Gene Symbol | Gldc |
Entrez Gene ID | 104174 |
Full Name | glycine decarboxylase |
Synonyms | D030049L12Rik,D19Wsu57e,b2b2679Clo |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Gldc cDNA ORF clone
Gene Symbol | Gldc |
Entrez Gene ID | 104174 |
Full Name | glycine decarboxylase |
Synonyms | D030049L12Rik,D19Wsu57e,b2b2679Clo |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_138595.2 | NP_613061.1 | glycine dehydrogenase (decarboxylating), mitochondrial precursor |
Homo sapiens (human) | GLDC | NP_000161.2 |
Danio rerio (zebrafish) | gldc | NP_955848.1 |
Saccharomyces cerevisiae (baker's yeast) | GCV2 | NP_013914.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_15038 | XP_003720581.1 |
Canis lupus familiaris (dog) | GLDC | XP_538655.2 |
Rattus norvegicus (Norway rat) | Gldc | NP_001101053.1 |
Caenorhabditis elegans (roundworm) | R12C12.1 | NP_495209.1 |
Kluyveromyces lactis | KLLA0D12738g | XP_453630.1 |
Xenopus tropicalis (tropical clawed frog) | gldc | XP_002934225.2 |
Pan troglodytes (chimpanzee) | GLDC | XP_001143144.1 |
GLDC | XP_001112651.1 | |
Mus musculus (house mouse) | Gldc | NP_613061.1 |
Arabidopsis thaliana (thale cress) | GLDP2 | NP_180178.1 |
Oryza sativa (rice) | Os01g0711400 | NP_001044046.1 |
Drosophila melanogaster (fruit fly) | CG3999 | NP_649989.1 |
Neurospora crassa | NCU02475 | XP_965069.2 |
Bos taurus (cattle) | GLDC | NP_001179880.1 |
Gallus gallus (chicken) | GLDC | NP_989653.1 |
Schizosaccharomyces pombe (fission yeast) | gcv2 | NP_592832.2 |
Arabidopsis thaliana (thale cress) | GLDP1 | NP_195027.1 |
Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.
Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE
Cell reports21(7)1795-1808(2017 Nov)
Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.
Autuori MC, Pai YJ, Stuckey DJ, Savery D, Marconi AM, Massa V, Lythgoe MF, Copp AJ, David AL, Greene ND
Prenatal diagnosis37(3)273-281(2017 Mar)
Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW
Nature521(7553)520-4(2015 May)
Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.
Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND
Nature communications66388(2015 Mar)
Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice.
Li X, Cui C, Guo Y, Yang G
Oncology research and treatment38(11)586-9(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Exencephaly and ventriculomegaly were detectable by High-frequency ultrasound in homozygous Gldc-deficient mouse embryos indicating this to be an effective tool to study CNS development.
Title: Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.
Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice through limiting supply of one-carbon units from mitochondrial folate metabolism.
Title: Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.
These studies support a direct relationship between p53 mutations and GLDC expression in B cell lymphoma.
Title: Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice.
Results suggest that there is a direct correlation between ischemic injury and extracellular glycine concentration maintained by glycine decarboxylase and the glycine cleavage multienzyme system.
Title: Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system.
The following Gldc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gldc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu14008 | |
Clone ID Related Accession (Same CDS sequence) | NM_138595.2 | |
Accession Version | NM_138595.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3078bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Mus musculus(house mouse) | |
Product | glycine dehydrogenase (decarboxylating), mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC157986.4, BC017135.1 and BF020198.1. On Feb 13, 2013 this sequence version replaced NM_138595.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017135.1, AK080937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164142 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## |
1 | ATGCAGCTGT GTGCCAGGGC ATGGGGGCTG CGCCTGGGCC GCGGAGCCGG GGGCGGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_613061.1 |
CDS | 182..3259 |
Translation |
Target ORF information:
Target ORF information:
|
NM_138595.2 |
1 | ATGCAGCTGT GTGCCAGGGC ATGGGGGCTG CGCCTGGGCC GCGGAGCCGG GGGCGGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure. |
Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice. |
Global genetic analysis in mice unveils central role for cilia in congenital heart disease. |
Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. |
Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice. |