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MAFB cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MAFB
Entrez Gene ID 9935
Full Name MAF bZIP transcription factor B
Synonyms DURS3,KRML,MCTO
General protein information
Preferred Names

MAF bZIP transcription factor B

Names

transcription factor MafB
Kreisler maf-related leucine zipper homolog
MAFB/Kreisler basic region/leucine zipper transcription factor
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

20

20q12

Summary The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008].
Disorder MIM:

608968


mRNA and Protein(s)

mRNA Protein Name
NM_005461.4 NP_005452.2 transcription factor MafB



Pan troglodytes (chimpanzee) MAFB XP_525325.3
Bos taurus (cattle) MAFB XP_002692508.1
Xenopus tropicalis (tropical clawed frog) mafb NP_001025694.1
Gallus gallus (chicken) MAFB NP_001026023.1
Homo sapiens (human) MAFB NP_005452.2
Mus musculus (house mouse) Mafb NP_034788.1
Rattus norvegicus (Norway rat) Mafb NP_062189.1
Macaca mulatta (rhesus monkey) LOC712578 XP_001101624.2


Related articles in PubMed

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT Jr, Powers AC, Gu G, Stein R
American journal of physiology. Endocrinology and metabolism310(1)E91-E102(2016 Jan)

MAFB as a novel regulator of human adipose tissue inflammation.
Pettersson AM, Acosta JR, Björk C, Krätzel J, Stenson B, Blomqvist L, Viguerie N, Langin D, Arner P, Laurencikiene J
Diabetologia58(9)2115-23(2015 Sep)

Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.
Han SI, Tsunekage Y, Kataoka K
Molecular and cellular endocrinology411113-20(2015 Aug)

Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case-control study.
Yang Q, Yin RX, Zhou YJ, Cao XL, Guo T, Chen WX
Lipids in health and disease1479(2015 Jul)

MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells.
Yang W, Lan X, Li D, Li T, Lu S
BMC cancer15461(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present study demonstrated that miR-152 was downregulated in NPC tissues and cell lines. In addition, miR-152 expression and MAFB knockdown inhibited cell proliferation, migration and invasion, and miR-152 suppressed the expression of MAFB at the mRNA and protein levels.
Title: MicroRNA‑152 inhibits cell proliferation, migration and invasion by directly targeting MAFB in nasopharyngeal carcinoma.

Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB.
Title: Epidermal differentiation gene regulatory networks controlled by MAF and MAFB.

Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.
Title: Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.

Results indicate a hepatocellular carcinoma (HCC) regulatory pathway involving MafB transcription factor and cyclin D1, the dysfunction of which drives proliferative character in HCC.
Title: Transcription Factor MafB Promotes Hepatocellular Carcinoma Cell Proliferation through Up-Regulation of Cyclin D1.

MAFB represents a unique signature and likely important regulator of the primate islet beta-cell.
Title: The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.

The following MAFB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAFB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25119 NM_005461.4
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Homo sapiens MAF bZIP transcription factor B (MAFB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25119
Clone ID Related Accession (Same CDS sequence) NM_005461.4
Accession Version NM_005461.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 972bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-07-27
Organism Homo sapiens(Human)
Product transcription factor MafB
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA719830.1, BC028098.1, AF134157.1 and BQ271704.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced NM_005461.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCCGCGG AGCTGAGCAT GGGGCCAGAG CTGCCCACCA GCCCGCTGGC CATGGAGTAT 
GTCAACGACT TCGACCTGCT CAAGTTCGAC GTGAAGAAGG AGCCACTGGG GCGCGCGGAG
CGTCCGGGCA GGCCCTGCAC ACGCCTGCAG CCAGCCGGCT CGGTGTCCTC CACACCGCTC
AGCACTCCGT GTAGCTCCGT GCCCTCGTCG CCCAGCTTCA GCCCGACCGA ACAGAAGACA
CACCTCGAGG ATCTGTACTG GATGGCGAGC AACTACCAGC AGATGAACCC CGAGGCGCTC
AACCTGACGC CCGAGGACGC GGTGGAAGCG CTCATCGGCT CGCACCCAGT GCCACAGCCG
CTGCAAAGCT TCGACAGCTT TCGCGGCGCT CACCACCACC ACCATCACCA CCACCCTCAC
CCGCACCACG CGTACCCGGG CGCCGGCGTG GCCCACGACG AGCTGGGCCC GCACGCTCAC
CCGCACCATC ACCATCATCA CCAAGCGTCG CCGCCGCCGT CCAGCGCCGC TAGCCCGGCG
CAACAGCTGC CCACTAGCCA CCCCGGGCCC GGGCCGCACG CGACGGCCTC GGCGACGGCG
GCGGGCGGCA ACGGCAGCGT GGAGGACCGC TTCTCCGACG ACCAGCTCGT GTCCATGTCC
GTGCGCGAGC TGAACCGCCA CCTGCGGGGC TTCACCAAGG ACGAGGTGAT CCGCCTGAAG
CAGAAGCGGC GGACCCTGAA GAACCGGGGC TACGCCCAGT CTTGCAGGTA TAAACGCGTC
CAGCAGAAGC ACCACCTGGA GAATGAGAAG ACGCAGCTCA TTCAGCAGGT GGAGCAGCTT
AAGCAGGAGG TGTCCCGGCT GGCCCGCGAG AGAGACGCCT ACAAGGTCAA GTGCGAGAAA
CTCGCCAACT CCGGCTTCAG GGAGGCGGGC TCCACCAGCG ACAGCCCCTC CTCTCCCGAG
TTCTTTCTGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005452.2
CDS391..1362
Misc Feature(1)64..66
Misc Feature(2)628..729
Misc Feature(3)1087..1296
Misc Feature(4)1087..1296
Misc Feature(5)1102..1179
Misc Feature(6)order(1108..1110,1117..1125,1129..1137,1141..1149,1153..1158,1162..1167)
Misc Feature(7)order(1165..1167,1186..1188,1195..1200,1207..1212,1216..1221,1228..1233,1237..1242,1249..1251,1258..1263,1270..1275,1279..1284)
Misc Feature(8)1186..1251
Exon (1)1..3393
Translation

Target ORF information:

RefSeq Version NM_005461.4
Organism Homo sapiens(Human)
Definition Homo sapiens MAF bZIP transcription factor B (MAFB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005461.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGCCGCGG AGCTGAGCAT GGGGCCAGAG CTGCCCACCA GCCCGCTGGC CATGGAGTAT 
GTCAACGACT TCGACCTGCT CAAGTTCGAC GTGAAGAAGG AGCCACTGGG GCGCGCGGAG
CGTCCGGGCA GGCCCTGCAC ACGCCTGCAG CCAGCCGGCT CGGTGTCCTC CACACCGCTC
AGCACTCCGT GTAGCTCCGT GCCCTCGTCG CCCAGCTTCA GCCCGACCGA ACAGAAGACA
CACCTCGAGG ATCTGTACTG GATGGCGAGC AACTACCAGC AGATGAACCC CGAGGCGCTC
AACCTGACGC CCGAGGACGC GGTGGAAGCG CTCATCGGCT CGCACCCAGT GCCACAGCCG
CTGCAAAGCT TCGACAGCTT TCGCGGCGCT CACCACCACC ACCATCACCA CCACCCTCAC
CCGCACCACG CGTACCCGGG CGCCGGCGTG GCCCACGACG AGCTGGGCCC GCACGCTCAC
CCGCACCATC ACCATCATCA CCAAGCGTCG CCGCCGCCGT CCAGCGCCGC TAGCCCGGCG
CAACAGCTGC CCACTAGCCA CCCCGGGCCC GGGCCGCACG CGACGGCCTC GGCGACGGCG
GCGGGCGGCA ACGGCAGCGT GGAGGACCGC TTCTCCGACG ACCAGCTCGT GTCCATGTCC
GTGCGCGAGC TGAACCGCCA CCTGCGGGGC TTCACCAAGG ACGAGGTGAT CCGCCTGAAG
CAGAAGCGGC GGACCCTGAA GAACCGGGGC TACGCCCAGT CTTGCAGGTA TAAACGCGTC
CAGCAGAAGC ACCACCTGGA GAATGAGAAG ACGCAGCTCA TTCAGCAGGT GGAGCAGCTT
AAGCAGGAGG TGTCCCGGCT GGCCCGCGAG AGAGACGCCT ACAAGGTCAA GTGCGAGAAA
CTCGCCAACT CCGGCTTCAG GGAGGCGGGC TCCACCAGCG ACAGCCCCTC CTCTCCCGAG
TTCTTTCTGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
American journal of physiology. Endocrinology and metabolism310(1)E91-E102(2016 Jan)
Conrad E,Dai C,Spaeth J,Guo M,Cyphert HA,Scoville D,Carroll J,Yu WM,Goodrich LV,Harlan DM,Grove KL,Roberts CT Jr,Powers AC,Gu G,Stein R


book

MAFB as a novel regulator of human adipose tissue inflammation.
Diabetologia58(9)2115-23(2015 Sep)
Pettersson AM,Acosta JR,Björk C,Krätzel J,Stenson B,Blomqvist L,Viguerie N,Langin D,Arner P,Laurencikiene J


book

Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.
Molecular and cellular endocrinology411113-20(2015 Aug)
Han SI,Tsunekage Y,Kataoka K


book

Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case-control study.
Lipids in health and disease1479(2015 Jul)
Yang Q,Yin RX,Zhou YJ,Cao XL,Guo T,Chen WX


book

MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells.
BMC cancer15461(2015 Jun)
Yang W,Lan X,Li D,Li T,Lu S


 
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