Gene Symbol | Capns1 |
Entrez Gene ID | 12336 |
Full Name | calpain, small subunit 1 |
Synonyms | Capa-4,Capa4,Capn4,Cdps,Css1,D7Ertd146e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Capns1 cDNA ORF clone
gRNAs
Gene Symbol | Capns1 |
Entrez Gene ID | 12336 |
Full Name | calpain, small subunit 1 |
Synonyms | Capa-4,Capa4,Capn4,Cdps,Css1,D7Ertd146e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006539488.2 | XP_006539551.1 | calpain small subunit 1 isoform X1 |
XM_011250419.2 | XP_011248721.1 | calpain small subunit 1 isoform X2 |
XM_011250419.3 | XP_011248721.1 | calpain small subunit 1 isoform X2 |
NM_009795.4 | NP_033925.2 | calpain small subunit 1 |
NM_009795.3 | NP_033925.2 | calpain small subunit 1 |
XM_006539488.3 | XP_006539551.1 | calpain small subunit 1 isoform X1 |
XM_011250420.1 | XP_011248722.1 | calpain small subunit 1 isoform X3 |
LOC712561 | XP_002808235.1 | |
Rattus norvegicus (Norway rat) | LOC100911363 | XP_003748884.1 |
Danio rerio (zebrafish) | capns1a | NP_001017899.2 |
Danio rerio (zebrafish) | capns1b | NP_001103176.1 |
Homo sapiens (human) | CAPNS1 | NP_001003962.1 |
Pan troglodytes (chimpanzee) | CAPNS1 | XP_003953505.1 |
Xenopus tropicalis (tropical clawed frog) | capns2 | NP_001016161.1 |
Canis lupus familiaris (dog) | CAPNS1 | XP_853634.1 |
Mus musculus (house mouse) | Capns1 | NP_033925.2 |
Rattus norvegicus (Norway rat) | Capns1 | NP_058814.1 |
Bos taurus (cattle) | CAPNS1 | NP_776686.1 |
Rattus norvegicus (Norway rat) | LOC100912380 | XP_003748875.2 |
Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.
Li S, Zhang L, Ni R, Cao T, Zheng D, Xiong S, Greer PA, Fan GC, Peng T
Biochimica et biophysica acta1862(11)2023-2033(2016 Nov)
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis.
Grieve S, Gao Y, Hall C, Hu J, Greer PA
Molecular and cellular biology36(15)2078-88(2016 Aug)
Calpain-2 activates Akt via TGF-?1-mTORC2 pathway in pulmonary artery smooth muscle cells.
Abeyrathna P, Kovacs L, Han W, Su Y
American journal of physiology. Cell physiology311(1)C24-34(2016 Jul)
Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.
Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y
American journal of respiratory cell and molecular biology54(3)384-93(2016 Mar)
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.
Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T
Diabetes65(1)255-68(2016 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mitochondrial calpain-1 disrupts ATP synthase, leading to mitochondrial reactive oxygen species generation, which promotes proinflammatory response and myocardial dysfunction during endotoxemia.
Title: Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Calpain in osteoblasts regulates cell proliferation through its regulation of p27Kip1. Osteoblast-specific capns1 knockout mice developed a high-fat diet-induced excess body weight gain and impaired glucose tolerance.
Title: Overview of calpain-mediated regulation of bone and fat mass in osteoblasts.
effects of Capn4 deletion may be mediated through prevention of IkappaB degradation and NF-kappaB activation, resulting in inhibition of inflammatory responses.
Title: Deficiency of Capn4 gene inhibits nuclear factor-?B (NF-?B) protein signaling/inflammation and reduces remodeling after myocardial infarction.
osteoblast-specific Capns1 knockout mice with osteoporosis and reduced bone resorptive function, exhibited reduced serum uncarboxylated osteocalcin levels and a lean phenotype under a normal chow diet.
Title: A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts.
Calpain 4 is essential for the tyrosine phosphorylation of galectin-3, and its ultimate secretion from the cell, and its secretion probably interferes with the production of traction forces.
Title: Galectin-3 secretion and tyrosine phosphorylation is dependent on the calpain small subunit, Calpain 4.
The following Capns1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Capns1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu67294 | |
Clone ID Related Accession (Same CDS sequence) | XM_011250420.1 | |
Accession Version | XM_011250420.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | calpain small subunit 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGTCA GCGCCACAGA ACTCATGAAT ATCCTCAACA AGGTCGTGAC CCGACACCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011248722.1 |
CDS | 630..1100 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGTCA GCGCCACAGA ACTCATGAAT ATCCTCAACA AGGTCGTGAC CCGACACCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67293 | |
Clone ID Related Accession (Same CDS sequence) | XM_011250419.2 , XM_011250419.3 | |
Accession Version | XM_011250419.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | calpain small subunit 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011250419.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGGAA AGGAGGGGTC AGACCATTCT CTTGATTGGA CCAGCGAGGC TGCTGCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011248721.1 |
CDS | 115..756 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGGAA AGGAGGGGTC AGACCATTCT CTTGATTGGA CCAGCGAGGC TGCTGCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22049 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539488.2 , NM_009795.4 , NM_009795.3 , XM_006539488.3 | |
Accession Version | NM_009795.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | calpain small subunit 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY133208.1, BY296628.1, BC090988.1 and BU700497.1. On Jan 19, 2017 this sequence version replaced NM_009795.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC090988.1, AF058298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033925.2 |
CDS | 164..970 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22049 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539488.2 , NM_009795.4 , NM_009795.3 , XM_006539488.3 | |
Accession Version | NM_009795.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-14 | |
Organism | Mus musculus(House mouse) | |
Product | calpain small subunit 1 | |
Comment |
1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033925.2 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22049 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539488.2 , NM_009795.4 , NM_009795.3 , XM_006539488.3 | |
Accession Version | XM_006539488.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | calpain small subunit 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006539488.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006539551.1 |
CDS | 212..1018 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22049 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539488.2 , NM_009795.4 , NM_009795.3 , XM_006539488.3 | |
Accession Version | XM_006539488.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | calpain small subunit 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006539488.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006539551.1 |
CDS | 301..1107 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTCTTGG TGAATTCGTT CTTGAAGGGC GGCGGTGGCG GTGGGGGAGG CGGGGGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67293 | |
Clone ID Related Accession (Same CDS sequence) | XM_011250419.2 , XM_011250419.3 | |
Accession Version | XM_011250419.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | calpain small subunit 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011250419.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGGAA AGGAGGGGTC AGACCATTCT CTTGATTGGA CCAGCGAGGC TGCTGCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011248721.1 |
CDS | 114..755 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGGAA AGGAGGGGTC AGACCATTCT CTTGATTGGA CCAGCGAGGC TGCTGCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress. |
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis. |
Calpain-2 activates Akt via TGF-?1-mTORC2 pathway in pulmonary artery smooth muscle cells. |
Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. |
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. |