Bcl2a1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Bcl2a1b
Entrez Gene ID	12045
Full Name	B cell leukemia/lymphoma 2 related protein A1b
Synonyms	A1-b
General protein information	Preferred Names B cell leukemia/lymphoma 2 related protein A1b Names B-cell leukemia/lymphoma 2 related protein A1b anti-apoptotic protein A1-b
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 E3.1

mRNA and Protein(s)

mRNA Protein Name

NM_007534.3 NP_031560.2 B-cell leukemia/lymphoma 2 related protein A1b
Pathways from BioSystems

mRNA	Protein	Name
NM_007534.3	NP_031560.2	B-cell leukemia/lymphoma 2 related protein A1b

Homologies

Pan troglodytes (chimpanzee)	BCL2A1	XP_003314865.1
	BCL2A1	XP_001109281.2
Mus musculus (house mouse)	Bcl2a1b	NP_031560.2
Mus musculus (house mouse)	Bcl2a1d	NP_031562.1
Canis lupus familiaris (dog)	BCL2A1	XP_545888.4
Bos taurus (cattle)	BCL2A1	NP_001032177.1
Rattus norvegicus (Norway rat)	Bcl2a1	NP_596907.1
Homo sapiens (human)	BCL2A1	NP_004040.1
Mus musculus (house mouse)	Bcl2a1a	NP_033872.1
Gallus gallus (chicken)	BCL2A1	NP_990197.1

Gene Ontology
Bibliography

Related articles in PubMed

Anti-apoptotic A1 is not essential for lymphoma development in E?-Myc mice but helps sustain transplanted E?-Myc tumour cells.
Mensink M, Anstee NS, Robati M, Schenk RL, Herold MJ, Cory S, Vandenberg CJ
Cell death and differentiation(2018 Jan)

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.
Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM
Cell death and differentiation24(5)878-888(2017 May)

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ
Cell death and differentiation24(3)534-545(2017 Mar)

Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.
Sochalska M, Tuzlak S, Egle A, Villunger A
The FEBS journal282(5)834-849(2015 Mar)

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.
Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J, Ohara O, Seino S
DNA research : an international journal for rapid publication of reports on genes and genomes11(5)315-23(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bcl2a1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl2a1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00345	NM_007534.3 Latest version!	Mus musculus B cell leukemia/lymphoma 2 related protein A1b (Bcl2a1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcl2a1b ( NM_007534.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031560.2 Mus musculus B cell leukemia/lymphoma 2 related protein A1b (Bcl2a1b), mRNA.

Price & Availability↑

CloneID	OMu00345
Clone ID Related Accession (Same CDS sequence)	NM_007534.3
Accession Version	NM_007534.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-01
Organism	Mus musculus(house mouse)
Product	B-cell leukemia/lymphoma 2 related protein A1b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT030686.6 and BC100462.1. On Oct 3, 2009 this sequence version replaced NM_007534.2. ##Evidence-Data-START## Transcript exon combination :: BC116241.1, AK138369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGT ACGAGTTCAT GTATATCCAC TCCCTGGCTG AGCACTATCT TCAGTATGTG 
CTACAGGTAC CCGCCTTTGA GTCGGCTCCA AGCAAAGCAT GCAGAGTGCT ACAAAGAGTT 
GCTTTCTCCG TTCAGAAGGA AGTTGAAAAG AATCTGAAGT CATACTTGGA TGACTTTCAC 
GTGGAATCCA TAGATACCGC CAGAATAATA TTCAACCAAG TGATGGAAAA AGAGTTTGAA 
GATGGCATCA TTAACTGGGG AAGGATTGTG ACTATATTTG CCTTTGGGGG TGTTCTCCTC 
AAAAAACTTC CGCAAGAGCA GATTGCCCTG GATGTAGGTG CTTACAAACA AGTTTCCAGT 
TTTGTGGCAG AATTCATAAT CAATAACACA GGAGAATGGA TACGGCGGAA TGGAGGTTGG 
GAAGATGGCT TCATAAAGAA GTTTGAACCC AAATCTGGCT GGCTGACTTT TCTGCAGATG 
ACAGGACAGT TCTGGGAAAT GCTCTTTCTC CTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031560.2
CDS	88..606
Translation	MAEYEFMYIHSLAEHYLQYVLQVPAFESAPSKACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVGAYKQVSSFVAEFIINNTGEWIRRNGGWEDGFIKKFEPKSGWLTFLQMTGQFWEMLFLLK

Target ORF information:

RefSeq Version	NM_007534.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus B cell leukemia/lymphoma 2 related protein A1b (Bcl2a1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007534.3

ORF Insert Sequence:

ATGGCTGAGT ACGAGTTCAT GTATATCCAC TCCCTGGCTG AGCACTATCT TCAGTATGTG 
CTACAGGTAC CCGCCTTTGA GTCGGCTCCA AGCAAAGCAT GCAGAGTGCT ACAAAGAGTT 
GCTTTCTCCG TTCAGAAGGA AGTTGAAAAG AATCTGAAGT CATACTTGGA TGACTTTCAC 
GTGGAATCCA TAGATACCGC CAGAATAATA TTCAACCAAG TGATGGAAAA AGAGTTTGAA 
GATGGCATCA TTAACTGGGG AAGGATTGTG ACTATATTTG CCTTTGGGGG TGTTCTCCTC 
AAAAAACTTC CGCAAGAGCA GATTGCCCTG GATGTAGGTG CTTACAAACA AGTTTCCAGT 
TTTGTGGCAG AATTCATAAT CAATAACACA GGAGAATGGA TACGGCGGAA TGGAGGTTGG 
GAAGATGGCT TCATAAAGAA GTTTGAACCC AAATCTGGCT GGCTGACTTT TCTGCAGATG 
ACAGGACAGT TCTGGGAAAT GCTCTTTCTC CTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Anti-apoptotic A1 is not essential for lymphoma development in E?-Myc mice but helps sustain transplanted E?-Myc tumour cells.
Cell death and differentiation(2018 Jan)
Mensink M,Anstee NS,Robati M,Schenk RL,Herold MJ,Cory S,Vandenberg CJ

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.
Cell death and differentiation24(5)878-888(2017 May)
Carrington EM,Zhan Y,Brady JL,Zhang JG,Sutherland RM,Anstee NS,Schenk RL,Vikstrom IB,Delconte RB,Segal D,Huntington ND,Bouillet P,Tarlinton DM,Huang DC,Strasser A,Cory S,Herold MJ,Lew AM

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Cell death and differentiation24(3)534-545(2017 Mar)
Schenk RL,Tuzlak S,Carrington EM,Zhan Y,Heinzel S,Teh CE,Gray DH,Tai L,Lew AM,Villunger A,Strasser A,Herold MJ

Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.
The FEBS journal282(5)834-849(2015 Mar)
Sochalska M,Tuzlak S,Egle A,Villunger A

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.
DNA research : an international journal for rapid publication of reports on genes and genomes11(5)315-23(2004 Oct)
Nishimura M,Yokoi N,Miki T,Horikawa Y,Yoshioka H,Takeda J,Ohara O,Seino S

REQUEST A QUOTE

EMAIL

[email protected]

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

Bcl2a1b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM

SUPPORT

COMPANY

SUPPORT

COMPANY