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MAD2L1BP cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAD2L1BP
Entrez Gene ID 9587
Full Name MAD2L1 binding protein
Synonyms CMT2
General protein information
Preferred Names
MAD2L1-binding protein
Names
MAD2L1-binding protein
caught by MAD2 protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.1

Summary The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. lac of sum

mRNA and Protein(s)

mRNA Protein Name
NM_014628 NP_055443 MAD2L1-binding protein isoform 2
NM_001003690 NP_001003690 MAD2L1-binding protein isoform 1


Homo sapiens (human) MAD2L1BP NP_055443.1
Pan troglodytes (chimpanzee) MAD2L1BP XP_518498.3
Macaca mulatta (Rhesus monkey) MAD2L1BP XP_001096335.1
Canis lupus familiaris (dog) MAD2L1BP XP_532151.2
Bos taurus (cattle) MAD2L1BP NP_001069849.1
Mus musculus (house mouse) Mad2l1bp NP_079925.2
Rattus norvegicus (Norway rat) Mad2l1bp NP_001009699.1
Gallus gallus (chicken) MAD2L1BP XP_419498.1
Danio rerio (zebrafish) LOC101886806 XP_005173079.1
Xenopus (Silurana) tropicalis (western clawed frog) mad2l1bp XP_002942195.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAD2L1BP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAD2L1BP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu13064
NM_014628 Homo sapiens MAD2L1 binding protein (MAD2L1BP), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
OHu13100 NM_001003690 Homo sapiens MAD2L1 binding protein (MAD2L1BP), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $216.30
$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu13064
Clone ID Related Accession (Same CDS sequence) NM_014628
Accession Version NM_014628.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 825bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product MAD2L1-binding protein isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB991410.1, BI255998.1, BC002904.2 and AA883912.1. On Aug 16, 2004 this sequence version replaced gi:7661917. Transcript Variant: This variant differs in the 5' region compared to variant 1, which includes a part of the coding sequence. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB997598.1, BC002904.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCGGCGC CGGAGGCGGA GGTTCTGTCC TCAGCCGCAG TCCCTGATTT GGAGTGGTAT 
GAGAAGTCCG AAGAAACTCA CGCCTCCCAG ATAGAACTAC TTGAGACAAG CTCTACGCAG
GAACCTCTCA ACGCTTCGGA GGCCTTTTGC CCAAGAGACT GCATGGTACC AGTGGTGTTT
CCTGGGCCTG TGAGCCAGGA AGGCTGCTGT CAGTTTACTT GTGAACTTCT AAAGCATATC
ATGTATCAAC GCCAGCAGCT CCCTCTGCCC TATGAACAGC TTAAGCACTT TTACCGAAAA
CCTTCTCCCC AGGCAGAGGA GATGCTGAAG AAGAAACCTC GGGCCACCAC TGAGGTGAGC
AGCAGGAAAT GCCAACAAGC CCTGGCAGAA CTGGAGAGTG TCCTCAGCCA CCTGGAGGAC
TTCTTTGCAC GGACACTAGT ACCGCGAGTG CTGATTCTCC TTGGGGGCAA TGCCCTAAGC
CCCAAGGAGT TCTATGAACT CGACTTGTCT CTGCTGGCCC CCTACAGCGT GGACCAGAGC
CTGAGCACAG CAGCTTGTTT GCGCCGTCTC TTCCGAGCCA TATTCATGGC TGATGCCTTT
AGCGAGCTTC AGGCTCCTCC ACTCATGGGC ACCGTCGTCA TGGCACAGGG ACACCGCAAC
TGTGGAGAAG ATTGGTTTCG ACCCAAGCTC AACTATCGAG TGCCCAGCCG GGGCCATAAA
CTGACTGTGA CCCTGTCATG TGGCAGACCT TCCATCCGAA CCACGGCTTG GGAAGACTAC
ATTTGGTTCC AGGCACCAGT GACATTTAAA GGCTTCCGCG AGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_055443.1
CDS37..861
Misc Feature(1)121..123(+)
Misc Feature(2)148..858(+)
Misc Feature(3)151..153(+)
Misc Feature(4)169..270(+)
Exon (1)1..82
Gene:MAD2L1BP
Gene Synonym:
Exon (2)83..348
Gene:MAD2L1BP
Gene Synonym:
Exon (3)349..1280
Gene:MAD2L1BP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_014628
Organism Homo sapiens (human)
Definition Homo sapiens MAD2L1 binding protein (MAD2L1BP), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014628

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCGGCGC CGGAGGCGGA GGTTCTGTCC TCAGCCGCAG TCCCTGATTT GGAGTGGTAT 
GAGAAGTCCG AAGAAACTCA CGCCTCCCAG ATAGAACTAC TTGAGACAAG CTCTACGCAG
GAACCTCTCA ACGCTTCGGA GGCCTTTTGC CCAAGAGACT GCATGGTACC AGTGGTGTTT
CCTGGGCCTG TGAGCCAGGA AGGCTGCTGT CAGTTTACTT GTGAACTTCT AAAGCATATC
ATGTATCAAC GCCAGCAGCT CCCTCTGCCC TATGAACAGC TTAAGCACTT TTACCGAAAA
CCTTCTCCCC AGGCAGAGGA GATGCTGAAG AAGAAACCTC GGGCCACCAC TGAGGTGAGC
AGCAGGAAAT GCCAACAAGC CCTGGCAGAA CTGGAGAGTG TCCTCAGCCA CCTGGAGGAC
TTCTTTGCAC GGACACTAGT ACCGCGAGTG CTGATTCTCC TTGGGGGCAA TGCCCTAAGC
CCCAAGGAGT TCTATGAACT CGACTTGTCT CTGCTGGCCC CCTACAGCGT GGACCAGAGC
CTGAGCACAG CAGCTTGTTT GCGCCGTCTC TTCCGAGCCA TATTCATGGC TGATGCCTTT
AGCGAGCTTC AGGCTCCTCC ACTCATGGGC ACCGTCGTCA TGGCACAGGG ACACCGCAAC
TGTGGAGAAG ATTGGTTTCG ACCCAAGCTC AACTATCGAG TGCCCAGCCG GGGCCATAAA
CTGACTGTGA CCCTGTCATG TGGCAGACCT TCCATCCGAA CCACGGCTTG GGAAGACTAC
ATTTGGTTCC AGGCACCAGT GACATTTAAA GGCTTCCGCG AGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu13100
Clone ID Related Accession (Same CDS sequence) NM_001003690
Accession Version NM_001003690.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 921bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product MAD2L1-binding protein isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL537692.3, BE297042.1, BU845738.1, BC002904.2 and AA883912.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL537692.3, AL522815.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCCGCG TGCCGCTGGG GCGGAGTCTC ACTCTGTCAC CCAGGCTGGA GCACAATGGC 
ATGACCTCAG CTCACCACAA CTTCCGCCTC CCAGGTTCAA GGGATTCTCC TGCCTCAGCC
TCCCAAGTAG CTGAGATTAT AGATTTGGAG TGGTATGAGA AGTCCGAAGA AACTCACGCC
TCCCAGATAG AACTACTTGA GACAAGCTCT ACGCAGGAAC CTCTCAACGC TTCGGAGGCC
TTTTGCCCAA GAGACTGCAT GGTACCAGTG GTGTTTCCTG GGCCTGTGAG CCAGGAAGGC
TGCTGTCAGT TTACTTGTGA ACTTCTAAAG CATATCATGT ATCAACGCCA GCAGCTCCCT
CTGCCCTATG AACAGCTTAA GCACTTTTAC CGAAAACCTT CTCCCCAGGC AGAGGAGATG
CTGAAGAAGA AACCTCGGGC CACCACTGAG GTGAGCAGCA GGAAATGCCA ACAAGCCCTG
GCAGAACTGG AGAGTGTCCT CAGCCACCTG GAGGACTTCT TTGCACGGAC ACTAGTACCG
CGAGTGCTGA TTCTCCTTGG GGGCAATGCC CTAAGCCCCA AGGAGTTCTA TGAACTCGAC
TTGTCTCTGC TGGCCCCCTA CAGCGTGGAC CAGAGCCTGA GCACAGCAGC TTGTTTGCGC
CGTCTCTTCC GAGCCATATT CATGGCTGAT GCCTTTAGCG AGCTTCAGGC TCCTCCACTC
ATGGGCACCG TCGTCATGGC ACAGGGACAC CGCAACTGTG GAGAAGATTG GTTTCGACCC
AAGCTCAACT ATCGAGTGCC CAGCCGGGGC CATAAACTGA CTGTGACCCT GTCATGTGGC
AGACCTTCCA TCCGAACCAC GGCTTGGGAA GACTACATTT GGTTCCAGGC ACCAGTGACA
TTTAAAGGCT TCCGCGAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001003690.1
CDS209..1129
Misc Feature(1)152..154(+)
Misc Feature(2)389..391(+)
Misc Feature(3)416..1126(+)
Misc Feature(4)419..421(+)
Exon (1)1..228
Gene:MAD2L1BP
Gene Synonym:
Exon (2)229..350
Gene:MAD2L1BP
Gene Synonym:
Exon (3)351..616
Gene:MAD2L1BP
Gene Synonym:
Exon (4)617..1548
Gene:MAD2L1BP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001003690
Organism Homo sapiens (human)
Definition Homo sapiens MAD2L1 binding protein (MAD2L1BP), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001003690

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCCGCG TGCCGCTGGG GCGGAGTCTC ACTCTGTCAC CCAGGCTGGA GCACAATGGC 
ATGACCTCAG CTCACCACAA CTTCCGCCTC CCAGGTTCAA GGGATTCTCC TGCCTCAGCC
TCCCAAGTAG CTGAGATTAT AGATTTGGAG TGGTATGAGA AGTCCGAAGA AACTCACGCC
TCCCAGATAG AACTACTTGA GACAAGCTCT ACGCAGGAAC CTCTCAACGC TTCGGAGGCC
TTTTGCCCAA GAGACTGCAT GGTACCAGTG GTGTTTCCTG GGCCTGTGAG CCAGGAAGGC
TGCTGTCAGT TTACTTGTGA ACTTCTAAAG CATATCATGT ATCAACGCCA GCAGCTCCCT
CTGCCCTATG AACAGCTTAA GCACTTTTAC CGAAAACCTT CTCCCCAGGC AGAGGAGATG
CTGAAGAAGA AACCTCGGGC CACCACTGAG GTGAGCAGCA GGAAATGCCA ACAAGCCCTG
GCAGAACTGG AGAGTGTCCT CAGCCACCTG GAGGACTTCT TTGCACGGAC ACTAGTACCG
CGAGTGCTGA TTCTCCTTGG GGGCAATGCC CTAAGCCCCA AGGAGTTCTA TGAACTCGAC
TTGTCTCTGC TGGCCCCCTA CAGCGTGGAC CAGAGCCTGA GCACAGCAGC TTGTTTGCGC
CGTCTCTTCC GAGCCATATT CATGGCTGAT GCCTTTAGCG AGCTTCAGGC TCCTCCACTC
ATGGGCACCG TCGTCATGGC ACAGGGACAC CGCAACTGTG GAGAAGATTG GTTTCGACCC
AAGCTCAACT ATCGAGTGCC CAGCCGGGGC CATAAACTGA CTGTGACCCT GTCATGTGGC
AGACCTTCCA TCCGAACCAC GGCTTGGGAA GACTACATTT GGTTCCAGGC ACCAGTGACA
TTTAAAGGCT TCCGCGAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Depletion of p31comet protein promotes sensitivity to antimitotic drugs
J. Biol. Chem. 287 (25), 21561-21569 (2012)
Ma HT, Chan YY, Chen X, On KF and Poon RY.


book

Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex
Proc. Natl. Acad. Sci. U.S.A. 109 (21), 8056-8060 (2012)
Miniowitz-Shemtov S, Eytan E, Ganoth D, Sitry-Shevah D, Dumin E and Hershko A.


book

p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit
J. Cell. Sci. 124 (PT 22), 3905-3916 (2011)
Westhorpe FG, Tighe A, Lara-Gonzalez P and Taylor SS.


book

p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment
Mol. Biol. Cell 22 (22), 4236-4246 (2011)
Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV and Sorger PK.


book

[Molecular pathogenesis of hereditary motor and sensory neuropathy]
Postepy Biochem. 57 (3), 283-293 (2011)
Kotruchow K, Kabzinska D, Karpinska K and Kochanski A.


book

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint
EMBO J. 23 (15), 3133-3143 (2004)
Xia G, Luo X, Habu T, Rizo J, Matsumoto T and Yu H.


book

The DNA sequence and analysis of human chromosome 6
Nature 425 (6960), 805-811 (2003)
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J and Beck S.


book

Identification of a MAD2-binding protein, CMT2, and its role in mitosis
EMBO J. 21 (23), 6419-6428 (2002)
Habu T, Kim SH, Weinstein J and Matsumoto T.


book

Protein-protein interaction panel using mouse full-length cDNAs
Genome Res. 11 (10), 1758-1765 (2001)
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y and Hayashizaki Y.


book

A visual intracellular classification strategy for uncharacterized human proteins
Exp. Cell Res. 259 (1), 239-246 (2000)
Hoja MR, Wahlestedt C and Hoog C.


 
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