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Casp14 cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Casp14
Entrez Gene ID 12365
Full Name caspase 14
Synonyms MICE,mini-ICE
General protein information
Preferred Names

caspase 14

Names

caspase-14
CASP-14
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

10

10|10 C1

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006513160.4 XP_006513223.1 caspase-14 isoform X1
XM_006513160.3 XP_006513223.1 caspase-14 isoform X1
NM_009809.5 NP_033939.1 caspase-14

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) CASP14 XP_001159009.2
Canis lupus familiaris (dog) CASP14 XP_853064.2
Mus musculus (house mouse) Casp14 NP_033939.1
Rattus norvegicus (Norway rat) Casp14 NP_001178705.1
Bos taurus (cattle) CASP14 NP_001192772.1
Homo sapiens (human) CASP14 NP_036246.1
CASP14 XP_001111598.1

Gene Ontology


Bibliography

Related articles in PubMed

Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation.
Urwyler-R?sselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W
The Journal of investigative dermatology(2018 Jan)

IKK? Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS
The American journal of pathology187(12)2635-2644(2017 Dec)

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK
Scientific reports7(1)13427(2017 Oct)

Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.
Svandova EB, Vesela B, Lesot H, Poliard A, Matalova E
Histochemistry and cell biology147(4)497-510(2017 Apr)

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T
The Journal of biological chemistry289(29)20026-38(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
Title: Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.

caspase-14 overexpression is not the cause of utricle formation
Title: Caspase-14 overexpression in hairless mice is not involved in utricle formation.

Caspase-14-deficient mice are more prone to the development of parakeratosis.
Title: Caspase-14-deficient mice are more prone to the development of parakeratosis.

Mere impairment of filaggrin degradation by loss of caspase 14 does not influence the inflammatory threshold of atopic dermatitis.
Title: Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis.

Transcript profiling studies identified caspase-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation and tumorigenesis.
Title: Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.

The following Casp14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu04890 NM_009809.5
Latest version!		 Mus musculus caspase 14 (Casp14), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00
OMu44164 XM_006513160.4
Latest version!		 Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OMu44164 XM_006513160.3 Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu04890
Clone ID Related Accession (Same CDS sequence) NM_009809.5
Accession Version NM_009809.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 774bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-27
Organism Mus musculus(house mouse)
Product caspase-14
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY134001.1, AK081645.1 and AJ007750.1. On Mar 27, 2010 this sequence version replaced NM_009809.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ007750.1, AK081645.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGAGCAC 
AGAGACCCCG GTGAGGAACT ACGTGGAAAT GAGGAACTAG GTGGAGATGA GGAACTAGGT 
GGAGATGAGG TTGCTGTGCT CAAGAACAAC CCCCAAAGTA TCCCAACCTA TACGGATACC 
CTCCACATCT ACTCCACGGT AGAGGGGTAC CTCTCCTATA GACATGACGA GAAAGGCTCT 
GGCTTCATCC AGACCCTGAC GGATGTGTTC ATTCATAAAA AAGGATCCAT CTTAGAACTG 
ACAGAAGAGA TCACCCGACT TATGGCAAAC ACGGAGGTGA TGCAGGAAGG AAAACCAAGG 
AAAGTGAACC CTGAAGTCCA AAGCACCCTC CGGAAGAAGC TCTATTTGCA ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_033939.1
CDS216..989
Translation

Target ORF information:

RefSeq Version NM_009809.5
Organism Mus musculus(house mouse)
Definition Mus musculus caspase 14 (Casp14), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_009809.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGAGCAC 
AGAGACCCCG GTGAGGAACT ACGTGGAAAT GAGGAACTAG GTGGAGATGA GGAACTAGGT 
GGAGATGAGG TTGCTGTGCT CAAGAACAAC CCCCAAAGTA TCCCAACCTA TACGGATACC 
CTCCACATCT ACTCCACGGT AGAGGGGTAC CTCTCCTATA GACATGACGA GAAAGGCTCT 
GGCTTCATCC AGACCCTGAC GGATGTGTTC ATTCATAAAA AAGGATCCAT CTTAGAACTG 
ACAGAAGAGA TCACCCGACT TATGGCAAAC ACGGAGGTGA TGCAGGAAGG AAAACCAAGG 
AAAGTGAACC CTGAAGTCCA AAGCACCCTC CGGAAGAAGC TCTATTTGCA ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu44164
Clone ID Related Accession (Same CDS sequence) XM_006513160.4 , XM_006513160.3
Accession Version XM_006513160.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 480bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-21
Organism Mus musculus(house mouse)
Product caspase-14 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513160.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006513223.1
CDS270..749
Translation

Target ORF information:

RefSeq Version XM_006513160.3
Organism Mus musculus(house mouse)
Definition Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006513160.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu44164
Clone ID Related Accession (Same CDS sequence) XM_006513160.4 , XM_006513160.3
Accession Version XM_006513160.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 480bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Mus musculus(house mouse)
Product caspase-14 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006513160.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006513223.1
CDS270..749
Translation

Target ORF information:

RefSeq Version XM_006513160.4
Organism Mus musculus(house mouse)
Definition Mus musculus caspase 14 (Casp14), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006513160.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGAGTCAG AGATGAGTGA TCCTCAGCCA TTGCAGGAGG AAAGATATGA TATGTCAGGT 
GCCCGCCTGG CCCTGACGCT GTGTGTCACC AAAGCCCGGG AGGGTTCCGA GGTAGACATG 
GAGGCCCTGG AACGCATGTT CCGTTACCTG AAATTTGAAA GCACCATGAA GAGGGATCCC 
ACCGCCCAGC AATTTCTGGA AGAGTTGGAT GAATTTCAGC AGACCATAGA TAATTGGGAA 
GAGCCTGTCA GCTGTGCCTT TGTGGTACTC ATGGCACATG GTGAGGAAGG CCTCCTCAAG 
GGAGAAGATG AGAAGATGGT CAGACTAGAA GACCTTTTTG AAGTCTTGAA CAACAAGAAC 
TGCAAGGCCC TGAGAGGCAA GCCAAAGGTG TACATCATCC AGGCTTGTAG AGGAGATCAC 
CCGACTTATG GCAAACACGG AGGTGATGCA GGAAGGAAAA CCAAGGAAAG TGAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation.
The Journal of investigative dermatology(2018 Jan)
Urwyler-R?sselet C,Tanghe G,Leurs K,Gilbert B,De Rycke R,De Bruyne M,Lippens S,Bartunkova S,De Groote P,Niessen C,Haftek M,Vandenabeele P,Declercq W


book

IKK? Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
The American journal of pathology187(12)2635-2644(2017 Dec)
McCoy AM,Herington JL,Stouch AN,Mukherjee AB,Lakhdari O,Blackwell TS,Prince LS


book

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Scientific reports7(1)13427(2017 Oct)
Li S,Teegarden A,Bauer EM,Choi J,Messaddeq N,Hendrix DA,Ganguli-Indra G,Leid M,Indra AK


book

Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.
Histochemistry and cell biology147(4)497-510(2017 Apr)
Svandova EB,Vesela B,Lesot H,Poliard A,Matalova E


book

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
The Journal of biological chemistry289(29)20026-38(2014 Jul)
Yamamoto-Tanaka M,Motoyama A,Miyai M,Matsunaga Y,Matsuda J,Tsuboi R,Hibino T