Gene Symbol | Casp14 |
Entrez Gene ID | 12365 |
Full Name | caspase 14 |
Synonyms | MICE,mini-ICE |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Casp14 cDNA ORF clone
gRNAs
Gene Symbol | Casp14 |
Entrez Gene ID | 12365 |
Full Name | caspase 14 |
Synonyms | MICE,mini-ICE |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006513160.4 | XP_006513223.1 | caspase-14 isoform X1 |
XM_006513160.3 | XP_006513223.1 | caspase-14 isoform X1 |
NM_009809.5 | NP_033939.1 | caspase-14 |
Pan troglodytes (chimpanzee) | CASP14 | XP_001159009.2 |
Canis lupus familiaris (dog) | CASP14 | XP_853064.2 |
Mus musculus (house mouse) | Casp14 | NP_033939.1 |
Rattus norvegicus (Norway rat) | Casp14 | NP_001178705.1 |
Bos taurus (cattle) | CASP14 | NP_001192772.1 |
Homo sapiens (human) | CASP14 | NP_036246.1 |
CASP14 | XP_001111598.1 |
Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation.
Urwyler-R?sselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W
The Journal of investigative dermatology(2018 Jan)
IKK? Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS
The American journal of pathology187(12)2635-2644(2017 Dec)
Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK
Scientific reports7(1)13427(2017 Oct)
Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.
Svandova EB, Vesela B, Lesot H, Poliard A, Matalova E
Histochemistry and cell biology147(4)497-510(2017 Apr)
Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T
The Journal of biological chemistry289(29)20026-38(2014 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
Title: Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
caspase-14 overexpression is not the cause of utricle formation
Title: Caspase-14 overexpression in hairless mice is not involved in utricle formation.
Caspase-14-deficient mice are more prone to the development of parakeratosis.
Title: Caspase-14-deficient mice are more prone to the development of parakeratosis.
Mere impairment of filaggrin degradation by loss of caspase 14 does not influence the inflammatory threshold of atopic dermatitis.
Title: Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis.
Transcript profiling studies identified caspase-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation and tumorigenesis.
Title: Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.
The following Casp14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu04890 | |
Clone ID Related Accession (Same CDS sequence) | NM_009809.5 | |
Accession Version | NM_009809.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | caspase-14 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY134001.1, AK081645.1 and AJ007750.1. On Mar 27, 2010 this sequence version replaced NM_009809.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ007750.1, AK081645.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033939.1 |
CDS | 216..989 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44164 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513160.4 , XM_006513160.3 | |
Accession Version | XM_006513160.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | caspase-14 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513160.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006513223.1 |
CDS | 270..749 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44164 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513160.4 , XM_006513160.3 | |
Accession Version | XM_006513160.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | caspase-14 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006513160.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006513223.1 |
CDS | 270..749 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation. |
IKK? Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. |
Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. |
Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination. |
Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation. |