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SYNGAP1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SYNGAP1
Entrez Gene ID 8831
Full Name synaptic Ras GTPase activating protein 1
Synonyms MRD5, RASA1, RASA5, SYNGAP
General protein information
Preferred Names
ras GTPase-activating protein SynGAP
Names
ras GTPase-activating protein SynGAP
neuronal RasGAP
synaptic Ras GTPase-activating protein 1
synaptic Ras GTPase activating protein, 135kDa
synaptic Ras GTPase activating protein 1 homolog
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009]. lac of sum
Disorder MIM:

603384

Disorder Html: Mental retardation, autosomal dominant 5, 612621 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_006772 NP_006763 ras/Rap GTPase-activating protein SynGAP



Homo sapiens (human) SYNGAP1 NP_006763.2
Pan troglodytes (chimpanzee) SYNGAP1 XP_003311264.1
Macaca mulatta (Rhesus monkey) SYNGAP1 XP_001109824.1
Canis lupus familiaris (dog) SYNGAP1 XP_005627810.1
Bos taurus (cattle) SYNGAP1 NP_001192395.1
Mus musculus (house mouse) Syngap1 NP_001268420.1
Rattus norvegicus (Norway rat) Syngap1 NP_851606.3
Danio rerio (zebrafish) LOC100151149 XP_001919204.4
Danio rerio (zebrafish) si:dkeyp-24a7.8 XP_005159373.1
Xenopus (Silurana) tropicalis (western clawed frog) syngap1 NP_001128288.1


Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SYNGAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SYNGAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18330 NM_006772 Homo sapiens synaptic Ras GTPase activating protein 1 (SYNGAP1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 25 $923.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18330
Clone ID Related Accession (Same CDS sequence) NM_006772
Accession Version NM_006772.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 4032bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ras/Rap GTPase-activating protein SynGAP
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA057307.1, AK307888.1, AK094225.1, AL713634.1, BX282051.1 and BM354009.1. This sequence is a reference standard in the RefSeqGene project. On Jul 15, 2008 this sequence version replaced gi:54607095. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
ATGAGCAGGT CTCGAGCCTC CATCCATCGG GGGAGCATCC CCGCGATGTC CTATGCCCCC 
TTCAGAGATG TACGGGGACC CTCTATGCAC CGAACCCAAT ACGTTCATTC CCCGTATGAT
CGTCCTGGTT GGAACCCTCG GTTCTGCATC ATCTCGGGGA ACCAGCTGCT CATGCTGGAT
GAGGATGAGA TACACCCCCT ACTGATCCGG GACCGGAGGA GCGAGTCCAG TCGCAACAAA
CTGCTGAGAC GCACAGTCTC CGTGCCGGTG GAGGGGCGGC CCCACGGCGA GCATGAATAC
CACTTGGGTC GCTCGAGGAG GAAGAGTGTC CCAGGGGGGA AGCAGTACAG CATGGAGGGT
GCCCCTGCTG CGCCCTTCCG GCCCTCGCAA GGCTTCCTGA GCCGACGGCT AAAAAGCTCC
ATCAAACGAA CGAAGTCACA ACCCAAACTT GACCGGACCA GCAGCTTTCG CCAGATCCTG
CCTCGCTTCC GAAGTGCTGA CCATGACCGG GCCCGGCTGA TGCAAAGCTT TAAGGAGTCA
CACTCTCATG AGTCCTTGCT GAGTCCTAGC AGTGCAGCTG AGGCATTGGA GCTCAACTTG
GATGAAGATT CCATTATCAA GCCAGTGCAC AGCTCCATCC TGGGCCAGGA GTTCTGTTTT
GAGGTAACAA CTTCATCAGG AACAAAATGC TTTGCCTGTC GGTCTGCGGC CGAAAGAGAC
AAATGGATTG AGAATCTGCA GCGGGCAGTA AAGCCCAACA AGGACAACAG CCGCCGGGTA
GACAATGTGC TAAAGCTGTG GATCATAGAG GCCCGGGAGC TGCCCCCCAA GAAGCGGTAC
TACTGTGAGC TCTGCCTGGA TGACATGCTG TATGCACGCA CCACCTCCAA GCCCCGCTCT
GCCTCTGGGG ACACCGTCTT CTGGGGCGAG CACTTCGAGT TTAACAACCT GCCGGCTGTC
CGTGCCCTGC GGCTGCATCT GTACCGTGAC TCAGACAAAA AGCGCAAGAA GGACAAGGCA
GGCTATGTCG GCCTGGTGAC TGTGCCAGTG GCCACCCTGG CTGGGCGCCA CTTCACAGAG
CAGTGGTACC CTGTAACCCT GCCAACAGGC AGTGGGGGAT CTGGGGGCAT GGGTTCGGGA
GGGGGAGGGG GCTCGGGGGG TGGCTCAGGG GGCAAGGGCA AAGGAGGTTG CCCGGCTGTG
CGGCTGAAAG CACGTTACCA GACAATGAGC ATCTTGCCCA TGGAGCTATA TAAAGAGTTT
GCAGAGTATG TCACCAACCA TTATCGGATG CTGTGTGCAG TCTTGGAGCC CGCCCTGAAT
GTCAAAGGCA AGGAGGAGGT TGCCAGTGCA CTAGTTCACA TCCTGCAGAG TACAGGCAAG
GCCAAGGACT TCCTTTCAGA CATGGCCATG TCTGAGGTAG ACCGGTTCAT GGAACGGGAG
CACCTCATAT TCCGCGAGAA CACGCTTGCC ACTAAAGCCA TAGAAGAGTA TATGAGACTG
ATTGGTCAGA AATACCTCAA GGATGCCATT GGAGAATTCA TCCGTGCTCT GTATGAATCT
GAGGAAAACT GCGAGGTAGA CCCTATCAAG TGCACAGCAT CCAGTTTGGC AGAGCACCAG
GCCAACCTGC GAATGTGCTG TGAGTTGGCC CTGTGCAAGG TGGTCAACTC CCACTGCGTG
TTCCCGAGGG AGCTGAAGGA GGTGTTTGCT TCGTGGCGGC TGCGCTGCGC AGAGCGAGGC
CGGGAGGACA TCGCAGACAG GCTTATCAGC GCCTCACTCT TCCTGCGCTT CCTCTGCCCA
GCGATTATGT CGCCCAGTCT CTTTGGGCTT ATGCAGGAGT ACCCAGATGA GCAGACCTCA
CGAACCCTCA CCCTCATTGC CAAGGTCATC CAGAACCTGG CCAACTTTTC CAAGTTTACC
TCAAAGGAGG ACTTTCTGGG CTTCATGAAT GAGTTTCTGG AGCTGGAATG GGGTTCCATG
CAGCAGTTTT TGTATGAGAT CTCCAATCTG GACACGCTAA CCAACAGCAG TAGCTTTGAG
GGTTACATCG ACTTGGGCCG AGAGCTCTCC ACACTGCATG CCCTACTCTG GGAGGTGCTG
CCCCAGCTCA GCAAGGAAGC CCTCCTGAAG CTGGGTCCAC TGCCCCGGCT CCTCAACGAC
ATCAGCACAG CTCTGAGGAA CCCCAACATC CAAAGGCAGC CAAGCCGCCA GAGTGAGCGG
CCCCGGCCTC AGCCTGTGGT ACTGCGGGGG CCATCGGCTG AGATGCAGGG CTACATGATG
CGGGACCTCA ACAGCTCCAT CGACCTTCAG TCCTTCATGG CTCGAGGCCT CAACAGCTCT
ATGGACATGG CTCGCCTCCC CTCCCCAACC AAGGAAAAGC CACCCCCACC ACCGCCTGGT
GGTGGTAAAG ACCTGTTCTA TGTAAGCCGT CCACCCCTGG CCCGTTCCTC ACCAGCATAC
TGCACGAGCA GCTCGGACAT CACAGAGCCA GAGCAGAAGA TGCTGAGTGT CAACAAGAGT
GTGTCCATGC TGGACTTACA GGGTGATGGG CCTGGTGGCC GCCTCAACAG CAGCAGTGTT
TCGAACCTGG CGGCCGTAGG GGACCTGCTG CACTCAAGCC AGGCCTCGCT GACAGCAGCC
TTGGGGCTAC GGCCTGCGCC TGCCGGACGC CTCTCCCAGG GGAGTGGCTC ATCCATCACG
GCGGCTGGCA TGCGCCTCAG CCAGATGGGT GTCACCACAG ACGGTGTCCC TGCCCAGCAA
CTGCGAATCC CCCTCTCCTT CCAGAACCCT CTCTTCCACA TGGCTGCTGA TGGGCCAGGT
CCCCCAGGCG GCCATGGAGG GGGCGGTGGC CATGGCCCAC CTTCCTCCCA TCACCACCAC
CACCACCATC ACCACCACCG AGGTGGAGAG CCCCCTGGGG ACACCTTTGC CCCATTCCAT
GGCTATAGCA AGAGTGAGGA CCTCTCTTCC GGGGTCCCCA AGCCCCCTGC TGCCTCCATC
CTTCATAGCC ACAGCTACAG TGATGAGTTT GGACCCTCTG GCACTGACTT CACCCGTCGG
CAGCTTTCAC TCCAGGACAA CCTGCAGCAC ATGCTGTCCC CTCCCCAGAT CACCATTGGT
CCCCAGAGGC CAGCCCCCTC AGGGCCTGGA GGTGGGAGCG GTGGGGGCAG CGGTGGGGGT
GGCGGGGGCC AGCCGCCTCC ATTGCAGAGG GGCAAGTCTC AGCAGTTGAC AGTCAGCGCA
GCCCAGAAAC CCCGGCCATC CAGCGGGAAT CTATTGCAGT CCCCAGAGCC AAGTTATGGC
CCCGCCCGTC CACGGCAACA GAGCCTCAGC AAGGAGGGCA GCATTGGGGG CAGCGGGGGC
AGCGGTGGCG GAGGGGGTGG GGGGCTGAAG CCCTCCATCA CCAAGCAGCA TTCTCAGACA
CCATCCACAT TGAACCCCAC AATGCCAGCC TCTGAGCGGA CAGTGGCCTG GGTCTCCAAC
ATGCCTCACC TGTCGGCTGA CATCGAGAGT GCCCACATCG AGCGGGAAGA GTACAAGCTC
AAGGAGTACT CAAAATCGAT GGATGAGAGC CGGCTGGATA GGGTGAAGGA GTACGAGGAG
GAGATTCACT CACTGAAAGA GCGGCTGCAC ATGTCCAACC GGAAGCTGGA AGAGTATGAG
CGGAGGCTGC TGTCCCAGGA AGAACAAACC AGCAAAATCC TGATGCAGTA TCAGGCCCGA
CTGGAGCAGA GTGAGAAGAG GCTAAGGCAG CAGCAGGCAG AGAAGGATTC CCAGATCAAG
AGCATCATTG GCAGGCTGAT GCTGGTGGAG GAGGAGCTGC GCCGGGACCA CCCCGCCATG
GCTGAGCCGC TGCCAGAACC CAAGAAGAGG CTGCTCGACG CTCAGGAGAG GCAGCTTCCC
CCCTTGGGTC CAACAAACCC GCGTGTGACG CTGGCCCCAC CGTGGAATGG CCTGGCCCCC
CCAGCCCCAC CACCCCCACC CCGGCTGCAG ATTACGGAGA ACGGCGAGTT CCGAAACACC
GCAGACCACT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006763.2
CDS196..4227
Misc Feature(1)559..1134(+)
Misc Feature(2)949..1437(+)
Misc Feature(3)1396..2355(+)
Misc Feature(4)1408..2379(+)
Misc Feature(5)1525..2124(+)
Misc Feature(6)2347..4131(+)
Misc Feature(7)2548..2640(+)
Misc Feature(8)3697..4089(+)
Exon (1)1..262
Gene:SYNGAP1
Gene Synonym:
Exon (2)263..384
Gene:SYNGAP1
Gene Synonym:
Exon (3)385..490
Gene:SYNGAP1
Gene Synonym:
Exon (4)491..582
Gene:SYNGAP1
Gene Synonym:
Exon (5)583..704
Gene:SYNGAP1
Gene Synonym:
Exon (6)705..858
Gene:SYNGAP1
Gene Synonym:
Exon (7)859..957
Gene:SYNGAP1
Gene Synonym:
Exon (8)958..1581
Gene:SYNGAP1
Gene Synonym:
Exon (9)1582..1726
Gene:SYNGAP1
Gene Synonym:
Exon (10)1727..1871
Gene:SYNGAP1
Gene Synonym:
Exon (11)1872..2108
Gene:SYNGAP1
Gene Synonym:
Exon (12)2109..2310
Gene:SYNGAP1
Gene Synonym:
Exon (13)2311..2489
Gene:SYNGAP1
Gene Synonym:
Exon (14)2490..2531
Gene:SYNGAP1
Gene Synonym:
Exon (15)2532..3603
Gene:SYNGAP1
Gene Synonym:
Exon (16)3604..3777
Gene:SYNGAP1
Gene Synonym:
Exon (17)3778..3989
Gene:SYNGAP1
Gene Synonym:
Exon (18)3990..4080
Gene:SYNGAP1
Gene Synonym:
Exon (19)4081..6010
Gene:SYNGAP1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006772
Organism Homo sapiens (human)
Definition Homo sapiens synaptic Ras GTPase activating protein 1 (SYNGAP1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006772

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
ATGAGCAGGT CTCGAGCCTC CATCCATCGG GGGAGCATCC CCGCGATGTC CTATGCCCCC 
TTCAGAGATG TACGGGGACC CTCTATGCAC CGAACCCAAT ACGTTCATTC CCCGTATGAT
CGTCCTGGTT GGAACCCTCG GTTCTGCATC ATCTCGGGGA ACCAGCTGCT CATGCTGGAT
GAGGATGAGA TACACCCCCT ACTGATCCGG GACCGGAGGA GCGAGTCCAG TCGCAACAAA
CTGCTGAGAC GCACAGTCTC CGTGCCGGTG GAGGGGCGGC CCCACGGCGA GCATGAATAC
CACTTGGGTC GCTCGAGGAG GAAGAGTGTC CCAGGGGGGA AGCAGTACAG CATGGAGGGT
GCCCCTGCTG CGCCCTTCCG GCCCTCGCAA GGCTTCCTGA GCCGACGGCT AAAAAGCTCC
ATCAAACGAA CGAAGTCACA ACCCAAACTT GACCGGACCA GCAGCTTTCG CCAGATCCTG
CCTCGCTTCC GAAGTGCTGA CCATGACCGG GCCCGGCTGA TGCAAAGCTT TAAGGAGTCA
CACTCTCATG AGTCCTTGCT GAGTCCTAGC AGTGCAGCTG AGGCATTGGA GCTCAACTTG
GATGAAGATT CCATTATCAA GCCAGTGCAC AGCTCCATCC TGGGCCAGGA GTTCTGTTTT
GAGGTAACAA CTTCATCAGG AACAAAATGC TTTGCCTGTC GGTCTGCGGC CGAAAGAGAC
AAATGGATTG AGAATCTGCA GCGGGCAGTA AAGCCCAACA AGGACAACAG CCGCCGGGTA
GACAATGTGC TAAAGCTGTG GATCATAGAG GCCCGGGAGC TGCCCCCCAA GAAGCGGTAC
TACTGTGAGC TCTGCCTGGA TGACATGCTG TATGCACGCA CCACCTCCAA GCCCCGCTCT
GCCTCTGGGG ACACCGTCTT CTGGGGCGAG CACTTCGAGT TTAACAACCT GCCGGCTGTC
CGTGCCCTGC GGCTGCATCT GTACCGTGAC TCAGACAAAA AGCGCAAGAA GGACAAGGCA
GGCTATGTCG GCCTGGTGAC TGTGCCAGTG GCCACCCTGG CTGGGCGCCA CTTCACAGAG
CAGTGGTACC CTGTAACCCT GCCAACAGGC AGTGGGGGAT CTGGGGGCAT GGGTTCGGGA
GGGGGAGGGG GCTCGGGGGG TGGCTCAGGG GGCAAGGGCA AAGGAGGTTG CCCGGCTGTG
CGGCTGAAAG CACGTTACCA GACAATGAGC ATCTTGCCCA TGGAGCTATA TAAAGAGTTT
GCAGAGTATG TCACCAACCA TTATCGGATG CTGTGTGCAG TCTTGGAGCC CGCCCTGAAT
GTCAAAGGCA AGGAGGAGGT TGCCAGTGCA CTAGTTCACA TCCTGCAGAG TACAGGCAAG
GCCAAGGACT TCCTTTCAGA CATGGCCATG TCTGAGGTAG ACCGGTTCAT GGAACGGGAG
CACCTCATAT TCCGCGAGAA CACGCTTGCC ACTAAAGCCA TAGAAGAGTA TATGAGACTG
ATTGGTCAGA AATACCTCAA GGATGCCATT GGAGAATTCA TCCGTGCTCT GTATGAATCT
GAGGAAAACT GCGAGGTAGA CCCTATCAAG TGCACAGCAT CCAGTTTGGC AGAGCACCAG
GCCAACCTGC GAATGTGCTG TGAGTTGGCC CTGTGCAAGG TGGTCAACTC CCACTGCGTG
TTCCCGAGGG AGCTGAAGGA GGTGTTTGCT TCGTGGCGGC TGCGCTGCGC AGAGCGAGGC
CGGGAGGACA TCGCAGACAG GCTTATCAGC GCCTCACTCT TCCTGCGCTT CCTCTGCCCA
GCGATTATGT CGCCCAGTCT CTTTGGGCTT ATGCAGGAGT ACCCAGATGA GCAGACCTCA
CGAACCCTCA CCCTCATTGC CAAGGTCATC CAGAACCTGG CCAACTTTTC CAAGTTTACC
TCAAAGGAGG ACTTTCTGGG CTTCATGAAT GAGTTTCTGG AGCTGGAATG GGGTTCCATG
CAGCAGTTTT TGTATGAGAT CTCCAATCTG GACACGCTAA CCAACAGCAG TAGCTTTGAG
GGTTACATCG ACTTGGGCCG AGAGCTCTCC ACACTGCATG CCCTACTCTG GGAGGTGCTG
CCCCAGCTCA GCAAGGAAGC CCTCCTGAAG CTGGGTCCAC TGCCCCGGCT CCTCAACGAC
ATCAGCACAG CTCTGAGGAA CCCCAACATC CAAAGGCAGC CAAGCCGCCA GAGTGAGCGG
CCCCGGCCTC AGCCTGTGGT ACTGCGGGGG CCATCGGCTG AGATGCAGGG CTACATGATG
CGGGACCTCA ACAGCTCCAT CGACCTTCAG TCCTTCATGG CTCGAGGCCT CAACAGCTCT
ATGGACATGG CTCGCCTCCC CTCCCCAACC AAGGAAAAGC CACCCCCACC ACCGCCTGGT
GGTGGTAAAG ACCTGTTCTA TGTAAGCCGT CCACCCCTGG CCCGTTCCTC ACCAGCATAC
TGCACGAGCA GCTCGGACAT CACAGAGCCA GAGCAGAAGA TGCTGAGTGT CAACAAGAGT
GTGTCCATGC TGGACTTACA GGGTGATGGG CCTGGTGGCC GCCTCAACAG CAGCAGTGTT
TCGAACCTGG CGGCCGTAGG GGACCTGCTG CACTCAAGCC AGGCCTCGCT GACAGCAGCC
TTGGGGCTAC GGCCTGCGCC TGCCGGACGC CTCTCCCAGG GGAGTGGCTC ATCCATCACG
GCGGCTGGCA TGCGCCTCAG CCAGATGGGT GTCACCACAG ACGGTGTCCC TGCCCAGCAA
CTGCGAATCC CCCTCTCCTT CCAGAACCCT CTCTTCCACA TGGCTGCTGA TGGGCCAGGT
CCCCCAGGCG GCCATGGAGG GGGCGGTGGC CATGGCCCAC CTTCCTCCCA TCACCACCAC
CACCACCATC ACCACCACCG AGGTGGAGAG CCCCCTGGGG ACACCTTTGC CCCATTCCAT
GGCTATAGCA AGAGTGAGGA CCTCTCTTCC GGGGTCCCCA AGCCCCCTGC TGCCTCCATC
CTTCATAGCC ACAGCTACAG TGATGAGTTT GGACCCTCTG GCACTGACTT CACCCGTCGG
CAGCTTTCAC TCCAGGACAA CCTGCAGCAC ATGCTGTCCC CTCCCCAGAT CACCATTGGT
CCCCAGAGGC CAGCCCCCTC AGGGCCTGGA GGTGGGAGCG GTGGGGGCAG CGGTGGGGGT
GGCGGGGGCC AGCCGCCTCC ATTGCAGAGG GGCAAGTCTC AGCAGTTGAC AGTCAGCGCA
GCCCAGAAAC CCCGGCCATC CAGCGGGAAT CTATTGCAGT CCCCAGAGCC AAGTTATGGC
CCCGCCCGTC CACGGCAACA GAGCCTCAGC AAGGAGGGCA GCATTGGGGG CAGCGGGGGC
AGCGGTGGCG GAGGGGGTGG GGGGCTGAAG CCCTCCATCA CCAAGCAGCA TTCTCAGACA
CCATCCACAT TGAACCCCAC AATGCCAGCC TCTGAGCGGA CAGTGGCCTG GGTCTCCAAC
ATGCCTCACC TGTCGGCTGA CATCGAGAGT GCCCACATCG AGCGGGAAGA GTACAAGCTC
AAGGAGTACT CAAAATCGAT GGATGAGAGC CGGCTGGATA GGGTGAAGGA GTACGAGGAG
GAGATTCACT CACTGAAAGA GCGGCTGCAC ATGTCCAACC GGAAGCTGGA AGAGTATGAG
CGGAGGCTGC TGTCCCAGGA AGAACAAACC AGCAAAATCC TGATGCAGTA TCAGGCCCGA
CTGGAGCAGA GTGAGAAGAG GCTAAGGCAG CAGCAGGCAG AGAAGGATTC CCAGATCAAG
AGCATCATTG GCAGGCTGAT GCTGGTGGAG GAGGAGCTGC GCCGGGACCA CCCCGCCATG
GCTGAGCCGC TGCCAGAACC CAAGAAGAGG CTGCTCGACG CTCAGGAGAG GCAGCTTCCC
CCCTTGGGTC CAACAAACCC GCGTGTGACG CTGGCCCCAC CGTGGAATGG CCTGGCCCCC
CCAGCCCCAC CACCCCCACC CCGGCTGCAG ATTACGGAGA ACGGCGAGTT CCGAAACACC
GCAGACCACT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1
Nat. Genet. 45 (7), 825-830 (2013)
Carvill GL, Heavin SB, Yendle SC, McMahon JM, O'Roak BJ, Cook J, Khan A, Dorschner MO, Weaver M, Calvert S, Malone S, Wallace G, Stanley T, Bye AM, Bleasel A, Howell KB, Kivity S, Mackay MT, Rodriguez-Casero V, Webster R, Korczyn A, Afawi Z, Zelnick N, Lerman-Sagie T, Lev D, Moller RS, Gill D, Andrade DM, Freeman JL, Sadleir LG, Shendure J, Berkovic SF, Scheffer IE and Mefford HC.


book

Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency
Hum. Mutat. 34 (2), 385-394 (2013)
Berryer MH, Hamdan FF, Klitten LL, Moller RS, Carmant L, Schwartzentruber J, Patry L, Dobrzeniecka S, Rochefort D, Neugnot-Cerioli M, Lacaille JC, Niu Z, Eng CM, Yang Y, Palardy S, Belhumeur C, Rouleau GA, Tommerup N, Immken L, Beauchamp MH, Patel GS, Majewski J, Tarnopolsky MA, Scheffzek K, Hjalgrim H, Michaud JL and Di Cristo G.


book

De novo SYNGAP1 mutations in nonsyndromic intellectual disability and autism
Biol. Psychiatry 69 (9), 898-901 (2011)
Hamdan FF, Daoud H, Piton A, Gauthier J, Dobrzeniecka S, Krebs MO, Joober R, Lacaille JC, Nadeau A, Milunsky JM, Wang Z, Carmant L, Mottron L, Beauchamp MH, Rouleau GA and Michaud JL.


book

De novo autosomal dominant mutation in SYNGAP1
Autism Res 4 (2), 155-156 (2011)
Cook EH Jr.


book

[De novo mutations in SYNGAP1 associated with non-syndromic mental retardation]
Med Sci (Paris) 26 (2), 133-135 (2010)
Hamdan FF, Gauthier J, Rouleau GA and Michaud JL.


book

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
Nat. Neurosci. 3 (7), 661-669 (2000)
Husi H, Ward MA, Choudhary JS, Blackstock WP and Grant SG.


book

A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
Neuron 20 (5), 895-904 (1998)
Chen HJ, Rojas-Soto M, Oguni A and Kennedy MB.


book

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family
Neuron 20 (4), 683-691 (1998)
Kim JH, Liao D, Lau LF and Huganir RL.


book

The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
J. Biol. Chem. 272 (51), 32521-32527 (1997)
Kroll J and Waltenberger J.


book

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
Cell 69 (3), 413-423 (1992)
Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F and Williams LT.


 
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