Cdkn2b cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Cdkn2b |
| Entrez Gene ID | 12579 |
| Full Name | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
| Synonyms | AV083695,INK4b,MTS2,p15,p15(INK4b),p15INK4b |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_007670.4 | NP_031696.1 | cyclin-dependent kinase 4 inhibitor B |
| Canis lupus familiaris (dog) | CDKN2B | NP_001139741.1 |
| Mus musculus (house mouse) | Cdkn2b | NP_031696.1 |
| Rattus norvegicus (Norway rat) | Cdkn2b | NP_570825.1 |
| Bos taurus (cattle) | CDKN2B | NP_001069362.1 |
| Homo sapiens (human) | CDKN2B | NP_004927.2 |
| Pan troglodytes (chimpanzee) | CDKN2B | XP_003312069.1 |
| CDKN2B | XP_001107263.1 | |
| Gallus gallus (chicken) | CDKN2B | NP_989764.1 |
Related articles in PubMed
CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A.
Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B, Yang D, An S, Lv L, Jiao B, Chen C, Lai R, Shi P, Zhao X
Oncogene37(1)128-138(2018 Jan)
Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development, and craniofacial morphogenesis.
Milstone ZJ, Lawson G, Trivedi CM
Developmental dynamics : an official publication of the American Association of Anatomists246(12)1015-1026(2017 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that the Wnt-effector hepatocyte nuclear factor 1-alpha (Tcf1) is recruited to and triggers transcription of the Ink4/Arf tumor suppressor locus, such as as p15Ink4b, p16Ink4a and p19Arf.
Title: Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus.
The expression of three tumor suppressor genes encoded in the INK4/ARF locus (p15(INK4b), p16(INK4a), and p19(ARF)) was decreased in E6AP(-/-) embryo fibroblasts.
Title: Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
miR-541 contributes to microcystin-LR-induced testicular toxicity by regulating the expression of p15 and promoting apoptosis.
Title: miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice.
Loss of CDKN2B may not only promote cardiovascular disease through the development of atherosclerosis but may also impair TGFbeta signaling and hypoxic neovessel maturation.
Title: CDKN2B Regulates TGF? Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.
Loss of Nf2 and Cdkn2a/b have synergistic effects with PDGF-B overexpression promoting meningioma malignant transformation.
Title: PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss.
The following Cdkn2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdkn2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu20576 | |
| Clone ID Related Accession (Same CDS sequence) | NM_007670.4 | |
| Accession Version | NM_007670.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Mus musculus(house mouse) | |
| Product | cyclin-dependent kinase 4 inhibitor B | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CAAA01036593.1, AF059567.1 and DT919921.1. On Dec 4, 2008 this sequence version replaced NM_007670.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF059567.1, AK144132.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGTTGGGCG GCAGCAGTGA CGCGGGCCTG GCCACCGCCG CGGCGCGGGG GCAAGTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_031696.1 |
| CDS | 236..628 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_007670.4 |
ORF Insert Sequence:
1 | ATGTTGGGCG GCAGCAGTGA CGCGGGCCTG GCCACCGCCG CGGCGCGGGG GCAAGTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A. |
|
Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development, and craniofacial morphogenesis. |