Blk cDNA ORF clone, Mus musculus(house mouse)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels.
Wu YY, Georg I, D?az-Barreiro A, Varela N, Lauwerys B, Kumar R, Bagavant H, Castillo-Mart?n M, El Salem F, Mara??n C, Alarc?n-Riquelme ME
Journal of immunology (Baltimore, Md. : 1950)194(12)5692-702(2015 Jun)

Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.
Samuelson EM, Laird RM, Papillion AM, Tatum AH, Princiotta MF, Hayes SM
PloS one9(3)e92054(2014)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique.
Tai G, Hohenstein P, Davies JA
Biology open2(4)416-23(2013 Apr)

our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
Title: Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels.

BLK risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.
Title: Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.

this study has revealed a previously unappreciated role for Blk in the development and activation of MZ B cells
Title: Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.

Data suggest a role of tyrosine kinase Btk in the regulation of immune cell unctions and innate inflammatory response.
Title: Tyrosine kinase Btk is required for NK cell activation.

BCR-ABL downregulates the Blk gene (encoding B-lymphoid kinase) through c-Myc in leukemic stem cells in chronic myeloid leukemia
Title: The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.