAGCTTCAGT GATCACAGTA GAGGTCTGAA ACGGAGAGGA
CCCACCAGCA AGAAGGAGCC ACGGAAGAGG CGGAAGGTGG ACGAGGCACC GTCCGAGGAC
CTGCTGGTGG CCATGGCTCT GTCCCGGTCG GAGATGGAGC CGGGTGCGGC TGTACCAGCG
CTCAGGCTGG AAAGTGCCTT TTCTGAGAGG ATAAGACCAG AAGCAGAGAA TAAAAGTCGC
AAGAAGAAAC CCCCGGTATC CCCCCCATTG TTGTTAGTCC AGGACTCTGA AACCACAGGC
CGACAGATAG AGGACCGTGT GGCCCTGCTC CTCTCTGAGG AAGTGGAATT GTCTAGCACG
CCACCACTTC CTGCCAGCAG GATTTTAAAG GAAGGGTGGG AAAGAGCGGG CCAGTGTCCT
CCTCCACCTG AACGCAAGCA GAGCTTTCTG TGGGAGGGCA GCGCACTGAC TGGGGCCTGG
GCCATGGAGG ACTTCTACAC GGCCAGGCTG GTCCCTCCTC TCGTGCCCCA GCGGCCTGCC
CAGGGCCTTA TGCAGGAGCC CGTGCCGCCT CTGGTGCCAC CTGAGCACTC AGAGCTGAGC
GAGCGAAGGT CACCCGCTCT CCACGGCACC CCCACTGCAG GCTGTGGCTC CAGGGGCCCG
TCGCCTTCGG CCAGCCAGAG GGAGCACCAG GCCCTGCAGG ACCTCGTGGA CCTGGCGAGG
GAGGGACTGA GCGCCAGCCC GTGGCCCGGC AGTGGGGGCC TGGCTGGCTC GGAAGGGACT
GCAGGGTTGG ACGTGGTGCC CGGCGGCCTT CCTCTGACTG GGTTTGTGGT GCCATCGCAG
GACAAGCACC CGGACAGGGG CGGCCGCACC TTGCTCTCCC TCGGGCTGCT GGTTGCTGAC
TTTGGCGCCA TGGTCAATAA CCCACACCTG AGTGATGTCC AGTTTCAGAC GGACAGCGGG
GAGGTGCTTT ACGCCCACAA GTTCGTGCTT TATGCCCGAT GCCCGCTCCT CATCCAGTAT
GTGAACAATG AAGGCTTCTC CGCTGTAGAG GACGGGGTTC TGACCCAGCG TGTCCTGCTG
GGTGACGTGA GCACCGAGGC CGCCCGCACG TTCCTGCACT ATCTCTACAC TGCGGACACT
GGCCTTCCTC CTGGCCTTAG CTCTGAGCTG AGCTCCCTGG CCCACAGGTT TGGCGTGAGT
GAGCTCGTTC ACCTGTGCGA ACAGGTGCCT ATTGCCACTG ACTCAGAGGG CAAACCATGG
GAGGAGAAGG AAGCAGAGAA TTGCGAAAGC AGGGCCGAGA ATTTCCAGGA ACTCTTGAGG
TCAATGTGGG CAGATGAAGA GGAGGAAGCG GAGACTTTGT TGAAATCCAA GGACCACGAA
GAAGATCAAG AAAACGTGAA TGAAGCAGAA ATGGAAGAAA TTTATGAATT TGCAGCTACT
CAGCGAAAGC TTCTCCAGGA AGAAAGGGCA GCGGGTGCCG GCGAGGACGC TGACTGGCTG
GAGGGTGGCA GTCCGGTTTC TGGGCAACTC CTAGCAGGTG TCCAGGTGCA GAAACAGTGG
GACAAGGTGG AGGAGATGGA GCCGTTGGAG CCAGGAAGAG ATGAGGCCGC CACCACCTGG
GAGAAGATGG GACAGTGCGC TCTCCCGCCA CCCCAGGGCC AGCACTCAGG GGCACGGGGA
GCAGAGGCCC CTGAGCAGGA GGCGCCAGAG GAGGCGCTTG GCCATTCCAG CTGCTCCAGC
CCTTCCAGGG ACTGCCAGGC AGAGAGAAAA GAAGGCTCTC TTCCGCACTC AGATGATGCC
GGGGATTACG AACAGCTCTT CTCATCAACT CAGGGAGAGA TCTCAGAGCC GTCCCAAATA
ACAAGTGAGC CCGAGGAACA AAGTGGCGCT GTCAGGGAAA GGGGGCTGGA GGTTTCTCAT
CGCCTGGCTC CCTGGCAGGC ATCTCCACCG CACCCGTGCC GCTTCCTATT GGGGCCTCCC
CAGGGCGGGA GTCCCCGCGG GTCTCATCAC ACAAGTGGGT CGTCCCTGTC AACACCCCGG
TCCCGTGGCG GAACTTCCCA GGTGGGCTCC CCAACCTTGC TGTCTCCAGC TGTGCCATCA
AAGCAGAAAA GGGACAGGAG CATCCTCACG CTGTCTAAAG AGCCAGGGCA CCAGAAAGGC
AAAGAGCGTC GGTCCGTGCT GGAGTGCAGA AATAAGGGGG TCCTGATGTT CCCAGAAAAA
TCTCCGTCTA TTGACCTAAC CCAGTCAAAT CCTGACCATT CGAGCTCCAG ATCTCAGAAA
TCTTCATCCA AACTGAACGA AGAAGATGAG GTCATCCTCT TACTGGACTC GGATGAGGAG
CTGGAGCTAG AACAAACCAA AATGAAGTCC ATTTCTAGTG ATCCTCTGGA AGAAAAGAAA
GCTCTAGAAA TTAGCCCTAG GTCCTGTGAG CTGTTTTCCA TCATTGATGT TGATGCAGAT
CAGGAACCTT CCCAGAGCCC ACCAAGAAGC GAAGCTGTGC TGCAGCAGGA GGATGAGGGG
GCGCTGCCGG AGAATCGGGG CTCTTTGGGC AGGAGAGGGG CTCCCTGGCT GTTCTGTGAC
CGTGAGAGCA GCCCCAGCGA GGCCAGCACC ACAGACACCT CGTGGCTGGT GCCCGCCACC
CCGCTGGCCA GCAGAAGCCG TGACTGTTCT TCCCAGACCC AAATCAGCAG CCTCAGGAGC
GGGCTGGCCG TGCAGGCGGT GACTCAGCAC ACGCCCAGGG CCTCAGTAGG AAACAGGGAA
GGGAACGAAG TCGCACAGAA GTTTTCTGTC ATCAGGCCCC AGACACCACC GCCCCAGACA
CCGTCCTCAT GCCTCACTCC CGTCTCTCCA GGAACTTCTG ACGGCAGAAG GCAAGGCCAC
AGAAGCCCTT CCCGTCCCCA CCCCGGGGGC CACCCGCACT CCTCTCCGCT GGCTCCACAT
CCCATCTCAG GGGACCGCGC CCACTTCAGC AGGCGGTTCC TGAAACACTC GCCGCCTGGG
CCAAGCTTCC TGAACCAGAC CCCAGCGGGT GAAGTGGTGG AAGTCGGAGA CAGTGACGAT
GAGCAGGAGG TGGCCTCCCA TCAGGCCAAC AGAAGCCCCC CACTGGACAG TGACCCCCCA
ATTCCAATTG ACGACTGCTG CTGGCACATG GAGCCCCTCT CGCCAATTCC CATTGACCAC
TGGAACCTGG AGCGGACCGG CCCCCTGAGC ACCAGCAGCC CCAGCCGCAG GATGAACGAG
GCCGCCGACA GCCGTGACTG TCGCTCCCCG GGACTCCTGG ACACCACCCC CATCCGAGGA
AGCTGCACTA CCCAGAGGAA ATTGCAAGAG AAGTCCTCGG GCGCGGGCTC CCTGGGGAAT
AGCAGGCCGA GCTTTCTGAA TTCGGCTCTG TGGGACGTTT GGGACGGGGA AGAGCAGAGG
CCTCCAGAGA CCCCTCCTCC GGCCCAGATG CCAAGCGCTG GTGGAGCTCA GAAGCCCGAA
GGGTTAGAGA CACCCAAAGG TGCTAATCGG AAGAAGAACT TGCCCCCCAA AGTGCCCATA
ACGCCGATGC CACAGTATTC CATTATGGAG ACGCCGGTGC TGAAGAAGGA ACTGGATAGG
TTTGGAGTCC GCCCTCTGCC TAAACGCCAG ATGGTTCTGA AGCTGAAGGA GATATTCCAG
TACACTCACC AGACCCTGGA CTCAGACTCC GAGGACGAGA GCCAGTCCTC ACAGCCGCTG
TTGCAGGCGC CTCACTGCCA GACCCTCGCC TCCCAGACCT ACAAGCCTTC AAGGGCAGGG
GTCCATGCCC AGCAGGAGGC CACCACAGGA CCTGGGGCCC ATAGGCCCAA GGGACCTGCT
AAGACCAAGG GCCCCCGACA TCAAAGGAAG CATCATGAAA GCATCACACC CCCAAGCAGG
TCGCCCACCA AGGAGGCACC TCCAGGCCTC AATGATGACG CCCAGATCCC AGCCTCTCAA
GAATCCGTGG CCACCTCTGT GGATGGCAGT GACAGCTCCT TGAGCTCACA GAGTTCTTCC
TCCTGTGAGT TTGGAGCGGC ATTTGAGTCT GCAGGTGAAG AGGAGGGCGA GGGGGAGGTC
AGTGCCTCGC AGGCAGCCGT GCAGGCGGCG GACACAGACG AGGCGCTGAG GTGCTACATC
CGCTCCAAGC CGGCCCTGTA CCAGAAGGTG CTGCTGTACC AGCCCTTTGA GCTGCGGGAG
CTGCAGGCAG AGCTGAGGCA GAACGGCCTC CGTGTGTCCT CGCGCAGGCT GTTGGACTTC
CTGGACACCC ACTGTATCAC CTTCACCACT GCCGCCACCC GCAGGGAGAA GCTCCAGGGC
AGGAGGCGGC AGCCTCGGGG CAAGAAGAAG GTGGAGCGGA ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115820.2
Translation

Target ORF information:

RefSeq Version NM_032444.2
Organism Homo sapiens(Human)
Definition Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032444.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
ATGAAACTGA GTGTGAATGA GGCTCAGCTA GGCTTCTACT TGGGTTCACT TTCTCATCTG 
TCTGCCTGTC CTGGGATTGA CCCTCGCTCC TCTGAAGACC AGCCTGAAAG CCTTAAAACT
GGTCAGATGA TGGATGAGTC TGATGAGGAC TTTAAAGAAC TCTGCGCTAG CTTTTTCCAA
AGGGTGAAAA AACATGGAAT CAAGGAAGTG TCAGGAGAAA GGAAGACACA AAAGGCTGCC
TCAAACGGCA CTCAGATAAG AAGCAAATTG AAAAGGACCA AACAAACTGC TACCAAGACC
AAAACCCTTC AAGGCCCTGC AGAGAAGAAA CCTCCGTCTG GCAGCCAGGC CCCTAGGACT
AAAAAGCAAA GGGTAACCAA ATGGCAAGCA AGTGAACCGG CCCACTCTGT GAATGGGGAG
GGGGGTGTGC TTGCCTCTGC TCCAGATCCA CCTGTGCTCC GGGAAACAGC ACAAAACACC
CAGACGGGTA ACCAGCAAGA ACCATCGCCA AACCTTTCCA GAGAGAAAAC CAGAGAGAAT
GTGCCCAACA GCGACTCCCA GCCTCCTCCT TCCTGTTTGA CAACAGCAGT GCCAAGTCCC
TCCAAACCCC GCACAGCACA ATTGGTCCTA CAGCGAATGC AGCAGTTCAA GAGAGCAGAC
CCCGAGCGTT TGAGACACGC TTCAGAAGAG TGCTCCCTCG AGGCTGCGCG GGAAGAAAAT
GTCCCAAAGG ATCCTCAAGA GGAGATGATG GCGGGGAATG TGTATGGGCT TGGGCCCCCT
GCCCCAGAGA GCGACGCTGC GGTGGCCTTG ACCCTGCAGC AGGAGTTTGC ACGGGTAGGA
GCATCGGCAC ATGATGATAG CCTGGAGGAA AAGGGTTTGT TCTTCTGCCA GATTTGTCAA
AAGAACCTCT CAGCCATGAA CGTGACCCGA AGGGAACAGC ATGTGAACAG GTGCTTGGAT
GAAGCTGAAA AGACACTAAG ACCTTCTGTG CCTCAGATCC CTGAGTGCCC GATTTGTGGG
AAACCGTTTC TTACCTTAAA GAGCAGAACC AGTCACTTGA AGCAGTGTGC TGTGAAGATG
GAGGTTGGCC CCCAGCTCCT GCTTCAGGCT GTGCGGCTGC AGACAGCACA GCCTGAGGGT
AGCAGCAGCC CACCCATGTT CAGCTTCAGT GATCACAGTA GAGGTCTGAA ACGGAGAGGA
CCCACCAGCA AGAAGGAGCC ACGGAAGAGG CGGAAGGTGG ACGAGGCACC GTCCGAGGAC
CTGCTGGTGG CCATGGCTCT GTCCCGGTCG GAGATGGAGC CGGGTGCGGC TGTACCAGCG
CTCAGGCTGG AAAGTGCCTT TTCTGAGAGG ATAAGACCAG AAGCAGAGAA TAAAAGTCGC
AAGAAGAAAC CCCCGGTATC CCCCCCATTG TTGTTAGTCC AGGACTCTGA AACCACAGGC
CGACAGATAG AGGACCGTGT GGCCCTGCTC CTCTCTGAGG AAGTGGAATT GTCTAGCACG
CCACCACTTC CTGCCAGCAG GATTTTAAAG GAAGGGTGGG AAAGAGCGGG CCAGTGTCCT
CCTCCACCTG AACGCAAGCA GAGCTTTCTG TGGGAGGGCA GCGCACTGAC TGGGGCCTGG
GCCATGGAGG ACTTCTACAC GGCCAGGCTG GTCCCTCCTC TCGTGCCCCA GCGGCCTGCC
CAGGGCCTTA TGCAGGAGCC CGTGCCGCCT CTGGTGCCAC CTGAGCACTC AGAGCTGAGC
GAGCGAAGGT CACCCGCTCT CCACGGCACC CCCACTGCAG GCTGTGGCTC CAGGGGCCCG
TCGCCTTCGG CCAGCCAGAG GGAGCACCAG GCCCTGCAGG ACCTCGTGGA CCTGGCGAGG
GAGGGACTGA GCGCCAGCCC GTGGCCCGGC AGTGGGGGCC TGGCTGGCTC GGAAGGGACT
GCAGGGTTGG ACGTGGTGCC CGGCGGCCTT CCTCTGACTG GGTTTGTGGT GCCATCGCAG
GACAAGCACC CGGACAGGGG CGGCCGCACC TTGCTCTCCC TCGGGCTGCT GGTTGCTGAC
TTTGGCGCCA TGGTCAATAA CCCACACCTG AGTGATGTCC AGTTTCAGAC GGACAGCGGG
GAGGTGCTTT ACGCCCACAA GTTCGTGCTT TATGCCCGAT GCCCGCTCCT CATCCAGTAT
GTGAACAATG AAGGCTTCTC CGCTGTAGAG GACGGGGTTC TGACCCAGCG TGTCCTGCTG
GGTGACGTGA GCACCGAGGC CGCCCGCACG TTCCTGCACT ATCTCTACAC TGCGGACACT
GGCCTTCCTC CTGGCCTTAG CTCTGAGCTG AGCTCCCTGG CCCACAGGTT TGGCGTGAGT
GAGCTCGTTC ACCTGTGCGA ACAGGTGCCT ATTGCCACTG ACTCAGAGGG CAAACCATGG
GAGGAGAAGG AAGCAGAGAA TTGCGAAAGC AGGGCCGAGA ATTTCCAGGA ACTCTTGAGG
TCAATGTGGG CAGATGAAGA GGAGGAAGCG GAGACTTTGT TGAAATCCAA GGACCACGAA
GAAGATCAAG AAAACGTGAA TGAAGCAGAA ATGGAAGAAA TTTATGAATT TGCAGCTACT
CAGCGAAAGC TTCTCCAGGA AGAAAGGGCA GCGGGTGCCG GCGAGGACGC TGACTGGCTG
GAGGGTGGCA GTCCGGTTTC TGGGCAACTC CTAGCAGGTG TCCAGGTGCA GAAACAGTGG
GACAAGGTGG AGGAGATGGA GCCGTTGGAG CCAGGAAGAG ATGAGGCCGC CACCACCTGG
GAGAAGATGG GACAGTGCGC TCTCCCGCCA CCCCAGGGCC AGCACTCAGG GGCACGGGGA
GCAGAGGCCC CTGAGCAGGA GGCGCCAGAG GAGGCGCTTG GCCATTCCAG CTGCTCCAGC
CCTTCCAGGG ACTGCCAGGC AGAGAGAAAA GAAGGCTCTC TTCCGCACTC AGATGATGCC
GGGGATTACG AACAGCTCTT CTCATCAACT CAGGGAGAGA TCTCAGAGCC GTCCCAAATA
ACAAGTGAGC CCGAGGAACA AAGTGGCGCT GTCAGGGAAA GGGGGCTGGA GGTTTCTCAT
CGCCTGGCTC CCTGGCAGGC ATCTCCACCG CACCCGTGCC GCTTCCTATT GGGGCCTCCC
CAGGGCGGGA GTCCCCGCGG GTCTCATCAC ACAAGTGGGT CGTCCCTGTC AACACCCCGG
TCCCGTGGCG GAACTTCCCA GGTGGGCTCC CCAACCTTGC TGTCTCCAGC TGTGCCATCA
AAGCAGAAAA GGGACAGGAG CATCCTCACG CTGTCTAAAG AGCCAGGGCA CCAGAAAGGC
AAAGAGCGTC GGTCCGTGCT GGAGTGCAGA AATAAGGGGG TCCTGATGTT CCCAGAAAAA
TCTCCGTCTA TTGACCTAAC CCAGTCAAAT CCTGACCATT CGAGCTCCAG ATCTCAGAAA
TCTTCATCCA AACTGAACGA AGAAGATGAG GTCATCCTCT TACTGGACTC GGATGAGGAG
CTGGAGCTAG AACAAACCAA AATGAAGTCC ATTTCTAGTG ATCCTCTGGA AGAAAAGAAA
GCTCTAGAAA TTAGCCCTAG GTCCTGTGAG CTGTTTTCCA TCATTGATGT TGATGCAGAT
CAGGAACCTT CCCAGAGCCC ACCAAGAAGC GAAGCTGTGC TGCAGCAGGA GGATGAGGGG
GCGCTGCCGG AGAATCGGGG CTCTTTGGGC AGGAGAGGGG CTCCCTGGCT GTTCTGTGAC
CGTGAGAGCA GCCCCAGCGA GGCCAGCACC ACAGACACCT CGTGGCTGGT GCCCGCCACC
CCGCTGGCCA GCAGAAGCCG TGACTGTTCT TCCCAGACCC AAATCAGCAG CCTCAGGAGC
GGGCTGGCCG TGCAGGCGGT GACTCAGCAC ACGCCCAGGG CCTCAGTAGG AAACAGGGAA
GGGAACGAAG TCGCACAGAA GTTTTCTGTC ATCAGGCCCC AGACACCACC GCCCCAGACA
CCGTCCTCAT GCCTCACTCC CGTCTCTCCA GGAACTTCTG ACGGCAGAAG GCAAGGCCAC
AGAAGCCCTT CCCGTCCCCA CCCCGGGGGC CACCCGCACT CCTCTCCGCT GGCTCCACAT
CCCATCTCAG GGGACCGCGC CCACTTCAGC AGGCGGTTCC TGAAACACTC GCCGCCTGGG
CCAAGCTTCC TGAACCAGAC CCCAGCGGGT GAAGTGGTGG AAGTCGGAGA CAGTGACGAT
GAGCAGGAGG TGGCCTCCCA TCAGGCCAAC AGAAGCCCCC CACTGGACAG TGACCCCCCA
ATTCCAATTG ACGACTGCTG CTGGCACATG GAGCCCCTCT CGCCAATTCC CATTGACCAC
TGGAACCTGG AGCGGACCGG CCCCCTGAGC ACCAGCAGCC CCAGCCGCAG GATGAACGAG
GCCGCCGACA GCCGTGACTG TCGCTCCCCG GGACTCCTGG ACACCACCCC CATCCGAGGA
AGCTGCACTA CCCAGAGGAA ATTGCAAGAG AAGTCCTCGG GCGCGGGCTC CCTGGGGAAT
AGCAGGCCGA GCTTTCTGAA TTCGGCTCTG TGGGACGTTT GGGACGGGGA AGAGCAGAGG
CCTCCAGAGA CCCCTCCTCC GGCCCAGATG CCAAGCGCTG GTGGAGCTCA GAAGCCCGAA
GGGTTAGAGA CACCCAAAGG TGCTAATCGG AAGAAGAACT TGCCCCCCAA AGTGCCCATA
ACGCCGATGC CACAGTATTC CATTATGGAG ACGCCGGTGC TGAAGAAGGA ACTGGATAGG
TTTGGAGTCC GCCCTCTGCC TAAACGCCAG ATGGTTCTGA AGCTGAAGGA GATATTCCAG
TACACTCACC AGACCCTGGA CTCAGACTCC GAGGACGAGA GCCAGTCCTC ACAGCCGCTG
TTGCAGGCGC CTCACTGCCA GACCCTCGCC TCCCAGACCT ACAAGCCTTC AAGGGCAGGG
GTCCATGCCC AGCAGGAGGC CACCACAGGA CCTGGGGCCC ATAGGCCCAA GGGACCTGCT
AAGACCAAGG GCCCCCGACA TCAAAGGAAG CATCATGAAA GCATCACACC CCCAAGCAGG
TCGCCCACCA AGGAGGCACC TCCAGGCCTC AATGATGACG CCCAGATCCC AGCCTCTCAA
GAATCCGTGG CCACCTCTGT GGATGGCAGT GACAGCTCCT TGAGCTCACA GAGTTCTTCC
TCCTGTGAGT TTGGAGCGGC ATTTGAGTCT GCAGGTGAAG AGGAGGGCGA GGGGGAGGTC
AGTGCCTCGC AGGCAGCCGT GCAGGCGGCG GACACAGACG AGGCGCTGAG GTGCTACATC
CGCTCCAAGC CGGCCCTGTA CCAGAAGGTG CTGCTGTACC AGCCCTTTGA GCTGCGGGAG
CTGCAGGCAG AGCTGAGGCA GAACGGCCTC CGTGTGTCCT CGCGCAGGCT GTTGGACTTC
CTGGACACCC ACTGTATCAC CTTCACCACT GCCGCCACCC GCAGGGAGAA GCTCCAGGGC
AGGAGGCGGC AGCCTCGGGG CAAGAAGAAG GTGGAGCGGA ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18199
Clone ID Related Accession (Same CDS sequence) NM_032444.2 , NM_032444.3
Accession Version NM_032444.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 5505bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-09-20
Organism Homo sapiens(Human)
Product structure-specific endonuclease subunit SLX4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY246029.1, BM541728.1, BE887716.1, BC029952.1, AI380342.1, DA242337.1, HY050233.1, AA279053.1, AK095411.1, AC006111.4 and AL442083.1. On Sep 20, 2016 this sequence version replaced NM_032444.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
ATGAAACTGA GTGTGAATGA GGCTCAGCTA GGCTTCTACT TGGGTTCACT TTCTCATCTG 
TCTGCCTGTC CTGGGATTGA CCCTCGCTCC TCTGAAGACC AGCCTGAAAG CCTTAAAACT
GGTCAGATGA TGGATGAGTC TGATGAGGAC TTTAAAGAAC TCTGCGCTAG CTTTTTCCAA
AGGGTGAAAA AACATGGAAT CAAGGAAGTG TCAGGAGAAA GGAAGACACA AAAGGCTGCC
TCAAACGGCA CTCAGATAAG AAGCAAATTG AAAAGGACCA AACAAACTGC TACCAAGACC
AAAACCCTTC AAGGCCCTGC AGAGAAGAAA CCTCCGTCTG GCAGCCAGGC CCCTAGGACT
AAAAAGCAAA GGGTAACCAA ATGGCAAGCA AGTGAACCGG CCCACTCTGT GAATGGGGAG
GGGGGTGTGC TTGCCTCTGC TCCAGATCCA CCTGTGCTCC GGGAAACAGC ACAAAACACC
CAGACGGGTA ACCAGCAAGA ACCATCGCCA AACCTTTCCA GAGAGAAAAC CAGAGAGAAT
GTGCCCAACA GCGACTCCCA GCCTCCTCCT TCCTGTTTGA CAACAGCAGT GCCAAGTCCC
TCCAAACCCC GCACAGCACA ATTGGTCCTA CAGCGAATGC AGCAGTTCAA GAGAGCAGAC
CCCGAGCGTT TGAGACACGC TTCAGAAGAG TGCTCCCTCG AGGCTGCGCG GGAAGAAAAT
GTCCCAAAGG ATCCTCAAGA GGAGATGATG GCGGGGAATG TGTATGGGCT TGGGCCCCCT
GCCCCAGAGA GCGACGCTGC GGTGGCCTTG ACCCTGCAGC AGGAGTTTGC ACGGGTAGGA
GCATCGGCAC ATGATGATAG CCTGGAGGAA AAGGGTTTGT TCTTCTGCCA GATTTGTCAA
AAGAACCTCT CAGCCATGAA CGTGACCCGA AGGGAACAGC ATGTGAACAG GTGCTTGGAT
GAAGCTGAAA AGACACTAAG ACCTTCTGTG CCTCAGATCC CTGAGTGCCC GATTTGTGGG
AAACCGTTTC TTACCTTAAA GAGCAGAACC AGTCACTTGA AGCAGTGTGC TGTGAAGATG
GAGGTTGGCC CCCAGCTCCT GCTTCAGGCT GTGCGGCTGC AGACAGCACA GCCTGAGGGT
AGCAGCAGCC CACCCATGTT CAGCTTCAGT GATCACAGTA GAGGTCTGAA ACGGAGAGGA
CCCACCAGCA AGAAGGAGCC ACGGAAGAGG CGGAAGGTGG ACGAGGCACC GTCCGAGGAC
CTGCTGGTGG CCATGGCTCT GTCCCGGTCG GAGATGGAGC CGGGTGCGGC TGTACCAGCG
CTCAGGCTGG AAAGTGCCTT TTCTGAGAGG ATAAGACCAG AAGCAGAGAA TAAAAGTCGC
AAGAAGAAAC CCCCGGTATC CCCCCCATTG TTGTTAGTCC AGGACTCTGA AACCACAGGC
CGACAGATAG AGGACCGTGT GGCCCTGCTC CTCTCTGAGG AAGTGGAATT GTCTAGCACG
CCACCACTTC CTGCCAGCAG GATTTTAAAG GAAGGGTGGG AAAGAGCGGG CCAGTGTCCT
CCTCCACCTG AACGCAAGCA GAGCTTTCTG TGGGAGGGCA GCGCACTGAC TGGGGCCTGG
GCCATGGAGG ACTTCTACAC GGCCAGGCTG GTCCCTCCTC TCGTGCCCCA GCGGCCTGCC
CAGGGCCTTA TGCAGGAGCC CGTGCCGCCT CTGGTGCCAC CTGAGCACTC AGAGCTGAGC
GAGCGAAGGT CACCCGCTCT CCACGGCACC CCCACTGCAG GCTGTGGCTC CAGGGGCCCG
TCGCCTTCGG CCAGCCAGAG GGAGCACCAG GCCCTGCAGG ACCTCGTGGA CCTGGCGAGG
GAGGGACTGA GCGCCAGCCC GTGGCCCGGC AGTGGGGGCC TGGCTGGCTC GGAAGGGACT
GCAGGGTTGG ACGTGGTGCC CGGCGGCCTT CCTCTGACTG GGTTTGTGGT GCCATCGCAG
GACAAGCACC CGGACAGGGG CGGCCGCACC TTGCTCTCCC TCGGGCTGCT GGTTGCTGAC
TTTGGCGCCA TGGTCAATAA CCCACACCTG AGTGATGTCC AGTTTCAGAC GGACAGCGGG
GAGGTGCTTT ACGCCCACAA GTTCGTGCTT TATGCCCGAT GCCCGCTCCT CATCCAGTAT
GTGAACAATG AAGGCTTCTC CGCTGTAGAG GACGGGGTTC TGACCCAGCG TGTCCTGCTG
GGTGACGTGA GCACCGAGGC CGCCCGCACG TTCCTGCACT ATCTCTACAC TGCGGACACT
GGCCTTCCTC CTGGCCTTAG CTCTGAGCTG AGCTCCCTGG CCCACAGGTT TGGCGTGAGT
GAGCTCGTTC ACCTGTGCGA ACAGGTGCCT ATTGCCACTG ACTCAGAGGG CAAACCATGG
GAGGAGAAGG AAGCAGAGAA TTGCGAAAGC AGGGCCGAGA ATTTCCAGGA ACTCTTGAGG
TCAATGTGGG CAGATGAAGA GGAGGAAGCG GAGACTTTGT TGAAATCCAA GGACCACGAA
GAAGATCAAG AAAACGTGAA TGAAGCAGAA ATGGAAGAAA TTTATGAATT TGCAGCTACT
CAGCGAAAGC TTCTCCAGGA AGAAAGGGCA GCGGGTGCCG GCGAGGACGC TGACTGGCTG
GAGGGTGGCA GTCCGGTTTC TGGGCAACTC CTAGCAGGTG TCCAGGTGCA GAAACAGTGG
GACAAGGTGG AGGAGATGGA GCCGTTGGAG CCAGGAAGAG ATGAGGCCGC CACCACCTGG
GAGAAGATGG GACAGTGCGC TCTCCCGCCA CCCCAGGGCC AGCACTCAGG GGCACGGGGA
GCAGAGGCCC CTGAGCAGGA GGCGCCAGAG GAGGCGCTTG GCCATTCCAG CTGCTCCAGC
CCTTCCAGGG ACTGCCAGGC AGAGAGAAAA GAAGGCTCTC TTCCGCACTC AGATGATGCC
GGGGATTACG AACAGCTCTT CTCATCAACT CAGGGAGAGA TCTCAGAGCC GTCCCAAATA
ACAAGTGAGC CCGAGGAACA AAGTGGCGCT GTCAGGGAAA GGGGGCTGGA GGTTTCTCAT
CGCCTGGCTC CCTGGCAGGC ATCTCCACCG CACCCGTGCC GCTTCCTATT GGGGCCTCCC
CAGGGCGGGA GTCCCCGCGG GTCTCATCAC ACAAGTGGGT CGTCCCTGTC AACACCCCGG
TCCCGTGGCG GAACTTCCCA GGTGGGCTCC CCAACCTTGC TGTCTCCAGC TGTGCCATCA
AAGCAGAAAA GGGACAGGAG CATCCTCACG CTGTCTAAAG AGCCAGGGCA CCAGAAAGGC
AAAGAGCGTC GGTCCGTGCT GGAGTGCAGA AATAAGGGGG TCCTGATGTT CCCAGAAAAA
TCTCCGTCTA TTGACCTAAC CCAGTCAAAT CCTGACCATT CGAGCTCCAG ATCTCAGAAA
TCTTCATCCA AACTGAACGA AGAAGATGAG GTCATCCTCT TACTGGACTC GGATGAGGAG
CTGGAGCTAG AACAAACCAA AATGAAGTCC ATTTCTAGTG ATCCTCTGGA AGAAAAGAAA
GCTCTAGAAA TTAGCCCTAG GTCCTGTGAG CTGTTTTCCA TCATTGATGT TGATGCAGAT
CAGGAACCTT CCCAGAGCCC ACCAAGAAGC GAAGCTGTGC TGCAGCAGGA GGATGAGGGG
GCGCTGCCGG AGAATCGGGG CTCTTTGGGC AGGAGAGGGG CTCCCTGGCT GTTCTGTGAC
CGTGAGAGCA GCCCCAGCGA GGCCAGCACC ACAGACACCT CGTGGCTGGT GCCCGCCACC
CCGCTGGCCA GCAGAAGCCG TGACTGTTCT TCCCAGACCC AAATCAGCAG CCTCAGGAGC
GGGCTGGCCG TGCAGGCGGT GACTCAGCAC ACGCCCAGGG CCTCAGTAGG AAACAGGGAA
GGGAACGAAG TCGCACAGAA GTTTTCTGTC ATCAGGCCCC AGACACCACC GCCCCAGACA
CCGTCCTCAT GCCTCACTCC CGTCTCTCCA GGAACTTCTG ACGGCAGAAG GCAAGGCCAC
AGAAGCCCTT CCCGTCCCCA CCCCGGGGGC CACCCGCACT CCTCTCCGCT GGCTCCACAT
CCCATCTCAG GGGACCGCGC CCACTTCAGC AGGCGGTTCC TGAAACACTC GCCGCCTGGG
CCAAGCTTCC TGAACCAGAC CCCAGCGGGT GAAGTGGTGG AAGTCGGAGA CAGTGACGAT
GAGCAGGAGG TGGCCTCCCA TCAGGCCAAC AGAAGCCCCC CACTGGACAG TGACCCCCCA
ATTCCAATTG ACGACTGCTG CTGGCACATG GAGCCCCTCT CGCCAATTCC CATTGACCAC
TGGAACCTGG AGCGGACCGG CCCCCTGAGC ACCAGCAGCC CCAGCCGCAG GATGAACGAG
GCCGCCGACA GCCGTGACTG TCGCTCCCCG GGACTCCTGG ACACCACCCC CATCCGAGGA
AGCTGCACTA CCCAGAGGAA ATTGCAAGAG AAGTCCTCGG GCGCGGGCTC CCTGGGGAAT
AGCAGGCCGA GCTTTCTGAA TTCGGCTCTG TGGGACGTTT GGGACGGGGA AGAGCAGAGG
CCTCCAGAGA CCCCTCCTCC GGCCCAGATG CCAAGCGCTG GTGGAGCTCA GAAGCCCGAA
GGGTTAGAGA CACCCAAAGG TGCTAATCGG AAGAAGAACT TGCCCCCCAA AGTGCCCATA
ACGCCGATGC CACAGTATTC CATTATGGAG ACGCCGGTGC TGAAGAAGGA ACTGGATAGG
TTTGGAGTCC GCCCTCTGCC TAAACGCCAG ATGGTTCTGA AGCTGAAGGA GATATTCCAG
TACACTCACC AGACCCTGGA CTCAGACTCC GAGGACGAGA GCCAGTCCTC ACAGCCGCTG
TTGCAGGCGC CTCACTGCCA GACCCTCGCC TCCCAGACCT ACAAGCCTTC AAGGGCAGGG
GTCCATGCCC AGCAGGAGGC CACCACAGGA CCTGGGGCCC ATAGGCCCAA GGGACCTGCT
AAGACCAAGG GCCCCCGACA TCAAAGGAAG CATCATGAAA GCATCACACC CCCAAGCAGG
TCGCCCACCA AGGAGGCACC TCCAGGCCTC AATGATGACG CCCAGATCCC AGCCTCTCAA
GAATCCGTGG CCACCTCTGT GGATGGCAGT GACAGCTCCT TGAGCTCACA GAGTTCTTCC
TCCTGTGAGT TTGGAGCGGC ATTTGAGTCT GCAGGTGAAG AGGAGGGCGA GGGGGAGGTC
AGTGCCTCGC AGGCAGCCGT GCAGGCGGCG GACACAGACG AGGCGCTGAG GTGCTACATC
CGCTCCAAGC CGGCCCTGTA CCAGAAGGTG CTGCTGTACC AGCCCTTTGA GCTGCGGGAG
CTGCAGGCAG AGCTGAGGCA GAACGGCCTC CGTGTGTCCT CGCGCAGGCT GTTGGACTTC
CTGGACACCC ACTGTATCAC CTTCACCACT GCCGCCACCC GCAGGGAGAA GCTCCAGGGC
AGGAGGCGGC AGCCTCGGGG CAAGAAGAAG GTGGAGCGGA ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115820.2
CDS650..6154
Misc Feature(1)635..637
Misc Feature(2)650..2656
Misc Feature(3)1154..1156
Misc Feature(4)1508..1510
Misc Feature(5)2690..3013
Misc Feature(6)2699..6151
Misc Feature(7)2744..3013
Misc Feature(8)3731..3733
Misc Feature(9)3779..3781
Misc Feature(10)3857..3859
Misc Feature(11)4010..4012
Misc Feature(12)4052..4054
Misc Feature(13)4202..4204
Misc Feature(14)4631..5593
Misc Feature(15)5039..5041
Misc Feature(16)5054..5056
Misc Feature(17)5477..5479
Misc Feature(18)5543..6151
Misc Feature(19)5909..6079
Exon (1)1..47
Exon (2)48..1184
Exon (3)1185..1409
Exon (4)1410..1599
Exon (5)1600..1812
Exon (6)1813..2015
Exon (7)2016..2332
Exon (8)2333..2573
Exon (9)2574..2662
Exon (10)2663..2809
Exon (11)2810..2976
Exon (12)2977..5285
Exon (13)5286..5388
Exon (14)5389..5802
Exon (15)5803..7315
Translation

Target ORF information:

RefSeq Version NM_032444.3
Organism Homo sapiens(Human)
Definition Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032444.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
ATGAAACTGA GTGTGAATGA GGCTCAGCTA GGCTTCTACT TGGGTTCACT TTCTCATCTG 
TCTGCCTGTC CTGGGATTGA CCCTCGCTCC TCTGAAGACC AGCCTGAAAG CCTTAAAACT
GGTCAGATGA TGGATGAGTC TGATGAGGAC TTTAAAGAAC TCTGCGCTAG CTTTTTCCAA
AGGGTGAAAA AACATGGAAT CAAGGAAGTG TCAGGAGAAA GGAAGACACA AAAGGCTGCC
TCAAACGGCA CTCAGATAAG AAGCAAATTG AAAAGGACCA AACAAACTGC TACCAAGACC
AAAACCCTTC AAGGCCCTGC AGAGAAGAAA CCTCCGTCTG GCAGCCAGGC CCCTAGGACT
AAAAAGCAAA GGGTAACCAA ATGGCAAGCA AGTGAACCGG CCCACTCTGT GAATGGGGAG
GGGGGTGTGC TTGCCTCTGC TCCAGATCCA CCTGTGCTCC GGGAAACAGC ACAAAACACC
CAGACGGGTA ACCAGCAAGA ACCATCGCCA AACCTTTCCA GAGAGAAAAC CAGAGAGAAT
GTGCCCAACA GCGACTCCCA GCCTCCTCCT TCCTGTTTGA CAACAGCAGT GCCAAGTCCC
TCCAAACCCC GCACAGCACA ATTGGTCCTA CAGCGAATGC AGCAGTTCAA GAGAGCAGAC
CCCGAGCGTT TGAGACACGC TTCAGAAGAG TGCTCCCTCG AGGCTGCGCG GGAAGAAAAT
GTCCCAAAGG ATCCTCAAGA GGAGATGATG GCGGGGAATG TGTATGGGCT TGGGCCCCCT
GCCCCAGAGA GCGACGCTGC GGTGGCCTTG ACCCTGCAGC AGGAGTTTGC ACGGGTAGGA
GCATCGGCAC ATGATGATAG CCTGGAGGAA AAGGGTTTGT TCTTCTGCCA GATTTGTCAA
AAGAACCTCT CAGCCATGAA CGTGACCCGA AGGGAACAGC ATGTGAACAG GTGCTTGGAT
GAAGCTGAAA AGACACTAAG ACCTTCTGTG CCTCAGATCC CTGAGTGCCC GATTTGTGGG
AAACCGTTTC TTACCTTAAA GAGCAGAACC AGTCACTTGA AGCAGTGTGC TGTGAAGATG
GAGGTTGGCC CCCAGCTCCT GCTTCAGGCT GTGCGGCTGC AGACAGCACA GCCTGAGGGT
AGCAGCAGCC CACCCATGTT CAGCTTCAGT GATCACAGTA GAGGTCTGAA ACGGAGAGGA
CCCACCAGCA AGAAGGAGCC ACGGAAGAGG CGGAAGGTGG ACGAGGCACC GTCCGAGGAC
CTGCTGGTGG CCATGGCTCT GTCCCGGTCG GAGATGGAGC CGGGTGCGGC TGTACCAGCG
CTCAGGCTGG AAAGTGCCTT TTCTGAGAGG ATAAGACCAG AAGCAGAGAA TAAAAGTCGC
AAGAAGAAAC CCCCGGTATC CCCCCCATTG TTGTTAGTCC AGGACTCTGA AACCACAGGC
CGACAGATAG AGGACCGTGT GGCCCTGCTC CTCTCTGAGG AAGTGGAATT GTCTAGCACG
CCACCACTTC CTGCCAGCAG GATTTTAAAG GAAGGGTGGG AAAGAGCGGG CCAGTGTCCT
CCTCCACCTG AACGCAAGCA GAGCTTTCTG TGGGAGGGCA GCGCACTGAC TGGGGCCTGG
GCCATGGAGG ACTTCTACAC GGCCAGGCTG GTCCCTCCTC TCGTGCCCCA GCGGCCTGCC
CAGGGCCTTA TGCAGGAGCC CGTGCCGCCT CTGGTGCCAC CTGAGCACTC AGAGCTGAGC
GAGCGAAGGT CACCCGCTCT CCACGGCACC CCCACTGCAG GCTGTGGCTC CAGGGGCCCG
TCGCCTTCGG CCAGCCAGAG GGAGCACCAG GCCCTGCAGG ACCTCGTGGA CCTGGCGAGG
GAGGGACTGA GCGCCAGCCC GTGGCCCGGC AGTGGGGGCC TGGCTGGCTC GGAAGGGACT
GCAGGGTTGG ACGTGGTGCC CGGCGGCCTT CCTCTGACTG GGTTTGTGGT GCCATCGCAG
GACAAGCACC CGGACAGGGG CGGCCGCACC TTGCTCTCCC TCGGGCTGCT GGTTGCTGAC
TTTGGCGCCA TGGTCAATAA CCCACACCTG AGTGATGTCC AGTTTCAGAC GGACAGCGGG
GAGGTGCTTT ACGCCCACAA GTTCGTGCTT TATGCCCGAT GCCCGCTCCT CATCCAGTAT
GTGAACAATG AAGGCTTCTC CGCTGTAGAG GACGGGGTTC TGACCCAGCG TGTCCTGCTG
GGTGACGTGA GCACCGAGGC CGCCCGCACG TTCCTGCACT ATCTCTACAC TGCGGACACT
GGCCTTCCTC CTGGCCTTAG CTCTGAGCTG AGCTCCCTGG CCCACAGGTT TGGCGTGAGT
GAGCTCGTTC ACCTGTGCGA ACAGGTGCCT ATTGCCACTG ACTCAGAGGG CAAACCATGG
GAGGAGAAGG AAGCAGAGAA TTGCGAAAGC AGGGCCGAGA ATTTCCAGGA ACTCTTGAGG
TCAATGTGGG CAGATGAAGA GGAGGAAGCG GAGACTTTGT TGAAATCCAA GGACCACGAA
GAAGATCAAG AAAACGTGAA TGAAGCAGAA ATGGAAGAAA TTTATGAATT TGCAGCTACT
CAGCGAAAGC TTCTCCAGGA AGAAAGGGCA GCGGGTGCCG GCGAGGACGC TGACTGGCTG
GAGGGTGGCA GTCCGGTTTC TGGGCAACTC CTAGCAGGTG TCCAGGTGCA GAAACAGTGG
GACAAGGTGG AGGAGATGGA GCCGTTGGAG CCAGGAAGAG ATGAGGCCGC CACCACCTGG
GAGAAGATGG GACAGTGCGC TCTCCCGCCA CCCCAGGGCC AGCACTCAGG GGCACGGGGA
GCAGAGGCCC CTGAGCAGGA GGCGCCAGAG GAGGCGCTTG GCCATTCCAG CTGCTCCAGC
CCTTCCAGGG ACTGCCAGGC AGAGAGAAAA GAAGGCTCTC TTCCGCACTC AGATGATGCC
GGGGATTACG AACAGCTCTT CTCATCAACT CAGGGAGAGA TCTCAGAGCC GTCCCAAATA
ACAAGTGAGC CCGAGGAACA AAGTGGCGCT GTCAGGGAAA GGGGGCTGGA GGTTTCTCAT
CGCCTGGCTC CCTGGCAGGC ATCTCCACCG CACCCGTGCC GCTTCCTATT GGGGCCTCCC
CAGGGCGGGA GTCCCCGCGG GTCTCATCAC ACAAGTGGGT CGTCCCTGTC AACACCCCGG
TCCCGTGGCG GAACTTCCCA GGTGGGCTCC CCAACCTTGC TGTCTCCAGC TGTGCCATCA
AAGCAGAAAA GGGACAGGAG CATCCTCACG CTGTCTAAAG AGCCAGGGCA CCAGAAAGGC
AAAGAGCGTC GGTCCGTGCT GGAGTGCAGA AATAAGGGGG TCCTGATGTT CCCAGAAAAA
TCTCCGTCTA TTGACCTAAC CCAGTCAAAT CCTGACCATT CGAGCTCCAG ATCTCAGAAA
TCTTCATCCA AACTGAACGA AGAAGATGAG GTCATCCTCT TACTGGACTC GGATGAGGAG
CTGGAGCTAG AACAAACCAA AATGAAGTCC ATTTCTAGTG ATCCTCTGGA AGAAAAGAAA
GCTCTAGAAA TTAGCCCTAG GTCCTGTGAG CTGTTTTCCA TCATTGATGT TGATGCAGAT
CAGGAACCTT CCCAGAGCCC ACCAAGAAGC GAAGCTGTGC TGCAGCAGGA GGATGAGGGG
GCGCTGCCGG AGAATCGGGG CTCTTTGGGC AGGAGAGGGG CTCCCTGGCT GTTCTGTGAC
CGTGAGAGCA GCCCCAGCGA GGCCAGCACC ACAGACACCT CGTGGCTGGT GCCCGCCACC
CCGCTGGCCA GCAGAAGCCG TGACTGTTCT TCCCAGACCC AAATCAGCAG CCTCAGGAGC
GGGCTGGCCG TGCAGGCGGT GACTCAGCAC ACGCCCAGGG CCTCAGTAGG AAACAGGGAA
GGGAACGAAG TCGCACAGAA GTTTTCTGTC ATCAGGCCCC AGACACCACC GCCCCAGACA
CCGTCCTCAT GCCTCACTCC CGTCTCTCCA GGAACTTCTG ACGGCAGAAG GCAAGGCCAC
AGAAGCCCTT CCCGTCCCCA CCCCGGGGGC CACCCGCACT CCTCTCCGCT GGCTCCACAT
CCCATCTCAG GGGACCGCGC CCACTTCAGC AGGCGGTTCC TGAAACACTC GCCGCCTGGG
CCAAGCTTCC TGAACCAGAC CCCAGCGGGT GAAGTGGTGG AAGTCGGAGA CAGTGACGAT
GAGCAGGAGG TGGCCTCCCA TCAGGCCAAC AGAAGCCCCC CACTGGACAG TGACCCCCCA
ATTCCAATTG ACGACTGCTG CTGGCACATG GAGCCCCTCT CGCCAATTCC CATTGACCAC
TGGAACCTGG AGCGGACCGG CCCCCTGAGC ACCAGCAGCC CCAGCCGCAG GATGAACGAG
GCCGCCGACA GCCGTGACTG TCGCTCCCCG GGACTCCTGG ACACCACCCC CATCCGAGGA
AGCTGCACTA CCCAGAGGAA ATTGCAAGAG AAGTCCTCGG GCGCGGGCTC CCTGGGGAAT
AGCAGGCCGA GCTTTCTGAA TTCGGCTCTG TGGGACGTTT GGGACGGGGA AGAGCAGAGG
CCTCCAGAGA CCCCTCCTCC GGCCCAGATG CCAAGCGCTG GTGGAGCTCA GAAGCCCGAA
GGGTTAGAGA CACCCAAAGG TGCTAATCGG AAGAAGAACT TGCCCCCCAA AGTGCCCATA
ACGCCGATGC CACAGTATTC CATTATGGAG ACGCCGGTGC TGAAGAAGGA ACTGGATAGG
TTTGGAGTCC GCCCTCTGCC TAAACGCCAG ATGGTTCTGA AGCTGAAGGA GATATTCCAG
TACACTCACC AGACCCTGGA CTCAGACTCC GAGGACGAGA GCCAGTCCTC ACAGCCGCTG
TTGCAGGCGC CTCACTGCCA GACCCTCGCC TCCCAGACCT ACAAGCCTTC AAGGGCAGGG
GTCCATGCCC AGCAGGAGGC CACCACAGGA CCTGGGGCCC ATAGGCCCAA GGGACCTGCT
AAGACCAAGG GCCCCCGACA TCAAAGGAAG CATCATGAAA GCATCACACC CCCAAGCAGG
TCGCCCACCA AGGAGGCACC TCCAGGCCTC AATGATGACG CCCAGATCCC AGCCTCTCAA
GAATCCGTGG CCACCTCTGT GGATGGCAGT GACAGCTCCT TGAGCTCACA GAGTTCTTCC
TCCTGTGAGT TTGGAGCGGC ATTTGAGTCT GCAGGTGAAG AGGAGGGCGA GGGGGAGGTC
AGTGCCTCGC AGGCAGCCGT GCAGGCGGCG GACACAGACG AGGCGCTGAG GTGCTACATC
CGCTCCAAGC CGGCCCTGTA CCAGAAGGTG CTGCTGTACC AGCCCTTTGA GCTGCGGGAG
CTGCAGGCAG AGCTGAGGCA GAACGGCCTC CGTGTGTCCT CGCGCAGGCT GTTGGACTTC
CTGGACACCC ACTGTATCAC CTTCACCACT GCCGCCACCC GCAGGGAGAA GCTCCAGGGC
AGGAGGCGGC AGCCTCGGGG CAAGAAGAAG GTGGAGCGGA ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73552
Clone ID Related Accession (Same CDS sequence) XM_011522715.2
Accession Version XM_011522715.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 5502bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product structure-specific endonuclease subunit SLX4 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011522715.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
ATGAAACTGA GTGTGAATGA GGCTCAGCTA GGCTTCTACT TGGGTTCACT TTCTCATCTG 
TCTGCCTGTC CTGGGATTGA CCCTCGCTCC TCTGAAGACC AGCCTGAAAG CCTTAAAACT
GGTCAGATGA TGGATGAGTC TGATGAGGAC TTTAAAGAAC TCTGCGCTAG CTTTTTCCAA
AGGGTGAAAA AACATGGAAT CAAGGAAGTG TCAGGAGAAA GGAAGACACA AAAGGCTGCC
TCAAACGGCA CTCAGATAAG AAGCAAATTG AAAAGGACCA AACAAACTGC TACCAAGACC
AAAACCCTTC AAGGCCCTGC AGAGAAGAAA CCTCCGTCTG GCAGCCAGGC CCCTAGGACT
AAAAAGCAAA GGGTAACCAA ATGGCAAGCA AGTGAACCGG CCCACTCTGT GAATGGGGAG
GGGGGTGTGC TTGCCTCTGC TCCAGATCCA CCTGTGCTCC GGGAAACAGC ACAAAACACC
CAGACGGGTA ACCAGCAAGA ACCATCGCCA AACCTTTCCA GAGAGAAAAC CAGAGAGAAT
GTGCCCAACA GCGACTCCCA GCCTCCTCCT TCCTGTTTGA CAACAGCAGT GCCAAGTCCC
TCCAAACCCC GCACAGCACA ATTGGTCCTA CAGCGAATGC AGCAGTTCAA GAGAGCAGAC
CCCGAGCGTT TGAGACACGC TTCAGAAGAG TGCTCCCTCG AGGCTGCGCG GGAAGAAAAT
GTCCCAAAGG ATCCTCAAGA GGAGATGATG GCGGGGAATG TGTATGGGCT TGGGCCCCCT
GCCCCAGAGA GCGACGCTGC GGTGGCCTTG ACCCTGCAGC AGGAGTTTGC ACGGGTAGGA
GCATCGGCAC ATGATGATAG CCTGGAGGAA AAGGGTTTGT TCTTCTGCCA GATTTGTCAA
AAGAACCTCT CAGCCATGAA CGTGACCCGA AGGGAACAGC ATGTGAACAG GTGCTTGGAT
GAAGCTGAAA AGACACTAAG ACCTTCTGTG CCTCAGATCC CTGAGTGCCC GATTTGTGGG
AAACCGTTTC TTACCTTAAA GAGCAGAACC AGTCACTTGA AGCAGTGTGC TGTGAAGATG
GAGGTTGGCC CCCAGCTCCT GCTTCAGGCT GTGCGGCTGC AGACAGCACA GCCTGAGGGT
AGCAGCAGCC CACCCATGTT CAGCTTCAGT GATCACAGTA GAGGTCTGAA ACGGAGAGGA
CCCACCAGCA AGAAGGAGCC ACGGAAGAGG CGGAAGGTGG ACGAGGCACC GTCCGAGGAC
CTGCTGGTGG CCATGGCTCT GTCCCGGTCG GAGATGGAGC CGGGTGCGGC TGTACCAGCG
CTCAGGCTGG AAAGTGCCTT TTCTGAGAGG ATAAGACCAG AAGCAGAGAA TAAAAGTCGC
AAGAAGAAAC CCCCGGTATC CCCCCCATTG TTGTTAGTCC AGGACTCTGA AACCACAGGC
CGACAGATAG AGGACCGTGT GGCCCTGCTC CTCTCTGAGG AAGTGGAATT GTCTAGCACG
CCACCACTTC CTGCCAGCAG GATTTTAAAG GAAGGGTGGG AAAGAGCGGG CCAGTGTCCT
CCTCCACCTG AACGCAAGCA GAGCTTTCTG TGGGAGGGCA GCGCACTGAC TGGGGCCTGG
GCCATGGAGG ACTTCTACAC GGCCAGGCTG GTCCCTCCTC TCGTGCCCCA GCGGCCTGCC
CAGGGCCTTA TGCAGGAGCC CGTGCCGCCT CTGGTGCCAC CTGAGCACTC AGAGCTGAGC
GAGCGAAGGT CACCCGCTCT CCACGGCACC CCCACTGCAG GCTGTGGCTC CAGGGGCCCG
TCGCCTTCGG CCAGCCAGAG GGAGCACCAG GCCCTGCAGG ACCTCGTGGA CCTGGCGAGG
GAGGGACTGA GCGCCAGCCC GTGGCCCGGC AGTGGGGGCC TGGCTGGCTC GGAAGGGACT
GCAGGGTTGG ACGTGGTGCC CGGCGGCCTT CCTCTGACTG GGTTTGTGGT GCCATCGCAG
GACAAGCACC CGGACAGGGG CGGCCGCACC TTGCTCTCCC TCGGGCTGCT GGTTGCTGAC
TTTGGCGCCA TGGTCAATAA CCCACACCTG AGTGATGTCC AGTTTCAGAC GGACAGCGGG
GAGGTGCTTT ACGCCCACAA GTTCGTGCTT TATGCCCGAT GCCCGCTCCT CATCCAGTAT
GTGAACAATG AAGGCTTCTC CGCTGTAGAG GACGGGGTTC TGACCCAGCG TGTCCTGCTG
GGTGACGTGA GCACCGAGGC CGCCCGCACG TTCCTGCACT ATCTCTACAC TGCGGACACT
GGCCTTCCTC CTGGCCTTAG CTCTGAGCTG AGCTCCCTGG CCCACAGGTT TGGCGTGAGT
GAGCTCGTTC ACCTGTGCGA ACAGGTGCCT ATTGCCACTG ACTCAGAGGG CAAACCATGG
GAGGAGAAGG AAGCAGAGAA TTGCGAAAGC AGGGCCGAGA ATTTCCAGGA ACTCTTGAGG
TCAATGTGGG CAGATGAAGA GGAGGAAGCG GAGACTTTGT TGAAATCCAA GGACCACGAA
GAAGATCAAG AAAACGTGAA TGAAGCAGAA ATGGAAGAAA TTTATGAATT TGCAGCTACT
CAGCGAAAGC TTCTCCAGGA AGAAAGGGCA GCGGGTGCCG GCGAGGACGC TGACTGGCTG
GAGGGTGGCA GTCCGGTTTC TGGGCAACTC CTAGCAGGTG TCCAGGTGCA GAAACAGTGG
GACAAGGTGG AGGAGATGGA GCCGTTGGAG CCAGGAAGAG ATGAGGCCGC CACCACCTGG
GAGAAGATGG GACAGTGCGC TCTCCCGCCA CCCCAGGGCC AGCACTCAGG GGCACGGGGA
GCAGAGGCCC CTGAGCAGGA GGCGCCAGAG GAGGCGCTTG GCCATTCCAG CTGCTCCAGC
CCTTCCAGGG ACTGCCAGGC AGAGAGAAAA GAAGGCTCTC TTCCGCACTC AGATGATGCC
GGGGATTACG AACAGCTCTT CTCATCAACT CAGGGAGAGA TCTCAGAGCC GTCCCAAATA
ACAAGTGAGC CCGAGGAACA AAGTGGCGCT GTCAGGGAAA GGGGGCTGGA GGTTTCTCAT
CGCCTGGCTC CCTGGCAGGC ATCTCCACCG CACCCGTGCC GCTTCCTATT GGGGCCTCCC
CAGGGCGGGA GTCCCCGCGG GTCTCATCAC ACAAGTGGGT CGTCCCTGTC AACACCCCGG
TCCCGTGGCG GAACTTCCCA GGTGGGCTCC CCAACCTTGC TGTCTCCAGC TGTGCCATCA
AAGCAGAAAA GGGACAGGAG CATCCTCACG CTGTCTAAAG AGCCAGGGCA CCAGAAAGGC
AAAGAGCGTC GGTCCGTGCT GGAGTGCAGA AATAAGGGGG TCCTGATGTT CCCAGAAAAA
TCTCCGTCTA TTGACCTAAC CCAGTCAAAT CCTGACCATT CGAGCTCCAG ATCTCAGAAA
TCTTCATCCA AACTGAACGA AGAAGATGAG GTCATCCTCT TACTGGACTC GGATGAGGAG
CTGGAGCTAG AACAAACCAA AATGAAGTCC ATTTCTAGTG ATCCTCTGGA AGAAAAGAAA
GCTCTAGAAA TTAGCCCTAG GTCCTGTGAG CTGTTTTCCA TCATTGATGT TGATGCAGAT
CAGGAACCTT CCCAGAGCCC ACCAAGAAGC GAAGCTGTGC TGCAGCAGGA GGATGAGGGG
GCGCTGCCGG AGAATCGGGG CTCTTTGGGC AGGAGAGGGG CTCCCTGGCT GTTCTGTGAC
CGTGAGAGCA GCCCCAGCGA GGCCAGCACC ACAGACACCT CGTGGCTGGT GCCCGCCACC
CCGCTGGCCA GCAGAAGCCG TGACTGTTCT TCCCAGACCC AAATCAGCAG CCTCAGGAGC
GGGCTGGCCG TGCAGGCGGT GACTCAGCAC ACGCCCAGGG CCTCAGTAGG AAACAGGGAA
GGGAACGAAG TCGCACAGAA GTTTTCTGTC ATCAGGCCCC AGACACCACC GCCCCAGACA
CCGTCCTCAT GCCTCACTCC CGTCTCTCCA GGAACTTCTG ACGGCAGAAG GCAAGGCCAC
AGAAGCCCTT CCCGTCCCCA CCCCGGGGGC CACCCGCACT CCTCTCCGCT GGCTCCACAT
CCCATCTCAG GGGACCGCGC CCACTTCAGC AGGCGGTTCC TGAAACACTC GCCGCCTGGG
CCAAGCTTCC TGAACCAGAC CCCAGCGGGT GAAGTGGTGG AAGTCGGAGA CAGTGACGAT
GAGCAGGAGG TGGCCTCCCA TCAGGCCAAC AGAAGCCCCC CACTGGACAG TGACCCCCCA
ATTCCAATTG ACGACTGCTG CTGGCACATG GAGCCCCTCT CGCCAATTCC CATTGACCAC
TGGAACCTGG AGCGGACCGG CCCCCTGAGC ACCAGCAGCC CCAGCCGCAG GATGAACGAG
GCCGCCGACA GCCGTGACTG TCGCTCCCCG GGACTCCTGG ACACCACCCC CATCCGAGGA
AGCTGCACTA CCCAGAGGAA ATTGCAAGAG AAGTCCTCGG GCGCGGGCTC CCTGGGGAAT
AGCAGGCCGA GCTTTCTGAA TTCGGCTCTG TGGGACGTTT GGGACGGGGA AGAGCAGAGG
CCTCCAGAGA CCCCTCCTCC GGCCCAGATG CCAAGCGCTG GTGGAGCTCA GAAGCCCGAA
GGGTTAGAGA CACCCAGTGC TAATCGGAAG AAGAACTTGC CCCCCAAAGT GCCCATAACG
CCGATGCCAC AGTATTCCAT TATGGAGACG CCGGTGCTGA AGAAGGAACT GGATAGGTTT
GGAGTCCGCC CTCTGCCTAA ACGCCAGATG GTTCTGAAGC TGAAGGAGAT ATTCCAGTAC
ACTCACCAGA CCCTGGACTC AGACTCCGAG GACGAGAGCC AGTCCTCACA GCCGCTGTTG
CAGGCGCCTC ACTGCCAGAC CCTCGCCTCC CAGACCTACA AGCCTTCAAG GGCAGGGGTC
CATGCCCAGC AGGAGGCCAC CACAGGACCT GGGGCCCATA GGCCCAAGGG ACCTGCTAAG
ACCAAGGGCC CCCGACATCA AAGGAAGCAT CATGAAAGCA TCACACCCCC AAGCAGGTCG
CCCACCAAGG AGGCACCTCC AGGCCTCAAT GATGACGCCC AGATCCCAGC CTCTCAAGAA
TCCGTGGCCA CCTCTGTGGA TGGCAGTGAC AGCTCCTTGA GCTCACAGAG TTCTTCCTCC
TGTGAGTTTG GAGCGGCATT TGAGTCTGCA GGTGAAGAGG AGGGCGAGGG GGAGGTCAGT
GCCTCGCAGG CAGCCGTGCA GGCGGCGGAC ACAGACGAGG CGCTGAGGTG CTACATCCGC
TCCAAGCCGG CCCTGTACCA GAAGGTGCTG CTGTACCAGC CCTTTGAGCT GCGGGAGCTG
CAGGCAGAGC TGAGGCAGAA CGGCCTCCGT GTGTCCTCGC GCAGGCTGTT GGACTTCCTG
GACACCCACT GTATCACCTT CACCACTGCC GCCACCCGCA GGGAGAAGCT CCAGGGCAGG
AGGCGGCAGC CTCGGGGCAA GAAGAAGGTG GAGCGGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011521017.1
CDS642..6143
Misc Feature(1)2682..3005
Misc Feature(2)2736..3005
Misc Feature(3)5898..6068
Translation

Target ORF information:

RefSeq Version XM_011522715.2
Organism Homo sapiens(Human)
Definition Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011522715.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
ATGAAACTGA GTGTGAATGA GGCTCAGCTA GGCTTCTACT TGGGTTCACT TTCTCATCTG 
TCTGCCTGTC CTGGGATTGA CCCTCGCTCC TCTGAAGACC AGCCTGAAAG CCTTAAAACT
GGTCAGATGA TGGATGAGTC TGATGAGGAC TTTAAAGAAC TCTGCGCTAG CTTTTTCCAA
AGGGTGAAAA AACATGGAAT CAAGGAAGTG TCAGGAGAAA GGAAGACACA AAAGGCTGCC
TCAAACGGCA CTCAGATAAG AAGCAAATTG AAAAGGACCA AACAAACTGC TACCAAGACC
AAAACCCTTC AAGGCCCTGC AGAGAAGAAA CCTCCGTCTG GCAGCCAGGC CCCTAGGACT
AAAAAGCAAA GGGTAACCAA ATGGCAAGCA AGTGAACCGG CCCACTCTGT GAATGGGGAG
GGGGGTGTGC TTGCCTCTGC TCCAGATCCA CCTGTGCTCC GGGAAACAGC ACAAAACACC
CAGACGGGTA ACCAGCAAGA ACCATCGCCA AACCTTTCCA GAGAGAAAAC CAGAGAGAAT
GTGCCCAACA GCGACTCCCA GCCTCCTCCT TCCTGTTTGA CAACAGCAGT GCCAAGTCCC
TCCAAACCCC GCACAGCACA ATTGGTCCTA CAGCGAATGC AGCAGTTCAA GAGAGCAGAC
CCCGAGCGTT TGAGACACGC TTCAGAAGAG TGCTCCCTCG AGGCTGCGCG GGAAGAAAAT
GTCCCAAAGG ATCCTCAAGA GGAGATGATG GCGGGGAATG TGTATGGGCT TGGGCCCCCT
GCCCCAGAGA GCGACGCTGC GGTGGCCTTG ACCCTGCAGC AGGAGTTTGC ACGGGTAGGA
GCATCGGCAC ATGATGATAG CCTGGAGGAA AAGGGTTTGT TCTTCTGCCA GATTTGTCAA
AAGAACCTCT CAGCCATGAA CGTGACCCGA AGGGAACAGC ATGTGAACAG GTGCTTGGAT
GAAGCTGAAA AGACACTAAG ACCTTCTGTG CCTCAGATCC CTGAGTGCCC GATTTGTGGG
AAACCGTTTC TTACCTTAAA GAGCAGAACC AGTCACTTGA AGCAGTGTGC TGTGAAGATG
GAGGTTGGCC CCCAGCTCCT GCTTCAGGCT GTGCGGCTGC AGACAGCACA GCCTGAGGGT
AGCAGCAGCC CACCCATGTT CAGCTTCAGT GATCACAGTA GAGGTCTGAA ACGGAGAGGA
CCCACCAGCA AGAAGGAGCC ACGGAAGAGG CGGAAGGTGG ACGAGGCACC GTCCGAGGAC
CTGCTGGTGG CCATGGCTCT GTCCCGGTCG GAGATGGAGC CGGGTGCGGC TGTACCAGCG
CTCAGGCTGG AAAGTGCCTT TTCTGAGAGG ATAAGACCAG AAGCAGAGAA TAAAAGTCGC
AAGAAGAAAC CCCCGGTATC CCCCCCATTG TTGTTAGTCC AGGACTCTGA AACCACAGGC
CGACAGATAG AGGACCGTGT GGCCCTGCTC CTCTCTGAGG AAGTGGAATT GTCTAGCACG
CCACCACTTC CTGCCAGCAG GATTTTAAAG GAAGGGTGGG AAAGAGCGGG CCAGTGTCCT
CCTCCACCTG AACGCAAGCA GAGCTTTCTG TGGGAGGGCA GCGCACTGAC TGGGGCCTGG
GCCATGGAGG ACTTCTACAC GGCCAGGCTG GTCCCTCCTC TCGTGCCCCA GCGGCCTGCC
CAGGGCCTTA TGCAGGAGCC CGTGCCGCCT CTGGTGCCAC CTGAGCACTC AGAGCTGAGC
GAGCGAAGGT CACCCGCTCT CCACGGCACC CCCACTGCAG GCTGTGGCTC CAGGGGCCCG
TCGCCTTCGG CCAGCCAGAG GGAGCACCAG GCCCTGCAGG ACCTCGTGGA CCTGGCGAGG
GAGGGACTGA GCGCCAGCCC GTGGCCCGGC AGTGGGGGCC TGGCTGGCTC GGAAGGGACT
GCAGGGTTGG ACGTGGTGCC CGGCGGCCTT CCTCTGACTG GGTTTGTGGT GCCATCGCAG
GACAAGCACC CGGACAGGGG CGGCCGCACC TTGCTCTCCC TCGGGCTGCT GGTTGCTGAC
TTTGGCGCCA TGGTCAATAA CCCACACCTG AGTGATGTCC AGTTTCAGAC GGACAGCGGG
GAGGTGCTTT ACGCCCACAA GTTCGTGCTT TATGCCCGAT GCCCGCTCCT CATCCAGTAT
GTGAACAATG AAGGCTTCTC CGCTGTAGAG GACGGGGTTC TGACCCAGCG TGTCCTGCTG
GGTGACGTGA GCACCGAGGC CGCCCGCACG TTCCTGCACT ATCTCTACAC TGCGGACACT
GGCCTTCCTC CTGGCCTTAG CTCTGAGCTG AGCTCCCTGG CCCACAGGTT TGGCGTGAGT
GAGCTCGTTC ACCTGTGCGA ACAGGTGCCT ATTGCCACTG ACTCAGAGGG CAAACCATGG
GAGGAGAAGG AAGCAGAGAA TTGCGAAAGC AGGGCCGAGA ATTTCCAGGA ACTCTTGAGG
TCAATGTGGG CAGATGAAGA GGAGGAAGCG GAGACTTTGT TGAAATCCAA GGACCACGAA
GAAGATCAAG AAAACGTGAA TGAAGCAGAA ATGGAAGAAA TTTATGAATT TGCAGCTACT
CAGCGAAAGC TTCTCCAGGA AGAAAGGGCA GCGGGTGCCG GCGAGGACGC TGACTGGCTG
GAGGGTGGCA GTCCGGTTTC TGGGCAACTC CTAGCAGGTG TCCAGGTGCA GAAACAGTGG
GACAAGGTGG AGGAGATGGA GCCGTTGGAG CCAGGAAGAG ATGAGGCCGC CACCACCTGG
GAGAAGATGG GACAGTGCGC TCTCCCGCCA CCCCAGGGCC AGCACTCAGG GGCACGGGGA
GCAGAGGCCC CTGAGCAGGA GGCGCCAGAG GAGGCGCTTG GCCATTCCAG CTGCTCCAGC
CCTTCCAGGG ACTGCCAGGC AGAGAGAAAA GAAGGCTCTC TTCCGCACTC AGATGATGCC
GGGGATTACG AACAGCTCTT CTCATCAACT CAGGGAGAGA TCTCAGAGCC GTCCCAAATA
ACAAGTGAGC CCGAGGAACA AAGTGGCGCT GTCAGGGAAA GGGGGCTGGA GGTTTCTCAT
CGCCTGGCTC CCTGGCAGGC ATCTCCACCG CACCCGTGCC GCTTCCTATT GGGGCCTCCC
CAGGGCGGGA GTCCCCGCGG GTCTCATCAC ACAAGTGGGT CGTCCCTGTC AACACCCCGG
TCCCGTGGCG GAACTTCCCA GGTGGGCTCC CCAACCTTGC TGTCTCCAGC TGTGCCATCA
AAGCAGAAAA GGGACAGGAG CATCCTCACG CTGTCTAAAG AGCCAGGGCA CCAGAAAGGC
AAAGAGCGTC GGTCCGTGCT GGAGTGCAGA AATAAGGGGG TCCTGATGTT CCCAGAAAAA
TCTCCGTCTA TTGACCTAAC CCAGTCAAAT CCTGACCATT CGAGCTCCAG ATCTCAGAAA
TCTTCATCCA AACTGAACGA AGAAGATGAG GTCATCCTCT TACTGGACTC GGATGAGGAG
CTGGAGCTAG AACAAACCAA AATGAAGTCC ATTTCTAGTG ATCCTCTGGA AGAAAAGAAA
GCTCTAGAAA TTAGCCCTAG GTCCTGTGAG CTGTTTTCCA TCATTGATGT TGATGCAGAT
CAGGAACCTT CCCAGAGCCC ACCAAGAAGC GAAGCTGTGC TGCAGCAGGA GGATGAGGGG
GCGCTGCCGG AGAATCGGGG CTCTTTGGGC AGGAGAGGGG CTCCCTGGCT GTTCTGTGAC
CGTGAGAGCA GCCCCAGCGA GGCCAGCACC ACAGACACCT CGTGGCTGGT GCCCGCCACC
CCGCTGGCCA GCAGAAGCCG TGACTGTTCT TCCCAGACCC AAATCAGCAG CCTCAGGAGC
GGGCTGGCCG TGCAGGCGGT GACTCAGCAC ACGCCCAGGG CCTCAGTAGG AAACAGGGAA
GGGAACGAAG TCGCACAGAA GTTTTCTGTC ATCAGGCCCC AGACACCACC GCCCCAGACA
CCGTCCTCAT GCCTCACTCC CGTCTCTCCA GGAACTTCTG ACGGCAGAAG GCAAGGCCAC
AGAAGCCCTT CCCGTCCCCA CCCCGGGGGC CACCCGCACT CCTCTCCGCT GGCTCCACAT
CCCATCTCAG GGGACCGCGC CCACTTCAGC AGGCGGTTCC TGAAACACTC GCCGCCTGGG
CCAAGCTTCC TGAACCAGAC CCCAGCGGGT GAAGTGGTGG AAGTCGGAGA CAGTGACGAT
GAGCAGGAGG TGGCCTCCCA TCAGGCCAAC AGAAGCCCCC CACTGGACAG TGACCCCCCA
ATTCCAATTG ACGACTGCTG CTGGCACATG GAGCCCCTCT CGCCAATTCC CATTGACCAC
TGGAACCTGG AGCGGACCGG CCCCCTGAGC ACCAGCAGCC CCAGCCGCAG GATGAACGAG
GCCGCCGACA GCCGTGACTG TCGCTCCCCG GGACTCCTGG ACACCACCCC CATCCGAGGA
AGCTGCACTA CCCAGAGGAA ATTGCAAGAG AAGTCCTCGG GCGCGGGCTC CCTGGGGAAT
AGCAGGCCGA GCTTTCTGAA TTCGGCTCTG TGGGACGTTT GGGACGGGGA AGAGCAGAGG
CCTCCAGAGA CCCCTCCTCC GGCCCAGATG CCAAGCGCTG GTGGAGCTCA GAAGCCCGAA
GGGTTAGAGA CACCCAGTGC TAATCGGAAG AAGAACTTGC CCCCCAAAGT GCCCATAACG
CCGATGCCAC AGTATTCCAT TATGGAGACG CCGGTGCTGA AGAAGGAACT GGATAGGTTT
GGAGTCCGCC CTCTGCCTAA ACGCCAGATG GTTCTGAAGC TGAAGGAGAT ATTCCAGTAC
ACTCACCAGA CCCTGGACTC AGACTCCGAG GACGAGAGCC AGTCCTCACA GCCGCTGTTG
CAGGCGCCTC ACTGCCAGAC CCTCGCCTCC CAGACCTACA AGCCTTCAAG GGCAGGGGTC
CATGCCCAGC AGGAGGCCAC CACAGGACCT GGGGCCCATA GGCCCAAGGG ACCTGCTAAG
ACCAAGGGCC CCCGACATCA AAGGAAGCAT CATGAAAGCA TCACACCCCC AAGCAGGTCG
CCCACCAAGG AGGCACCTCC AGGCCTCAAT GATGACGCCC AGATCCCAGC CTCTCAAGAA
TCCGTGGCCA CCTCTGTGGA TGGCAGTGAC AGCTCCTTGA GCTCACAGAG TTCTTCCTCC
TGTGAGTTTG GAGCGGCATT TGAGTCTGCA GGTGAAGAGG AGGGCGAGGG GGAGGTCAGT
GCCTCGCAGG CAGCCGTGCA GGCGGCGGAC ACAGACGAGG CGCTGAGGTG CTACATCCGC
TCCAAGCCGG CCCTGTACCA GAAGGTGCTG CTGTACCAGC CCTTTGAGCT GCGGGAGCTG
CAGGCAGAGC TGAGGCAGAA CGGCCTCCGT GTGTCCTCGC GCAGGCTGTT GGACTTCCTG
GACACCCACT GTATCACCTT CACCACTGCC GCCACCCGCA GGGAGAAGCT CCAGGGCAGG
AGGCGGCAGC CTCGGGGCAA GAAGAAGGTG GAGCGGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation.
International journal of radiation oncology, biology, physics95(1)78-85(2016 May)
Liu Q,Underwood TS,Kung J,Wang M,Lu HM,Paganetti H,Held KD,Hong TS,Efstathiou JA,Willers H


book

Physical interaction between SLX4 (FANCP) and XPF (FANCQ) proteins and biological consequences of interaction-defective missense mutations.
DNA repair3548-54(2015 Nov)
Hashimoto K,Wada K,Matsumoto K,Moriya M


book

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.
EMBO reports16(4)512-9(2015 Apr)
González-Prieto R,Cuijpers SA,Luijsterburg MS,van Attikum H,Vertegaal AC


book

Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.
Molecular cell57(1)108-22(2015 Jan)
Ouyang J,Garner E,Hallet A,Nguyen HD,Rickman KA,Gill G,Smogorzewska A,Zou L


book

The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.
Molecular cell57(1)123-37(2015 Jan)
Guervilly JH,Takedachi A,Naim V,Scaglione S,Chawhan C,Lovera Y,Despras E,Kuraoka I,Kannouche P,Rosselli F,Gaillard PH


 
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