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KCNE2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol KCNE2
Entrez Gene ID 9992
Full Name potassium channel, voltage gated subfamily E regulatory beta subunit 2
Synonyms ATFB4, LQT5, LQT6, MIRP1
General protein information
Preferred Names
potassium voltage-gated channel subfamily E member 2
Names
potassium voltage-gated channel subfamily E member 2
minK-related peptide 1
minK-related peptide-1
potassium channel subunit, MiRP1
potassium channel subunit beta MiRP1
voltage-gated K+ channel subunit MIRP1
minimum potassium ion channel-related peptide 1
cardiac voltage-gated potassium channel accessory subunit 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q22.12

Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

603796

Disorder Html: Long QT syndrome-6, 613693 (3); Atrial fibrillation, familial, 4,

mRNA and Protein(s)

mRNA Protein Name
NM_172201 NP_751951 potassium voltage-gated channel subfamily E member 2



Homo sapiens (human) KCNE2 NP_751951.1
Pan troglodytes (chimpanzee) KCNE2 XP_001167267.1
Macaca mulatta (Rhesus monkey) KCNE2 XP_001089749.1
Canis lupus familiaris (dog) KCNE2 NP_001181892.1
Bos taurus (cattle) KCNE2 NP_001070552.1
Mus musculus (house mouse) Kcne2 NP_598871.1
Rattus norvegicus (Norway rat) Kcne2 NP_598287.1
Gallus gallus (chicken) KCNE2 XP_004934590.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100490092 XP_002937553.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KCNE2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNE2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25916
NM_172201 Homo sapiens potassium voltage-gated channel, Isk-related family, member 2 (KCNE2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25916
Clone ID Related Accession (Same CDS sequence) NM_172201
Accession Version NM_172201.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 372bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product potassium voltage-gated channel subfamily E member 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF302095.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF302095.1, BC112087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA
ATGTCCCCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_751951.1
CDS141..512
Misc Feature(1)126..128(+)
Misc Feature(2)285..347(+)
Misc Feature(3)291..464(+)
Exon (1)1..128
Gene:KCNE2
Gene Synonym:
Exon (2)129..803
Gene:KCNE2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_172201
Organism Homo sapiens (human)
Definition Homo sapiens potassium voltage-gated channel, Isk-related family, member 2 (KCNE2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_172201

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA
ATGTCCCCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

BACE1 and presenilin/gamma-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels
FASEB J. 27 (6), 2458-2467 (2013)
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM and Kim DY.


book

Do LQTS gene single nucleotide polymorphisms alter QTc intervals at rest and during exercise stress testing?
Ann Noninvasive Electrocardiol 18 (3), 288-293 (2013)
Aziz PF, Wieand TS, Ganley J, Henderson J, McBride M and Shah MJ.


book

Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study
Hum. Genet. 132 (3), 323-336 (2013)
Velez Edwards DR, Naj AC, Monda K, North KE, Neuhouser M, Magvanjav O, Kusimo I, Vitolins MZ, Manson JE, O'Sullivan MJ, Rampersaud E and Edwards TL.


book

Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression
World J. Gastroenterol. 19 (8), 1314-1317 (2013)
Kuwahara N, Kitazawa R, Fujiishi K, Nagai Y, Haraguchi R and Kitazawa S.


book

KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner
Am. J. Physiol. Heart Circ. Physiol. 302 (4), H910-H922 (2012)
Zhang M, Wang Y, Jiang M, Zankov DP, Chowdhury S, Kasirajan V and Tseng GN.


book

Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2
J. Biol. Chem. 276 (20), 17244-17251 (2001)
Cui J, Kagan A, Qin D, Mathew J, Melman YF and McDonald TV.


book

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
EMBO J. 19 (23), 6326-6330 (2000)
Tinel N, Diochot S, Borsotto M, Lazdunski M and Barhanin J.


book

M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit
FEBS Lett. 480 (2-3), 137-141 (2000)
Tinel N, Diochot S, Lauritzen I, Barhanin J, Lazdunski M and Borsotto M.


book

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
Cell 97 (2), 175-187 (1999)
Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT and Goldstein SA.


book

Romano-Ward Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Alders,M. and Mannens,M.M.A.M.


 
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