Cfc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Cfc1
Entrez Gene ID	12627
Full Name	cripto, FRL-1, cryptic family 1
Synonyms	AV265756,b2b970Clo,cryptic
General protein information	Preferred Names cripto, FRL-1, cryptic family 1 Names cryptic protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 B

mRNA and Protein(s)

mRNA Protein Name

NM_007685.2 NP_031711.1 cryptic protein precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_007685.2	NP_031711.1	cryptic protein precursor

Homologies

Canis lupus familiaris (dog)	LOC609557	XP_005631906.1
Mus musculus (house mouse)	Cfc1	NP_031711.1
Rattus norvegicus (Norway rat)	Cfc1	NP_001102774.1
Gallus gallus (chicken)	CFC1B	NP_990031.1
Pan troglodytes (chimpanzee)	CFC1	XP_001144170.1
Homo sapiens (human)	CFC1B	NP_001072998.1
Homo sapiens (human)	CFC1	NP_115934.1

Gene Ontology
Bibliography

Related articles in PubMed

Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.
Aykul S, Parenti A, Chu KY, Reske J, Floer M, Ralston A, Martinez-Hackert E
The Journal of biological chemistry292(10)4138-4151(2017 03)

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.
Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL
PLoS biology14(9)e2000197(2016 Sep)

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW
Nature521(7553)520-4(2015 May)

Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.
Shiratori H, Yashiro K, Iwai N, Oki S, Minegishi K, Ikawa Y, Kanata K, Hamada H
Developmental biology395(2)331-41(2014 Nov)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Functional redundancy of the Cfc1 gene in epiblast and extraembryonic patterning during early mouse embryogenesis is reported.
Title: Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.

cells coexpressing GRP78 and Cripto grow much more rapidly in soft agar than do cells expressing either protein individually
Title: GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.

Cripto, which encodes a Nodal co-receptor, is a primary target of beta-catenin signals in embryogenesis.
Title: Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.

The following Cfc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cfc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00604	NM_007685.2 Latest version!	Mus musculus cripto, FRL-1, cryptic family 1 (Cfc1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cfc1 ( NM_007685.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031711.1 Mus musculus cripto, FRL-1, cryptic family 1 (Cfc1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu00604
Clone ID Related Accession (Same CDS sequence)	NM_007685.2
Accession Version	NM_007685.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	cryptic protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U57720.1. On Apr 6, 2007 this sequence version replaced NM_007685.1. Transcript Variant: This variant (1) represents the longer, protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U57720.1, BC100705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN01164136 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGAGCGA ACTCACCAAC CCAGGGTATC AGTTTGAAAA TGCATCAAGC CAGGCCTCTG 
TTTTTGGTGA CTGTCGCGCT GCAGCTCATC GGTCTGGGAT ACAGTTATCA GAGCGAAGGA 
GATGGTGCCA GAGAAGTCAG CAATATCCTC TCTCCAGTGA TCCCCGGGAC GACACTGGAC 
AGAACTCTGA GTAATTCCAG CAGAAAGAAT GACATTCCGG AGGGGGCGCG CCTATGGGAT 
TCCCTTCCTG ACTCCAGCAC TTTGGGAGAG AGTGCAGTCC CTGTATCCCG CTGTTGCCAC 
AATGGCGGCA CCTGTGTTCT GGGCAGTTTC TGCGTGTGCC CTGCCTATTT CACTGGTCGC 
TATTGCGAGC ACGACCAGAG GCGCAGAGAC TGTGGTGCCC TAGGGCATGG AGCTTGGACC 
CTGCACAGCT GCCGCCTATG CAGGTGCATC TTCTCAGCCC TGTACTGCCT CCCACACCAA 
ACGTTCAGCC ACTGTGACCT GAAAAGCTTC CTTTCTTCAG GCGCCAGAGG ATCAAGAGAA 
TGCAGCATCC CAAGCCTCCT CCTGCTGGTG CTCTGCCTCC TCCTGCAGGG TGTGGCTGGT 
AAGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031711.1
CDS	256..864
Translation	MRANSPTQGISLKMHQARPLFLVTVALQLIGLGYSYQSEGDGAREVSNILSPVIPGTTLDRTLSNSSRKNDIPEGARLWDSLPDSSTLGESAVPVSRCCHNGGTCVLGSFCVCPAYFTGRYCEHDQRRRDCGALGHGAWTLHSCRLCRCIFSALYCLPHQTFSHCDLKSFLSSGARGSRECSIPSLLLLVLCLLLQGVAGKG

Target ORF information:

RefSeq Version	NM_007685.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cripto, FRL-1, cryptic family 1 (Cfc1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007685.2

ORF Insert Sequence:

ATGAGAGCGA ACTCACCAAC CCAGGGTATC AGTTTGAAAA TGCATCAAGC CAGGCCTCTG 
TTTTTGGTGA CTGTCGCGCT GCAGCTCATC GGTCTGGGAT ACAGTTATCA GAGCGAAGGA 
GATGGTGCCA GAGAAGTCAG CAATATCCTC TCTCCAGTGA TCCCCGGGAC GACACTGGAC 
AGAACTCTGA GTAATTCCAG CAGAAAGAAT GACATTCCGG AGGGGGCGCG CCTATGGGAT 
TCCCTTCCTG ACTCCAGCAC TTTGGGAGAG AGTGCAGTCC CTGTATCCCG CTGTTGCCAC 
AATGGCGGCA CCTGTGTTCT GGGCAGTTTC TGCGTGTGCC CTGCCTATTT CACTGGTCGC 
TATTGCGAGC ACGACCAGAG GCGCAGAGAC TGTGGTGCCC TAGGGCATGG AGCTTGGACC 
CTGCACAGCT GCCGCCTATG CAGGTGCATC TTCTCAGCCC TGTACTGCCT CCCACACCAA 
ACGTTCAGCC ACTGTGACCT GAAAAGCTTC CTTTCTTCAG GCGCCAGAGG ATCAAGAGAA 
TGCAGCATCC CAAGCCTCCT CCTGCTGGTG CTCTGCCTCC TCCTGCAGGG TGTGGCTGGT 
AAGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.
The Journal of biological chemistry292(10)4138-4151(2017 03)
Aykul S,Parenti A,Chu KY,Reske J,Floer M,Ralston A,Martinez-Hackert E

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.
PLoS biology14(9)e2000197(2016 Sep)
Santos R,Kawauchi S,Jacobs RE,Lopez-Burks ME,Choi H,Wikenheiser J,Hallgrimsson B,Jamniczky HA,Fraser SE,Lander AD,Calof AL

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Nature521(7553)520-4(2015 May)
Li Y,Klena NT,Gabriel GC,Liu X,Kim AJ,Lemke K,Chen Y,Chatterjee B,Devine W,Damerla RR,Chang C,Yagi H,San Agustin JT,Thahir M,Anderton S,Lawhead C,Vescovi A,Pratt H,Morgan J,Haynes L,Smith CL,Eppig JT,Reinholdt L,Francis R,Leatherbury L,Ganapathiraju MK,Tobita K,Pazour GJ,Lo CW

Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.
Developmental biology395(2)331-41(2014 Nov)
Shiratori H,Yashiro K,Iwai N,Oki S,Minegishi K,Ikawa Y,Kanata K,Hamada H

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Cfc1 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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