Acvr2a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Acvr2a
Entrez Gene ID	11480
Full Name	activin receptor IIA
Synonyms	ActrIIa,Acvr2,TactrII
General protein information	Preferred Names activin receptor IIA Names activin receptor type-2A ACTR-IIA activin receptor type IIA
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 C1.1\|2 28.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007396.4	NP_031422.3	activin receptor type-2A precursor
XM_006497623.3	XP_006497686.1	activin receptor type-2A isoform X1
XM_006497623.4	XP_006497686.1	activin receptor type-2A isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ACVR2A	NP_001265508.1
	ACVR2A	XP_001095960.2
Pan troglodytes (chimpanzee)	ACVR2A	XP_003949946.1
Canis lupus familiaris (dog)	ACVR2A	XP_005632022.1
Mus musculus (house mouse)	Acvr2a	NP_031422.3
Danio rerio (zebrafish)	acvr2aa	NP_001103748.1
Xenopus tropicalis (tropical clawed frog)	acvr2a	NP_001135613.1
Bos taurus (cattle)	ACVR2A	NP_776652.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000763	XP_311300.4
Rattus norvegicus (Norway rat)	Acvr2a	NP_113759.1
Gallus gallus (chicken)	ACVR2A	NP_990698.1
Drosophila melanogaster (fruit fly)	put	NP_001262574.1

Gene Ontology
Bibliography

Related articles in PubMed

The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease.
Williams MJ, Sugatani T, Agapova OA, Fang Y, Gaut JP, Faugere MC, Malluche HH, Hruska KA
Kidney international93(1)147-158(2018 Jan)

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura.
Tischfield MA, Robson CD, Gilette NM, Chim SM, Sofela FA, DeLisle MM, Gelber A, Barry BJ, MacKinnon S, Dagi LR, Nathans J, Engle EC
Developmental cell42(5)445-461.e5(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B-deficient mice exhibit no significant change in any bone parameter.
Title: Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass.

miR-125b regulated the activin/Smad2 signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a
Title: MiR-125b Regulates Primordial Follicle Assembly by Targeting Activin Receptor Type 2a in Neonatal Mouse Ovary.

Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies.
Title: ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments.

Our study shows that a miR-590/Acvr2a/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.
Title: A miR-590/Acvr2a/Rad51b axis regulates DNA damage repair during mESC proliferation.

Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.
Title: A pair of transmembrane receptors essential for the retention and pigmentation of hair.

The following Acvr2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acvr2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20223	NM_007396.4 Latest version!	Mus musculus activin receptor IIA (Acvr2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$300.30 $429.00
OMu29255	XM_006497623.4 Latest version!	Mus musculus activin receptor IIA (Acvr2a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu29255	XM_006497623.3	Mus musculus activin receptor IIA (Acvr2a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acvr2a ( NM_007396.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031422.3 Mus musculus activin receptor IIA (Acvr2a), mRNA.

Price & Availability↑

CloneID	OMu20223
Clone ID Related Accession (Same CDS sequence)	NM_007396.4
Accession Version	NM_007396.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	activin receptor type-2A precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY014959.1, AK041246.1, AK143186.1, BG066107.2 and CK340532.1. On Nov 16, 2007 this sequence version replaced NM_007396.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK041246.1, BC138823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 
ATACTTGGCA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 
AGAACCAACC AGACTGGTGT TGAACCTTGC TATGGTGATA AAGATAAACG GCGACATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 
TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCTGTT ACACCGAAGC CACCCTATTA CAACATTCTG 
CTGTATTCCT TGGTACCACT AATGTTAATT GCAGGAATTG TCATTTGTGC ATTTTGGGTG 
TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAAGA CCCAGGACCA 
CCCCCACCTT CCCCATTACT AGGGTTGAAG CCATTGCAGC TGTTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTCAATG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCCTGGCAG AATGAATATG AAGTCTATAG TCTACCTGGA 
ATGAAGCATG AGAACATACT ACAGTTCATT GGTGCAGAGA AAAGAGGCAC CAGTGTGGAT 
GTGGACCTGT GGCTAATCAC AGCATTTCAT GAAAAGGGCT CACTGTCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTTTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCTTA AAAGATGGCC ACAAGCCTGC AATCTCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAATC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAGTT CGAGGCTGGC AAGTCTGCAG GTGACACCCA TGGGCAGGTT 
GGTACCCGGA GGTATATGGC TCCAGAGGTG TTGGAGGGTG CTATAAACTT CCAAAGGGAC 
GCATTTCTGA GGATAGATAT GTACGCCATG GGATTAGTCC TATGGGAATT GGCTTCTCGT 
TGCACTGCTG CAGATGGACC CGTAGATGAG TACATGTTAC CATTTGAGGA AGAAATTGGC 
CAGCATCCAT CTCTTGAAGA TATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCAGGA ATGGCAATGC TCTGTGAAAC GATAGAAGAA 
TGTTGGGATC ATGATGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACT 
CAGATGCAAA GACTAACAAA TATCATTACT ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031422.3
CDS	664..2205
Translation	MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	NM_007396.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus activin receptor IIA (Acvr2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007396.4

ORF Insert Sequence:

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 
ATACTTGGCA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 
AGAACCAACC AGACTGGTGT TGAACCTTGC TATGGTGATA AAGATAAACG GCGACATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 
TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCTGTT ACACCGAAGC CACCCTATTA CAACATTCTG 
CTGTATTCCT TGGTACCACT AATGTTAATT GCAGGAATTG TCATTTGTGC ATTTTGGGTG 
TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAAGA CCCAGGACCA 
CCCCCACCTT CCCCATTACT AGGGTTGAAG CCATTGCAGC TGTTAGAAGT GAAAGCAAGG 
GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTCAATG AATATGTGGC TGTCAAAATA 
TTTCCAATAC AGGACAAACA GTCCTGGCAG AATGAATATG AAGTCTATAG TCTACCTGGA 
ATGAAGCATG AGAACATACT ACAGTTCATT GGTGCAGAGA AAAGAGGCAC CAGTGTGGAT 
GTGGACCTGT GGCTAATCAC AGCATTTCAT GAAAAGGGCT CACTGTCAGA CTTTCTTAAG 
GCTAATGTGG TCTCTTGGAA TGAACTTTGT CATATTGCAG AAACCATGGC TAGAGGATTG 
GCATATTTAC ATGAGGATAT ACCTGGCTTA AAAGATGGCC ACAAGCCTGC AATCTCTCAC 
AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAATC TGACAGCTTG CATTGCTGAC 
TTTGGGTTGG CCTTAAAGTT CGAGGCTGGC AAGTCTGCAG GTGACACCCA TGGGCAGGTT 
GGTACCCGGA GGTATATGGC TCCAGAGGTG TTGGAGGGTG CTATAAACTT CCAAAGGGAC 
GCATTTCTGA GGATAGATAT GTACGCCATG GGATTAGTCC TATGGGAATT GGCTTCTCGT 
TGCACTGCTG CAGATGGACC CGTAGATGAG TACATGTTAC CATTTGAGGA AGAAATTGGC 
CAGCATCCAT CTCTTGAAGA TATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 
TTAAGAGATT ATTGGCAGAA ACATGCAGGA ATGGCAATGC TCTGTGAAAC GATAGAAGAA 
TGTTGGGATC ATGATGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACT 
CAGATGCAAA GACTAACAAA TATCATTACT ACAGAGGACA TTGTAACAGT GGTCACAATG 
GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acvr2a ( XM_006497623.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006497686.1 Mus musculus activin receptor IIA (Acvr2a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu29255
Clone ID Related Accession (Same CDS sequence)	XM_006497623.3 , XM_006497623.4
Accession Version	XM_006497623.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	activin receptor type-2A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006497623.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 
ATACTTGGCA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 
AGAACCAACC AGACTGGTGT TGAACCTTGC TATGGTGATA AAGATAAACG GCGACATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 
TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCTGTT ACACCGAAGC CACCCTATTA CAACATTCTG 
CTGTATTCCT TGGTACCACT AATGTTAATT GCAGGAATTG TCATTTGTGC ATTTTGGGTG 
TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAACA CGCCTTTCAT 
ATAATGATAG AGGACCCAGG ACCACCCCCA CCTTCCCCAT TACTAGGGTT GAAGCCATTG 
CAGCTGTTAG AAGTGAAAGC AAGGGGAAGA TTTGGTTGTG TCTGGAAAGC CCAGTTGCTC 
AATGAATATG TGGCTGTCAA AATATTTCCA ATACAGGACA AACAGTCCTG GCAGAATGAA 
TATGAAGTCT ATAGTCTACC TGGAATGAAG CATGAGAACA TACTACAGTT CATTGGTGCA 
GAGAAAAGAG GCACCAGTGT GGATGTGGAC CTGTGGCTAA TCACAGCATT TCATGAAAAG 
GGCTCACTGT CAGACTTTCT TAAGGCTAAT GTGGTCTCTT GGAATGAACT TTGTCATATT 
GCAGAAACCA TGGCTAGAGG ATTGGCATAT TTACATGAGG ATATACCTGG CTTAAAAGAT 
GGCCACAAGC CTGCAATCTC TCACAGGGAC ATCAAAAGTA AAAATGTGCT GTTGAAAAAC 
AATCTGACAG CTTGCATTGC TGACTTTGGG TTGGCCTTAA AGTTCGAGGC TGGCAAGTCT 
GCAGGTGACA CCCATGGGCA GGTTGGTACC CGGAGGTATA TGGCTCCAGA GGTGTTGGAG 
GGTGCTATAA ACTTCCAAAG GGACGCATTT CTGAGGATAG ATATGTACGC CATGGGATTA 
GTCCTATGGG AATTGGCTTC TCGTTGCACT GCTGCAGATG GACCCGTAGA TGAGTACATG 
TTACCATTTG AGGAAGAAAT TGGCCAGCAT CCATCTCTTG AAGATATGCA GGAAGTTGTT 
GTGCATAAAA AAAAGAGGCC TGTTTTAAGA GATTATTGGC AGAAACATGC AGGAATGGCA 
ATGCTCTGTG AAACGATAGA AGAATGTTGG GATCATGATG CAGAAGCCAG GTTATCAGCT 
GGATGTGTAG GTGAAAGAAT TACTCAGATG CAAAGACTAA CAAATATCAT TACTACAGAG 
GACATTGTAA CAGTGGTCAC AATGGTGACA AATGTTGACT TTCCTCCCAA AGAATCTAGT 
CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497686.1
CDS	15..1580
Translation	MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQHAFHIMIEDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	XM_006497623.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus activin receptor IIA (Acvr2a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497623.3

ORF Insert Sequence:

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 
ATACTTGGCA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 
AGAACCAACC AGACTGGTGT TGAACCTTGC TATGGTGATA AAGATAAACG GCGACATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 
TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCTGTT ACACCGAAGC CACCCTATTA CAACATTCTG 
CTGTATTCCT TGGTACCACT AATGTTAATT GCAGGAATTG TCATTTGTGC ATTTTGGGTG 
TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAACA CGCCTTTCAT 
ATAATGATAG AGGACCCAGG ACCACCCCCA CCTTCCCCAT TACTAGGGTT GAAGCCATTG 
CAGCTGTTAG AAGTGAAAGC AAGGGGAAGA TTTGGTTGTG TCTGGAAAGC CCAGTTGCTC 
AATGAATATG TGGCTGTCAA AATATTTCCA ATACAGGACA AACAGTCCTG GCAGAATGAA 
TATGAAGTCT ATAGTCTACC TGGAATGAAG CATGAGAACA TACTACAGTT CATTGGTGCA 
GAGAAAAGAG GCACCAGTGT GGATGTGGAC CTGTGGCTAA TCACAGCATT TCATGAAAAG 
GGCTCACTGT CAGACTTTCT TAAGGCTAAT GTGGTCTCTT GGAATGAACT TTGTCATATT 
GCAGAAACCA TGGCTAGAGG ATTGGCATAT TTACATGAGG ATATACCTGG CTTAAAAGAT 
GGCCACAAGC CTGCAATCTC TCACAGGGAC ATCAAAAGTA AAAATGTGCT GTTGAAAAAC 
AATCTGACAG CTTGCATTGC TGACTTTGGG TTGGCCTTAA AGTTCGAGGC TGGCAAGTCT 
GCAGGTGACA CCCATGGGCA GGTTGGTACC CGGAGGTATA TGGCTCCAGA GGTGTTGGAG 
GGTGCTATAA ACTTCCAAAG GGACGCATTT CTGAGGATAG ATATGTACGC CATGGGATTA 
GTCCTATGGG AATTGGCTTC TCGTTGCACT GCTGCAGATG GACCCGTAGA TGAGTACATG 
TTACCATTTG AGGAAGAAAT TGGCCAGCAT CCATCTCTTG AAGATATGCA GGAAGTTGTT 
GTGCATAAAA AAAAGAGGCC TGTTTTAAGA GATTATTGGC AGAAACATGC AGGAATGGCA 
ATGCTCTGTG AAACGATAGA AGAATGTTGG GATCATGATG CAGAAGCCAG GTTATCAGCT 
GGATGTGTAG GTGAAAGAAT TACTCAGATG CAAAGACTAA CAAATATCAT TACTACAGAG 
GACATTGTAA CAGTGGTCAC AATGGTGACA AATGTTGACT TTCCTCCCAA AGAATCTAGT 
CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acvr2a ( XM_006497623.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006497686.1 Mus musculus activin receptor IIA (Acvr2a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu29255
Clone ID Related Accession (Same CDS sequence)	XM_006497623.3 , XM_006497623.4
Accession Version	XM_006497623.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	activin receptor type-2A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497623.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 
ATACTTGGCA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 
AGAACCAACC AGACTGGTGT TGAACCTTGC TATGGTGATA AAGATAAACG GCGACATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 
TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCTGTT ACACCGAAGC CACCCTATTA CAACATTCTG 
CTGTATTCCT TGGTACCACT AATGTTAATT GCAGGAATTG TCATTTGTGC ATTTTGGGTG 
TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAACA CGCCTTTCAT 
ATAATGATAG AGGACCCAGG ACCACCCCCA CCTTCCCCAT TACTAGGGTT GAAGCCATTG 
CAGCTGTTAG AAGTGAAAGC AAGGGGAAGA TTTGGTTGTG TCTGGAAAGC CCAGTTGCTC 
AATGAATATG TGGCTGTCAA AATATTTCCA ATACAGGACA AACAGTCCTG GCAGAATGAA 
TATGAAGTCT ATAGTCTACC TGGAATGAAG CATGAGAACA TACTACAGTT CATTGGTGCA 
GAGAAAAGAG GCACCAGTGT GGATGTGGAC CTGTGGCTAA TCACAGCATT TCATGAAAAG 
GGCTCACTGT CAGACTTTCT TAAGGCTAAT GTGGTCTCTT GGAATGAACT TTGTCATATT 
GCAGAAACCA TGGCTAGAGG ATTGGCATAT TTACATGAGG ATATACCTGG CTTAAAAGAT 
GGCCACAAGC CTGCAATCTC TCACAGGGAC ATCAAAAGTA AAAATGTGCT GTTGAAAAAC 
AATCTGACAG CTTGCATTGC TGACTTTGGG TTGGCCTTAA AGTTCGAGGC TGGCAAGTCT 
GCAGGTGACA CCCATGGGCA GGTTGGTACC CGGAGGTATA TGGCTCCAGA GGTGTTGGAG 
GGTGCTATAA ACTTCCAAAG GGACGCATTT CTGAGGATAG ATATGTACGC CATGGGATTA 
GTCCTATGGG AATTGGCTTC TCGTTGCACT GCTGCAGATG GACCCGTAGA TGAGTACATG 
TTACCATTTG AGGAAGAAAT TGGCCAGCAT CCATCTCTTG AAGATATGCA GGAAGTTGTT 
GTGCATAAAA AAAAGAGGCC TGTTTTAAGA GATTATTGGC AGAAACATGC AGGAATGGCA 
ATGCTCTGTG AAACGATAGA AGAATGTTGG GATCATGATG CAGAAGCCAG GTTATCAGCT 
GGATGTGTAG GTGAAAGAAT TACTCAGATG CAAAGACTAA CAAATATCAT TACTACAGAG 
GACATTGTAA CAGTGGTCAC AATGGTGACA AATGTTGACT TTCCTCCCAA AGAATCTAGT 
CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497686.1
CDS	647..2212
Translation	MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQHAFHIMIEDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Target ORF information:

RefSeq Version	XM_006497623.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus activin receptor IIA (Acvr2a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497623.4

ORF Insert Sequence:

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 
ATACTTGGCA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 
AGAACCAACC AGACTGGTGT TGAACCTTGC TATGGTGATA AAGATAAACG GCGACATTGT 
TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 
GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 
TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 
GAAGTCACAC AGCCCACTTC AAATCCTGTT ACACCGAAGC CACCCTATTA CAACATTCTG 
CTGTATTCCT TGGTACCACT AATGTTAATT GCAGGAATTG TCATTTGTGC ATTTTGGGTG 
TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAACA CGCCTTTCAT 
ATAATGATAG AGGACCCAGG ACCACCCCCA CCTTCCCCAT TACTAGGGTT GAAGCCATTG 
CAGCTGTTAG AAGTGAAAGC AAGGGGAAGA TTTGGTTGTG TCTGGAAAGC CCAGTTGCTC 
AATGAATATG TGGCTGTCAA AATATTTCCA ATACAGGACA AACAGTCCTG GCAGAATGAA 
TATGAAGTCT ATAGTCTACC TGGAATGAAG CATGAGAACA TACTACAGTT CATTGGTGCA 
GAGAAAAGAG GCACCAGTGT GGATGTGGAC CTGTGGCTAA TCACAGCATT TCATGAAAAG 
GGCTCACTGT CAGACTTTCT TAAGGCTAAT GTGGTCTCTT GGAATGAACT TTGTCATATT 
GCAGAAACCA TGGCTAGAGG ATTGGCATAT TTACATGAGG ATATACCTGG CTTAAAAGAT 
GGCCACAAGC CTGCAATCTC TCACAGGGAC ATCAAAAGTA AAAATGTGCT GTTGAAAAAC 
AATCTGACAG CTTGCATTGC TGACTTTGGG TTGGCCTTAA AGTTCGAGGC TGGCAAGTCT 
GCAGGTGACA CCCATGGGCA GGTTGGTACC CGGAGGTATA TGGCTCCAGA GGTGTTGGAG 
GGTGCTATAA ACTTCCAAAG GGACGCATTT CTGAGGATAG ATATGTACGC CATGGGATTA 
GTCCTATGGG AATTGGCTTC TCGTTGCACT GCTGCAGATG GACCCGTAGA TGAGTACATG 
TTACCATTTG AGGAAGAAAT TGGCCAGCAT CCATCTCTTG AAGATATGCA GGAAGTTGTT 
GTGCATAAAA AAAAGAGGCC TGTTTTAAGA GATTATTGGC AGAAACATGC AGGAATGGCA 
ATGCTCTGTG AAACGATAGA AGAATGTTGG GATCATGATG CAGAAGCCAG GTTATCAGCT 
GGATGTGTAG GTGAAAGAAT TACTCAGATG CAAAGACTAA CAAATATCAT TACTACAGAG 
GACATTGTAA CAGTGGTCAC AATGGTGACA AATGTTGACT TTCCTCCCAA AGAATCTAGT 
CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease.
Kidney international93(1)147-158(2018 Jan)
Williams MJ,Sugatani T,Agapova OA,Fang Y,Gaut JP,Faugere MC,Malluche HH,Hruska KA

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura.
Developmental cell42(5)445-461.e5(2017 09)
Tischfield MA,Robson CD,Gilette NM,Chim SM,Sofela FA,DeLisle MM,Gelber A,Barry BJ,MacKinnon S,Dagi LR,Nathans J,Engle EC

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Acvr2a cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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