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KCNE2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol KCNE2
Entrez Gene ID 9992
Full Name potassium voltage-gated channel subfamily E regulatory subunit 2
Synonyms ATFB4,LQT5,LQT6,MIRP1
General protein information
Preferred Names

potassium voltage-gated channel subfamily E regulatory subunit 2

Names

potassium voltage-gated channel subfamily E member 2
cardiac voltage-gated potassium channel accessory subunit 2
minK-related peptide-1
minimum potassium ion channel-related peptide 1
potassium channel subunit beta MiRP1
potassium channel subunit, MiRP1
potassium channel, voltage gated subfamily E regulatory beta subunit 2
potassium voltage-gated channel, Isk-related family, member 2
voltage-gated K+ channel subunit MIRP1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

21

21q22.11

Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008].
Disorder MIM:

603796

Disorder Html: Long QT syndrome-6, 613693 (3); Atrial fibrillation, familial, 4,

mRNA and Protein(s)

mRNA Protein Name
NM_172201.1 NP_751951.1 potassium voltage-gated channel subfamily E member 2



Pan troglodytes (chimpanzee) KCNE2 XP_001167267.1
Bos taurus (cattle) KCNE2 NP_001070552.1
Gallus gallus (chicken) KCNE2 XP_004934590.1
Macaca mulatta (rhesus monkey) KCNE2 XP_001089749.1
Homo sapiens (human) KCNE2 NP_751951.1
Mus musculus (house mouse) Kcne2 NP_598871.1
Xenopus tropicalis (tropical clawed frog) LOC100490092 XP_002937553.1
Rattus norvegicus (Norway rat) Kcne2 NP_598287.1
Canis lupus familiaris (dog) KCNE2 NP_001181892.1


Related articles in PubMed

Filamin C: a novel component of the KCNE2 interactome during hypoxia.
Neethling A, Mouton J, Loos B, Corfield V, de Villiers C, Kinnear C
Cardiovascular journal of Africa27(1)4-11(2016 Jan-Feb)

The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.
Abbott GW
Gene569(2)162-72(2015 Sep)

Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women.
Parkington HC, Stevenson J, Tonta MA, Paul J, Butler T, Maiti K, Chan EC, Sheehan PM, Brennecke SP, Coleman HA, Smith R
Nature communications54108(2014 Jun)

Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.
Li P, Liu H, Lai C, Sun P, Zeng W, Wu F, Zhang L, Wang S, Tian C, Ding J
Scientific reports44973(2014 May)

Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation.
Nielsen JB, Bentzen BH, Olesen MS, David JP, Olesen SP, Haunsø S, Svendsen JH, Schmitt N
Biomarkers in medicine8(4)557-70(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cardiac KCNE2 expression is decreased and contributes to the development of hypertrophy via activation of calcineurin-NFAT and mitogen-activated protein kinase pathways.
Title: Decreased KCNE2 Expression Participates in the Development of Cardiac Hypertrophy by Regulation of Calcineurin-NFAT (Nuclear Factor of Activated T Cells) and Mitogen-Activated Protein Kinase Pathways.

The identification of Filamin C as a novel KCNE2 ligand not only enhances current understanding of ion channel function and regulation, but also provides valuable information about possible pathways likely to be involved in long-QT syndrome pathogenesis
Title: Filamin C: a novel component of the KCNE2 interactome during hypoxia.

KCNE2 has been widely studied since its role in the heart was discovered; it is association with inherited and acquired human Long QT syndrome; physiological analyses together with genetics studies have uncovered a startling array of functions for KCNE2, in the heart, stomach, thyroid and choroid plexus. [Review]
Title: The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.

Women with elevated BMI have enhanced hERG activity as a result of low beta-inhibitory protein expression, which likely contributes to weak contractions and poor labour outcomes.
Title: Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women.

The transmembrane domains (TMDs) of KCNE1 and KCNE2 were illustrated to associate with the KCNQ1 channel in different modes.
Title: Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.

The following KCNE2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNE2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25916
NM_172201.1
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Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25916
Clone ID Related Accession (Same CDS sequence) NM_172201.1
Accession Version NM_172201.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 372bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-25
Organism Homo sapiens(Human)
Product potassium voltage-gated channel subfamily E member 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF302095.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF302095.1, BC112087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA
ATGTCCCCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_751951.1
CDS141..512
Misc Feature(1)126..128
Misc Feature(2)285..347
Misc Feature(3)<288..>479
Exon (1)1..128
Exon (2)129..803
Translation

Target ORF information:

RefSeq Version NM_172201.1
Organism Homo sapiens(Human)
Definition Homo sapiens potassium voltage-gated channel subfamily E regulatory subunit 2 (KCNE2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_172201.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGTCTACTT TATCCAATTT CACACAGACG CTGGAAGACG TCTTCCGAAG GATTTTTATT 
ACTTATATGG ACAATTGGCG CCAGAACACA ACAGCTGAGC AAGAGGCCCT CCAAGCCAAA
GTTGATGCTG AGAACTTCTA CTATGTCATC CTGTACCTCA TGGTGATGAT TGGAATGTTC
TCTTTCATCA TCGTGGCCAT CCTGGTGAGC ACTGTGAAAT CCAAGAGACG GGAACACTCC
AATGACCCCT ACCACCAGTA CATTGTAGAG GACTGGCAGG AAAAGTACAA GAGCCAAATC
TTGAATCTAG AAGAATCGAA GGCCACCATC CATGAGAACA TTGGTGCGGC TGGGTTCAAA
ATGTCCCCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Filamin C: a novel component of the KCNE2 interactome during hypoxia.
Cardiovascular journal of Africa27(1)4-11(2016 Jan-Feb)
Neethling A,Mouton J,Loos B,Corfield V,de Villiers C,Kinnear C


book

The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.
Gene569(2)162-72(2015 Sep)
Abbott GW


book

Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women.
Nature communications54108(2014 Jun)
Parkington HC,Stevenson J,Tonta MA,Paul J,Butler T,Maiti K,Chan EC,Sheehan PM,Brennecke SP,Coleman HA,Smith R


book

Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.
Scientific reports44973(2014 May)
Li P,Liu H,Lai C,Sun P,Zeng W,Wu F,Zhang L,Wang S,Tian C,Ding J


book

Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation.
Biomarkers in medicine8(4)557-70(2014)
Nielsen JB,Bentzen BH,Olesen MS,David JP,Olesen SP,Haunsø S,Svendsen JH,Schmitt N


 
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