TOX4 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | TOX4 |
| Entrez Gene ID | 9878 |
| Full Name | TOX high mobility group box family member 4 |
| Synonyms | C14orf92,KIAA0737,LCP1,MIG7 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001303523.1 | NP_001290452.1 | TOX high mobility group box family member 4 isoform 2 |
| NM_014828.3 | NP_055643.1 | TOX high mobility group box family member 4 isoform 1 |
| Homo sapiens (human) | TOX4 | NP_055643.1 |
| TOX4 | NP_001165884.1 | |
| Xenopus tropicalis (tropical clawed frog) | tox4 | NP_001090624.1 |
| Mus musculus (house mouse) | Tox4 | NP_075923.2 |
| Canis lupus familiaris (dog) | TOX4 | XP_532626.2 |
| Bos taurus (cattle) | TOX4 | NP_001069175.1 |
| Pan troglodytes (chimpanzee) | TOX4 | XP_003314295.1 |
| Rattus norvegicus (Norway rat) | Tox4 | NP_775446.2 |
Related articles in PubMed
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)
A quantitative telomeric chromatin isolation protocol identifies different telomeric states.
Grolimund L, Aeby E, Hamelin R, Armand F, Chiappe D, Moniatte M, Lingner J
Nature communications42848(2013)
TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication.
Morchikh M, Naughtin M, Di Nunzio F, Xavier J, Charneau P, Jacob Y, Lavigne M
PloS one8(11)e81217(2013)
[Mig-7 enhances vasculogenic mimicry in gastric cancer cells].
Li WL, Gao Q
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology28(11)1142-5(2012 Nov)
Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.
Tessema M, Yingling CM, Grimes MJ, Thomas CL, Liu Y, Leng S, Joste N, Belinsky SA
PloS one7(4)e34850(2012)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
a regulation of LEDGF interaction with chromatin by cellular partners of its PWWP domain could be involved in several processes linked to LEDGF tethering properties, such as lentiviral integration, DNA repair or transcriptional regulation
Title: TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication.
The formation of vasculogenic mimicry is inhibited by reducing the expression of Mig-7 in gastric cancer cells.
Title: [Mig-7 enhances vasculogenic mimicry in gastric cancer cells].
Compared with TOX4, expression of TOX1, TOX2 and TOX3 in normal lung was 25, 44, and 88%lower, respectively, supporting the premise that reduced promoter activity confers increased susceptibility to methylation during lung carcinogenesis.
Title: Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.
interaction between TOX4 and platinated DNA
Title: TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs.
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
Title: Identification and characterization of a novel human PP1 phosphatase complex.
The following TOX4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOX4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu30127 | |
| Clone ID Related Accession (Same CDS sequence) | NM_014828.3 | |
| Accession Version | NM_014828.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1866bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-30 | |
| Organism | Homo sapiens(human) | |
| Product | TOX high mobility group box family member 4 isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA334895.1, BC020292.1, AL161747.5 and N63399.1. On Jan 8, 2015 this sequence version replaced NM_014828.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.86633.1, SRR1803611.262124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGTTTC CCGGAGGAAA TGACAATTAC CTGACGATCA CAGGGCCTTC GCACCCCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_055643.1 |
| CDS | 104..1969 |
| Misc Feature(1) | 77..79 |
| Misc Feature(2) | 521..>1021 |
| Misc Feature(3) | 629..631 |
| Misc Feature(4) | 635..637 |
| Misc Feature(5) | 644..646 |
| Misc Feature(6) | 647..649 |
| Misc Feature(7) | 740..757 |
| Misc Feature(8) | 770..967 |
| Misc Feature(9) | order(776..778,782..787,791..796,803..808,815..817,827..829,866..868,875..877,884..886,941..943) |
| Misc Feature(10) | 1040..1042 |
| Misc Feature(11) | 1046..1048 |
| Misc Feature(12) | 1544..1546 |
| Misc Feature(13) | 1700..1702 |
| Misc Feature(14) | 1751..1753 |
| Misc Feature(15) | 1757..1759 |
| Misc Feature(16) | 1781..1783 |
| Misc Feature(17) | 1787..1789 |
| Misc Feature(18) | 1802..1804 |
| Exon (1) | 1..109 |
| Exon (2) | 110..178 |
| Exon (3) | 179..421 |
| Exon (4) | 422..682 |
| Exon (5) | 683..913 |
| Exon (6) | 914..994 |
| Exon (7) | 995..1744 |
| Exon (8) | 1745..1908 |
| Exon (9) | 1909..4540 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_014828.3 |
ORF Insert Sequence:
1 | ATGGAGTTTC CCGGAGGAAA TGACAATTAC CTGACGATCA CAGGGCCTTC GCACCCCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu63438 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001303523.1 | |
| Accession Version | NM_001303523.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1797bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-30 | |
| Organism | Homo sapiens(human) | |
| Product | TOX high mobility group box family member 4 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA334895.1, AK298555.1, BC020292.1, AL161747.5 and N63399.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162823, SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGACAT TCCATACACC AAGCTTGGGT GATGAGGAAT TTGAAATCCC ACCTATCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001290452.1 |
| CDS | 104..1900 |
| Misc Feature(1) | 77..79 |
| Misc Feature(2) | 452..>952 |
| Misc Feature(3) | 701..898 |
| Misc Feature(4) | order(707..709,713..718,722..727,734..739,746..748,758..760,797..799,806..808,815..817,872..874) |
| Exon (1) | 1..109 |
| Exon (2) | 110..352 |
| Exon (3) | 353..613 |
| Exon (4) | 614..844 |
| Exon (5) | 845..925 |
| Exon (6) | 926..1675 |
| Exon (7) | 1676..1839 |
| Exon (8) | 1840..4471 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001303523.1 |
ORF Insert Sequence:
1 | ATGGAGACAT TCCATACACC AAGCTTGGGT GATGAGGAAT TTGAAATCCC ACCTATCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. |
|
A quantitative telomeric chromatin isolation protocol identifies different telomeric states. |
|
TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication. |
|
[Mig-7 enhances vasculogenic mimicry in gastric cancer cells]. |
|
Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers. |