Casp14 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Casp14
Entrez Gene ID	12365
Full Name	caspase 14
Synonyms	MICE,mini-ICE
General protein information	Preferred Names caspase 14 Names caspase-14 CASP-14
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C1

mRNA and Protein(s)

mRNA Protein Name

XM_006513160.4 XP_006513223.1 caspase-14 isoform X1

XM_006513160.3 XP_006513223.1 caspase-14 isoform X1

NM_009809.5 NP_033939.1 caspase-14
Pathways from BioSystems

mRNA	Protein	Name
XM_006513160.4	XP_006513223.1	caspase-14 isoform X1
XM_006513160.3	XP_006513223.1	caspase-14 isoform X1
NM_009809.5	NP_033939.1	caspase-14

Homologies

Pan troglodytes (chimpanzee)	CASP14	XP_001159009.2
Canis lupus familiaris (dog)	CASP14	XP_853064.2
Mus musculus (house mouse)	Casp14	NP_033939.1
Rattus norvegicus (Norway rat)	Casp14	NP_001178705.1
Bos taurus (cattle)	CASP14	NP_001192772.1
Homo sapiens (human)	CASP14	NP_036246.1
	CASP14	XP_001111598.1

Gene Ontology
Bibliography

Related articles in PubMed

Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation.
Urwyler-R?sselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W
The Journal of investigative dermatology(2018 Jan)

IKK? Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS
The American journal of pathology187(12)2635-2644(2017 Dec)

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK
Scientific reports7(1)13427(2017 Oct)

Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.
Svandova EB, Vesela B, Lesot H, Poliard A, Matalova E
Histochemistry and cell biology147(4)497-510(2017 Apr)

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T
The Journal of biological chemistry289(29)20026-38(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
Title: Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.

caspase-14 overexpression is not the cause of utricle formation
Title: Caspase-14 overexpression in hairless mice is not involved in utricle formation.

Caspase-14-deficient mice are more prone to the development of parakeratosis.
Title: Caspase-14-deficient mice are more prone to the development of parakeratosis.

Mere impairment of filaggrin degradation by loss of caspase 14 does not influence the inflammatory threshold of atopic dermatitis.
Title: Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis.

Transcript profiling studies identified caspase-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation and tumorigenesis.
Title: Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.

The following Casp14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu04890	NM_009809.5 Latest version!	Mus musculus caspase 14 (Casp14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu44164	XM_006513160.4 Latest version!	Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu44164	XM_006513160.3	Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp14 ( NM_009809.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033939.1 Mus musculus caspase 14 (Casp14), mRNA.

Price & Availability↑

CloneID	OMu04890
Clone ID Related Accession (Same CDS sequence)	NM_009809.5
Accession Version	NM_009809.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	caspase-14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY134001.1, AK081645.1 and AJ007750.1. On Mar 27, 2010 this sequence version replaced NM_009809.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ007750.1, AK081645.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END##

ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGAGCAC 
AGAGACCCCG GTGAGGAACT ACGTGGAAAT GAGGAACTAG GTGGAGATGA GGAACTAGGT 
GGAGATGAGG TTGCTGTGCT CAAGAACAAC CCCCAAAGTA TCCCAACCTA TACGGATACC 
CTCCACATCT ACTCCACGGT AGAGGGGTAC CTCTCCTATA GACATGACGA GAAAGGCTCT 
GGCTTCATCC AGACCCTGAC GGATGTGTTC ATTCATAAAA AAGGATCCAT CTTAGAACTG 
ACAGAAGAGA TCACCCGACT TATGGCAAAC ACGGAGGTGA TGCAGGAAGG AAAACCAAGG 
AAAGTGAACC CTGAAGTCCA AAGCACCCTC CGGAAGAAGC TCTATTTGCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033939.1
CDS	216..989
Translation	MESEMSDPQPLQEERYDMSGARLALTLCVTKAREGSEVDMEALERMFRYLKFESTMKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLMAHGEEGLLKGEDEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGEHRDPGEELRGNEELGGDEELGGDEVAVLKNNPQSIPTYTDTLHIYSTVEGYLSYRHDEKGSGFIQTLTDVFIHKKGSILELTEEITRLMANTEVMQEGKPRKVNPEVQSTLRKKLYLQ

Target ORF information:

RefSeq Version	NM_009809.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 14 (Casp14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009809.5

ORF Insert Sequence:

ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGAGCAC 
AGAGACCCCG GTGAGGAACT ACGTGGAAAT GAGGAACTAG GTGGAGATGA GGAACTAGGT 
GGAGATGAGG TTGCTGTGCT CAAGAACAAC CCCCAAAGTA TCCCAACCTA TACGGATACC 
CTCCACATCT ACTCCACGGT AGAGGGGTAC CTCTCCTATA GACATGACGA GAAAGGCTCT 
GGCTTCATCC AGACCCTGAC GGATGTGTTC ATTCATAAAA AAGGATCCAT CTTAGAACTG 
ACAGAAGAGA TCACCCGACT TATGGCAAAC ACGGAGGTGA TGCAGGAAGG AAAACCAAGG 
AAAGTGAACC CTGAAGTCCA AAGCACCCTC CGGAAGAAGC TCTATTTGCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp14 ( XM_006513160.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006513223.1 Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu44164
Clone ID Related Accession (Same CDS sequence)	XM_006513160.4 , XM_006513160.3
Accession Version	XM_006513160.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	caspase-14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513160.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006513223.1
CDS	270..749
Translation	MESEMSDPQPLQEERYDMSGARLALTLCVTKAREGSEVDMEALERMFRYLKFESTMKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLMAHGEEGLLKGEDEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGDHPTYGKHGGDAGRKTKESEP

Target ORF information:

RefSeq Version	XM_006513160.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006513160.3

ORF Insert Sequence:

ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp14 ( XM_006513160.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006513223.1 Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu44164
Clone ID Related Accession (Same CDS sequence)	XM_006513160.4 , XM_006513160.3
Accession Version	XM_006513160.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	caspase-14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006513160.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006513223.1
CDS	270..749
Translation	MESEMSDPQPLQEERYDMSGARLALTLCVTKAREGSEVDMEALERMFRYLKFESTMKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLMAHGEEGLLKGEDEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGDHPTYGKHGGDAGRKTKESEP

Target ORF information:

RefSeq Version	XM_006513160.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006513160.4

ORF Insert Sequence:

ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation.
The Journal of investigative dermatology(2018 Jan)
Urwyler-R?sselet C,Tanghe G,Leurs K,Gilbert B,De Rycke R,De Bruyne M,Lippens S,Bartunkova S,De Groote P,Niessen C,Haftek M,Vandenabeele P,Declercq W

IKK? Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
The American journal of pathology187(12)2635-2644(2017 Dec)
McCoy AM,Herington JL,Stouch AN,Mukherjee AB,Lakhdari O,Blackwell TS,Prince LS

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Scientific reports7(1)13427(2017 Oct)
Li S,Teegarden A,Bauer EM,Choi J,Messaddeq N,Hendrix DA,Ganguli-Indra G,Leid M,Indra AK

Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.
Histochemistry and cell biology147(4)497-510(2017 Apr)
Svandova EB,Vesela B,Lesot H,Poliard A,Matalova E

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
The Journal of biological chemistry289(29)20026-38(2014 Jul)
Yamamoto-Tanaka M,Motoyama A,Miyai M,Matsunaga Y,Matsuda J,Tsuboi R,Hibino T

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Casp14 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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