HIST1H2BJ cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | HIST1H2BJ |
| Entrez Gene ID | 8970 |
| Full Name | histone cluster 1 H2B family member j |
| Synonyms | H2B/r,H2BFR,H2BJ |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_021058.4 | NP_066402.2 | histone H2B type 1-J |
| NM_021058.3 | NP_066402.2 | histone H2B type 1-J |
| Homo sapiens (human) | HIST1H2BJ | NP_066402.2 |
| HIST1H2BJ | XP_001092573.2 | |
| Canis lupus familiaris (dog) | LOC488288 | XP_005640170.1 |
| Mus musculus (house mouse) | Hist2h2be | NP_835586.2 |
| Drosophila melanogaster (fruit fly) | His2B:CG33886 | NP_001027340.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33884 | NP_001027345.1 |
| Anopheles gambiae (African malaria mosquito) | H2B_ANOGA_c | XP_320329.2 |
| Caenorhabditis elegans (roundworm) | his-15 | NP_496888.1 |
| Caenorhabditis elegans (roundworm) | his-4 | NP_507031.2 |
| Caenorhabditis elegans (roundworm) | his-66 | NP_502149.1 |
| Caenorhabditis elegans (roundworm) | his-48 | NP_502132.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101731234 | XP_004919908.1 |
| Xenopus tropicalis (tropical clawed frog) | hist1h2bm | XP_004917054.1 |
| Xenopus tropicalis (tropical clawed frog) | hist1h2bj | NP_001017251.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100492632 | XP_004919110.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101730940 | XP_004919326.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100497242 | XP_004913915.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100486870 | XP_004915674.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101735218 | XP_004913904.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100487485 | XP_002943394.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100498329 | XP_002941396.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101731067 | XP_004919328.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100496436 | XP_002940881.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100485294 | XP_002941400.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100497915 | XP_002941393.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33900 | NP_001027305.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33896 | NP_001027315.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33890 | NP_001027330.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33882 | NP_001027350.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33876 | NP_001027365.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33874 | NP_001027370.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33868 | NP_001027385.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG17949 | NP_724342.1 |
| Caenorhabditis elegans (roundworm) | his-29 | NP_501403.1 |
| Caenorhabditis elegans (roundworm) | his-44 | NP_496897.1 |
| Caenorhabditis elegans (roundworm) | his-20 | NP_505295.1 |
| Caenorhabditis elegans (roundworm) | his-41 | NP_505464.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101733828 | XP_004917048.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100495041 | XP_004913863.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100498553 | XP_002942903.2 |
| Xenopus tropicalis (tropical clawed frog) | LOC101734862 | XP_004915671.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100498072 | XP_002941394.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100496181 | XP_002940879.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33904 | NP_001027296.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33880 | NP_001027355.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33872 | NP_001027375.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33870 | NP_001027380.1 |
| Anopheles gambiae (African malaria mosquito) | H2B_ANOGA_d | XP_001238300.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012894 | XP_306255.2 |
| Caenorhabditis elegans (roundworm) | his-54 | NP_505279.1 |
| Caenorhabditis elegans (roundworm) | his-34 | NP_501409.1 |
| Caenorhabditis elegans (roundworm) | his-62 | NP_501202.1 |
| Xenopus tropicalis (tropical clawed frog) | hist1h2bk | NP_001006891.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101735164 | XP_004915676.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100495415 | XP_002933938.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101734494 | XP_004917058.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101733489 | XP_004917045.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100497082 | XP_004919476.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101731852 | XP_004919469.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101731959 | XP_004913866.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100487281 | XP_004913921.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101733171 | XP_004919930.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100498647 | XP_002941398.1 |
| Pan troglodytes (chimpanzee) | HIST1H2BK | XP_003339164.1 |
| Rattus norvegicus (Norway rat) | Hist2h2be | XP_227459.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33902 | NP_001027300.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33898 | NP_001027310.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33894 | NP_001027320.1 |
| Anopheles gambiae (African malaria mosquito) | H2B_ANOGA_e | XP_320334.2 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012710 | XP_307082.2 |
| Xenopus tropicalis (tropical clawed frog) | LOC100495578 | XP_002933939.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100495396 | XP_002943313.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC101731748 | XP_004913927.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100486150 | XP_002940832.1 |
| Bos taurus (cattle) | LOC522960 | XP_002697546.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33878 | NP_001027360.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33910 | NP_001027283.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33908 | NP_001027287.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33906 | NP_001027291.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33892 | NP_001027325.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33888 | NP_001027335.1 |
| Caenorhabditis elegans (roundworm) | his-11 | NP_496892.1 |
| Caenorhabditis elegans (roundworm) | his-22 | NP_505294.1 |
| Caenorhabditis elegans (roundworm) | his-52 | NP_505278.2 |
| Caenorhabditis elegans (roundworm) | his-8 | NP_505197.1 |
| Caenorhabditis elegans (roundworm) | his-58 | NP_502140.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100496445 | XP_004919472.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100485134 | XP_004919084.1 |
Related articles in PubMed
Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
Latrick CM, Marek M, Ouararhni K, Papin C, Stoll I, Ignatyeva M, Obri A, Ennifar E, Dimitrov S, Romier C, Hamiche A
Nature structural & molecular biology23(4)309-16(2016 Apr)
No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia.
Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics159B(4)456-64(2012 Jun)
Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)
Crystal structure of the human centromeric nucleosome containing CENP-A.
Tachiwana H, Kagawa W, Shiga T, Osakabe A, Miya Y, Saito K, Hayashi-Takanaka Y, Oda T, Sato M, Park SY, Kimura H, Kurumizaka H
Nature476(7359)232-5(2011 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The genes HIST1H2BJ, PRSS16, and PGBD1 were not associated with Japanese patients with schizophrenia.
Title: No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia.
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Common variants on chromosome 6p22.1 are associated with schizophrenia.
Histone H2A and H2B antimicrobial peptides exhibit antibacterial activity and endotoxin-neutralizing activity in the placenta.
Title: Endotoxin-neutralizing antimicrobial proteins of the human placenta.
The following HIST1H2BJ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H2BJ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu30548 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_021058.4 , NM_021058.3 | |
| Accession Version | NM_021058.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-19 | |
| Organism | Homo sapiens(human) | |
| Product | histone H2B type 1-J | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL021807.2. On Dec 3, 2019 this sequence version replaced NM_021058.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BX956575.1, AK311849.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 11859126 RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGCCAGAGC CAGCGAAGTC TGCTCCCGCC CCGAAAAAGG GCTCCAAGAA GGCGGTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_066402.2 |
| CDS | 46..426 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_021058.4 |
ORF Insert Sequence:
1 | ATGCCAGAGC CAGCGAAGTC TGCTCCCGCC CCGAAAAAGG GCTCCAAGAA GGCGGTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu30548 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_021058.4 , NM_021058.3 | |
| Accession Version | NM_021058.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-05 | |
| Organism | Homo sapiens(human) | |
| Product | histone H2B type 1-J | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X00088.1. On Apr 29, 2002 this sequence version replaced NM_021058.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 11859126 RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGCCAGAGC CAGCGAAGTC TGCTCCCGCC CCGAAAAAGG GCTCCAAGAA GGCGGTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_066402.2 |
| CDS | 47..427 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_021058.3 |
ORF Insert Sequence:
1 | ATGCCAGAGC CAGCGAAGTC TGCTCCCGCC CCGAAAAAGG GCTCCAAGAA GGCGGTGACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1. |
|
No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia. |
|
Proteomic characterization of the human sperm nucleus. |
|
Crystal structure of the human centromeric nucleosome containing CENP-A. |