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NCR2 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol NCR2
Entrez Gene ID 9436
Full Name natural cytotoxicity triggering receptor 2
Synonyms CD336,LY95,NK-p44,NKP44,dJ149M18.1
General protein information
Preferred Names

natural cytotoxicity triggering receptor 2

Names

natural cytotoxicity triggering receptor 2
NK cell activating receptor (NKp44)
NK cell-activating receptor
lymphocyte antigen 95 (activating NK-receptor; NK-p44)
lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44)
natural killer cell p44-related protein
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

6

6p21.1
Disorder MIM:

604531


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001199509.1 NP_001186438.1 natural cytotoxicity triggering receptor 2 isoform 2 precursor
NM_004828.3 NP_004819.2 natural cytotoxicity triggering receptor 2 isoform 1 precursor
NM_001199510.1 NP_001186439.1 natural cytotoxicity triggering receptor 2 isoform 3 precursor
XM_017011500.1 XP_016866989.1 natural cytotoxicity triggering receptor 2 isoform X1

Pathways from BioSystems


Homologies


Homo sapiens (human) NCR2 NP_004819.2
Pan troglodytes (chimpanzee) NCR2 NP_001181874.1
NCR2 XP_001082574.1
Canis lupus familiaris (dog) NCR2 XP_005627372.1

Gene Ontology


Bibliography

Related articles in PubMed

Increased expressions of NKp44, NKp46 on NK/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection.
Das R, Tripathy A
Medical microbiology and immunology203(5)303-14(2014 Oct)

Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.
Teunissen MBM, Munneke JM, Bernink JH, Spuls PI, Res PCM, Te Velde A, Cheuk S, Brouwer MWD, Menting SP, Eidsmo L, Spits H, Hazenberg MD, Mj?sberg J
The Journal of investigative dermatology134(9)2351-2360(2014 Sep)

Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Nielsen N, Pascal V, Fasth AE, Sundstr?m Y, Galsgaard ED, Ahern D, Andersen M, Baslund B, Bartels EM, Bliddal H, Feldmann M, Malmstr?m V, Berg L, Spee P, S?derstr?m K
Immunology142(4)581-93(2014 Aug)

Augmenting the expression of NKp44 molecule and the natural killer activity in peripheral blood mononuclear cells from patients with malignant colorectal carcinoma.
Sheikhi A, Saadati K, Jafarzadeh A, Karimi H, Mousavinasab N
Drug research64(6)281-6(2014 Jun)

Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis.
Villanova F, Flutter B, Tosi I, Grys K, Sreeneebus H, Perera GK, Chapman A, Smith CH, Di Meglio P, Nestle FO
The Journal of investigative dermatology134(4)984-991(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

On CD56(+) CD3(-) cells, NKp44 and NKp46 expressions were high in the acute hepatitis E patients, whereas NKp30, NKp44, NKp46 and NKG2D were high in the recovered individuals.
Title: Increased expressions of NKp44, NKp46 on NK/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection.

NCR(+) ILC3 from skin and blood of psoriasis patients produced IL-22, which is regarded as a key driver of epidermal thickening, suggesting that NCR(+) ILC3 may participate in psoriasis pathology.
Title: Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.

Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Title: Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

demonstrated that the mitogen and iK562 exposure to peripheral blood mononuclear cells can significantly improve NK activity which is co-related to the higher expression of NKp44 and NKG2D
Title: Augmenting the expression of NKp44 molecule and the natural killer activity in peripheral blood mononuclear cells from patients with malignant colorectal carcinoma.

NKp44+ ILC3 are expressed in human skin and blood and may have a role in psoriasis pathogenesis
Title: Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis.

The following NCR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NCR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu32157 NM_004828.3
Latest version!		 Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $154.50-$216.30
$309.00
OHu00030 NM_001199510.1
Latest version!		 Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu11897 NM_001199509.1
Latest version!		 Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu96919 XM_017011500.1
Latest version!		 Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu32157
Clone ID Related Accession (Same CDS sequence) NM_004828.3
Accession Version NM_004828.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 831bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-11-27
Organism Homo sapiens(human)
Product natural cytotoxicity triggering receptor 2 isoform 1 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL136967.5. On Jul 26, 2007 this sequence version replaced NM_004828.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCCTGGC GAGCCCTACA CCCACTGCTA CTGCTGCTGC TGCTGTTCCC AGGCTCTCAG 
GCACAATCCA AGGCTCAGGT ACTTCAAAGT GTGGCAGGGC AGACGCTAAC CGTGAGATGC 
CAGTACCCGC CCACGGGCAG TCTCTACGAG AAGAAAGGCT GGTGTAAGGA GGCTTCAGCA 
CTTGTGTGCA TCAGGTTAGT CACCAGCTCC AAGCCCAGGA CGATGGCTTG GACCTCTCGA 
TTCACAATCT GGGACGACCC TGATGCTGGC TTCTTCACTG TCACCATGAC TGATCTGAGA 
GAGGAAGACT CAGGACATTA CTGGTGTAGA ATCTACCGCC CTTCTGACAA CTCTGTCTCT 
AAGTCCGTCA GATTCTATCT GGTGGTATCT CCAGCCTCTG CCTCCACACA GACCTCCTGG 
ACTCCCCGCG ACCTGGTCTC TTCACAGACC CAGACCCAGA GCTGTGTGCC TCCCACTGCA 
GGAGCCAGAC AAGCCCCTGA GTCTCCATCT ACCATCCCTG TCCCTTCACA GCCACAGAAC 
TCCACGCTCC GCCCTGGCCC TGCAGCCCCC ATTGCCCTGG TGCCTGTGTT CTGTGGACTC 
CTCGTAGCCA AGAGCCTGGT GCTGTCAGCC CTGCTCGTCT GGTGGGGGGA CATATGGTGG 
AAAACCATGA TGGAGCTCAG GAGCCTGGAT ACCCAAAAAG CCACCTGCCA CCTTCAACAG 
GTCACGGACC TTCCCTGGAC CTCAGTTTCC TCACCTGTAG AGAGAGAAAT ATTATATCAC 
ACTGTTGCAA GGACTAAGAT AAGCGATGAT GATGATGAAC ACACTTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004819.2
CDS88..918
Misc Feature(1)166..459
Misc Feature(2)178..474
Misc Feature(3)235..243
Misc Feature(4)<364..>612
Misc Feature(5)664..726
Exon (1)1..139
Exon (2)140..481
Exon (3)482..617
Exon (4)618..731
Exon (5)732..941
Translation

Target ORF information:

RefSeq Version NM_004828.3
Organism Homo sapiens(human)
Definition Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004828.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCCTGGC GAGCCCTACA CCCACTGCTA CTGCTGCTGC TGCTGTTCCC AGGCTCTCAG 
GCACAATCCA AGGCTCAGGT ACTTCAAAGT GTGGCAGGGC AGACGCTAAC CGTGAGATGC 
CAGTACCCGC CCACGGGCAG TCTCTACGAG AAGAAAGGCT GGTGTAAGGA GGCTTCAGCA 
CTTGTGTGCA TCAGGTTAGT CACCAGCTCC AAGCCCAGGA CGATGGCTTG GACCTCTCGA 
TTCACAATCT GGGACGACCC TGATGCTGGC TTCTTCACTG TCACCATGAC TGATCTGAGA 
GAGGAAGACT CAGGACATTA CTGGTGTAGA ATCTACCGCC CTTCTGACAA CTCTGTCTCT 
AAGTCCGTCA GATTCTATCT GGTGGTATCT CCAGCCTCTG CCTCCACACA GACCTCCTGG 
ACTCCCCGCG ACCTGGTCTC TTCACAGACC CAGACCCAGA GCTGTGTGCC TCCCACTGCA 
GGAGCCAGAC AAGCCCCTGA GTCTCCATCT ACCATCCCTG TCCCTTCACA GCCACAGAAC 
TCCACGCTCC GCCCTGGCCC TGCAGCCCCC ATTGCCCTGG TGCCTGTGTT CTGTGGACTC 
CTCGTAGCCA AGAGCCTGGT GCTGTCAGCC CTGCTCGTCT GGTGGGGGGA CATATGGTGG 
AAAACCATGA TGGAGCTCAG GAGCCTGGAT ACCCAAAAAG CCACCTGCCA CCTTCAACAG 
GTCACGGACC TTCCCTGGAC CTCAGTTTCC TCACCTGTAG AGAGAGAAAT ATTATATCAC 
ACTGTTGCAA GGACTAAGAT AAGCGATGAT GATGATGAAC ACACTTTGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu00030
Clone ID Related Accession (Same CDS sequence) NM_001199510.1
Accession Version NM_001199510.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 777bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-11-28
Organism Homo sapiens(human)
Product natural cytotoxicity triggering receptor 2 isoform 3 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL136967.5. Transcript Variant: This variant (3) has an additional exon which results in frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ010099.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01820695 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCTGGC GAGCCCTACA CCCACTGCTA CTGCTGCTGC TGCTGTTCCC AGGCTCTCAG 
GCACAATCCA AGGCTCAGGT ACTTCAAAGT GTGGCAGGGC AGACGCTAAC CGTGAGATGC 
CAGTACCCGC CCACGGGCAG TCTCTACGAG AAGAAAGGCT GGTGTAAGGA GGCTTCAGCA 
CTTGTGTGCA TCAGGTTAGT CACCAGCTCC AAGCCCAGGA CGATGGCTTG GACCTCTCGA 
TTCACAATCT GGGACGACCC TGATGCTGGC TTCTTCACTG TCACCATGAC TGATCTGAGA 
GAGGAAGACT CAGGACATTA CTGGTGTAGA ATCTACCGCC CTTCTGACAA CTCTGTCTCT 
AAGTCCGTCA GATTCTATCT GGTGGTATCT CCAGCCTCTG CCTCCACACA GACCTCCTGG 
ACTCCCCGCG ACCTGGTCTC TTCACAGACC CAGACCCAGA GCTGTGTGCC TCCCACTGCA 
GGAGCCAGAC AAGCCCCTGA GTCTCCATCT ACCATCCCTG TCCCTTCACA GCCACAGAAC 
TCCACGCTCC GCCCTGGCCC TGCAGCCCCC ATTGCCCTGG TGCCTGTGTT CTGTGGACTC 
CTCGTAGCCA AGAGCCTGGT GCTGTCAGCC CTGCTCGTCT GGTGGGTTTT AAGGAATCGG 
CACATGCAGC ATCAAGGGAG GTCTCTGCTG CACCCAGCTC AGCCCAGGCC CCAGGCCCAT 
AGACACTTCC CACTGAGCCA CAGGGCACCA GGGGGGACAT ATGGTGGAAA ACCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001186439.1
CDS88..864
Misc Feature(1)166..459
Misc Feature(2)178..474
Misc Feature(3)235..243
Misc Feature(4)664..726
Exon (1)1..139
Exon (2)140..481
Exon (3)482..617
Exon (4)618..731
Exon (5)732..838
Exon (6)839..1048
Translation

Target ORF information:

RefSeq Version NM_001199510.1
Organism Homo sapiens(human)
Definition Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001199510.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCTGGC GAGCCCTACA CCCACTGCTA CTGCTGCTGC TGCTGTTCCC AGGCTCTCAG 
GCACAATCCA AGGCTCAGGT ACTTCAAAGT GTGGCAGGGC AGACGCTAAC CGTGAGATGC 
CAGTACCCGC CCACGGGCAG TCTCTACGAG AAGAAAGGCT GGTGTAAGGA GGCTTCAGCA 
CTTGTGTGCA TCAGGTTAGT CACCAGCTCC AAGCCCAGGA CGATGGCTTG GACCTCTCGA 
TTCACAATCT GGGACGACCC TGATGCTGGC TTCTTCACTG TCACCATGAC TGATCTGAGA 
GAGGAAGACT CAGGACATTA CTGGTGTAGA ATCTACCGCC CTTCTGACAA CTCTGTCTCT 
AAGTCCGTCA GATTCTATCT GGTGGTATCT CCAGCCTCTG CCTCCACACA GACCTCCTGG 
ACTCCCCGCG ACCTGGTCTC TTCACAGACC CAGACCCAGA GCTGTGTGCC TCCCACTGCA 
GGAGCCAGAC AAGCCCCTGA GTCTCCATCT ACCATCCCTG TCCCTTCACA GCCACAGAAC 
TCCACGCTCC GCCCTGGCCC TGCAGCCCCC ATTGCCCTGG TGCCTGTGTT CTGTGGACTC 
CTCGTAGCCA AGAGCCTGGT GCTGTCAGCC CTGCTCGTCT GGTGGGTTTT AAGGAATCGG 
CACATGCAGC ATCAAGGGAG GTCTCTGCTG CACCCAGCTC AGCCCAGGCC CCAGGCCCAT 
AGACACTTCC CACTGAGCCA CAGGGCACCA GGGGGGACAT ATGGTGGAAA ACCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu11897
Clone ID Related Accession (Same CDS sequence) NM_001199509.1
Accession Version NM_001199509.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 813bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-11-28
Organism Homo sapiens(human)
Product natural cytotoxicity triggering receptor 2 isoform 2 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL136967.5. Transcript Variant: This variant (2) has an additional in-frame segment and an additional exon which results in frame-shift, as compared to variant 1. The resulting isoform (2) has an additional internal segment and a shorter and distinct C-terminus, as compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ010100.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCCTGGC GAGCCCTACA CCCACTGCTA CTGCTGCTGC TGCTGTTCCC AGGCTCTCAG 
GCACAATCCA AGGCTCAGGT ACTTCAAAGT GTGGCAGGGC AGACGCTAAC CGTGAGATGC 
CAGTACCCGC CCACGGGCAG TCTCTACGAG AAGAAAGGCT GGTGTAAGGA GGCTTCAGCA 
CTTGTGTGCA TCAGGTTAGT CACCAGCTCC AAGCCCAGGA CGATGGCTTG GACCTCTCGA 
TTCACAATCT GGGACGACCC TGATGCTGGC TTCTTCACTG TCACCATGAC TGATCTGAGA 
GAGGAAGACT CAGGACATTA CTGGTGTAGA ATCTACCGCC CTTCTGACAA CTCTGTCTCT 
AAGTCCGTCA GATTCTATCT GGTGGTATCT CCAGCCTCTG CCTCCACACA GACCTCCTGG 
ACTCCCCGCG ACCTGGTCTC TTCACAGACC CAGACCCAGA GCTGTGTGCC TCCCACTGCA 
GGAGCCAGAC AAGCCCCTGA GTCTCCATCT ACCATCCCTG TCCCTTCACA CCCGTCCTCT 
CCCCTTCCTG TCCCTCTGCC TTCCAGGCCA CAGAACTCCA CGCTCCGCCC TGGCCCTGCA 
GCCCCCATTG CCCTGGTGCC TGTGTTCTGT GGACTCCTCG TAGCCAAGAG CCTGGTGCTG 
TCAGCCCTGC TCGTCTGGTG GGTTTTAAGG AATCGGCACA TGCAGCATCA AGGGAGGTCT 
CTGCTGCACC CAGCTCAGCC CAGGCCCCAG GCCCATAGAC ACTTCCCACT GAGCCACAGG 
GCACCAGGGG GGACATATGG TGGAAAACCA TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001186438.1
CDS88..900
Misc Feature(1)166..459
Misc Feature(2)178..474
Misc Feature(3)235..243
Exon (1)1..139
Exon (2)140..481
Exon (3)482..617
Exon (4)618..767
Exon (5)768..874
Exon (6)875..1084
Translation

Target ORF information:

RefSeq Version NM_001199509.1
Organism Homo sapiens(human)
Definition Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001199509.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCCTGGC GAGCCCTACA CCCACTGCTA CTGCTGCTGC TGCTGTTCCC AGGCTCTCAG 
GCACAATCCA AGGCTCAGGT ACTTCAAAGT GTGGCAGGGC AGACGCTAAC CGTGAGATGC 
CAGTACCCGC CCACGGGCAG TCTCTACGAG AAGAAAGGCT GGTGTAAGGA GGCTTCAGCA 
CTTGTGTGCA TCAGGTTAGT CACCAGCTCC AAGCCCAGGA CGATGGCTTG GACCTCTCGA 
TTCACAATCT GGGACGACCC TGATGCTGGC TTCTTCACTG TCACCATGAC TGATCTGAGA 
GAGGAAGACT CAGGACATTA CTGGTGTAGA ATCTACCGCC CTTCTGACAA CTCTGTCTCT 
AAGTCCGTCA GATTCTATCT GGTGGTATCT CCAGCCTCTG CCTCCACACA GACCTCCTGG 
ACTCCCCGCG ACCTGGTCTC TTCACAGACC CAGACCCAGA GCTGTGTGCC TCCCACTGCA 
GGAGCCAGAC AAGCCCCTGA GTCTCCATCT ACCATCCCTG TCCCTTCACA CCCGTCCTCT 
CCCCTTCCTG TCCCTCTGCC TTCCAGGCCA CAGAACTCCA CGCTCCGCCC TGGCCCTGCA 
GCCCCCATTG CCCTGGTGCC TGTGTTCTGT GGACTCCTCG TAGCCAAGAG CCTGGTGCTG 
TCAGCCCTGC TCGTCTGGTG GGTTTTAAGG AATCGGCACA TGCAGCATCA AGGGAGGTCT 
CTGCTGCACC CAGCTCAGCC CAGGCCCCAG GCCCATAGAC ACTTCCCACT GAGCCACAGG 
GCACCAGGGG GGACATATGG TGGAAAACCA TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu96919
Clone ID Related Accession (Same CDS sequence) XM_017011500.1
Accession Version XM_017011500.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 825bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(human)
Product natural cytotoxicity triggering receptor 2 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAGCGCAC AGGAAAAGGA CCACATGGCC TGGCGAGCCC TACACCCACT GCTACTGCTG 
CTGCTGCTGT TCCCAGGCTC TCAGGCACAA TCCAAGGCTC AGGTACTTCA AAGTGTGGCA 
GGGCAGACGC TAACCGTGAG ATGCCAGTAC CCGCCCACGG GCAGTCTCTA CGAGAAGAAA 
GGCTGGTGTA AGGAGGCTTC AGCACTTGTG TGCATCAGGT TAGTCACCAG CTCCAAGCCC 
AGGACGATGG CTTGGACCTC TCGATTCACA ATCTGGGACG ACCCTGATGC TGGCTTCTTC 
ACTGTCACCA TGACTGATCT GAGAGAGGAA GACTCAGGAC ATTACTGGTG TAGAATCTAC 
CGCCCTTCTG ACAACTCTGT CTCTAAGTCC GTCAGATTCT ATCTGGTGGT ATCTCCAGCC 
TCTGCCTCCA CACAGACCTC CTGGACTCCC CGCGACCTGG TCTCTTCACA GACCCAGACC 
CAGAGCTGTG TGCCTCCCAC TGCAGGAGCC AGACAAGCCC CTGAGTCTCC ATCTACCATC 
CCTGTCCCTT CACAGCCACA GAACTCCACG CTCCGCCCTG GCCCTGCAGC CCCCATTGCC 
CTGGTGCCTG TGTTCTGTGG ACTCCTCGTA GCCAAGAGCC TGGTGCTGTC AGCCCTGCTC 
GTCTGGTGGG TTTTAAGGAA TCGGCACATG CAGCATCAAG GGAGGTCTCT GCTGCACCCA 
GCTCAGCCCA GGCCCCAGGC CCATAGACAC TTCCCACTGA GCCACAGGGC ACCAGGTGGG 
CGGCCAGTCT CCAACAAGGC TGGGCTCCCA GCAGCTCCTC CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016866989.1
CDS234..1058
Translation

Target ORF information:

RefSeq Version XM_017011500.1
Organism Homo sapiens(human)
Definition Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017011500.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGAGCGCAC AGGAAAAGGA CCACATGGCC TGGCGAGCCC TACACCCACT GCTACTGCTG 
CTGCTGCTGT TCCCAGGCTC TCAGGCACAA TCCAAGGCTC AGGTACTTCA AAGTGTGGCA 
GGGCAGACGC TAACCGTGAG ATGCCAGTAC CCGCCCACGG GCAGTCTCTA CGAGAAGAAA 
GGCTGGTGTA AGGAGGCTTC AGCACTTGTG TGCATCAGGT TAGTCACCAG CTCCAAGCCC 
AGGACGATGG CTTGGACCTC TCGATTCACA ATCTGGGACG ACCCTGATGC TGGCTTCTTC 
ACTGTCACCA TGACTGATCT GAGAGAGGAA GACTCAGGAC ATTACTGGTG TAGAATCTAC 
CGCCCTTCTG ACAACTCTGT CTCTAAGTCC GTCAGATTCT ATCTGGTGGT ATCTCCAGCC 
TCTGCCTCCA CACAGACCTC CTGGACTCCC CGCGACCTGG TCTCTTCACA GACCCAGACC 
CAGAGCTGTG TGCCTCCCAC TGCAGGAGCC AGACAAGCCC CTGAGTCTCC ATCTACCATC 
CCTGTCCCTT CACAGCCACA GAACTCCACG CTCCGCCCTG GCCCTGCAGC CCCCATTGCC 
CTGGTGCCTG TGTTCTGTGG ACTCCTCGTA GCCAAGAGCC TGGTGCTGTC AGCCCTGCTC 
GTCTGGTGGG TTTTAAGGAA TCGGCACATG CAGCATCAAG GGAGGTCTCT GCTGCACCCA 
GCTCAGCCCA GGCCCCAGGC CCATAGACAC TTCCCACTGA GCCACAGGGC ACCAGGTGGG 
CGGCCAGTCT CCAACAAGGC TGGGCTCCCA GCAGCTCCTC CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Increased expressions of NKp44, NKp46 on NK/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection.
Medical microbiology and immunology203(5)303-14(2014 Oct)
Das R,Tripathy A


book

Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.
The Journal of investigative dermatology134(9)2351-2360(2014 Sep)
Teunissen MBM,Munneke JM,Bernink JH,Spuls PI,Res PCM,Te Velde A,Cheuk S,Brouwer MWD,Menting SP,Eidsmo L,Spits H,Hazenberg MD,Mj?sberg J


book

Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Immunology142(4)581-93(2014 Aug)
Nielsen N,Pascal V,Fasth AE,Sundstr?m Y,Galsgaard ED,Ahern D,Andersen M,Baslund B,Bartels EM,Bliddal H,Feldmann M,Malmstr?m V,Berg L,Spee P,S?derstr?m K


book

Augmenting the expression of NKp44 molecule and the natural killer activity in peripheral blood mononuclear cells from patients with malignant colorectal carcinoma.
Drug research64(6)281-6(2014 Jun)
Sheikhi A,Saadati K,Jafarzadeh A,Karimi H,Mousavinasab N


book

Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis.
The Journal of investigative dermatology134(4)984-991(2014 Apr)
Villanova F,Flutter B,Tosi I,Grys K,Sreeneebus H,Perera GK,Chapman A,Smith CH,Di Meglio P,Nestle FO