RNF10 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | RNF10 |
Entrez Gene ID | 9921 |
Full Name | ring finger protein 10 |
Synonyms | RIE2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
XM_017020283.1 | XP_016875772.1 | RING finger protein 10 isoform X4 |
NM_001330474.1 | NP_001317403.1 | RING finger protein 10 isoform 2 |
NM_001330474.2 | NP_001317403.1 | RING finger protein 10 isoform 2 |
XM_017020283.2 | XP_016875772.1 | RING finger protein 10 isoform X3 |
NM_014868.4 | NP_055683.3 | RING finger protein 10 isoform 1 |
XM_005254013.2 | XP_005254070.1 | RING finger protein 10 isoform X1 |
XM_017020282.1 | XP_016875771.1 | RING finger protein 10 isoform X2 |
NM_014868.5 | NP_055683.3 | RING finger protein 10 isoform 1 |

Drosophila melanogaster (fruit fly) | CG12099 | NP_647623.1 |
Bos taurus (cattle) | RNF10 | NP_001070337.1 |
Rattus norvegicus (Norway rat) | Rnf10 | NP_001011904.1 |
Homo sapiens (human) | RNF10 | NP_055683.3 |
Canis lupus familiaris (dog) | RNF10 | XP_851332.2 |
Danio rerio (zebrafish) | rnf10 | NP_001116727.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP007954 | XP_317518.4 |
RNF10 | XP_002798843.1 | |
Mus musculus (house mouse) | Rnf10 | NP_057907.2 |
Gallus gallus (chicken) | RNF10 | XP_415267.2 |
Xenopus tropicalis (tropical clawed frog) | rnf10 | NP_989388.1 |
Pan troglodytes (chimpanzee) | RNF10 | XP_001161754.2 |

Related articles in PubMed
Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
Huang K, Nair AK, Muller YL, Piaggi P, Bian L, Del Rosario M, Knowler WC, Kobes S, Hanson RL, Bogardus C, Baier LJ
Obesity (Silver Spring, Md.)22(4)984-8(2014 Apr)
Protein microarray characterization of the S-nitrosoproteome.
Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Hu J, Ghasemi M, Ischiropoulos H, Qian J, Zhu H, Blackshaw S, Dawson VL, Dawson TM
Molecular & cellular proteomics : MCP13(1)63-72(2014 Jan)
New susceptibility loci associated with kidney disease in type 1 diabetes.
Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, M?kinen VP, Swan EJ, Palmer C, Boright AP, Ahlqvist E, Deshmukh HA, Keller BJ, Huang H, Ahola AJ, Fagerholm E, Gordin D, Harjutsalo V, He B, Heikkil? O, Hietala K, Kyt? J, Lahermo P, Lehto M, Lithovius R, Osterholm AM, Parkkonen M, Pitk?niemi J, Roseng?rd-B?rlund M, Saraheimo M, Sarti C, S?derlund J, Soro-Paavonen A, Syreeni A, Thorn LM, Tikkanen H, Tolonen N, Tryggvason K, Tuomilehto J, Wad?n J, Gill GV, Prior S, Guiducci C, Mirel DB, Taylor A, Hosseini SM, , Parving HH, Rossing P, Tarnow L, Ladenvall C, Alhenc-Gelas F, Lefebvre P, Rigalleau V, Roussel R, Tregouet DA, Maestroni A, Maestroni S, Falhammar H, Gu T, M?llsten A, Cimponeriu D, Ioana M, Mota M, Mota E, Serafinceanu C, Stavarachi M, Hanson RL, Nelson RG, Kretzler M, Colhoun HM, Panduru NM, Gu HF, Brismar K, Zerbini G, Hadjadj S, Marre M, Groop L, Lajer M, Bull SB, Waggott D, Paterson AD, Savage DA, Bain SC, Martin F, Hirschhorn JN, Godson C, Florez JC, Groop PH, Maxwell AP
PLoS genetics8(9)e1002921(2012 Sep)
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK, Safari A, Liu D, Songyang Z
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)
A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.
Hoshikawa S, Ogata T, Fujiwara S, Nakamura K, Tanaka S
PloS one3(10)e3464(2008)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CYB5A, which has a role in stearyl-CoA-desaturase activity, and RNF10, with an unknown role in weight regulating pathways, associated with adiposity and nominally increased the risk for T2D in American Indians.
Title: Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
RNF10 is a trans-acting protein regulating MAG expression and is required for myelin formation.
Title: A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.
MEOX2 and Meox2 binding to RNF10 protein was characterized.
Title: Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.
The following RNF10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu31406![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_014868.4 , NM_014868.5 | |
Accession Version | NM_014868.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2436bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA103961.1, BC016622.1, DB526099.1 and BQ015862.1. On Aug 31, 2007 this sequence version replaced NM_014868.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660807.18609.1, SRR1660809.29793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055683.3 |
CDS | 484..2919 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31406![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_014868.4 , NM_014868.5 | |
Accession Version | NM_014868.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2436bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-16 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA103961.1, BC016622.1, DB526099.1 and BQ015862.1. On Nov 22, 2018 this sequence version replaced NM_014868.4. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660807.177399.1, SRR1660807.18609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000325954.9/ ENSP00000322242.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055683.3 |
CDS | 457..2892 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47004 | |
Clone ID Related Accession (Same CDS sequence) | NM_001330474.1 , NM_001330474.2 | |
Accession Version | NM_001330474.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2451bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA956437.1, AB027196.1, BU184035.1, HY376488.1 and BQ015862.1. On Aug 25, 2016 this sequence version replaced XM_006719717.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer, but has the same N- and C-termini compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.201022.1, SRR1803613.265303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317403.1 |
CDS | 483..2933 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47004 | |
Clone ID Related Accession (Same CDS sequence) | NM_001330474.1 , NM_001330474.2 | |
Accession Version | NM_001330474.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2451bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA956437.1, AB027196.1, BU184035.1, HY376488.1 and BQ015862.1. On May 31, 2019 this sequence version replaced NM_001330474.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer, but has the same N- and C-termini compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.141311.1, SRR1803611.201022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317403.1 |
CDS | 457..2907 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47005 | |
Clone ID Related Accession (Same CDS sequence) | XM_005254013.2 | |
Accession Version | XM_005254013.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2301bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005254013.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGGATG GAAAGAACTC CAGTGGATCC AAGCGTTATA ATCGCAAACG TGAACTTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005254070.1 |
CDS | 711..3011 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGATGGATG GAAAGAACTC CAGTGGATCC AAGCGTTATA ATCGCAAACG TGAACTTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84364 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020282.1 | |
Accession Version | XM_017020282.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2286bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGGATG GAAAGAACTC CAGTGGATCC AAGCGTTATA ATCGCAAACG TGAACTTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875771.1 |
CDS | 711..2996 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGATGGATG GAAAGAACTC CAGTGGATCC AAGCGTTATA ATCGCAAACG TGAACTTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84365 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020283.1 , XM_017020283.2 | |
Accession Version | XM_017020283.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875772.1 |
CDS | 504..2708 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu84365 | |
Clone ID Related Accession (Same CDS sequence) | XM_017020283.1 , XM_017020283.2 | |
Accession Version | XM_017020283.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RING finger protein 10 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017020283.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016875772.1 |
CDS | 460..2664 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCCGCTGA GCTCCCCCAA CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes. |
![]() |
Protein microarray characterization of the S-nitrosoproteome. |
![]() |
New susceptibility loci associated with kidney disease in type 1 diabetes. |
![]() |
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. |
![]() |
A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells. |