Cacybp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cacybp
Entrez Gene ID	12301
Full Name	calcyclin binding protein
Synonyms	SIP
General protein information	Preferred Names calcyclin binding protein Names calcyclin-binding protein siah-interacting protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H2.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_009786.2	NP_033916.1	calcyclin-binding protein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cacybp	NP_001004208.1
Oryza sativa (rice)	Os01g0757500	NP_001044294.1
Homo sapiens (human)	CACYBP	NP_055227.1
	CACYBP	XP_001097867.2
Bos taurus (cattle)	CACYBP	NP_001029981.1
Mus musculus (house mouse)	Cacybp	NP_033916.1
Arabidopsis thaliana (thale cress)	AT1G30070	NP_001185113.1
Drosophila melanogaster (fruit fly)	CG3226	NP_572332.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002107	XP_320934.4
Gallus gallus (chicken)	CACYBP	XP_422279.1
Pan troglodytes (chimpanzee)	CACYBP	XP_514016.3
Canis lupus familiaris (dog)	CACYBP	XP_537183.1
Danio rerio (zebrafish)	cacybp	NP_998052.1
Xenopus tropicalis (tropical clawed frog)	cacybp	NP_001011170.1

Gene Ontology
Bibliography

Related articles in PubMed

MAP kinase p38 is a novel target of CacyBP/SIP phosphatase.
Topolska-Wo? AM, Rosi?ska S, Filipek A
Amino acids49(6)1069-1076(2017 Jun)

The potential role of CacyBP/SIP in tumorigenesis.
Ning X, Chen Y, Wang X, Li Q, Sun S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(8)10785-91(2016 Aug)

Distinct effect of CacyBP/SIP on the ERK1/2-CREB-BDNF pathway in undifferentiated and differentiated neuroblastoma NB2a cells.
Rosi?ska S, Le?niak W, Filipek A
Neurochemistry international9765-72(2016 07)

Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome.
Ishihara K, Kanai S, Sago H, Yamakawa K, Akiba S
Neuroscience2811-15(2014 Dec)

The CacyBP/SIP protein is sumoylated in neuroblastoma NB2a cells.
Wasik U, Filipek A
Neurochemical research38(11)2427-32(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 in the Ehrlich ascites tumor cells and later as a Siah-1-interacting protein. Its role has been studied in various mouse tumors and cell lines. Review.
Title: The potential role of CacyBP/SIP in tumorigenesis.

In undifferentiated and differentiated tumor cells, CacyBP level has an effect on the ERK1/2-CREB-BDNF pathway.
Title: Distinct effect of CacyBP/SIP on the ERK1/2-CREB-BDNF pathway in undifferentiated and differentiated neuroblastoma NB2a cells.

sumoylated CacyBP/SIP is present in the cytoplasmic and not in the nuclear fraction. We have also established that lysine 16 is the residue which undergoes sumoylation in the CacyBP/SIP protein.
Title: The CacyBP/SIP protein is sumoylated in neuroblastoma NB2a cells.

different activity of CacyBP/SIP in neuroblastoma NB2a and colon cancer HCT116 cells might affect the ERK1/2 pathway in the differentiation or proliferation processes
Title: CacyBP/SIP phosphatase activity in neuroblastoma NB2a and colon cancer HCT116 cells.

new insight into the interaction between S100 proteins and CacyBP/SIP
Title: S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis.

The following Cacybp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cacybp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22991	NM_009786.2 Latest version!	Mus musculus calcyclin binding protein (Cacybp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cacybp ( NM_009786.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033916.1 Mus musculus calcyclin binding protein (Cacybp), mRNA.

Price & Availability↑

CloneID	OMu22991
Clone ID Related Accession (Same CDS sequence)	NM_009786.2
Accession Version	NM_009786.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	calcyclin-binding protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154873.6 and AK013924.1. On Feb 26, 2011 this sequence version replaced NM_009786.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK089043.1, SRR1660819.20266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCG TTTTGGAAGA GTTGCAGAAA GACCTAGAAG AGGTCAAAGT ATTGCTGGAA 
AAGTCCACTA GGAAAAGACT ACGTGATACT CTTACAAGTG AAAAGTCCAA GATTGAGACG 
GAACTCAAGA ACAAGATGCA ACAGAAGTCG CAGAAGAAAC CAGAACTTGA TAATGAAAAG 
CCAGCTGCTG TGGTTGCTCC TCTTACAACA GGATACACCG TGAAAATCAG TAATTATGGA 
TGGGATCAGT CAGATAAGTT TGTGAAAATC TACATTACCT TGACTGGCGT CCATCAGGTG 
CCCACTGAGA ACGTGCAGGT GCACTTCACA GAGAGGTCAT TTGATCTTCT GGTAAAAAAC 
CTCAATGGCA AGAATTACTC CATGATTGTG AACAATCTTT TGAAACCTAT CTCTGTGGAA 
AGCAGTTCAA AAAAAGTCAA GACTGATACA GTAATTATTC TATGTAGAAA GAAAGCAGAA 
AACACAAGAT GGGACTACTT AACACAGGTG GAAAAGGAAT GCAAAGAGAA AGAAAAGCCT 
TCCTACGACA CGGAGGCAGA CCCTAGTGAG GGATTAATGA ATGTTCTAAA GAAAATTTAT 
GAAGACGGAG ACGATGATAT GAAGCGAACC ATTAATAAAG CGTGGGTGGA ATCCAGAGAG 
AAGCAAGCCA GAGAAGACAC GGAATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033916.1
CDS	226..915
Translation	MASVLEELQKDLEEVKVLLEKSTRKRLRDTLTSEKSKIETELKNKMQQKSQKKPELDNEKPAAVVAPLTTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKNYSMIVNNLLKPISVESSSKKVKTDTVIILCRKKAENTRWDYLTQVEKECKEKEKPSYDTEADPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAREDTEF

Target ORF information:

RefSeq Version	NM_009786.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcyclin binding protein (Cacybp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009786.2

ORF Insert Sequence:

ATGGCTTCCG TTTTGGAAGA GTTGCAGAAA GACCTAGAAG AGGTCAAAGT ATTGCTGGAA 
AAGTCCACTA GGAAAAGACT ACGTGATACT CTTACAAGTG AAAAGTCCAA GATTGAGACG 
GAACTCAAGA ACAAGATGCA ACAGAAGTCG CAGAAGAAAC CAGAACTTGA TAATGAAAAG 
CCAGCTGCTG TGGTTGCTCC TCTTACAACA GGATACACCG TGAAAATCAG TAATTATGGA 
TGGGATCAGT CAGATAAGTT TGTGAAAATC TACATTACCT TGACTGGCGT CCATCAGGTG 
CCCACTGAGA ACGTGCAGGT GCACTTCACA GAGAGGTCAT TTGATCTTCT GGTAAAAAAC 
CTCAATGGCA AGAATTACTC CATGATTGTG AACAATCTTT TGAAACCTAT CTCTGTGGAA 
AGCAGTTCAA AAAAAGTCAA GACTGATACA GTAATTATTC TATGTAGAAA GAAAGCAGAA 
AACACAAGAT GGGACTACTT AACACAGGTG GAAAAGGAAT GCAAAGAGAA AGAAAAGCCT 
TCCTACGACA CGGAGGCAGA CCCTAGTGAG GGATTAATGA ATGTTCTAAA GAAAATTTAT 
GAAGACGGAG ACGATGATAT GAAGCGAACC ATTAATAAAG CGTGGGTGGA ATCCAGAGAG 
AAGCAAGCCA GAGAAGACAC GGAATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MAP kinase p38 is a novel target of CacyBP/SIP phosphatase.
Amino acids49(6)1069-1076(2017 Jun)
Topolska-Wo? AM,Rosi?ska S,Filipek A

The potential role of CacyBP/SIP in tumorigenesis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(8)10785-91(2016 Aug)
Ning X,Chen Y,Wang X,Li Q,Sun S

Distinct effect of CacyBP/SIP on the ERK1/2-CREB-BDNF pathway in undifferentiated and differentiated neuroblastoma NB2a cells.
Neurochemistry international9765-72(2016 07)
Rosi?ska S,Le?niak W,Filipek A

Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome.
Neuroscience2811-15(2014 Dec)
Ishihara K,Kanai S,Sago H,Yamakawa K,Akiba S

The CacyBP/SIP protein is sumoylated in neuroblastoma NB2a cells.
Neurochemical research38(11)2427-32(2013 Nov)
Wasik U,Filipek A