Bmx cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Bmx
Entrez Gene ID	12169
Full Name	BMX non-receptor tyrosine kinase
Synonyms	Etk,Etk/Bmx,Tyro8
General protein information	Preferred Names BMX non-receptor tyrosine kinase Names cytoplasmic tyrosine-protein kinase BMX TYRO8 protein tyrosine kinase 8 bone marrow tyrosine kinase gene in chromosome X protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X F5

mRNA and Protein(s)

mRNA Protein Name

NM_009759.4 NP_033889.2 cytoplasmic tyrosine-protein kinase BMX
Pathways from BioSystems

mRNA	Protein	Name
NM_009759.4	NP_033889.2	cytoplasmic tyrosine-protein kinase BMX

Homologies

Mus musculus (house mouse)	Bmx	NP_033889.2
Rattus norvegicus (Norway rat)	Bmx	NP_001102486.1
Pan troglodytes (chimpanzee)	BMX	XP_003317419.1
Homo sapiens (human)	BMX	NP_001712.1
Canis lupus familiaris (dog)	BMX	XP_005641189.1
	BMX	XP_001101349.1
Bos taurus (cattle)	BMX	NP_001179636.2
Gallus gallus (chicken)	BMX	XP_425573.3

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.
Holopainen T, R?s?nen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivel? R, Alitalo K
Proceedings of the National Academy of Sciences of the United States of America112(42)13063-8(2015 Oct)

The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG
Journal of immunology (Baltimore, Md. : 1950)195(1)246-56(2015 Jul)

Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Chen S, Jiang X, Gewinner CA, Asara JM, Simon NI, Cai C, Cantley LC, Balk SP
Science signaling6(277)ra40(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that the endothelial Bmx tyrosine kinase could provide a target to attenuate the development of cardiac hypertrophy
Title: Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.

Btk, Tec, Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
Title: The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.

Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Title: Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.

Our findings therefore indicate that Bmx activity contributes to tumor angiogenesis and growth.
Title: Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.

genetic ablation of BMX conferred protection in arthritis model confirming BMX an essential mediator of inflammation in vivo; conclude BMX an essential component of inflammatory cytokine signaling and catalytic as well noncatalytic functions are involved
Title: The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.

The following Bmx gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmx cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04782	NM_009759.4 Latest version!	Mus musculus BMX non-receptor tyrosine kinase (Bmx), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmx ( NM_009759.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033889.2 Mus musculus BMX non-receptor tyrosine kinase (Bmx), mRNA.

Price & Availability↑

CloneID	OMu04782
Clone ID Related Accession (Same CDS sequence)	NM_009759.4
Accession Version	NM_009759.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	cytoplasmic tyrosine-protein kinase BMX
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK040936.1 and AK036707.1. On Apr 14, 2009 this sequence version replaced NM_009759.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK040936.1, U88091.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGACGACA ATATGGAGAG TAAATCCATT CTGGAAGAAC TGCTTCTCAA AAAGTCACAG 
CAAAAGAAGA AAATGTCACC AAATAATTAC AAGGAGCGGC TTTTTGTTCT AACCAAAACA 
AGCCTTTCCT ACTATGAATA CGACAAAATG AAAAGAGGAA GCAGAAAAGG ATCAATAGAA 
ATTAAGAAAA TCAGATGTGT GGAAAAAGTC AACCTTGAGG AGCAGACACC GGTGGAGAGA 
CAGTACCCAT TTCAGATTGT GTATAAAGAT GGGCTTCTTT ATGTCTATGC ATCGAATGAA 
GAGAGCCGAT GTCAGTGGTT AAAAGCGCTG CAAAAAGAGA TACGGGGCAA CCCTCACCTG 
TTGATCAAGT ATCACAGTGG CTTCTTTGTG GATGGAAAGT TCCTGTGTTG CCAGCAGAGC 
TGCAAAGCAG CCCCAGGATG CACTCTCTGG GAAGCATATG CTGATCTGCA CATCGCAATC 
AGTGATGAGA AACACAGAGC TCCCACTTTC CCAGAGAGGC TACTGAAGAT TCCAAGGGCA 
GTTCCCGTTC TCAAAATGGA TGCATCATCT TCAGGTGCCA TTCTACCCCA ATATGACAGC 
TATTCAAAGA AAAGTTGTGG TTCCCAGCCA ACCAGCAACA TACGCTATAT TCCAAGGGAA 
GACTGCCCTG ACTGGTGGCA AGTAAGAAAA CTGAAAAGCG AGGAAGACAT TGCATGCAGT 
AACCAACTGG AAAGAAATAT CGCCTCTCAC AGCACCTCAA AGATGTCATG GGGATTCCCT 
GAGTCAAGTT CATCAGAAGA AGAGGAAAAT CTGCATGCTT ATGACTGGTT TGCTGGGAAT 
ATCTCCAGGT CACAATCTGA GCAGTTACTG AGACAAAAGG GAAAAGAAGG AGCATTTATG 
GTTCGGAATT CCAGCCAGAT GGGAATGTAC ACTGTGTCCT TATTTAGTAA GGCTGTAAAT 
GATAAAAAAG GAACTGTCAA GCATTACCAC GTGCATACTA ATGCTGAAAA TAAATTATAC 
CTGGCTGAAA ACTACTGCTT TGATTCCATT CCAAAGCTCA TTCACTATCA CCAACATAAT 
TCAGCAGGCA TGATCACACG GCTCCGCCAC CCAGTGTCAA CCAAGGCCAA CAAGGTCCCG 
GTGTCTGTGG CTCTGGGAAG TGGAATTTGG GAACTGAAAA GAGAAGAGAT TACCTTGCTG 
AAGGAGCTGG GCAATGGCCA GTTTGGAGTG GTCCAGCTGG GCCAGTGGAA GGGGCAATAT 
GATGTGGCTG TAAAGATGAT CAAGGAGGGT GCCATGTCAG AAGATGAATT CTTTCAGGAG 
GCCCAGACCA TGATGAAACT CAGCCATCCC AAGCTGGTGA AGTTCTACGG AGTATGCTCA 
AAGAAATACC CCATCTATAT AGTAACTGAG TATATAACAA ATGGTTGCTT GCTTAATTAC 
CTGAAGAGTC ATGGGAAAGG ACTAGAAAGT TGCCAGCTCT TAGAAATGTG TTATGATGTC 
TGTGAAGGCA TGGCCTTCTT GGAGAGCCAT CAGTTCATAC ATCGAGATTT GGCTGCTCGG 
AACTGTTTGG TGGACAGTGA TCTCTCTGTG AAAGTCTCAG ACTTTGGAAT GACGAGATAT 
GTCCTTGATG ATCAGTATGT CAGCTCAGTA GGAACCAAGT TTCCAGTCAA GTGGTCAGCT 
CCAGAGGTGT TTCACTACTT CAAATACAGC AGCAAGTCGG ATGTATGGGC ATTTGGGATC 
CTGATGTGGG AGGTGTTTAG TCTAGGGAAG CAGCCCTATG ACTTATATGA TAACTCCGAG 
GTGGTTGTGA AGGTCTCCCA GGGCCACAGA CTCTACCGGC CCCAACTGGC ATCAGACACC 
ATCTACCAGA TCATGTACAG CTGCTGGCAT GAGCTTCCAG AAAAGCGCCC CACATTTCAG 
CAACTCCTGT CTGCCATAGA ACCACTTCGG GAACAAGATA AACCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033889.2
CDS	144..2111
Translation	MDDNMESKSILEELLLKKSQQKKKMSPNNYKERLFVLTKTSLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRCQWLKALQKEIRGNPHLLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYADLHIAISDEKHRAPTFPERLLKIPRAVPVLKMDASSSGAILPQYDSYSKKSCGSQPTSNIRYIPREDCPDWWQVRKLKSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGIWELKREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAIEPLREQDKP

Target ORF information:

RefSeq Version	NM_009759.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus BMX non-receptor tyrosine kinase (Bmx), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009759.4

ORF Insert Sequence:

ATGGACGACA ATATGGAGAG TAAATCCATT CTGGAAGAAC TGCTTCTCAA AAAGTCACAG 
CAAAAGAAGA AAATGTCACC AAATAATTAC AAGGAGCGGC TTTTTGTTCT AACCAAAACA 
AGCCTTTCCT ACTATGAATA CGACAAAATG AAAAGAGGAA GCAGAAAAGG ATCAATAGAA 
ATTAAGAAAA TCAGATGTGT GGAAAAAGTC AACCTTGAGG AGCAGACACC GGTGGAGAGA 
CAGTACCCAT TTCAGATTGT GTATAAAGAT GGGCTTCTTT ATGTCTATGC ATCGAATGAA 
GAGAGCCGAT GTCAGTGGTT AAAAGCGCTG CAAAAAGAGA TACGGGGCAA CCCTCACCTG 
TTGATCAAGT ATCACAGTGG CTTCTTTGTG GATGGAAAGT TCCTGTGTTG CCAGCAGAGC 
TGCAAAGCAG CCCCAGGATG CACTCTCTGG GAAGCATATG CTGATCTGCA CATCGCAATC 
AGTGATGAGA AACACAGAGC TCCCACTTTC CCAGAGAGGC TACTGAAGAT TCCAAGGGCA 
GTTCCCGTTC TCAAAATGGA TGCATCATCT TCAGGTGCCA TTCTACCCCA ATATGACAGC 
TATTCAAAGA AAAGTTGTGG TTCCCAGCCA ACCAGCAACA TACGCTATAT TCCAAGGGAA 
GACTGCCCTG ACTGGTGGCA AGTAAGAAAA CTGAAAAGCG AGGAAGACAT TGCATGCAGT 
AACCAACTGG AAAGAAATAT CGCCTCTCAC AGCACCTCAA AGATGTCATG GGGATTCCCT 
GAGTCAAGTT CATCAGAAGA AGAGGAAAAT CTGCATGCTT ATGACTGGTT TGCTGGGAAT 
ATCTCCAGGT CACAATCTGA GCAGTTACTG AGACAAAAGG GAAAAGAAGG AGCATTTATG 
GTTCGGAATT CCAGCCAGAT GGGAATGTAC ACTGTGTCCT TATTTAGTAA GGCTGTAAAT 
GATAAAAAAG GAACTGTCAA GCATTACCAC GTGCATACTA ATGCTGAAAA TAAATTATAC 
CTGGCTGAAA ACTACTGCTT TGATTCCATT CCAAAGCTCA TTCACTATCA CCAACATAAT 
TCAGCAGGCA TGATCACACG GCTCCGCCAC CCAGTGTCAA CCAAGGCCAA CAAGGTCCCG 
GTGTCTGTGG CTCTGGGAAG TGGAATTTGG GAACTGAAAA GAGAAGAGAT TACCTTGCTG 
AAGGAGCTGG GCAATGGCCA GTTTGGAGTG GTCCAGCTGG GCCAGTGGAA GGGGCAATAT 
GATGTGGCTG TAAAGATGAT CAAGGAGGGT GCCATGTCAG AAGATGAATT CTTTCAGGAG 
GCCCAGACCA TGATGAAACT CAGCCATCCC AAGCTGGTGA AGTTCTACGG AGTATGCTCA 
AAGAAATACC CCATCTATAT AGTAACTGAG TATATAACAA ATGGTTGCTT GCTTAATTAC 
CTGAAGAGTC ATGGGAAAGG ACTAGAAAGT TGCCAGCTCT TAGAAATGTG TTATGATGTC 
TGTGAAGGCA TGGCCTTCTT GGAGAGCCAT CAGTTCATAC ATCGAGATTT GGCTGCTCGG 
AACTGTTTGG TGGACAGTGA TCTCTCTGTG AAAGTCTCAG ACTTTGGAAT GACGAGATAT 
GTCCTTGATG ATCAGTATGT CAGCTCAGTA GGAACCAAGT TTCCAGTCAA GTGGTCAGCT 
CCAGAGGTGT TTCACTACTT CAAATACAGC AGCAAGTCGG ATGTATGGGC ATTTGGGATC 
CTGATGTGGG AGGTGTTTAG TCTAGGGAAG CAGCCCTATG ACTTATATGA TAACTCCGAG 
GTGGTTGTGA AGGTCTCCCA GGGCCACAGA CTCTACCGGC CCCAACTGGC ATCAGACACC 
ATCTACCAGA TCATGTACAG CTGCTGGCAT GAGCTTCCAG AAAAGCGCCC CACATTTCAG 
CAACTCCTGT CTGCCATAGA ACCACTTCGG GAACAAGATA AACCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.
Proceedings of the National Academy of Sciences of the United States of America112(42)13063-8(2015 Oct)
Holopainen T,R?s?nen M,Anisimov A,Tuomainen T,Zheng W,Tvorogov D,Hulmi JJ,Andersson LC,Cenni B,Tavi P,Mervaala E,Kivel? R,Alitalo K

The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
Journal of immunology (Baltimore, Md. : 1950)195(1)246-56(2015 Jul)
Tampella G,Kerns HM,Niu D,Singh S,Khim S,Bosch KA,Garrett ME,Moguche A,Evans E,Browning B,Jahan TA,Nacht M,Wolf-Yadlin A,Plebani A,Hamerman JA,Rawlings DJ,James RG

Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Science signaling6(277)ra40(2013 May)
Chen S,Jiang X,Gewinner CA,Asara JM,Simon NI,Cai C,Cantley LC,Balk SP

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Bmx cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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