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HES7 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol HES7
Entrez Gene ID 84667
Full Name hes family bHLH transcription factor 7
Synonyms SCDO4,bHLHb37
General protein information
Preferred Names

hes family bHLH transcription factor 7

Names

transcription factor HES-7
bHLH factor Hes7
class B basic helix-loop-helix protein 37
hHes7
hairy and enhancer of split 7

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

17

17p13.1

Summary This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
Disorder MIM:

608059

Disorder Html: Spondylocostal dysostosis 4, autosomal recessive, 613686 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_032580.3 NP_115969.2 transcription factor HES-7 isoform 2
NM_001165967.1 NP_001159439.1 transcription factor HES-7 isoform 1
XM_017025232.1 XP_016880721.1 transcription factor HES-7 isoform X1
XM_011524041.2 XP_011522343.1 transcription factor HES-7 isoform X2



Mus musculus (house mouse) Hes7 NP_149030.2
Homo sapiens (human) HES7 NP_115969.2
Canis lupus familiaris (dog) HES7 XP_850055.2
Rattus norvegicus (Norway rat) Hes7 NP_001099262.1
Bos taurus (cattle) HES7 NP_001193208.1
Xenopus tropicalis (tropical clawed frog) LOC100135364 NP_001107508.1


Related articles in PubMed

Whole exome sequencing in an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation.
Netravathi M, Kumari R, Kapoor S, Dakle P, Dwivedi MK, Roy SD, Pandey P, Saini J, Ramakrishna A, Navalli D, Satishchandra P, Pal PK, Kumar A, Faruq M
BMC medical genetics165(2015 Feb)

Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus.
Sparrow DB, Faqeih EA, Sallout B, Alswaid A, Ababneh F, Al-Sayed M, Rukban H, Eyaid WM, Kageyama R, Ellard S, Turnpenny PD, Dunwoodie SL
American journal of medical genetics. Part A161A(9)2244-9(2013 Sep)

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.
Qiu XS, Zhou S, Jiang H, Ji ML, Ding Q, Lv F, Liu Z, Tang N, Cheng JC, Qiu Y
Studies in health technology and informatics17652-5(2012)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D
Human immunology71(7)727-30(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation
Title: Whole exome sequencing in an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation.

mutation of HES7 is uniquely associated with defects in vertebral, heart and neural tube formation, and this observation will help provide a discriminatory diagnostic guide in patients with SCD, as well as inform molecular genetic testing.
Title: Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus.

MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Title: Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.

The following HES7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HES7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu22574 NM_001165967.1
Latest version!
Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $188.30
$269.00
OHu22579 NM_032580.3
Latest version!
Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $188.30
$269.00
OHu73665 XM_017025232.1
Latest version!
Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
OHu73667 XM_011524041.2
Latest version!
Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22574
Clone ID Related Accession (Same CDS sequence) NM_001165967.1
Accession Version NM_001165967.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 693bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-09-16
Organism Homo sapiens(Human)
Product transcription factor HES-7 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI259590.1, BC039887.1 and AC129492.6. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039887.1, BI335370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02400288, SAMN02400289 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGCCGC CGCGGCTCCA
GGGGTTCCCC GGTCCCCAGT CCAGGACGCC GAGGCGCTCG CCAGCTGCTA CTTGTCCGGT
TTCCGCGAGT GCCTGCTTCG CTTGGCGGCC TTCGCGCACG ACGCCAGCCC GGCCGCCCGC
GCCCAGCTCT TCTCCGCGCT GCACGGCTAT CTGCGCCCCA AACCGCCCCG GCCCAAGCCG
GTAGATCCGA GGCCTCCAGC GCCGCGCCCA TCCCTGGACC CCGCCGCACC GGCCCTTGGC
CCTGCGCTGC ACCAGCGCCC CCCAGTGCAC CAGGGCCACC CTAGCCCGCG CTGCGCATGG
TCCCCATCCC TCTGCTCCCC GCGCGCCGGG GATTCTGGCG CGCCGGCGCC CCTCACCGGA
CTGCTGCCGC CGCCACCGCC GCCTCACAGA CAAGACGGGG CGCCCAAGGC CCCGCTGCCC
CCGCCGCCCG CTTTCTGGAG ACCTTGGCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001159439.1
CDS9..701
Misc Feature(1)48..227
Misc Feature(2)order(48..50,66..74,78..80,162..164,171..173)
Misc Feature(3)69..71
Misc Feature(4)order(87..92,99..104,108..113,174..176,183..185,195..197,201..206,216..218,222..227)
Exon (1)1..50
Exon (2)51..146
Exon (3)147..234
Exon (4)235..1682
Translation

Target ORF information:

RefSeq Version NM_001165967.1
Organism Homo sapiens(Human)
Definition Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001165967.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGCCGC CGCGGCTCCA
GGGGTTCCCC GGTCCCCAGT CCAGGACGCC GAGGCGCTCG CCAGCTGCTA CTTGTCCGGT
TTCCGCGAGT GCCTGCTTCG CTTGGCGGCC TTCGCGCACG ACGCCAGCCC GGCCGCCCGC
GCCCAGCTCT TCTCCGCGCT GCACGGCTAT CTGCGCCCCA AACCGCCCCG GCCCAAGCCG
GTAGATCCGA GGCCTCCAGC GCCGCGCCCA TCCCTGGACC CCGCCGCACC GGCCCTTGGC
CCTGCGCTGC ACCAGCGCCC CCCAGTGCAC CAGGGCCACC CTAGCCCGCG CTGCGCATGG
TCCCCATCCC TCTGCTCCCC GCGCGCCGGG GATTCTGGCG CGCCGGCGCC CCTCACCGGA
CTGCTGCCGC CGCCACCGCC GCCTCACAGA CAAGACGGGG CGCCCAAGGC CCCGCTGCCC
CCGCCGCCCG CTTTCTGGAG ACCTTGGCCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22579
Clone ID Related Accession (Same CDS sequence) NM_032580.3
Accession Version NM_032580.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 678bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-12-31
Organism Homo sapiens(Human)
Product transcription factor HES-7 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI259590.1, AB049064.1, AC129492.6 and BC039887.1. This sequence is a reference standard in the RefSeqGene project. On Oct 1, 2009 this sequence version replaced NM_032580.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) lacks a five amino acid segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB049064.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115969.2
CDS9..686
Misc Feature(1)48..227
Misc Feature(2)order(48..50,66..74,78..80,162..164,171..173)
Misc Feature(3)69..71
Misc Feature(4)order(87..92,99..104,108..113,174..176,183..185,195..197,201..206,216..218,222..227)
Misc Feature(5)516..518
Misc Feature(6)669..680
Exon (1)1..50
Exon (2)51..146
Exon (3)147..234
Exon (4)235..1667
Translation

Target ORF information:

RefSeq Version NM_032580.3
Organism Homo sapiens(Human)
Definition Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032580.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGTCACCC GGGATCGAGC TGAGAATAGG GACGGCCCCA AGATGCTCAA GCCGCTTGTG 
GAGAAGCGGC GCCGGGACCG CATCAACCGC AGCCTGGAAG AGCTGAGGCT GCTGCTGCTG
GAGCGGACCC GGGACCAGAA CCTCCGGAAC CCGAAGCTGG AGAAAGCGGA GATATTGGAG
TTCGCCGTGG GCTACTTGAG GGAGCGAAGC CGGGTGGAGC CCCCGGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73665
Clone ID Related Accession (Same CDS sequence) XM_017025232.1
Accession Version XM_017025232.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 798bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product transcription factor HES-7 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTCGAAGG GGGCGGGGTC GGGTCCTATC CCTCCTACCC TTGGGCCGCG GAATATAAGG 
CTCCAGGCGA GCAGGGAACC GGTCCACACA GGGTCCGGAG GAGCAATGGT CACCCGGGAT
CGAGCTGAGA ATAGGGACGG CCCCAAGATG CTCAAGCCGC TTGTGGAGAA GCGGCGCCGG
GACCGCATCA ACCGCAGCCT GGAAGAGCTG AGGCTGCTGC TGCTGGAGCG GACCCGGGAC
CAGAACCTCC GGAACCCGAA GCTGGAGAAA GCGGAGATAT TGGAGTTCGC CGTGGGCTAC
TTGAGGGAGC GAAGCCGGGT GGAGCCCCCG GCCGCCGCGG CTCCAGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016880721.1
CDS1498..2295
Misc Feature(1)1642..1821
Misc Feature(2)order(1642..1644,1660..1668,1672..1674,1756..1758,1765..1767)
Misc Feature(3)1663..1665
Misc Feature(4)order(1681..1686,1693..1695,1735..1737,1741..1746,1768..1770,1777..1779,1789..1791,1795..1800,1810..1812,1816..1821)
Translation

Target ORF information:

RefSeq Version XM_017025232.1
Organism Homo sapiens(Human)
Definition Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017025232.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTCGAAGG GGGCGGGGTC GGGTCCTATC CCTCCTACCC TTGGGCCGCG GAATATAAGG 
CTCCAGGCGA GCAGGGAACC GGTCCACACA GGGTCCGGAG GAGCAATGGT CACCCGGGAT
CGAGCTGAGA ATAGGGACGG CCCCAAGATG CTCAAGCCGC TTGTGGAGAA GCGGCGCCGG
GACCGCATCA ACCGCAGCCT GGAAGAGCTG AGGCTGCTGC TGCTGGAGCG GACCCGGGAC
CAGAACCTCC GGAACCCGAA GCTGGAGAAA GCGGAGATAT TGGAGTTCGC CGTGGGCTAC
TTGAGGGAGC GAAGCCGGGT GGAGCCCCCG GCCGCCGCGG CTCCAGGGGT TCCCCGGTCC
CCAGTCCAGG ACGCCGAGGC GCTCGCCAGC TGCTACTTGT CCGGTTTCCG CGAGTGCCTG
CTTCGCTTGG CGGCCTTCGC GCACGACGCC AGCCCGGCCG CCCGCGCCCA GCTCTTCTCC
GCGCTGCACG GCTATCTGCG CCCCAAACCG CCCCGGCCCA AGCCGGTAGA TCCGAGGCCT
CCAGCGCCGC GCCCATCCCT GGACCCCGCC GCACCGGCCC TTGGCCCTGC GCTGCACCAG
CGCCCCCCAG TGCACCAGGG CCACCCTAGC CCGCGCTGCG CATGGTCCCC ATCCCTCTGC
TCCCCGCGCG CCGGGGATTC TGGCGCGCCG GCGCCCCTCA CCGGACTGCT GCCGCCGCCA
CCGCCGCCTC ACAGACAAGA CGGGGCGCCC AAGGCCCCGC TGCCCCCGCC GCCCGCTTTC
TGGAGACCTT GGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu73667
Clone ID Related Accession (Same CDS sequence) XM_011524041.2
Accession Version XM_011524041.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 780bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product transcription factor HES-7 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011524041.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCAGGG GCGGCCCCAC ACCCGGGTGC GAACAGCCGG GGGCCCCCAG CCTCGCGTGC 
AGACACTTTG TCCTGAAGCC CTCGAGTGGT CAGGCATCGT TCTGCGGAGG GTCATGCTCT
TGGTTTGAGA TGCTCAAGCC GCTTGTGGAG AAGCGGCGCC GGGACCGCAT CAACCGCAGC
CTGGAAGAGC TGAGGCTGCT GCTGCTGGAG CGGACCCGGG ACCAGAACCT CCGGAACCCG
AAGCTGGAGA AAGCGGAGAT ATTGGAGTTC GCCGTGGGCT ACTTGAGGGA GCGAAGCCGG
GTGGAGCCCC CGGCCGCCGC GGCTCCAGGG GTTCCCCGGT CCCCAGTCCA GGACGCCGAG
GCGCTCGCCA GCTGCTACTT GTCCGGTTTC CGCGAGTGCC TGCTTCGCTT GGCGGCCTTC
GCGCACGACG CCAGCCCGGC CGCCCGCGCC CAGCTCTTCT CCGCGCTGCA CGGCTATCTG
CGCCCCAAAC CGCCCCGGCC CAAGCCGGTA GATCCGAGGC CTCCAGCGCC GCGCCCATCC
CTGGACCCCG CCGCACCGGC CCTTGGCCCT GCGCTGCACC AGCGCCCCCC AGTGCACCAG
GGCCACCCTA GCCCGCGCTG CGCATGGTCC CCATCCCTCT GCTCCCCGCG CGCCGGGGAT
TCTGGCGCGC CGGCGCCCCT CACCGGACTG CTGCCGCCGC CACCGCCGCC TCACAGACAA
GACGGGGCGC CCAAGGCCCC GCTGCCCCCG CCGCCCGCTT TCTGGAGACC TTGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011522343.1
CDS460..1239
Misc Feature(1)595..765
Misc Feature(2)607..609
Misc Feature(3)order(625..630,637..639,679..681,685..690,712..714,721..723,733..735,739..744,754..756,760..765)
Translation

Target ORF information:

RefSeq Version XM_011524041.2
Organism Homo sapiens(Human)
Definition Homo sapiens hes family bHLH transcription factor 7 (HES7), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011524041.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCAGGG GCGGCCCCAC ACCCGGGTGC GAACAGCCGG GGGCCCCCAG CCTCGCGTGC 
AGACACTTTG TCCTGAAGCC CTCGAGTGGT CAGGCATCGT TCTGCGGAGG GTCATGCTCT
TGGTTTGAGA TGCTCAAGCC GCTTGTGGAG AAGCGGCGCC GGGACCGCAT CAACCGCAGC
CTGGAAGAGC TGAGGCTGCT GCTGCTGGAG CGGACCCGGG ACCAGAACCT CCGGAACCCG
AAGCTGGAGA AAGCGGAGAT ATTGGAGTTC GCCGTGGGCT ACTTGAGGGA GCGAAGCCGG
GTGGAGCCCC CGGCCGCCGC GGCTCCAGGG GTTCCCCGGT CCCCAGTCCA GGACGCCGAG
GCGCTCGCCA GCTGCTACTT GTCCGGTTTC CGCGAGTGCC TGCTTCGCTT GGCGGCCTTC
GCGCACGACG CCAGCCCGGC CGCCCGCGCC CAGCTCTTCT CCGCGCTGCA CGGCTATCTG
CGCCCCAAAC CGCCCCGGCC CAAGCCGGTA GATCCGAGGC CTCCAGCGCC GCGCCCATCC
CTGGACCCCG CCGCACCGGC CCTTGGCCCT GCGCTGCACC AGCGCCCCCC AGTGCACCAG
GGCCACCCTA GCCCGCGCTG CGCATGGTCC CCATCCCTCT GCTCCCCGCG CGCCGGGGAT
TCTGGCGCGC CGGCGCCCCT CACCGGACTG CTGCCGCCGC CACCGCCGCC TCACAGACAA
GACGGGGCGC CCAAGGCCCC GCTGCCCCCG CCGCCCGCTT TCTGGAGACC TTGGCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Whole exome sequencing in an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation.
BMC medical genetics165(2015 Feb)
Netravathi M,Kumari R,Kapoor S,Dakle P,Dwivedi MK,Roy SD,Pandey P,Saini J,Ramakrishna A,Navalli D,Satishchandra P,Pal PK,Kumar A,Faruq M


book

Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus.
American journal of medical genetics. Part A161A(9)2244-9(2013 Sep)
Sparrow DB,Faqeih EA,Sallout B,Alswaid A,Ababneh F,Al-Sayed M,Rukban H,Eyaid WM,Kageyama R,Ellard S,Turnpenny PD,Dunwoodie SL


book

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.
Studies in health technology and informatics17652-5(2012)
Qiu XS,Zhou S,Jiang H,Ji ML,Ding Q,Lv F,Liu Z,Tang N,Cheng JC,Qiu Y


book

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,


book

Polymorphisms in innate immunity genes and risk of childhood leukemia.
Human immunology71(7)727-30(2010 Jul)
Han S,Lan Q,Park AK,Lee KM,Park SK,Ahn HS,Shin HY,Kang HJ,Koo HH,Seo JJ,Choi JE,Ahn YO,Chanock SJ,Kim H,Rothman N,Kang D


 
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