Gene Symbol | ORAI3 |
Entrez Gene ID | 93129 |
Full Name | ORAI calcium release-activated calcium modulator 3 |
Synonyms | TMEM142C |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » ORAI3 cDNA ORF clone
Gene Symbol | ORAI3 |
Entrez Gene ID | 93129 |
Full Name | ORAI calcium release-activated calcium modulator 3 |
Synonyms | TMEM142C |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_152288.3 | NP_689501.1 | protein orai-3 |
NM_152288.2 | NP_689501.1 | protein orai-3 |
Pan troglodytes (chimpanzee) | ORAI3 | XP_003315113.1 |
Canis lupus familiaris (dog) | ORAI3 | XP_849021.1 |
Mus musculus (house mouse) | Orai3 | NP_940816.1 |
ORAI3 | XP_001111639.1 | |
Homo sapiens (human) | ORAI3 | NP_689501.1 |
Rattus norvegicus (Norway rat) | Orai3 | NP_001014046.1 |
Bos taurus (cattle) | ORAI3 | NP_001180131.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005071 | XP_001688479.1 |
Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection.
Hasna J, Hague F, Rodat-Despoix L, Geerts D, Leroy C, Tulasne D, Ouadid-Ahidouch H, Kischel P
Cell death and differentiation(2018 Jan)
Communication between N-terminus and Loop2 tunes Orai activation.
Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I
The Journal of biological chemistry(2017 Dec)
Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus.
Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C
The Journal of biological chemistry(2017 Dec)
ORAI channels are critical for receptor-mediated endocytosis of albumin.
Zeng B, Chen GL, Garcia-Vaz E, Bhandari S, Daskoulidou N, Berglund LM, Jiang H, Hallett T, Zhou LP, Huang L, Xu ZH, Nair V, Nelson RG, Ju W, Kretzler M, Atkin SL, Gomez MF, Xu SZ
Nature communications8(1)1920(2017 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
Title: A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
Overall high Orai3/Orai1 ratios in human prostate epithelial cells and androgen-insensitive cancer cells contribute to their ROS resistance and thereby may have a share in making the prostate one of the most prominent cancer susceptible organs
Title: Differential Redox Regulation of Ca?? Signaling and Viability in Normal and Malignant Prostate Cells.
Orai3 down-tunes efficient STIM1 gating when in a heteromeric complex with Orai1.
Title: Facilitation of Orai3 targeting and store-operated function by Orai1.
Suggest disrupted dynamic equilibrium of channel-forming ORAI proteins as an oncogenic mechanism in prostate cancer.
Title: Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer.
A channel chimera of Orai3 with the N terminus of Orai1 was able to couple local Ca(2+) entry to NFAT activation, identifying the N-terminal domain of Orai1 as central to Ca(2+) nanodomain-transcription coupling.
Title: Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.
The following ORAI3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORAI3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu13559 | |
Clone ID Related Accession (Same CDS sequence) | NM_152288.2 | |
Accession Version | NM_152288.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | protein orai-3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI561433.1, BC022786.1 and BC016150.1. On Dec 5, 2008 this sequence version replaced NM_152288.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015555.1, SRR1660803.90188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689501.1 |
CDS | 207..1094 |
Translation |
Target ORF information:
Target ORF information:
|
NM_152288.2 |
1 | ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu107394 | |
Clone ID Related Accession (Same CDS sequence) | NM_152288.3 | |
Accession Version | NM_152288.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-15 | |
Organism | Homo sapiens(human) | |
Product | protein orai-3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC135048.2. On Nov 23, 2018 this sequence version replaced NM_152288.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015555.1, SRR1660807.216679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000318663.5/ ENSP00000322249.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689501.1 |
CDS | 223..1110 |
Translation |
Target ORF information:
Target ORF information:
|
NM_152288.3 |
1 | ATGAAGGGCG GCGAGGGGGA CGCGGGCGAG CAGGCCCCGC TGAACCCTGA GGGCGAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection. |
Communication between N-terminus and Loop2 tunes Orai activation. |
Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus. |
ORAI channels are critical for receptor-mediated endocytosis of albumin. |