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EIF3G cDNA ORF clone, Homo sapiens(Human)

Gene Symbol EIF3G
Entrez Gene ID 8666
Full Name eukaryotic translation initiation factor 3 subunit G
Synonyms EIF3-P42,EIF3S4,eIF3-delta,eIF3-p44
General protein information
Preferred Names

eukaryotic translation initiation factor 3 subunit G

Names

eukaryotic translation initiation factor 3 subunit G
eukaryotic translation initiation factor 3 RNA-binding subunit
eukaryotic translation initiation factor 3 subunit p42
eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

19

19p13.2

Summary This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016].
Disorder MIM:

603913


mRNA and Protein(s)

mRNA Protein Name
NM_003755.3 NP_003746.2 eukaryotic translation initiation factor 3 subunit G
NM_003755.4 NP_003746.2 eukaryotic translation initiation factor 3 subunit G



Gallus gallus (chicken) EIF3G XP_004950534.1
Danio rerio (zebrafish) eif3g NP_957293.1
Caenorhabditis elegans (roundworm) eif-3.G NP_495778.1
Eremothecium gossypii AGOS_ADR189W NP_984285.1
Neurospora crassa NCU08046 XP_962716.2
Homo sapiens (human) EIF3G NP_003746.2
Mus musculus (house mouse) Eif3g NP_058572.2
Oryza sativa (rice) Os02g0788400 NP_001048347.1
Macaca mulatta (rhesus monkey) EIF3G XP_001104633.2
Drosophila melanogaster (fruit fly) CG10881 NP_650887.1
Magnaporthe oryzae (rice blast fungus) MGG_07109 XP_003715298.1
Xenopus tropicalis (tropical clawed frog) eif3s4 NP_001016749.1
Drosophila melanogaster (fruit fly) CG8636 NP_570011.1
Anopheles gambiae (African malaria mosquito) EIF3G_ANOGA XP_308202.3
Kluyveromyces lactis KLLA0B00847g XP_451568.1
Pan troglodytes (chimpanzee) EIF3G XP_001162705.1
Canis lupus familiaris (dog) EIF3G XP_854113.1
Bos taurus (cattle) EIF3G NP_001073091.1
Rattus norvegicus (Norway rat) Eif3g NP_001013113.1
Saccharomyces cerevisiae (baker's yeast) TIF35 NP_010717.1
Schizosaccharomyces pombe (fission yeast) tif35 NP_595727.1


Related articles in PubMed

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Simonetti A, Brito Querido J, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y
Molecular cell63(2)206-17(2016 Jul)

Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells.
Zheng Q, Liu H, Ye J, Zhang H, Jia Z, Cao J
Molecular medicine reports13(4)2973-80(2016 Apr)

EIF3G is associated with narcolepsy across ethnicities.
Holm A, Lin L, Faraco J, Mostafavi S, Battle A, Zhu X, Levinson DF, Han F, Gammeltoft S, Jennum P, Mignot E, Kornum BR
European journal of human genetics : EJHG23(11)1573-80(2015 Nov)

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.
Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N
Molecular and cellular biology34(6)1046-53(2014 Mar)

Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).
Kim JT, Lee SJ, Kim BY, Lee CH, Yeom YI, Choe YK, Yoon DY, Chae SK, Kim JW, Yang Y, Lim JS, Lee HG
FEBS letters587(22)3668-74(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The disease-associated allele increases EIF3G mRNA expression. EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression.
Title: EIF3G is associated with narcolepsy across ethnicities.

Important roles for eIF3g in the translation initiation machinery and in DNA degradation during apoptosis.
Title: Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).

down-regulation of eIF3g inhibits the efficiency of nonsense-mediated mRNA decay, which is tightly coupled to CT but not to ET
Title: Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.

PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
Title: Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.

AIF overexpression specifically resulted in the activation of caspase-7, thereby amplifying the inhibition of protein
Title: Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).

The following EIF3G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF3G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu03521 NM_003755.4
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Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
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OHu03521 NM_003755.3 Homo sapiens eukaryotic translation initiation factor 3, subunit G (EIF3G), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu03521
Clone ID Related Accession (Same CDS sequence) NM_003755.3 , NM_003755.4
Accession Version NM_003755.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 963bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product eukaryotic translation initiation factor 3 subunit G
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003746.2
Translation

Target ORF information:

RefSeq Version NM_003755.3
Organism Homo sapiens(Human)
Definition Homo sapiens eukaryotic translation initiation factor 3, subunit G (EIF3G), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003755.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03521
Clone ID Related Accession (Same CDS sequence) NM_003755.3 , NM_003755.4
Accession Version NM_003755.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 963bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-07-22
Organism Homo sapiens(Human)
Product eukaryotic translation initiation factor 3 subunit G
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from DC356593.1, BC000733.2 and AA588881.1. This sequence is a reference standard in the RefSeqGene project. On Jul 14, 2016 this sequence version replaced NM_003755.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.189429.1, BC008469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003746.2
CDS66..1028
Misc Feature(1)87..89
Misc Feature(2)96..98
Misc Feature(3)177..179
Misc Feature(4)186..188
Misc Feature(5)186..188
Misc Feature(6)186..188
Misc Feature(7)189..191
Misc Feature(8)189..191
Misc Feature(9)249..584
Misc Feature(10)603..>1016
Misc Feature(11)630..632
Misc Feature(12)732..734
Misc Feature(13)783..1013
Misc Feature(14)855..857
Exon (1)1..85
Exon (2)86..132
Exon (3)133..216
Exon (4)217..305
Exon (5)306..365
Exon (6)366..470
Exon (7)471..660
Exon (8)661..768
Exon (9)769..905
Exon (10)906..1012
Exon (11)1013..1128
Translation

Target ORF information:

RefSeq Version NM_003755.4
Organism Homo sapiens(Human)
Definition Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003755.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Molecular cell63(2)206-17(2016 Jul)
Simonetti A,Brito Querido J,Myasnikov AG,Mancera-Martinez E,Renaud A,Kuhn L,Hashem Y


book

Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells.
Molecular medicine reports13(4)2973-80(2016 Apr)
Zheng Q,Liu H,Ye J,Zhang H,Jia Z,Cao J


book

EIF3G is associated with narcolepsy across ethnicities.
European journal of human genetics : EJHG23(11)1573-80(2015 Nov)
Holm A,Lin L,Faraco J,Mostafavi S,Battle A,Zhu X,Levinson DF,Han F,Gammeltoft S,Jennum P,Mignot E,Kornum BR


book

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.
Molecular and cellular biology34(6)1046-53(2014 Mar)
Martineau Y,Wang X,Alain T,Petroulakis E,Shahbazian D,Fabre B,Bousquet-Dubouch MP,Monsarrat B,Pyronnet S,Sonenberg N


book

Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).
FEBS letters587(22)3668-74(2013 Nov)
Kim JT,Lee SJ,Kim BY,Lee CH,Yeom YI,Choe YK,Yoon DY,Chae SK,Kim JW,Yang Y,Lim JS,Lee HG


 
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