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Agtrap cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Agtrap
Entrez Gene ID 11610
Full Name angiotensin II, type I receptor-associated protein
Synonyms 3300002E14Rik,AT1R,Atrap,D4Wsu124e
General protein information
Preferred Names

angiotensin II, type I receptor-associated protein

Names

type-1 angiotensin II receptor-associated protein
AT1 receptor-associated protein
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

4

4 E2|4 78.67 cM

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017319922.1 XP_017175411.1 type-1 angiotensin II receptor-associated protein isoform X1
NM_001301281.1 NP_001288210.1 type-1 angiotensin II receptor-associated protein isoform 2
NM_009642.4 NP_033772.2 type-1 angiotensin II receptor-associated protein isoform 1
NM_009642.5 NP_033772.2 type-1 angiotensin II receptor-associated protein isoform 1

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) AGTRAP XP_005618054.1
Xenopus tropicalis (tropical clawed frog) agtrap NP_001015751.1
Mus musculus (house mouse) Agtrap NP_033772.2
Gallus gallus (chicken) AGTRAP XP_417646.2
Danio rerio (zebrafish) agtrap NP_001188274.1
Pan troglodytes (chimpanzee) AGTRAP XP_514392.1
Rattus norvegicus (Norway rat) Agtrap NP_001007655.1
Homo sapiens (human) AGTRAP NP_065083.3
AGTRAP XP_001118851.2
Bos taurus (cattle) AGTRAP NP_001068831.1

Gene Ontology


Bibliography

Related articles in PubMed

Adipose angiotensin II type 1 receptor-associated protein ameliorates metabolic disorders via promoting adipose tissue adipogenesis and browning.
Luo C, Lv N, Chang Z, Qu Q, Huang J
European journal of cell biology96(6)567-578(2017 Sep)

Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin.
Uneda K, Wakui H, Maeda A, Azushima K, Kobayashi R, Haku S, Ohki K, Haruhara K, Kinguchi S, Matsuda M, Ohsawa M, Minegishi S, Ishigami T, Toya Y, Atobe Y, Yamashita A, Umemura S, Tamura K
Journal of the American Heart Association6(8)(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
Title: An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in a chronic kidney disease model.

ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Title: ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice.

These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
Title: Angiotensin ? induces the differentiation of mouse epicardial progenitor cells into vascular smooth muscle-like cells.

Identify Atrap as a novel regulatory protein of the cardiac Ca(2+)-ATPase SERCA2a. Suggest that Atrap enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation.
Title: The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a.

These results suggest that increased formation of AT1R-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II.
Title: Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.

The following Agtrap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Agtrap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu67087 NM_001301281.1
Latest version!		 Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OMu67087 XM_017319922.1
Latest version!		 Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OMu19708 NM_009642.5
Latest version!		 Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
View Old Accession Versions >>
OMu19708 NM_009642.4 Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu67087
Clone ID Related Accession (Same CDS sequence) XM_017319922.1 , NM_001301281.1
Accession Version NM_001301281.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 321bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-27
Organism Mus musculus(house mouse)
Product type-1 angiotensin II receptor-associated protein isoform 2
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL606929.13. On Aug 1, 2014 this sequence version replaced XM_006535911.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR that causes translation initiation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV579018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
ATGTTTCTTG GTGGCTTGGT TGCCACCATC TTCCTGGACA TTATCTACAT TAGCATCTTC 
TACTCGAGTG TTGCCACTGG GGACACTGGC CGCTTCGGCG CCGGCATGGC CATCCTCAGC 
TTGCTGCTGA AGCCCTTCTC TTGCTGCCTC GTCTACCACA TGCACCGTGA ACGAGGGGGT 
GAGCTCCCCC TCCGCCCCGA TTTCTTCGGA CCCTCTCAGG AGCACAGTGC CTACCAGACA 
ATTGACTCAT CATCAGACGC TGCTGCAGAC CCCTTTGCAA GCCTGGAGAA CAAGGGCCAA 
GCTGTCCCCC GGGGGTACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001288210.1
CDS240..560
Translation

Target ORF information:

RefSeq Version NM_001301281.1
Organism Mus musculus(house mouse)
Definition Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001301281.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGTTTCTTG GTGGCTTGGT TGCCACCATC TTCCTGGACA TTATCTACAT TAGCATCTTC 
TACTCGAGTG TTGCCACTGG GGACACTGGC CGCTTCGGCG CCGGCATGGC CATCCTCAGC 
TTGCTGCTGA AGCCCTTCTC TTGCTGCCTC GTCTACCACA TGCACCGTGA ACGAGGGGGT 
GAGCTCCCCC TCCGCCCCGA TTTCTTCGGA CCCTCTCAGG AGCACAGTGC CTACCAGACA 
ATTGACTCAT CATCAGACGC TGCTGCAGAC CCCTTTGCAA GCCTGGAGAA CAAGGGCCAA 
GCTGTCCCCC GGGGGTACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu67087
Clone ID Related Accession (Same CDS sequence) XM_017319922.1 , NM_001301281.1
Accession Version XM_017319922.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 321bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-21
Organism Mus musculus(house mouse)
Product type-1 angiotensin II receptor-associated protein isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
ATGTTTCTTG GTGGCTTGGT TGCCACCATC TTCCTGGACA TTATCTACAT TAGCATCTTC 
TACTCGAGTG TTGCCACTGG GGACACTGGC CGCTTCGGCG CCGGCATGGC CATCCTCAGC 
TTGCTGCTGA AGCCCTTCTC TTGCTGCCTC GTCTACCACA TGCACCGTGA ACGAGGGGGT 
GAGCTCCCCC TCCGCCCCGA TTTCTTCGGA CCCTCTCAGG AGCACAGTGC CTACCAGACA 
ATTGACTCAT CATCAGACGC TGCTGCAGAC CCCTTTGCAA GCCTGGAGAA CAAGGGCCAA 
GCTGTCCCCC GGGGGTACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017175411.1
CDS336..656
Translation

Target ORF information:

RefSeq Version XM_017319922.1
Organism Mus musculus(house mouse)
Definition Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017319922.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGTTTCTTG GTGGCTTGGT TGCCACCATC TTCCTGGACA TTATCTACAT TAGCATCTTC 
TACTCGAGTG TTGCCACTGG GGACACTGGC CGCTTCGGCG CCGGCATGGC CATCCTCAGC 
TTGCTGCTGA AGCCCTTCTC TTGCTGCCTC GTCTACCACA TGCACCGTGA ACGAGGGGGT 
GAGCTCCCCC TCCGCCCCGA TTTCTTCGGA CCCTCTCAGG AGCACAGTGC CTACCAGACA 
ATTGACTCAT CATCAGACGC TGCTGCAGAC CCCTTTGCAA GCCTGGAGAA CAAGGGCCAA 
GCTGTCCCCC GGGGGTACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu19708
Clone ID Related Accession (Same CDS sequence) NM_009642.4 , NM_009642.5
Accession Version NM_009642.4 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 486bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-02-14
Organism Mus musculus(House mouse)
Product type-1 angiotensin II receptor-associated protein isoform 1
Comment 

1
61
121
181
241
301
361
421
481
ATGGAGCTGC CTGCCGTGAA CTTGAAGGTT ATTCTCCTGG TTCACTGGCT GTTGACAACC 
TGGGGCTGCT TGGTGTTCTC AAGCTCCTAT GCTTGGGGCA ACTTCACTAT CCTGGCCCTG 
GGTGTGTGGG CTGTGGCCCA GCGGGACTCT ATAGATGCCA TAGGCATGTT TCTTGGTGGC 
TTGGTTGCCA CCATCTTCCT GGACATTATC TACATTAGCA TCTTCTACTC GAGTGTTGCC 
ACTGGGGACA CTGGCCGCTT CGGCGCCGGC ATGGCCATCC TCAGCTTGCT GCTGAAGCCC 
TTCTCTTGCT GCCTCGTCTA CCACATGCAC CGTGAACGAG GGGGTGAGCT CCCCCTCCGC 
CCCGATTTCT TCGGACCCTC TCAGGAGCAC AGTGCCTACC AGACAATTGA CTCATCATCA 
GACGCTGCTG CAGACCCCTT TGCAAGCCTG GAGAACAAGG GCCAAGCTGT CCCCCGGGGG 
TACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_033772.2
Translation

Target ORF information:

RefSeq Version NM_009642.4
Organism Mus musculus(House mouse)
Definition Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_009642.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAGCTGC CTGCCGTGAA CTTGAAGGTT ATTCTCCTGG TTCACTGGCT GTTGACAACC 
TGGGGCTGCT TGGTGTTCTC AAGCTCCTAT GCTTGGGGCA ACTTCACTAT CCTGGCCCTG 
GGTGTGTGGG CTGTGGCCCA GCGGGACTCT ATAGATGCCA TAGGCATGTT TCTTGGTGGC 
TTGGTTGCCA CCATCTTCCT GGACATTATC TACATTAGCA TCTTCTACTC GAGTGTTGCC 
ACTGGGGACA CTGGCCGCTT CGGCGCCGGC ATGGCCATCC TCAGCTTGCT GCTGAAGCCC 
TTCTCTTGCT GCCTCGTCTA CCACATGCAC CGTGAACGAG GGGGTGAGCT CCCCCTCCGC 
CCCGATTTCT TCGGACCCTC TCAGGAGCAC AGTGCCTACC AGACAATTGA CTCATCATCA 
GACGCTGCTG CAGACCCCTT TGCAAGCCTG GAGAACAAGG GCCAAGCTGT CCCCCGGGGG 
TACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu19708
Clone ID Related Accession (Same CDS sequence) NM_009642.4 , NM_009642.5
Accession Version NM_009642.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 486bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-29
Organism Mus musculus(house mouse)
Product type-1 angiotensin II receptor-associated protein isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK152467.1, AL606929.13 and CO040736.1. On Sep 8, 2016 this sequence version replaced NM_009642.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK152467.1, AK036598.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
ATGGAGCTGC CTGCCGTGAA CTTGAAGGTT ATTCTCCTGG TTCACTGGCT GTTGACAACC 
TGGGGCTGCT TGGTGTTCTC AAGCTCCTAT GCTTGGGGCA ACTTCACTAT CCTGGCCCTG 
GGTGTGTGGG CTGTGGCCCA GCGGGACTCT ATAGATGCCA TAGGCATGTT TCTTGGTGGC 
TTGGTTGCCA CCATCTTCCT GGACATTATC TACATTAGCA TCTTCTACTC GAGTGTTGCC 
ACTGGGGACA CTGGCCGCTT CGGCGCCGGC ATGGCCATCC TCAGCTTGCT GCTGAAGCCC 
TTCTCTTGCT GCCTCGTCTA CCACATGCAC CGTGAACGAG GGGGTGAGCT CCCCCTCCGC 
CCCGATTTCT TCGGACCCTC TCAGGAGCAC AGTGCCTACC AGACAATTGA CTCATCATCA 
GACGCTGCTG CAGACCCCTT TGCAAGCCTG GAGAACAAGG GCCAAGCTGT CCCCCGGGGG 
TACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_033772.2
CDS122..607
Translation

Target ORF information:

RefSeq Version NM_009642.5
Organism Mus musculus(house mouse)
Definition Mus musculus angiotensin II, type I receptor-associated protein (Agtrap), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_009642.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAGCTGC CTGCCGTGAA CTTGAAGGTT ATTCTCCTGG TTCACTGGCT GTTGACAACC 
TGGGGCTGCT TGGTGTTCTC AAGCTCCTAT GCTTGGGGCA ACTTCACTAT CCTGGCCCTG 
GGTGTGTGGG CTGTGGCCCA GCGGGACTCT ATAGATGCCA TAGGCATGTT TCTTGGTGGC 
TTGGTTGCCA CCATCTTCCT GGACATTATC TACATTAGCA TCTTCTACTC GAGTGTTGCC 
ACTGGGGACA CTGGCCGCTT CGGCGCCGGC ATGGCCATCC TCAGCTTGCT GCTGAAGCCC 
TTCTCTTGCT GCCTCGTCTA CCACATGCAC CGTGAACGAG GGGGTGAGCT CCCCCTCCGC 
CCCGATTTCT TCGGACCCTC TCAGGAGCAC AGTGCCTACC AGACAATTGA CTCATCATCA 
GACGCTGCTG CAGACCCCTT TGCAAGCCTG GAGAACAAGG GCCAAGCTGT CCCCCGGGGG 
TACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Adipose angiotensin II type 1 receptor-associated protein ameliorates metabolic disorders via promoting adipose tissue adipogenesis and browning.
European journal of cell biology96(6)567-578(2017 Sep)
Luo C,Lv N,Chang Z,Qu Q,Huang J


book

Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin.
Journal of the American Heart Association6(8)(2017 Jul)
Uneda K,Wakui H,Maeda A,Azushima K,Kobayashi R,Haku S,Ohki K,Haruhara K,Kinguchi S,Matsuda M,Ohsawa M,Minegishi S,Ishigami T,Toya Y,Atobe Y,Yamashita A,Umemura S,Tamura K