HOMER1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOMER1
Entrez Gene ID	9456
Full Name	homer scaffolding protein 1
Synonyms	HOMER,HOMER1A,HOMER1B,HOMER1C,SYN47,Ves-1
General protein information	Preferred Names homer scaffolding protein 1 Names homer protein homolog 1 homer homolog 1 homer, neuronal immediate early gene, 1 homer-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q14.1
Summary	This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008].
Disorder MIM:	604798

mRNA and Protein(s)

mRNA	Protein	Name
NM_001277078.1	NP_001264007.1	homer protein homolog 1 isoform 3
XM_017010059.2	XP_016865548.1	homer protein homolog 1 isoform X1
NM_001277077.1	NP_001264006.1	homer protein homolog 1 isoform 2
NM_004272.5	NP_004263.1	homer protein homolog 1 isoform 1
NM_004272.4	NP_004263.1	homer protein homolog 1 isoform 1
XM_017010059.1	XP_016865548.1	homer protein homolog 1 isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	homer1	XP_005165595.1
Bos taurus (cattle)	HOMER1	NP_001069520.1
	HOMER1	XP_001109170.1
Mus musculus (house mouse)	Homer1	NP_001271118.1
Rattus norvegicus (Norway rat)	Homer1	NP_113895.1
Gallus gallus (chicken)	HOMER1	XP_424768.3
Danio rerio (zebrafish)	homer1b	NP_001002496.2
Xenopus tropicalis (tropical clawed frog)	homer1	NP_001106603.1
Homo sapiens (human)	HOMER1	NP_004263.1
Pan troglodytes (chimpanzee)	HOMER1	XP_001139767.1
Canis lupus familiaris (dog)	HOMER1	XP_849709.1

Gene Ontology
Bibliography

Related articles in PubMed

A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: A multimodal genetic imaging study.
Benedetti F, Poletti S, Locatelli C, Mazza E, Lorenzi C, Vitali A, Riberto M, Brioschi S, Vai B, Bollettini I, Melloni E, Aggio V, Falini A, De Bartolomeis A, Colombo C
Progress in neuro-psychopharmacology & biological psychiatry8188-95(2018 Feb)

Homer1a protein expression in schizophrenia, bipolar disorder, and major depression.
Leber SL, Llenos IC, Miller CL, Dulay JR, Haybaeck J, Weis S
Journal of neural transmission (Vienna, Austria : 1996)124(10)1261-1273(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Resequencing three candidate genes (HOMER1, SLC6A4, and TEF) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.
Title: Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.

Study shows that Homer1b/c is constitutively expressed in astrocytes, where it clusters with mGlu5 and endoplasmic reticulum tubules to form sub-plasmalemmal microdomains; propose that Homer1a may represent one of the cellular mechanisms by which inflammatory astrocytic reactions are beneficial for limiting brain injury
Title: Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes.

The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma
Title: Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells.

The main focus of the present review is to offer an overview of the current knowledge about the potential role of Homer1a in depression and the signaling pathways responsible for Homer1a regulation. [review]
Title: Signaling pathways regulating Homer1a expression: implications for antidepressant therapy.

Homer1 and Homer2 might be considered as novel diagnostic biomarkers for large-artery atherosclerosis stroke.
Title: Diagnostic Potential of Differentially Expressed Homer1 and Homer2 in Ischemic Stroke.

The following HOMER1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOMER1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20598	NM_004272.5 Latest version!	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu21132	NM_001277078.1 Latest version!	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu21646	NM_001277077.1 Latest version!	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu96197	XM_017010059.2 Latest version!	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu20598	NM_004272.4	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu96197	XM_017010059.1	Homo sapiens homer scaffolding protein 1 (HOMER1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOMER1 ( NM_004272.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004263.1 Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20598
Clone ID Related Accession (Same CDS sequence)	NM_004272.5 , NM_004272.4
Accession Version	NM_004272.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	homer protein homolog 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093270.3, AK312481.1, BC047438.1 and AC020898.6. On May 17, 2019 this sequence version replaced NM_004272.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047438.1, SRR1163657.511109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334082.11/ ENSP00000334382.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGTTC AGCAATCAGC 
AAACATTGGG AGGCTGAACT GGCTACCCTC AAAGGAAATA ATGCCAAACT CACTGCAGCC 
CTGCTGGAGT CCACTGCCAA TGTGAAACAA TGGAAACAGC AACTTGCTGC CTATCAAGAG 
GAAGCAGAAC GTCTGCACAA GCGGGTGACT GAACTTGAAT GTGTTAGTAG CCAAGCAAAT 
GCAGTACATA CTCATAAGAC AGAATTAAAT CAGACAATAC AAGAACTGGA AGAGACACTG 
AAACTGAAGG AAGAGGAAAT AGAAAGGTTA AAACAAGAAA TTGATAATGC CAGAGAACTA 
CAAGAACAGA GGGATTCTTT GACTCAGAAA CTACAGGAAG TAGAAATTCG GAACAAAGAC 
CTGGAGGGAC AACTGTCTGA CTTAGAGCAA CGTCTGGAGA AAAGTCAGAA TGAACAAGAA 
GCTTTTCGCA ATAACCTGAA GACACTCTTA GAAATTCTGG ATGGAAAGAT ATTTGAACTA 
ACAGAATTAC GAGATAACTT GGCCAAGCTA CTAGAATGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004263.1
CDS	1361..2425
Translation	MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS

Target ORF information:

RefSeq Version	NM_004272.5
Organism	Homo sapiens(human)
Definition	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004272.5

ORF Insert Sequence:

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGTTC AGCAATCAGC 
AAACATTGGG AGGCTGAACT GGCTACCCTC AAAGGAAATA ATGCCAAACT CACTGCAGCC 
CTGCTGGAGT CCACTGCCAA TGTGAAACAA TGGAAACAGC AACTTGCTGC CTATCAAGAG 
GAAGCAGAAC GTCTGCACAA GCGGGTGACT GAACTTGAAT GTGTTAGTAG CCAAGCAAAT 
GCAGTACATA CTCATAAGAC AGAATTAAAT CAGACAATAC AAGAACTGGA AGAGACACTG 
AAACTGAAGG AAGAGGAAAT AGAAAGGTTA AAACAAGAAA TTGATAATGC CAGAGAACTA 
CAAGAACAGA GGGATTCTTT GACTCAGAAA CTACAGGAAG TAGAAATTCG GAACAAAGAC 
CTGGAGGGAC AACTGTCTGA CTTAGAGCAA CGTCTGGAGA AAAGTCAGAA TGAACAAGAA 
GCTTTTCGCA ATAACCTGAA GACACTCTTA GAAATTCTGG ATGGAAAGAT ATTTGAACTA 
ACAGAATTAC GAGATAACTT GGCCAAGCTA CTAGAATGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOMER1 ( NM_004272.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004263.1 Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20598
Clone ID Related Accession (Same CDS sequence)	NM_004272.5 , NM_004272.4
Accession Version	NM_004272.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	homer protein homolog 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093270.3, AK312481.1, BC047438.1 and AC020898.6. On Mar 5, 2013 this sequence version replaced NM_004272.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047438.1, SRR1163657.511109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGTTC AGCAATCAGC 
AAACATTGGG AGGCTGAACT GGCTACCCTC AAAGGAAATA ATGCCAAACT CACTGCAGCC 
CTGCTGGAGT CCACTGCCAA TGTGAAACAA TGGAAACAGC AACTTGCTGC CTATCAAGAG 
GAAGCAGAAC GTCTGCACAA GCGGGTGACT GAACTTGAAT GTGTTAGTAG CCAAGCAAAT 
GCAGTACATA CTCATAAGAC AGAATTAAAT CAGACAATAC AAGAACTGGA AGAGACACTG 
AAACTGAAGG AAGAGGAAAT AGAAAGGTTA AAACAAGAAA TTGATAATGC CAGAGAACTA 
CAAGAACAGA GGGATTCTTT GACTCAGAAA CTACAGGAAG TAGAAATTCG GAACAAAGAC 
CTGGAGGGAC AACTGTCTGA CTTAGAGCAA CGTCTGGAGA AAAGTCAGAA TGAACAAGAA 
GCTTTTCGCA ATAACCTGAA GACACTCTTA GAAATTCTGG ATGGAAAGAT ATTTGAACTA 
ACAGAATTAC GAGATAACTT GGCCAAGCTA CTAGAATGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004263.1
CDS	1063..2127
Translation	MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS

Target ORF information:

RefSeq Version	NM_004272.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004272.4

ORF Insert Sequence:

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGTTC AGCAATCAGC 
AAACATTGGG AGGCTGAACT GGCTACCCTC AAAGGAAATA ATGCCAAACT CACTGCAGCC 
CTGCTGGAGT CCACTGCCAA TGTGAAACAA TGGAAACAGC AACTTGCTGC CTATCAAGAG 
GAAGCAGAAC GTCTGCACAA GCGGGTGACT GAACTTGAAT GTGTTAGTAG CCAAGCAAAT 
GCAGTACATA CTCATAAGAC AGAATTAAAT CAGACAATAC AAGAACTGGA AGAGACACTG 
AAACTGAAGG AAGAGGAAAT AGAAAGGTTA AAACAAGAAA TTGATAATGC CAGAGAACTA 
CAAGAACAGA GGGATTCTTT GACTCAGAAA CTACAGGAAG TAGAAATTCG GAACAAAGAC 
CTGGAGGGAC AACTGTCTGA CTTAGAGCAA CGTCTGGAGA AAAGTCAGAA TGAACAAGAA 
GCTTTTCGCA ATAACCTGAA GACACTCTTA GAAATTCTGG ATGGAAAGAT ATTTGAACTA 
ACAGAATTAC GAGATAACTT GGCCAAGCTA CTAGAATGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOMER1 ( NM_001277078.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001264007.1 Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu21132
Clone ID Related Accession (Same CDS sequence)	NM_001277078.1
Accession Version	NM_001277078.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	homer protein homolog 1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093270.3, AY189941.1 and AC020898.6. Transcript Variant: This variant (3, also known as HOMER1H) lacks three consecutive coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264007.1
CDS	1063..1596
Translation	MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHRK

Target ORF information:

RefSeq Version	NM_001277078.1
Organism	Homo sapiens(human)
Definition	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277078.1

ORF Insert Sequence:

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOMER1 ( NM_001277077.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001264006.1 Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21646
Clone ID Related Accession (Same CDS sequence)	NM_001277077.1
Accession Version	NM_001277077.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	homer protein homolog 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093270.3, AY189939.1 and AC020898.6. Transcript Variant: This variant (2, also known as HOMER1E) lacks three consecutive coding exons compared to variant 1. The missing segment is in-frame, so the resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAAGTGACT 
GAACTTGAAT GTGTTAGTAG CCAAGCAAAT GCAGTACATA CTCATAAGAC AGAATTAAAT 
CAGACAATAC AAGAACTGGA AGAGACACTG AAACTGAAGG AAGAGGAAAT AGAAAGGTTA 
AAACAAGAAA TTGATAATGC CAGAGAACTA CAAGAACAGA GGGATTCTTT GACTCAGAAA 
CTACAGGAAG TAGAAATTCG GAACAAAGAC CTGGAGGGAC AACTGTCTGA CTTAGAGCAA 
CGTCTGGAGA AAAGTCAGAA TGAACAAGAA GCTTTTCGCA ATAACCTGAA GACACTCTTA 
GAAATTCTGG ATGGAAAGAT ATTTGAACTA ACAGAATTAC GAGATAACTT GGCCAAGCTA 
CTAGAATGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264006.1
CDS	1063..1737
Translation	MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS

Target ORF information:

RefSeq Version	NM_001277077.1
Organism	Homo sapiens(human)
Definition	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277077.1

ORF Insert Sequence:

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAAGTGACT 
GAACTTGAAT GTGTTAGTAG CCAAGCAAAT GCAGTACATA CTCATAAGAC AGAATTAAAT 
CAGACAATAC AAGAACTGGA AGAGACACTG AAACTGAAGG AAGAGGAAAT AGAAAGGTTA 
AAACAAGAAA TTGATAATGC CAGAGAACTA CAAGAACAGA GGGATTCTTT GACTCAGAAA 
CTACAGGAAG TAGAAATTCG GAACAAAGAC CTGGAGGGAC AACTGTCTGA CTTAGAGCAA 
CGTCTGGAGA AAAGTCAGAA TGAACAAGAA GCTTTTCGCA ATAACCTGAA GACACTCTTA 
GAAATTCTGG ATGGAAAGAT ATTTGAACTA ACAGAATTAC GAGATAACTT GGCCAAGCTA 
CTAGAATGCA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOMER1 ( XM_017010059.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865548.1 Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96197
Clone ID Related Accession (Same CDS sequence)	XM_017010059.2 , XM_017010059.1
Accession Version	XM_017010059.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	homer protein homolog 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017010059.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGCCA GTTTCCCTTG 
GTGGATGATT TCTCTGATCA TCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865548.1
CDS	328..894
Translation	MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSQFPLVDDFSDHL

Target ORF information:

RefSeq Version	XM_017010059.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017010059.2

ORF Insert Sequence:

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGCCA GTTTCCCTTG 
GTGGATGATT TCTCTGATCA TCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOMER1 ( XM_017010059.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865548.1 Homo sapiens homer scaffolding protein 1 (HOMER1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96197
Clone ID Related Accession (Same CDS sequence)	XM_017010059.2 , XM_017010059.1
Accession Version	XM_017010059.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	homer protein homolog 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGCCA GTTTCCCTTG 
GTGGATGATT TCTCTGATCA TCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865548.1
CDS	1795..2361
Translation	MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSQFPLVDDFSDHL

Target ORF information:

RefSeq Version	XM_017010059.1
Organism	Homo sapiens(human)
Definition	Homo sapiens homer scaffolding protein 1 (HOMER1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017010059.1

ORF Insert Sequence:

ATGGGGGAAC AACCTATCTT CAGCACTCGA GCTCATGTCT TCCAAATTGA CCCAAACACA 
AAGAAGAACT GGGTACCCAC CAGCAAGCAT GCAGTTACTG TGTCTTATTT CTATGACAGC 
ACAAGAAATG TGTATAGGAT AATCAGTTTA GATGGCTCAA AGGCAATAAT AAATAGTACC 
ATCACCCCAA ACATGACATT TACTAAAACA TCTCAGAAGT TTGGCCAGTG GGCTGATAGC 
CGGGCAAACA CCGTTTATGG ATTGGGATTC TCCTCTGAGC ATCATCTTTC GAAATTTGCA 
GAAAAGTTTC AGGAATTTAA AGAAGCTGCT CGACTAGCAA AGGAAAAATC ACAAGAGAAG 
ATGGAACTTA CCAGTACACC TTCACAGGAA TCCGCAGGCG GGGATCTTCA GTCTCCTTTA 
ACACCGGAAA GTATCAACGG GACAGATGAT GAAAGAACAC CTGATGTGAC ACAGAACTCA 
GAGCCAAGGG CTGAACCAAC TCAGAATGCA TTGCCATTTT CACATAGCCA GTTTCCCTTG 
GTGGATGATT TCTCTGATCA TCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: A multimodal genetic imaging study.
Progress in neuro-psychopharmacology & biological psychiatry8188-95(2018 Feb)
Benedetti F,Poletti S,Locatelli C,Mazza E,Lorenzi C,Vitali A,Riberto M,Brioschi S,Vai B,Bollettini I,Melloni E,Aggio V,Falini A,De Bartolomeis A,Colombo C

Homer1a protein expression in schizophrenia, bipolar disorder, and major depression.
Journal of neural transmission (Vienna, Austria : 1996)124(10)1261-1273(2017 Oct)
Leber SL,Llenos IC,Miller CL,Dulay JR,Haybaeck J,Weis S

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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HOMER1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

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Target ORF information:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

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