Gene Symbol | FCHSD2 |
Entrez Gene ID | 9873 |
Full Name | FCH and double SH3 domains 2 |
Synonyms | NWK,SH3MD3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » FCHSD2 cDNA ORF clone
Gene Symbol | FCHSD2 |
Entrez Gene ID | 9873 |
Full Name | FCH and double SH3 domains 2 |
Synonyms | NWK,SH3MD3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_017018632.1 | XP_016874121.1 | F-BAR and double SH3 domains protein 2 isoform X1 |
XM_011545409.1 | XP_011543711.1 | F-BAR and double SH3 domains protein 2 isoform X1 |
NM_014824.3 | NP_055639.2 | F-BAR and double SH3 domains protein 2 |
NM_014824.2 | NP_055639.2 | F-BAR and double SH3 domains protein 2 |
XM_011545410.2 | XP_011543712.1 | F-BAR and double SH3 domains protein 2 isoform X2 |
FCHSD2 | XP_002799736.1 | |
Rattus norvegicus (Norway rat) | Fchsd2 | NP_001101009.1 |
Pan troglodytes (chimpanzee) | FCHSD2 | XP_001174760.3 |
Bos taurus (cattle) | FCHSD2 | XP_002693485.1 |
Gallus gallus (chicken) | FCHSD2 | XP_417258.4 |
Danio rerio (zebrafish) | LOC100536453 | XP_003199428.2 |
Xenopus tropicalis (tropical clawed frog) | fchsd2 | NP_001096157.1 |
Homo sapiens (human) | FCHSD2 | NP_055639.2 |
Danio rerio (zebrafish) | LOC100536596 | XP_003199430.2 |
Drosophila melanogaster (fruit fly) | nwk | NP_001246692.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006774 | XP_308970.4 |
Canis lupus familiaris (dog) | FCHSD2 | XP_005633604.1 |
Mus musculus (house mouse) | Fchsd2 | NP_950177.2 |
Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom.
Xu Y, Xia J, Liu S, Stein S, Ramon C, Xi H, Wang L, Xiong X, Zhang L, He D, Yang W, Zhao X, Cheng X, Yang X, Wang H
Frontiers in bioscience (Landmark edition)221439-1457(2017 Mar)
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
Lessard CJ, Sajuthi S, Zhao J, Kim K, Ice JA, Li H, Ainsworth H, Rasmussen A, Kelly JA, Marion M, Bang SY, Joo YB, Choi J, Lee HS, Kang YM, Suh CH, Chung WT, Lee SK, Choe JY, Shim SC, Oh JH, Kim YJ, Han BG, Shen N, Howe HS, Wakeland EK, Li QZ, Song YW, Gaffney PM, Alarc?n-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Vyse TJ, Harley JB, Sivils KL, Bae SC, Langefeld CD, Tsao BP
Arthritis & rheumatology (Hoboken, N.J.)68(5)1197-1209(2016 05)
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Yang SK, Hong M, Zhao W, Jung Y, Baek J, Tayebi N, Kim KM, Ye BD, Kim KJ, Park SH, Lee I, Lee EJ, Kim WH, Cheon JH, Kim YH, Jang BI, Kim HS, Choi JH, Koo JS, Lee JH, Jung SA, Lee YJ, Jang JY, Shin HD, Kang D, Youn HS, Liu J, Song K
Gut63(1)80-7(2014 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Established 3 models of Carom-receptor complexes and their intracellular trafficking based on protein interaction and subcellular localization. Carom may mediate receptor endocytosis and transport endocytic receptors to the cytoplasm for receptor signaling and lysosome/proteasome degradation. Review.
Title: Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom.
A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2.
Title: Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
our study, for the first time, demonstrates FCHSD2 as a predictor of outcome for Acute myeloid leukemia patients
Title: FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The following FCHSD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FCHSD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu09095 | |
Clone ID Related Accession (Same CDS sequence) | NM_014824.3 , NM_014824.2 | |
Accession Version | NM_014824.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-29 | |
Organism | Homo sapiens(human) | |
Product | F-BAR and double SH3 domains protein 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP002455.4, AP004241.2 and AP002381.3. On Nov 23, 2018 this sequence version replaced NM_014824.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.8584.1, SRR1803614.240764.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000409418.9/ ENSP00000386722.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCAGCCGC CGCCGAGGAA GGTGAAAGTT ACACAAGAAC TGAAAAACAT TCAAGTTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055639.2 |
CDS | 442..2664 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014824.3 |
1 | ATGCAGCCGC CGCCGAGGAA GGTGAAAGTT ACACAAGAAC TGAAAAACAT TCAAGTTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu09095 | |
Clone ID Related Accession (Same CDS sequence) | NM_014824.3 , NM_014824.2 | |
Accession Version | NM_014824.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | F-BAR and double SH3 domains protein 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD358961.1, AL133567.1, BC017751.1 and BQ007622.1. On Apr 12, 2008 this sequence version replaced NM_014824.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.112023.1, SRR1803614.100612.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAGCCGC CGCCGAGGAA GGTGAAAGTT ACACAAGAAC TGAAAAACAT TCAAGTTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055639.2 |
CDS | 222..2444 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014824.2 |
1 | ATGCAGCCGC CGCCGAGGAA GGTGAAAGTT ACACAAGAAC TGAAAAACAT TCAAGTTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu63432 | |
Clone ID Related Accession (Same CDS sequence) | XM_017018632.1 , XM_011545409.1 | |
Accession Version | XM_017018632.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2160bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-BAR and double SH3 domains protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAAAAC TTCAAGCCAA ACATCAAGCA GAATGTGATT TGCTTGAAGA TATGAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016874121.1 |
CDS | 344..2503 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017018632.1 |
1 | ATGACAAAAC TTCAAGCCAA ACATCAAGCA GAATGTGATT TGCTTGAAGA TATGAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu63432 | |
Clone ID Related Accession (Same CDS sequence) | XM_017018632.1 , XM_011545409.1 | |
Accession Version | XM_011545409.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2160bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-BAR and double SH3 domains protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAAAAC TTCAAGCCAA ACATCAAGCA GAATGTGATT TGCTTGAAGA TATGAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011543711.1 |
CDS | 167..2326 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011545409.1 |
1 | ATGACAAAAC TTCAAGCCAA ACATCAAGCA GAATGTGATT TGCTTGAAGA TATGAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu63433 | |
Clone ID Related Accession (Same CDS sequence) | XM_011545410.2 | |
Accession Version | XM_011545410.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2148bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-BAR and double SH3 domains protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011545410.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCACAGAG TTTGGCTGCC GAGATTTAGA AAGCTGTGTG ATCAGAGTTC TATGGAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011543712.1 |
CDS | 112..2259 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011545410.2 |
1 | ATGCACAGAG TTTGGCTGCC GAGATTTAGA AAGCTGTGTG ATCAGAGTTC TATGGAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom. |
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. |
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. |