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Boc cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Boc
Entrez Gene ID 117606
Full Name biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
Synonyms 4732455C11,mFLJ00376
General protein information
Preferred Names

biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein

Names

brother of CDO
biregional Cdon binding protein
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

16

16|16 B4

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_172506.2 NP_766094.1 brother of CDO precursor

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Boc NP_766094.1
Danio rerio (zebrafish) boc NP_001005393.1
Xenopus tropicalis (tropical clawed frog) boc NP_001072742.1
Homo sapiens (human) BOC NP_150279.1
Pan troglodytes (chimpanzee) BOC XP_516653.2
Canis lupus familiaris (dog) BOC XP_005639543.1
Bos taurus (cattle) BOC NP_001193148.1
Gallus gallus (chicken) BOC XP_004938273.1
Rattus norvegicus (Norway rat) Boc XP_006248416.1
BOC XP_001106251.1

Gene Ontology


Bibliography

Related articles in PubMed

Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point.
Peng J, Fabre PJ, Dolique T, Swikert SM, Kermasson L, Shimogori T, Charron F
Neuron97(2)326-340.e4(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
Title: A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.

Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc
Title: Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc.

Elevated Boc levels induce proliferation of granule cell precursors in early medulloblastoma.
Title: The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors.

The results of this study proposed that expression of Boc in cells from the ventrotemporal crescent of the retina is required to sustain Zic2 expression, likely by regulating the levels of Shh signaling from the nearby cRGCs. Zic2.
Title: Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.

Genetic loss-of-function of GAS1, Cdon and BOC in SHH is associated with defective cell proliferation.
Title: Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.

The following Boc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Boc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu03585 NM_172506.2
Latest version!		 Mus musculus biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein (Boc), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 20 $650.30
$929.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu03585
Clone ID Related Accession (Same CDS sequence) NM_172506.2
Accession Version NM_172506.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 3333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-31
Organism Mus musculus(house mouse)
Product brother of CDO precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK028889.1. On Apr 6, 2007 this sequence version replaced NM_172506.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028889.1, BC078631.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
ATGACGACGT GCCGAAGAGA GCGGCCTATA CTTACACTGC TTTGGATTCT CATGGCCACA 
GCAGGCTGCC TTGCTGATTT GAATGAGGTT CCTCAGGTCA CAGTCCAGCC CATGTCCACT 
GTCCAGAAGC TGGGAGGAAC TGTGATCCTG GGCTGTGTGG TGGAGCCACC ATGGATGAAC 
GTGACTTGGC GCTTCAACGG AAAGGAGCTA AATGGCTCTG ATGATGCTCT GGGTGTCTTC 
ATCACCCGTG GGACCCTTGT CATTGCTGCC CTCAACAACC ACACTGTGGG ACGGTACCAG 
TGTGTGGCAC GGATGCCTGC AGGAGCTGTG GCCAGTGTGC CAGCCACAGT GACGCTAGCC 
AATCTCCAGG ACTTTAAATT AGATGTGCAG CATGTGATTG AAGTAGACGA GGGGAACACA 
GCCGTCATTG CCTGCCACCT GCCTGAGAGC CACCCAAAAG CCCAGGTCCG GTACAGTGTC 
AAACAGGAGT GGCTGGAGGC CTCTAGAGAC AACTACCTGA TCATGCCATC CGGGAATCTC 
CAAATTGTCA ATGCCAGCCA AGAGGACGAA GGCATGTACA AGTGTGCCGC CTACAACCCG 
GTGACCCAGG AAGTGAAAAC CTCCGGCTCC GGCGACAGGC TGCGCGTGCG CCGGTCCACT 
GCTGAGGCTG CCCGCATCAT CTACCCACTG GAAGCCCAGA CCGTCATTGT CACCAAAGGC 
CAGAGTCTCA TACTGGAGTG TGTGGCCAGT GGAATCCCAC CACCTCGAGT CACATGGGCC 
AAGGATGGGT CCAGCATTGC TGCCTATAAC AAGACTCGCT TCCTGCTGAG TAATTTGCTT 
ATTGACACCA CCAGCGAGGA GGACTCAGGC ACCTACCGAT GTATGGCCAG CAATGGGGTT 
GGGGATCCTG GGGCAGCAGT CATCCTCTAC AATGTCCAGG TGTTCGAACC CCCTGAGGTC 
ACGGTGGAGC TGTCCCAGCT GGTCATCCCA TGGGGCCAGA GTGCAAAGCT CACCTGTGAG 
GTTCGAGGAA ACCCCCCACC CTCTGTACTA TGGCTGAGGA ATGCAGTGCC CCTCACCTCC 
AGCCAGCGCC TCCGGCTGTC ACGTAGAGCC CTGCGGGTGG TCAGTGTTGG GCCAGAGGAC 
GAAGGCGTGT ACCAGTGCAT GGCTGAGAAT GCGGTTGGCA GTGCCCACGC TGTGGTCCAA 
CTGAGGACCG CCCGGCCAGA CACAACCCTG AGACCCGGGA GGGATACCAA GCCGATTGCT 
GCCACACCCC CCATGCCACC CTCCAGACCC AGCAGACCTG ACCAGATGCT TCGGGAACAA 
CCGGGGCTTG TTAAGCCCCC AACGTCGTCG GTACAGCCTA CTTCCCTGAA GTGCCCGGGA 
GAAGAGCAGG TAGCCCCTGC AGAGGCACCT ATCATCCTCA GCTCACCCCG GACCTCCAAG 
ACGGACTCCT ATGAGCTGGT GTGGCGGCCT CGCCATGAGG GGAGCAGCCG GACACCCATC 
CTGTACTACG TAGTGAAGCA TCGTAAGGTC ACGAACTCCT CTGACGACTG GACCATTTCT 
GGCATTCCAG CCAACCAGCA CCGCCTCACC CTGACCAGGC TTGACCCTGG AAGCTTGTAC 
GAAGTGGAGA TGGCAGCCTA CAACTGTGCT GGCGAGGGCC AGACAGCTAT GGTCACCTTC 
CGAACAGGAC GGCGGCCCAA ACCTGAGATC GTGGCCAGTA AGGAGCAGCA GATCCAGAGA 
GATGACCCTG GTGCCAGTCT CCAGAGCAGC AGCCAGCCTG ACCATGGCCG CCTCTCCCCC 
CCAGAAGCTC CAGACAGACC CACCATCTCC ACAGCTTCTG AGACCTCCGT GTACGTAACC 
TGGATTCCCC GAGGGAACGG CGGCTTCCCG ATTCAGTCTT TCCGTGTAGA GTACAAGAAG 
CTAAAAAAAG TGGGAGATTG GATACTGGCT ACCAGTGCCA TACCTCCCTC GAGGCTCTCT 
GTGGAGATCA CAGGCCTAGA GAAAGGTATT TCTTACAAGT TCCGAGTTCG TGCTTTGAAC 
ATGTTAGGGG AGAGTGAGCC CAGTGCTCCC TCCCGGCCCT ACGTGGTGTC AGGCTACAGT 
GGCCGTGTAT ATGAGAGGCC CGTGGCAGGA CCTTACATCA CCTTCACTGA TGCAGTCAAT 
GAGACCACTA TTATGCTCAA GTGGATGTAT ATCCCAGCCA GTAACAACAA CACCCCAATC 
CATGGCTTCT ATATCTACTA CCGACCCACA GACAGTGACA ATGACAGTGA CTACAAGAAG 
GACATGGTAG AAGGGGACAG GTACTGGCAC TCCATCAGCC ACCTGCAGCC AGAGACTTCC 
TATGACATTA AAATGCAGTG CTTCAATGAA GGAGGGGAGA GCGAGTTCAG CAATGTCATG 
ATCTGCGAGA CCAAAGCTCG GAAATTTTCT GGTCAGCCTG GAAGACCCCC ACCCTTGACT 
CTAGCTCCAC CACAGCCTCC GCCCCTAGAA ACCATGGAAC GGCCGGTGGG CACTGGAGCC 
ATGGTGGCAC GGGCCAGCGA CCTGCCCTAT CTGATTGTCG GGGTTGTTCT GGGCTCTATA 
GTCCTCATCA TCGTCACCTT CATCCCCTTC TGCCTATGGA GGGCCTGGTC TAAGCAGAAA 
CACACAACAG ATCTGGGTTT TCCTCGGAGT GCCCTCCTGT CTTCTTCGTG CCAGTACACA 
ATGGTGCCAT TGGAGGGACT TCCAGGTCAC CAAGCCAACG GGCAGCCCTA CCTTGGTGGC 
GTCAGTGGAC GGGCCTGTGT CAGTCGAGTG CACGGAAGCA GGGGCTGCCC TGCTGCTACA 
GTGGGCTGTC CAGGCAGGAA GCCTCAGCAG CACTGCCCAG GGGAGCTTGC CCAGCAGCGG 
GAAGACACCA ACAGCCAACT GAGGCAGCCC ATTGTTAGCA ACGGATATGA CCTCCAGAAC 
CAGCAGGTTG CCAGAGGTCC CCAGTGTGCC TCAGGAGTAG GAGCTTTCTT ATACACGCTG 
CCTGATGACT CAACTCACCA GCTGCTCCAA CCTCAAGACT GCTGTCACCT CCAGAAGCAA 
CCCGTCACCA CATGCCAAAC AGCAGTGAGG CGAACGTCTG AAAGTCCTGG ACTAGAATCT 
TCATGGGACC CTCCATATCA TTCAGGGCCC CAGTGCTGTT TAGGTCTTGT ACCAGTTGAA 
GAAGTAGACA GTTCTGACTC CTGCCAAGTG GGTGGAGGAG ACTGGAGTTC CCAGCATCCA 
TCAGGGACCT ACACAGGACA GGAACGTGGG ATGCGGTTCT CGCCTAGCCC ATCAGTTCAT 
GTGTCCTTTG AAACACCACC TCCCACAATT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_766094.1
CDS529..3861
Translation

Target ORF information:

RefSeq Version NM_172506.2
Organism Mus musculus(house mouse)
Definition Mus musculus biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein (Boc), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_172506.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
ATGACGACGT GCCGAAGAGA GCGGCCTATA CTTACACTGC TTTGGATTCT CATGGCCACA 
GCAGGCTGCC TTGCTGATTT GAATGAGGTT CCTCAGGTCA CAGTCCAGCC CATGTCCACT 
GTCCAGAAGC TGGGAGGAAC TGTGATCCTG GGCTGTGTGG TGGAGCCACC ATGGATGAAC 
GTGACTTGGC GCTTCAACGG AAAGGAGCTA AATGGCTCTG ATGATGCTCT GGGTGTCTTC 
ATCACCCGTG GGACCCTTGT CATTGCTGCC CTCAACAACC ACACTGTGGG ACGGTACCAG 
TGTGTGGCAC GGATGCCTGC AGGAGCTGTG GCCAGTGTGC CAGCCACAGT GACGCTAGCC 
AATCTCCAGG ACTTTAAATT AGATGTGCAG CATGTGATTG AAGTAGACGA GGGGAACACA 
GCCGTCATTG CCTGCCACCT GCCTGAGAGC CACCCAAAAG CCCAGGTCCG GTACAGTGTC 
AAACAGGAGT GGCTGGAGGC CTCTAGAGAC AACTACCTGA TCATGCCATC CGGGAATCTC 
CAAATTGTCA ATGCCAGCCA AGAGGACGAA GGCATGTACA AGTGTGCCGC CTACAACCCG 
GTGACCCAGG AAGTGAAAAC CTCCGGCTCC GGCGACAGGC TGCGCGTGCG CCGGTCCACT 
GCTGAGGCTG CCCGCATCAT CTACCCACTG GAAGCCCAGA CCGTCATTGT CACCAAAGGC 
CAGAGTCTCA TACTGGAGTG TGTGGCCAGT GGAATCCCAC CACCTCGAGT CACATGGGCC 
AAGGATGGGT CCAGCATTGC TGCCTATAAC AAGACTCGCT TCCTGCTGAG TAATTTGCTT 
ATTGACACCA CCAGCGAGGA GGACTCAGGC ACCTACCGAT GTATGGCCAG CAATGGGGTT 
GGGGATCCTG GGGCAGCAGT CATCCTCTAC AATGTCCAGG TGTTCGAACC CCCTGAGGTC 
ACGGTGGAGC TGTCCCAGCT GGTCATCCCA TGGGGCCAGA GTGCAAAGCT CACCTGTGAG 
GTTCGAGGAA ACCCCCCACC CTCTGTACTA TGGCTGAGGA ATGCAGTGCC CCTCACCTCC 
AGCCAGCGCC TCCGGCTGTC ACGTAGAGCC CTGCGGGTGG TCAGTGTTGG GCCAGAGGAC 
GAAGGCGTGT ACCAGTGCAT GGCTGAGAAT GCGGTTGGCA GTGCCCACGC TGTGGTCCAA 
CTGAGGACCG CCCGGCCAGA CACAACCCTG AGACCCGGGA GGGATACCAA GCCGATTGCT 
GCCACACCCC CCATGCCACC CTCCAGACCC AGCAGACCTG ACCAGATGCT TCGGGAACAA 
CCGGGGCTTG TTAAGCCCCC AACGTCGTCG GTACAGCCTA CTTCCCTGAA GTGCCCGGGA 
GAAGAGCAGG TAGCCCCTGC AGAGGCACCT ATCATCCTCA GCTCACCCCG GACCTCCAAG 
ACGGACTCCT ATGAGCTGGT GTGGCGGCCT CGCCATGAGG GGAGCAGCCG GACACCCATC 
CTGTACTACG TAGTGAAGCA TCGTAAGGTC ACGAACTCCT CTGACGACTG GACCATTTCT 
GGCATTCCAG CCAACCAGCA CCGCCTCACC CTGACCAGGC TTGACCCTGG AAGCTTGTAC 
GAAGTGGAGA TGGCAGCCTA CAACTGTGCT GGCGAGGGCC AGACAGCTAT GGTCACCTTC 
CGAACAGGAC GGCGGCCCAA ACCTGAGATC GTGGCCAGTA AGGAGCAGCA GATCCAGAGA 
GATGACCCTG GTGCCAGTCT CCAGAGCAGC AGCCAGCCTG ACCATGGCCG CCTCTCCCCC 
CCAGAAGCTC CAGACAGACC CACCATCTCC ACAGCTTCTG AGACCTCCGT GTACGTAACC 
TGGATTCCCC GAGGGAACGG CGGCTTCCCG ATTCAGTCTT TCCGTGTAGA GTACAAGAAG 
CTAAAAAAAG TGGGAGATTG GATACTGGCT ACCAGTGCCA TACCTCCCTC GAGGCTCTCT 
GTGGAGATCA CAGGCCTAGA GAAAGGTATT TCTTACAAGT TCCGAGTTCG TGCTTTGAAC 
ATGTTAGGGG AGAGTGAGCC CAGTGCTCCC TCCCGGCCCT ACGTGGTGTC AGGCTACAGT 
GGCCGTGTAT ATGAGAGGCC CGTGGCAGGA CCTTACATCA CCTTCACTGA TGCAGTCAAT 
GAGACCACTA TTATGCTCAA GTGGATGTAT ATCCCAGCCA GTAACAACAA CACCCCAATC 
CATGGCTTCT ATATCTACTA CCGACCCACA GACAGTGACA ATGACAGTGA CTACAAGAAG 
GACATGGTAG AAGGGGACAG GTACTGGCAC TCCATCAGCC ACCTGCAGCC AGAGACTTCC 
TATGACATTA AAATGCAGTG CTTCAATGAA GGAGGGGAGA GCGAGTTCAG CAATGTCATG 
ATCTGCGAGA CCAAAGCTCG GAAATTTTCT GGTCAGCCTG GAAGACCCCC ACCCTTGACT 
CTAGCTCCAC CACAGCCTCC GCCCCTAGAA ACCATGGAAC GGCCGGTGGG CACTGGAGCC 
ATGGTGGCAC GGGCCAGCGA CCTGCCCTAT CTGATTGTCG GGGTTGTTCT GGGCTCTATA 
GTCCTCATCA TCGTCACCTT CATCCCCTTC TGCCTATGGA GGGCCTGGTC TAAGCAGAAA 
CACACAACAG ATCTGGGTTT TCCTCGGAGT GCCCTCCTGT CTTCTTCGTG CCAGTACACA 
ATGGTGCCAT TGGAGGGACT TCCAGGTCAC CAAGCCAACG GGCAGCCCTA CCTTGGTGGC 
GTCAGTGGAC GGGCCTGTGT CAGTCGAGTG CACGGAAGCA GGGGCTGCCC TGCTGCTACA 
GTGGGCTGTC CAGGCAGGAA GCCTCAGCAG CACTGCCCAG GGGAGCTTGC CCAGCAGCGG 
GAAGACACCA ACAGCCAACT GAGGCAGCCC ATTGTTAGCA ACGGATATGA CCTCCAGAAC 
CAGCAGGTTG CCAGAGGTCC CCAGTGTGCC TCAGGAGTAG GAGCTTTCTT ATACACGCTG 
CCTGATGACT CAACTCACCA GCTGCTCCAA CCTCAAGACT GCTGTCACCT CCAGAAGCAA 
CCCGTCACCA CATGCCAAAC AGCAGTGAGG CGAACGTCTG AAAGTCCTGG ACTAGAATCT 
TCATGGGACC CTCCATATCA TTCAGGGCCC CAGTGCTGTT TAGGTCTTGT ACCAGTTGAA 
GAAGTAGACA GTTCTGACTC CTGCCAAGTG GGTGGAGGAG ACTGGAGTTC CCAGCATCCA 
TCAGGGACCT ACACAGGACA GGAACGTGGG ATGCGGTTCT CGCCTAGCCC ATCAGTTCAT 
GTGTCCTTTG AAACACCACC TCCCACAATT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point.
Neuron97(2)326-340.e4(2018 Jan)
Peng J,Fabre PJ,Dolique T,Swikert SM,Kermasson L,Shimogori T,Charron F