This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008].
The following FEZ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FEZ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
fasciculation and elongation protein zeta-1 isoform 1
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA697171.1, BC009545.1, BM663785.1 and AP000708.5. On May 17, 2019 this sequence version replaced NM_005103.4.
Transcript Variant: This variant (1) encodes the full-length isoform (1), which has a longer C-terminal end compared to isoform 2.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803617.98314.1, SRR1803615.25693.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000278919.8/ ENSP00000278919.3
RefSeq Select criteria :: based on conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
fasciculation and elongation protein zeta-1 isoform 1
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA697171.1, BC009545.1 and BM663785.1. On Sep 3, 2010 this sequence version replaced NM_005103.3.
Transcript Variant: This variant (1) encodes the full-length isoform (1), which has a longer C-terminal end compared to isoform 2.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163657.258637.1, SRR1803616.23050.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
fasciculation and elongation protein zeta-1 isoform 2
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA697171.1, CN310685.1, AP000708.5 and U60062.1. On Sep 3, 2010 this sequence version replaced NM_022549.2.
Transcript Variant: This variant (2) encodes a protein isoform (2) that is truncated at the C-terminal end compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803617.174089.1, SRR1803615.174835.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2467147 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
fasciculation and elongation protein zeta-1 isoform X1
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process
On Mar 12, 2015 this sequence version replaced XM_005271734.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
fasciculation and elongation protein zeta-1 isoform X1
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process
On Mar 12, 2015 this sequence version replaced XM_005271735.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
User Manual
NM_005103.5
