Chrna6 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Chrna6 |
| Entrez Gene ID | 11440 |
| Full Name | cholinergic receptor, nicotinic, alpha polypeptide 6 |
| Synonyms | Acra6,Nica6 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_021369.2 | NP_067344.2 | neuronal acetylcholine receptor subunit alpha-6 precursor |
| Pan troglodytes (chimpanzee) | CHRNA6 | NP_001029266.1 |
| Drosophila melanogaster (fruit fly) | nAcRalpha-7E | NP_525079.3 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000329 | XP_310786.3 |
| Homo sapiens (human) | CHRNA6 | NP_004189.1 |
| Bos taurus (cattle) | CHRNA6 | XP_002698774.2 |
| Gallus gallus (chicken) | CHRNA6 | NP_990695.1 |
| CHRNA6 | XP_001099152.1 | |
| Rattus norvegicus (Norway rat) | Chrna6 | NP_476532.1 |
| Caenorhabditis elegans (roundworm) | unc-38 | NP_491472.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100495287 | XP_002942944.2 |
| Canis lupus familiaris (dog) | CHRNA6 | XP_539951.2 |
| Mus musculus (house mouse) | Chrna6 | NP_067344.2 |
| Danio rerio (zebrafish) | chrna6 | NP_001036149.1 |
Related articles in PubMed
?6?2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption.
Kamens HM, Peck C, Garrity C, Gechlik A, Jenkins BC, Rajan A
Alcohol (Fayetteville, N.Y.)6143-49(2017 Jun)
Different Hypothalamic Nicotinic ?7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats.
Nuutinen S, Panula P, Salminen O
Alcoholism, clinical and experimental research40(2)329-34(2016 Feb)
?6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.
Berry JN, Engle SE, McIntosh JM, Drenan RM
Neuroscience304161-75(2015 Sep)
Evidence for a role for ?6(?) nAChRs in l-dopa-induced dyskinesias using Parkinsonian ?6(?) nAChR gain-of-function mice.
Bordia T, McGregor M, McIntosh JM, Drenan RM, Quik M
Neuroscience295187-97(2015 Jun)
The nicotinic ?6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS
Science translational medicine7(287)287ra72(2015 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Using behavioral and cellular measures of alpha6 * nAChR function, study demonstrated that the ventral tegmental area is a key site of action for nicotine at alpha6 * nAChRs
Title: ?6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.
The present data show that alpha6beta2( *) nAChRs are key regulators of LIDs, and may be useful therapeutic targets for their management in Parkinson's disease.
Title: Evidence for a role for ?6(?) nAChRs in l-dopa-induced dyskinesias using Parkinsonian ?6(?) nAChR gain-of-function mice.
enhanced alpha6beta2* nAChR activity in nucleus accumbens can stimulate dopamine production
Title: Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function ?6* nAChRs.
these data indicate that a6)nAChR do not have an impact on motor output.
Title: A role for ?4(non-?6)* nicotinic acetylcholine receptors in motor behavior.
Chrna6 expression decreases with death of RGCs in glaucomatous DBA/2J mice and after optic nerve crush injury, further supporting Chrna6 as a reliable RGC marker.
Title: Effects of glaucoma on Chrna6 expression in the retina.
The following Chrna6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chrna6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu12256 | |
| Clone ID Related Accession (Same CDS sequence) | NM_021369.2 | |
| Accession Version | NM_021369.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Mus musculus(house mouse) | |
| Product | neuronal acetylcholine receptor subunit alpha-6 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC031985.1. On Jun 9, 2003 this sequence version replaced NM_021369.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031985.1, AK149262.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCTGAACA GCCGGGACCA GGGAAACCTG CACTCCGGTT TATGTCTGTG GCTATGTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_067344.2 |
| CDS | 243..1727 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_021369.2 |
ORF Insert Sequence:
1 | ATGCTGAACA GCCGGGACCA GGGAAACCTG CACTCCGGTT TATGTCTGTG GCTATGTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
?6?2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption. |
|
Different Hypothalamic Nicotinic ?7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats. |
|
?6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity. |
|
Evidence for a role for ?6(?) nAChRs in l-dopa-induced dyskinesias using Parkinsonian ?6(?) nAChR gain-of-function mice. |
|
The nicotinic ?6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. |