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SQSTM1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SQSTM1
Entrez Gene ID 8878
Full Name sequestosome 1
Synonyms A170,DMRV,FTDALS3,NADGP,OSIL,PDB3,ZIP3,p60,p62,p62B
General protein information
Preferred Names

sequestosome 1

Names

sequestosome-1
EBI3-associated protein of 60 kDa
EBI3-associated protein p60
EBIAP
oxidative stress induced like
phosphotyrosine independent ligand for the Lck SH2 domain p62
phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
ubiquitin-binding protein p62

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

5

5q35.3

Summary This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009].
Disorder MIM:

601530

Disorder Html: Paget disease of bone, 602080 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001142299.1 NP_001135771.1 sequestosome-1 isoform 2
NM_003900.4 NP_003891.1 sequestosome-1 isoform 1
XM_011534683.2 XP_011532985.1 sequestosome-1 isoform X2
NM_001142298.1 NP_001135770.1 sequestosome-1 isoform 2
XM_017010010.1 XP_016865499.1 sequestosome-1 isoform X1



Macaca mulatta (rhesus monkey) SQSTM1 XP_001102347.1
Homo sapiens (human) SQSTM1 NP_003891.1
Mus musculus (house mouse) Sqstm1 NP_035148.1
Pan troglodytes (chimpanzee) SQSTM1 XP_001153075.1
Bos taurus (cattle) SQSTM1 NP_788814.1
Gallus gallus (chicken) SQSTM1 XP_001233249.2
Rattus norvegicus (Norway rat) Sqstm1 NP_787037.2
Xenopus tropicalis (tropical clawed frog) sqstm1 NP_001007894.1
Danio rerio (zebrafish) sqstm1 NP_998338.1


Related articles in PubMed

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Park JS, Oh SY, Lee DH, Lee YS, Sung SH, Ji HW, Lee MJ, Lee YH, Rhee SG, Bae SH
Free radical research50(12)1408-1421(2016 Dec)

Autophagy is involved in aldosterone‑induced mesangial cell proliferation.
Yang M, Wang B, Miao L, Xu X, He X
Molecular medicine reports14(5)4638-4642(2016 Nov)

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.
Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J
Cancer cell30(4)595-609(2016 Oct)

p62 in Cancer: Signaling Adaptor Beyond Autophagy.
Moscat J, Karin M, Diaz-Meco MT
Cell167(3)606-609(2016 Oct)

Absence of the Autophagy Adaptor SQSTM1/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy.
Haack TB, Ignatius E, Calvo-Garrido J, Iuso A, Isohanni P, Maffezzini C, Lönnqvist T, Suomalainen A, Gorza M, Kremer LS, Graf E, Hartig M, Berutti R, Paucar M, Svenningsson P, Stranneheim H, Brandberg G, Wedell A, Kurian MA, Hayflick SA, Venco P, Tiranti V, Strom TM, Dichgans M, Horvath R, Holinski-Feder E, Freyer C, Meitinger T, Prokisch H, Senderek J, Wredenberg A, Carroll CJ, Klopstock T
American journal of human genetics99(3)735-743(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that phosphorylation of SQSTM1 by AMP-activated protein kinase (AMPK) and translocation of SQSTM1 to mitochondria drives autophagic cell death in adult hippocampal neural stem cells; activation of AMPK promotes autophagic cell death; inhibition of AMPK (by enzyme inhibitor or RNA interference) suppresses autophagic cell death. (SQSTM1 = sequestosome 1)
Title: Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells.

necessary for retinal pigmented epithelial cytoprotection under oxidative stress; NFkappaB p65 activity may be critical upstream initiator of p62 expression in retinal pigmented epithelial cells under oxidative stress
Title: Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.

Results show that Nrf2 prevents TM-induced apoptotic cell death and that TM promotes p62-dependent autophagic Keap1 degradation, leading to Nrf2 activation. In addition, we identified that p62 is essential to protect cells against TM-mediated oxidative damage through Nrf2 activation.
Title: p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.

Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation
Title: Autophagy is involved in aldosterone‑induced mesangial cell proliferation.

new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma. [Review]
Title: p62 in Cancer: Signaling Adaptor Beyond Autophagy.

The following SQSTM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SQSTM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu26176 NM_003900.4
Latest version!
Homo sapiens sequestosome 1 (SQSTM1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu26213 NM_001142298.1
Latest version!
Homo sapiens sequestosome 1 (SQSTM1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu26213 NM_001142299.1
Latest version!
Homo sapiens sequestosome 1 (SQSTM1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu26213 XM_017010010.1
Latest version!
Homo sapiens sequestosome 1 (SQSTM1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu62276 XM_011534683.2
Latest version!
Homo sapiens sequestosome 1 (SQSTM1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26176
Clone ID Related Accession (Same CDS sequence) NM_003900.4
Accession Version NM_003900.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1323bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product sequestosome-1 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC398116.1, BC000951.2, BC017222.1 and AI333228.1. On May 16, 2008 this sequence version replaced NM_003900.3. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017222.1, SRR1803611.27484.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCGTCGC TCACCGTGAA GGCCTACCTT CTGGGCAAGG AGGACGCGGC GCGCGAGATT 
CGCCGCTTCA GCTTCTGCTG CAGCCCCGAG CCTGAGGCGG AAGCCGAGGC TGCGGCGGGT
CCGGGACCCT GCGAGCGGCT GCTGAGCCGG GTGGCCGCCC TGTTCCCCGC GCTGCGGCCT
GGCGGCTTCC AGGCGCACTA CCGCGATGAG GACGGGGACT TGGTTGCCTT TTCCAGTGAC
GAGGAATTGA CAATGGCCAT GTCCTACGTG AAGGATGACA TCTTCCGAAT CTACATTAAA
GAGAAAAAAG AGTGCCGGCG GGACCACCGC CCACCGTGTG CTCAGGAGGC GCCCCGCAAC
ATGGTGCACC CCAATGTGAT CTGCGATGGC TGCAATGGGC CTGTGGTAGG AACCCGCTAC
AAGTGCAGCG TCTGCCCAGA CTACGACTTG TGTAGCGTCT GCGAGGGAAA GGGCTTGCAC
CGGGGGCACA CCAAGCTCGC ATTCCCCAGC CCCTTCGGGC ACCTGTCTGA GGGCTTCTCG
CACAGCCGCT GGCTCCGGAA GGTGAAACAC GGACACTTCG GGTGGCCAGG ATGGGAAATG
GGTCCACCAG GAAACTGGAG CCCACGTCCT CCTCGTGCAG GGGAGGCCCG CCCTGGCCCC
ACGGCAGAAT CAGCTTCTGG TCCATCGGAG GATCCGAGTG TGAATTTCCT GAAGAACGTT
GGGGAGAGTG TGGCAGCTGC CCTTAGCCCT CTGGGCATTG AAGTTGATAT CGATGTGGAG
CACGGAGGGA AAAGAAGCCG CCTGACCCCC GTCTCTCCAG AGAGTTCCAG CACAGAGGAG
AAGAGCAGCT CACAGCCAAG CAGCTGCTGC TCTGACCCCA GCAAGCCGGG TGGGAATGTT
GAGGGCGCCA CGCAGTCTCT GGCGGAGCAG ATGAGGAAGA TCGCCTTGGA GTCCGAGGGG
CGCCCTGAGG AACAGATGGA GTCGGATAAC TGTTCAGGAG GAGATGATGA CTGGACCCAT
CTGTCTTCAA AAGAAGTGGA CCCGTCTACA GGTGAACTCC AGTCCCTACA GATGCCAGAA
TCCGAAGGGC CAAGCTCTCT GGACCCCTCC CAGGAGGGAC CCACAGGGCT GAAGGAAGCT
GCCTTGTACC CACATCTCCC GCCAGAGGCT GACCCGCGGC TGATTGAGTC CCTCTCCCAG
ATGCTGTCCA TGGGCTTCTC TGATGAAGGC GGCTGGCTCA CCAGGCTCCT GCAGACCAAG
AACTATGACA TCGGAGCGGC TCTGGACACC ATCCAGTATT CAAAGCATCC CCCGCCGTTG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003891.1
CDS96..1418
Misc Feature(1)99..245
Misc Feature(2)99..101
Misc Feature(3)105..401
Misc Feature(4)165..167
Misc Feature(5)177..179
Misc Feature(6)222..416
Misc Feature(7)243..335
Misc Feature(8)360..362
Misc Feature(9)459..767
Misc Feature(10)471..599
Misc Feature(11)order(477..479,486..488,519..521,528..530,546..548,555..557,573..575,582..584)
Misc Feature(12)order(477..479,486..488,546..548,555..557)
Misc Feature(13)order(480..482,510..512,516..518,534..536,540..542)
Misc Feature(14)order(513..515,588..590,597..599)
Misc Feature(15)order(519..521,528..530,573..575,582..584)
Misc Feature(16)537..539
Misc Feature(17)603..755
Misc Feature(18)603..605
Misc Feature(19)621..623
Misc Feature(20)633..635
Misc Feature(21)639..641
Misc Feature(22)714..716
Misc Feature(23)777..794
Misc Feature(24)792..794
Misc Feature(25)840..842
Misc Feature(26)891..893
Misc Feature(27)891..893
Misc Feature(28)900..1415
Misc Feature(29)900..902
Misc Feature(30)900..902
Misc Feature(31)900..902
Misc Feature(32)909..911
Misc Feature(33)909..911
Misc Feature(34)909..911
Misc Feature(35)918..920
Misc Feature(36)921..923
Misc Feature(37)924..926
Misc Feature(38)927..929
Misc Feature(39)939..941
Misc Feature(40)942..944
Misc Feature(41)945..947
Misc Feature(42)1011..1013
Misc Feature(43)1047..1049
Misc Feature(44)1056..1121
Misc Feature(45)1077..1079
Misc Feature(46)1077..1079
Misc Feature(47)1089..1091
Misc Feature(48)1089..1091
Misc Feature(49)1101..1118
Misc Feature(50)1110..1112
Misc Feature(51)1119..1121
Misc Feature(52)1122..1124
Misc Feature(53)1158..1160
Misc Feature(54)1176..1178
Misc Feature(55)1188..1190
Misc Feature(56)1188..1190
Misc Feature(57)1191..1193
Misc Feature(58)1191..1193
Misc Feature(59)1203..1205
Misc Feature(60)1218..1220
Misc Feature(61)1230..1412
Misc Feature(62)1302..1304
Misc Feature(63)order(1305..1313,1320..1331,1338..1343,1350..1352,1383..1391)
Exon (1)1..300
Exon (2)301..396
Exon (3)397..626
Exon (4)627..768
Exon (5)769..849
Exon (6)850..1064
Exon (7)1065..1260
Exon (8)1261..2903
Translation

Target ORF information:

RefSeq Version NM_003900.4
Organism Homo sapiens(Human)
Definition Homo sapiens sequestosome 1 (SQSTM1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003900.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCGTCGC TCACCGTGAA GGCCTACCTT CTGGGCAAGG AGGACGCGGC GCGCGAGATT 
CGCCGCTTCA GCTTCTGCTG CAGCCCCGAG CCTGAGGCGG AAGCCGAGGC TGCGGCGGGT
CCGGGACCCT GCGAGCGGCT GCTGAGCCGG GTGGCCGCCC TGTTCCCCGC GCTGCGGCCT
GGCGGCTTCC AGGCGCACTA CCGCGATGAG GACGGGGACT TGGTTGCCTT TTCCAGTGAC
GAGGAATTGA CAATGGCCAT GTCCTACGTG AAGGATGACA TCTTCCGAAT CTACATTAAA
GAGAAAAAAG AGTGCCGGCG GGACCACCGC CCACCGTGTG CTCAGGAGGC GCCCCGCAAC
ATGGTGCACC CCAATGTGAT CTGCGATGGC TGCAATGGGC CTGTGGTAGG AACCCGCTAC
AAGTGCAGCG TCTGCCCAGA CTACGACTTG TGTAGCGTCT GCGAGGGAAA GGGCTTGCAC
CGGGGGCACA CCAAGCTCGC ATTCCCCAGC CCCTTCGGGC ACCTGTCTGA GGGCTTCTCG
CACAGCCGCT GGCTCCGGAA GGTGAAACAC GGACACTTCG GGTGGCCAGG ATGGGAAATG
GGTCCACCAG GAAACTGGAG CCCACGTCCT CCTCGTGCAG GGGAGGCCCG CCCTGGCCCC
ACGGCAGAAT CAGCTTCTGG TCCATCGGAG GATCCGAGTG TGAATTTCCT GAAGAACGTT
GGGGAGAGTG TGGCAGCTGC CCTTAGCCCT CTGGGCATTG AAGTTGATAT CGATGTGGAG
CACGGAGGGA AAAGAAGCCG CCTGACCCCC GTCTCTCCAG AGAGTTCCAG CACAGAGGAG
AAGAGCAGCT CACAGCCAAG CAGCTGCTGC TCTGACCCCA GCAAGCCGGG TGGGAATGTT
GAGGGCGCCA CGCAGTCTCT GGCGGAGCAG ATGAGGAAGA TCGCCTTGGA GTCCGAGGGG
CGCCCTGAGG AACAGATGGA GTCGGATAAC TGTTCAGGAG GAGATGATGA CTGGACCCAT
CTGTCTTCAA AAGAAGTGGA CCCGTCTACA GGTGAACTCC AGTCCCTACA GATGCCAGAA
TCCGAAGGGC CAAGCTCTCT GGACCCCTCC CAGGAGGGAC CCACAGGGCT GAAGGAAGCT
GCCTTGTACC CACATCTCCC GCCAGAGGCT GACCCGCGGC TGATTGAGTC CCTCTCCCAG
ATGCTGTCCA TGGGCTTCTC TGATGAAGGC GGCTGGCTCA CCAGGCTCCT GCAGACCAAG
AACTATGACA TCGGAGCGGC TCTGGACACC ATCCAGTATT CAAAGCATCC CCCGCCGTTG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26213
Clone ID Related Accession (Same CDS sequence) NM_001142299.1 , NM_001142298.1 , XM_017010010.1
Accession Version NM_001142299.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1071bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product sequestosome-1 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA541885.1, BC000951.2, BC017222.1 and BU625974.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an in-frame downstream start codon compared to variant 1. This results in an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 3 differ in the 5' UTR, but encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.24896.1, SRR1803611.191829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCCATGT CCTACGTGAA GGATGACATC TTCCGAATCT ACATTAAAGA GAAAAAAGAG 
TGCCGGCGGG ACCACCGCCC ACCGTGTGCT CAGGAGGCGC CCCGCAACAT GGTGCACCCC
AATGTGATCT GCGATGGCTG CAATGGGCCT GTGGTAGGAA CCCGCTACAA GTGCAGCGTC
TGCCCAGACT ACGACTTGTG TAGCGTCTGC GAGGGAAAGG GCTTGCACCG GGGGCACACC
AAGCTCGCAT TCCCCAGCCC CTTCGGGCAC CTGTCTGAGG GCTTCTCGCA CAGCCGCTGG
CTCCGGAAGG TGAAACACGG ACACTTCGGG TGGCCAGGAT GGGAAATGGG TCCACCAGGA
AACTGGAGCC CACGTCCTCC TCGTGCAGGG GAGGCCCGCC CTGGCCCCAC GGCAGAATCA
GCTTCTGGTC CATCGGAGGA TCCGAGTGTG AATTTCCTGA AGAACGTTGG GGAGAGTGTG
GCAGCTGCCC TTAGCCCTCT GGGCATTGAA GTTGATATCG ATGTGGAGCA CGGAGGGAAA
AGAAGCCGCC TGACCCCCGT CTCTCCAGAG AGTTCCAGCA CAGAGGAGAA GAGCAGCTCA
CAGCCAAGCA GCTGCTGCTC TGACCCCAGC AAGCCGGGTG GGAATGTTGA GGGCGCCACG
CAGTCTCTGG CGGAGCAGAT GAGGAAGATC GCCTTGGAGT CCGAGGGGCG CCCTGAGGAA
CAGATGGAGT CGGATAACTG TTCAGGAGGA GATGATGACT GGACCCATCT GTCTTCAAAA
GAAGTGGACC CGTCTACAGG TGAACTCCAG TCCCTACAGA TGCCAGAATC CGAAGGGCCA
AGCTCTCTGG ACCCCTCCCA GGAGGGACCC ACAGGGCTGA AGGAAGCTGC CTTGTACCCA
CATCTCCCGC CAGAGGCTGA CCCGCGGCTG ATTGAGTCCC TCTCCCAGAT GCTGTCCATG
GGCTTCTCTG ATGAAGGCGG CTGGCTCACC AGGCTCCTGC AGACCAAGAA CTATGACATC
GGAGCGGCTC TGGACACCAT CCAGTATTCA AAGCATCCCC CGCCGTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001135771.1
CDS278..1348
Misc Feature(1)179..181
Misc Feature(2)<278..331
Misc Feature(3)401..529
Misc Feature(4)order(407..409,416..418,449..451,458..460,476..478,485..487,503..505,512..514)
Misc Feature(5)order(407..409,416..418,476..478,485..487)
Misc Feature(6)order(410..412,440..442,446..448,464..466,470..472)
Misc Feature(7)order(443..445,518..520,527..529)
Misc Feature(8)order(449..451,458..460,503..505,512..514)
Misc Feature(9)1160..1342
Misc Feature(10)order(1235..1243,1250..1261,1268..1273,1280..1282,1313..1321)
Exon (1)1..121
Exon (2)122..230
Exon (3)231..326
Exon (4)327..556
Exon (5)557..698
Exon (6)699..779
Exon (7)780..994
Exon (8)995..1190
Exon (9)1191..2833
Translation

Target ORF information:

RefSeq Version NM_001142299.1
Organism Homo sapiens(Human)
Definition Homo sapiens sequestosome 1 (SQSTM1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001142299.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCCATGT CCTACGTGAA GGATGACATC TTCCGAATCT ACATTAAAGA GAAAAAAGAG 
TGCCGGCGGG ACCACCGCCC ACCGTGTGCT CAGGAGGCGC CCCGCAACAT GGTGCACCCC
AATGTGATCT GCGATGGCTG CAATGGGCCT GTGGTAGGAA CCCGCTACAA GTGCAGCGTC
TGCCCAGACT ACGACTTGTG TAGCGTCTGC GAGGGAAAGG GCTTGCACCG GGGGCACACC
AAGCTCGCAT TCCCCAGCCC CTTCGGGCAC CTGTCTGAGG GCTTCTCGCA CAGCCGCTGG
CTCCGGAAGG TGAAACACGG ACACTTCGGG TGGCCAGGAT GGGAAATGGG TCCACCAGGA
AACTGGAGCC CACGTCCTCC TCGTGCAGGG GAGGCCCGCC CTGGCCCCAC GGCAGAATCA
GCTTCTGGTC CATCGGAGGA TCCGAGTGTG AATTTCCTGA AGAACGTTGG GGAGAGTGTG
GCAGCTGCCC TTAGCCCTCT GGGCATTGAA GTTGATATCG ATGTGGAGCA CGGAGGGAAA
AGAAGCCGCC TGACCCCCGT CTCTCCAGAG AGTTCCAGCA CAGAGGAGAA GAGCAGCTCA
CAGCCAAGCA GCTGCTGCTC TGACCCCAGC AAGCCGGGTG GGAATGTTGA GGGCGCCACG
CAGTCTCTGG CGGAGCAGAT GAGGAAGATC GCCTTGGAGT CCGAGGGGCG CCCTGAGGAA
CAGATGGAGT CGGATAACTG TTCAGGAGGA GATGATGACT GGACCCATCT GTCTTCAAAA
GAAGTGGACC CGTCTACAGG TGAACTCCAG TCCCTACAGA TGCCAGAATC CGAAGGGCCA
AGCTCTCTGG ACCCCTCCCA GGAGGGACCC ACAGGGCTGA AGGAAGCTGC CTTGTACCCA
CATCTCCCGC CAGAGGCTGA CCCGCGGCTG ATTGAGTCCC TCTCCCAGAT GCTGTCCATG
GGCTTCTCTG ATGAAGGCGG CTGGCTCACC AGGCTCCTGC AGACCAAGAA CTATGACATC
GGAGCGGCTC TGGACACCAT CCAGTATTCA AAGCATCCCC CGCCGTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26213
Clone ID Related Accession (Same CDS sequence) NM_001142299.1 , NM_001142298.1 , XM_017010010.1
Accession Version NM_001142298.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1071bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product sequestosome-1 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI549805.1, BC000951.2, BC017222.1 and BU625974.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an in-frame downstream start codon compared to variant 1. This results in an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.233699.1, SRR1660809.237310.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCCATGT CCTACGTGAA GGATGACATC TTCCGAATCT ACATTAAAGA GAAAAAAGAG 
TGCCGGCGGG ACCACCGCCC ACCGTGTGCT CAGGAGGCGC CCCGCAACAT GGTGCACCCC
AATGTGATCT GCGATGGCTG CAATGGGCCT GTGGTAGGAA CCCGCTACAA GTGCAGCGTC
TGCCCAGACT ACGACTTGTG TAGCGTCTGC GAGGGAAAGG GCTTGCACCG GGGGCACACC
AAGCTCGCAT TCCCCAGCCC CTTCGGGCAC CTGTCTGAGG GCTTCTCGCA CAGCCGCTGG
CTCCGGAAGG TGAAACACGG ACACTTCGGG TGGCCAGGAT GGGAAATGGG TCCACCAGGA
AACTGGAGCC CACGTCCTCC TCGTGCAGGG GAGGCCCGCC CTGGCCCCAC GGCAGAATCA
GCTTCTGGTC CATCGGAGGA TCCGAGTGTG AATTTCCTGA AGAACGTTGG GGAGAGTGTG
GCAGCTGCCC TTAGCCCTCT GGGCATTGAA GTTGATATCG ATGTGGAGCA CGGAGGGAAA
AGAAGCCGCC TGACCCCCGT CTCTCCAGAG AGTTCCAGCA CAGAGGAGAA GAGCAGCTCA
CAGCCAAGCA GCTGCTGCTC TGACCCCAGC AAGCCGGGTG GGAATGTTGA GGGCGCCACG
CAGTCTCTGG CGGAGCAGAT GAGGAAGATC GCCTTGGAGT CCGAGGGGCG CCCTGAGGAA
CAGATGGAGT CGGATAACTG TTCAGGAGGA GATGATGACT GGACCCATCT GTCTTCAAAA
GAAGTGGACC CGTCTACAGG TGAACTCCAG TCCCTACAGA TGCCAGAATC CGAAGGGCCA
AGCTCTCTGG ACCCCTCCCA GGAGGGACCC ACAGGGCTGA AGGAAGCTGC CTTGTACCCA
CATCTCCCGC CAGAGGCTGA CCCGCGGCTG ATTGAGTCCC TCTCCCAGAT GCTGTCCATG
GGCTTCTCTG ATGAAGGCGG CTGGCTCACC AGGCTCCTGC AGACCAAGAA CTATGACATC
GGAGCGGCTC TGGACACCAT CCAGTATTCA AAGCATCCCC CGCCGTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001135770.1
CDS361..1431
Misc Feature(1)262..264
Misc Feature(2)<361..414
Misc Feature(3)484..612
Misc Feature(4)order(490..492,499..501,532..534,541..543,559..561,568..570,586..588,595..597)
Misc Feature(5)order(490..492,499..501,559..561,568..570)
Misc Feature(6)order(493..495,523..525,529..531,547..549,553..555)
Misc Feature(7)order(526..528,601..603,610..612)
Misc Feature(8)order(532..534,541..543,586..588,595..597)
Misc Feature(9)1243..1425
Misc Feature(10)order(1318..1326,1333..1344,1351..1356,1363..1365,1396..1404)
Exon (1)1..204
Exon (2)205..313
Exon (3)314..409
Exon (4)410..639
Exon (5)640..781
Exon (6)782..862
Exon (7)863..1077
Exon (8)1078..1273
Exon (9)1274..2916
Translation

Target ORF information:

RefSeq Version NM_001142298.1
Organism Homo sapiens(Human)
Definition Homo sapiens sequestosome 1 (SQSTM1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001142298.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCCATGT CCTACGTGAA GGATGACATC TTCCGAATCT ACATTAAAGA GAAAAAAGAG 
TGCCGGCGGG ACCACCGCCC ACCGTGTGCT CAGGAGGCGC CCCGCAACAT GGTGCACCCC
AATGTGATCT GCGATGGCTG CAATGGGCCT GTGGTAGGAA CCCGCTACAA GTGCAGCGTC
TGCCCAGACT ACGACTTGTG TAGCGTCTGC GAGGGAAAGG GCTTGCACCG GGGGCACACC
AAGCTCGCAT TCCCCAGCCC CTTCGGGCAC CTGTCTGAGG GCTTCTCGCA CAGCCGCTGG
CTCCGGAAGG TGAAACACGG ACACTTCGGG TGGCCAGGAT GGGAAATGGG TCCACCAGGA
AACTGGAGCC CACGTCCTCC TCGTGCAGGG GAGGCCCGCC CTGGCCCCAC GGCAGAATCA
GCTTCTGGTC CATCGGAGGA TCCGAGTGTG AATTTCCTGA AGAACGTTGG GGAGAGTGTG
GCAGCTGCCC TTAGCCCTCT GGGCATTGAA GTTGATATCG ATGTGGAGCA CGGAGGGAAA
AGAAGCCGCC TGACCCCCGT CTCTCCAGAG AGTTCCAGCA CAGAGGAGAA GAGCAGCTCA
CAGCCAAGCA GCTGCTGCTC TGACCCCAGC AAGCCGGGTG GGAATGTTGA GGGCGCCACG
CAGTCTCTGG CGGAGCAGAT GAGGAAGATC GCCTTGGAGT CCGAGGGGCG CCCTGAGGAA
CAGATGGAGT CGGATAACTG TTCAGGAGGA GATGATGACT GGACCCATCT GTCTTCAAAA
GAAGTGGACC CGTCTACAGG TGAACTCCAG TCCCTACAGA TGCCAGAATC CGAAGGGCCA
AGCTCTCTGG ACCCCTCCCA GGAGGGACCC ACAGGGCTGA AGGAAGCTGC CTTGTACCCA
CATCTCCCGC CAGAGGCTGA CCCGCGGCTG ATTGAGTCCC TCTCCCAGAT GCTGTCCATG
GGCTTCTCTG ATGAAGGCGG CTGGCTCACC AGGCTCCTGC AGACCAAGAA CTATGACATC
GGAGCGGCTC TGGACACCAT CCAGTATTCA AAGCATCCCC CGCCGTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26213
Clone ID Related Accession (Same CDS sequence) NM_001142299.1 , NM_001142298.1 , XM_017010010.1
Accession Version XM_017010010.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1071bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product sequestosome-1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCCATGT CCTACGTGAA GGATGACATC TTCCGAATCT ACATTAAAGA GAAAAAAGAG 
TGCCGGCGGG ACCACCGCCC ACCGTGTGCT CAGGAGGCGC CCCGCAACAT GGTGCACCCC
AATGTGATCT GCGATGGCTG CAATGGGCCT GTGGTAGGAA CCCGCTACAA GTGCAGCGTC
TGCCCAGACT ACGACTTGTG TAGCGTCTGC GAGGGAAAGG GCTTGCACCG GGGGCACACC
AAGCTCGCAT TCCCCAGCCC CTTCGGGCAC CTGTCTGAGG GCTTCTCGCA CAGCCGCTGG
CTCCGGAAGG TGAAACACGG ACACTTCGGG TGGCCAGGAT GGGAAATGGG TCCACCAGGA
AACTGGAGCC CACGTCCTCC TCGTGCAGGG GAGGCCCGCC CTGGCCCCAC GGCAGAATCA
GCTTCTGGTC CATCGGAGGA TCCGAGTGTG AATTTCCTGA AGAACGTTGG GGAGAGTGTG
GCAGCTGCCC TTAGCCCTCT GGGCATTGAA GTTGATATCG ATGTGGAGCA CGGAGGGAAA
AGAAGCCGCC TGACCCCCGT CTCTCCAGAG AGTTCCAGCA CAGAGGAGAA GAGCAGCTCA
CAGCCAAGCA GCTGCTGCTC TGACCCCAGC AAGCCGGGTG GGAATGTTGA GGGCGCCACG
CAGTCTCTGG CGGAGCAGAT GAGGAAGATC GCCTTGGAGT CCGAGGGGCG CCCTGAGGAA
CAGATGGAGT CGGATAACTG TTCAGGAGGA GATGATGACT GGACCCATCT GTCTTCAAAA
GAAGTGGACC CGTCTACAGG TGAACTCCAG TCCCTACAGA TGCCAGAATC CGAAGGGCCA
AGCTCTCTGG ACCCCTCCCA GGAGGGACCC ACAGGGCTGA AGGAAGCTGC CTTGTACCCA
CATCTCCCGC CAGAGGCTGA CCCGCGGCTG ATTGAGTCCC TCTCCCAGAT GCTGTCCATG
GGCTTCTCTG ATGAAGGCGG CTGGCTCACC AGGCTCCTGC AGACCAAGAA CTATGACATC
GGAGCGGCTC TGGACACCAT CCAGTATTCA AAGCATCCCC CGCCGTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016865499.1
CDS580..1650
Misc Feature(1)<580..633
Misc Feature(2)703..831
Misc Feature(3)order(709..711,718..720,751..753,760..762,778..780,787..789,805..807,814..816)
Misc Feature(4)order(709..711,718..720,778..780,787..789)
Misc Feature(5)order(712..714,742..744,748..750,766..768,772..774)
Misc Feature(6)order(745..747,820..822,829..831)
Misc Feature(7)order(751..753,760..762,805..807,814..816)
Misc Feature(8)1462..1644
Misc Feature(9)order(1537..1545,1552..1563,1570..1575,1582..1584,1615..1623)
Translation

Target ORF information:

RefSeq Version XM_017010010.1
Organism Homo sapiens(Human)
Definition Homo sapiens sequestosome 1 (SQSTM1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017010010.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCCATGT CCTACGTGAA GGATGACATC TTCCGAATCT ACATTAAAGA GAAAAAAGAG 
TGCCGGCGGG ACCACCGCCC ACCGTGTGCT CAGGAGGCGC CCCGCAACAT GGTGCACCCC
AATGTGATCT GCGATGGCTG CAATGGGCCT GTGGTAGGAA CCCGCTACAA GTGCAGCGTC
TGCCCAGACT ACGACTTGTG TAGCGTCTGC GAGGGAAAGG GCTTGCACCG GGGGCACACC
AAGCTCGCAT TCCCCAGCCC CTTCGGGCAC CTGTCTGAGG GCTTCTCGCA CAGCCGCTGG
CTCCGGAAGG TGAAACACGG ACACTTCGGG TGGCCAGGAT GGGAAATGGG TCCACCAGGA
AACTGGAGCC CACGTCCTCC TCGTGCAGGG GAGGCCCGCC CTGGCCCCAC GGCAGAATCA
GCTTCTGGTC CATCGGAGGA TCCGAGTGTG AATTTCCTGA AGAACGTTGG GGAGAGTGTG
GCAGCTGCCC TTAGCCCTCT GGGCATTGAA GTTGATATCG ATGTGGAGCA CGGAGGGAAA
AGAAGCCGCC TGACCCCCGT CTCTCCAGAG AGTTCCAGCA CAGAGGAGAA GAGCAGCTCA
CAGCCAAGCA GCTGCTGCTC TGACCCCAGC AAGCCGGGTG GGAATGTTGA GGGCGCCACG
CAGTCTCTGG CGGAGCAGAT GAGGAAGATC GCCTTGGAGT CCGAGGGGCG CCCTGAGGAA
CAGATGGAGT CGGATAACTG TTCAGGAGGA GATGATGACT GGACCCATCT GTCTTCAAAA
GAAGTGGACC CGTCTACAGG TGAACTCCAG TCCCTACAGA TGCCAGAATC CGAAGGGCCA
AGCTCTCTGG ACCCCTCCCA GGAGGGACCC ACAGGGCTGA AGGAAGCTGC CTTGTACCCA
CATCTCCCGC CAGAGGCTGA CCCGCGGCTG ATTGAGTCCC TCTCCCAGAT GCTGTCCATG
GGCTTCTCTG ATGAAGGCGG CTGGCTCACC AGGCTCCTGC AGACCAAGAA CTATGACATC
GGAGCGGCTC TGGACACCAT CCAGTATTCA AAGCATCCCC CGCCGTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu62276
Clone ID Related Accession (Same CDS sequence) XM_011534683.2
Accession Version XM_011534683.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 732bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product sequestosome-1 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011534683.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCCGGG GGACCGGGGC CGGGGCGCAG GGGTCGGAAG GCGGCGGCGG CGGCGGCAGG 
GGCCCCGGCC CCGGGTCGGG GAGGGGCGGG GGGCCCGGGG CCGGGCGGGG ACCGGGCCAG
GGAGCGCGCC GGCCGCCCCT CAGGGCGCAA GCTTTGTGCC CTGTACTCAG GGAAGAGGAA
CAGGCTCAGA AGGGCAGAGG CAGGTATCAG GCTCACTGCA GATATCAGGG GCGCGGGACA
CTGGCGGCCT CGCCTCCGCG GCAGGGCCGG GCCGGGCCGG GCTGGGCTGG GCTGGGCGGC
GAGAGCCGCG GCCCGGCCTG GATCTGGGGC CTGGATCTGG GGCCGCCGCG GAGTCGACGG
CGCAGGGCGG GGCGGCCCGG ATTTAAAGGG GCCGCAGCAC CGCCGTCGCC GGCGCCGCGA
GGGGGTGGGG TGGGGGCCGG CGGCCGGGAT CCCGATCGGC TCCCGCAGCC CCGCGTGGGC
TCGTGCGAGT CGGCCTCAGT GTCTGCGAGA TTAATCTCTC ATGGCCGCTG CACAAGAACC
TGGCTTTTAG CTGAACTAAG GAGAAAGTCC TACAACAGTT TGGCGTGCAA CATGGGGCTT
GAGAAAGGGT TTTCAGCAGC TTCCGGAGGC CGCCTGGACT GCAGAAGGCG CCCTGGGCGT
GTGTACTTCC ACCTCCGCAG GCGCTGGCAT CTCCAGGCTG CTTCAGGCCG CTTTGGACCT
CACCATCGGT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011532985.1
CDS16..747
Translation

Target ORF information:

RefSeq Version XM_011534683.2
Organism Homo sapiens(Human)
Definition Homo sapiens sequestosome 1 (SQSTM1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011534683.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCCGGG GGACCGGGGC CGGGGCGCAG GGGTCGGAAG GCGGCGGCGG CGGCGGCAGG 
GGCCCCGGCC CCGGGTCGGG GAGGGGCGGG GGGCCCGGGG CCGGGCGGGG ACCGGGCCAG
GGAGCGCGCC GGCCGCCCCT CAGGGCGCAA GCTTTGTGCC CTGTACTCAG GGAAGAGGAA
CAGGCTCAGA AGGGCAGAGG CAGGTATCAG GCTCACTGCA GATATCAGGG GCGCGGGACA
CTGGCGGCCT CGCCTCCGCG GCAGGGCCGG GCCGGGCCGG GCTGGGCTGG GCTGGGCGGC
GAGAGCCGCG GCCCGGCCTG GATCTGGGGC CTGGATCTGG GGCCGCCGCG GAGTCGACGG
CGCAGGGCGG GGCGGCCCGG ATTTAAAGGG GCCGCAGCAC CGCCGTCGCC GGCGCCGCGA
GGGGGTGGGG TGGGGGCCGG CGGCCGGGAT CCCGATCGGC TCCCGCAGCC CCGCGTGGGC
TCGTGCGAGT CGGCCTCAGT GTCTGCGAGA TTAATCTCTC ATGGCCGCTG CACAAGAACC
TGGCTTTTAG CTGAACTAAG GAGAAAGTCC TACAACAGTT TGGCGTGCAA CATGGGGCTT
GAGAAAGGGT TTTCAGCAGC TTCCGGAGGC CGCCTGGACT GCAGAAGGCG CCCTGGGCGT
GTGTACTTCC ACCTCCGCAG GCGCTGGCAT CTCCAGGCTG CTTCAGGCCG CTTTGGACCT
CACCATCGGT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Free radical research50(12)1408-1421(2016 Dec)
Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH


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Molecular medicine reports14(5)4638-4642(2016 Nov)
Yang M,Wang B,Miao L,Xu X,He X


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p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.
Cancer cell30(4)595-609(2016 Oct)
Duran A,Hernandez ED,Reina-Campos M,Castilla EA,Subramaniam S,Raghunandan S,Roberts LR,Kisseleva T,Karin M,Diaz-Meco MT,Moscat J


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p62 in Cancer: Signaling Adaptor Beyond Autophagy.
Cell167(3)606-609(2016 Oct)
Moscat J,Karin M,Diaz-Meco MT


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Absence of the Autophagy Adaptor SQSTM1/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy.
American journal of human genetics99(3)735-743(2016 Sep)
Haack TB,Ignatius E,Calvo-Garrido J,Iuso A,Isohanni P,Maffezzini C,Lönnqvist T,Suomalainen A,Gorza M,Kremer LS,Graf E,Hartig M,Berutti R,Paucar M,Svenningsson P,Stranneheim H,Brandberg G,Wedell A,Kurian MA,Hayflick SA,Venco P,Tiranti V,Strom TM,Dichgans M,Horvath R,Holinski-Feder E,Freyer C,Meitinger T,Prokisch H,Senderek J,Wredenberg A,Carroll CJ,Klopstock T


 
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