Gene Symbol | Cnga3 |
Entrez Gene ID | 12790 |
Full Name | cyclic nucleotide gated channel alpha 3 |
Synonyms | CNG3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cnga3 cDNA ORF clone
Gene Symbol | Cnga3 |
Entrez Gene ID | 12790 |
Full Name | cyclic nucleotide gated channel alpha 3 |
Synonyms | CNG3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017313748.2 | XP_017169237.1 | cyclic nucleotide-gated cation channel alpha-3 isoform X2 |
NM_001282010.1 | NP_001268939.1 | cyclic nucleotide-gated cation channel alpha-3 isoform 1 |
NM_009918.2 | NP_034048.1 | cyclic nucleotide-gated cation channel alpha-3 isoform 2 |
XM_017313748.1 | XP_017169237.1 | cyclic nucleotide-gated cation channel alpha-3 isoform X2 |
XM_017313745.2 | XP_017169234.1 | cyclic nucleotide-gated cation channel alpha-3 isoform X1 |
XM_017313745.1 | XP_017169234.1 | cyclic nucleotide-gated cation channel alpha-3 isoform X1 |
Caenorhabditis elegans (roundworm) | tax-4 | NP_499033.1 |
Homo sapiens (human) | CNGA3 | NP_001289.1 |
Mus musculus (house mouse) | Cnga3 | NP_001268939.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494840 | XP_002931690.2 |
CNGA3 | XP_001101944.2 | |
Gallus gallus (chicken) | CNGA3 | NP_990552.1 |
Canis lupus familiaris (dog) | CNGA3 | XP_538462.3 |
Rattus norvegicus (Norway rat) | Cnga3 | NP_445947.1 |
Danio rerio (zebrafish) | cnga3a | XP_005166141.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009050 | XP_319802.4 |
Pan troglodytes (chimpanzee) | CNGA3 | XP_001156943.1 |
Bos taurus (cattle) | CNGA3 | NP_776704.1 |
Drosophila melanogaster (fruit fly) | Cng | NP_477116.1 |
Rods progressively escape saturation to drive visual responses in daylight conditions.
Tikidji-Hamburyan A, Reinhard K, Storchi R, Dietter J, Seitter H, Davis KE, Idrees S, Mutter M, Walmsley L, Bedford RA, Ueffing M, Ala-Laurila P, Brown TM, Lucas RJ, M?nch TA
Nature communications8(1)1813(2017 Nov)
Long-term retinal cone rescue using a capsid mutant AAV8 vector in a mouse model of CNGA3-achromatopsia.
Dai X, He Y, Zhang H, Zhang Y, Liu Y, Wang M, Chen H, Pang JJ
PloS one12(11)e0188032(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
AAV8 with capsid Y-F and T-V mutations may be one of the most effective AAV vectors for long-term treatment in a naturally occurring mouse model of CNGA3 achromatopsia
Title: Long-term retinal cone rescue using a capsid mutant AAV8 vector in a mouse model of CNGA3-achromatopsia.
cGMP/protein kinase G signaling suppresses Itpr1 phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice.
Title: cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.
CNGA3 expression restored cone function in in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia.
Title: Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia.
Homologous to the human disease, CNGA3 deficient mice reveal a loss of cone specific functionality leading to degeneration of affected cone photoreceptors. (review)
Title: [Gene replacement therapy in achromatopsia type 2].
This work investigated the functional modulation of cone CNG channel by exploring the channel-interacting proteins.
Title: Exploration of cone cyclic nucleotide-gated channel-interacting proteins using affinity purification and mass spectrometry.
The following Cnga3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnga3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19825 | |
Clone ID Related Accession (Same CDS sequence) | NM_001282010.1 | |
Accession Version | NM_001282010.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2010bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-11 | |
Organism | Mus musculus(house mouse) | |
Product | cyclic nucleotide-gated cation channel alpha-3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC133096.3, CJ167467.1 and BC035272.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849377 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001268939.1 |
CDS | 312..2321 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001282010.1 |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19785 | |
Clone ID Related Accession (Same CDS sequence) | NM_009918.2 , XM_017313745.2 , XM_017313745.1 | |
Accession Version | NM_009918.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-11 | |
Organism | Mus musculus(house mouse) | |
Product | cyclic nucleotide-gated cation channel alpha-3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ243933.1 and BC035272.1. On Aug 14, 2013 this sequence version replaced NM_009918.1. Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) is shorter missing an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035272.1, AJ243933.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034048.1 |
CDS | 371..2266 |
Translation |
Target ORF information:
Target ORF information:
|
NM_009918.2 |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19785 | |
Clone ID Related Accession (Same CDS sequence) | NM_009918.2 , XM_017313745.2 , XM_017313745.1 | |
Accession Version | XM_017313745.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | cyclic nucleotide-gated cation channel alpha-3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017313745.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169234.1 |
CDS | 349..2244 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017313745.2 |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19785 | |
Clone ID Related Accession (Same CDS sequence) | NM_009918.2 , XM_017313745.2 , XM_017313745.1 | |
Accession Version | XM_017313745.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | cyclic nucleotide-gated cation channel alpha-3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169234.1 |
CDS | 349..2244 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017313745.1 |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu76952 | |
Clone ID Related Accession (Same CDS sequence) | XM_017313748.2 , XM_017313748.1 | |
Accession Version | XM_017313748.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | cyclic nucleotide-gated cation channel alpha-3 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017313748.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169237.1 |
CDS | 349..2241 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017313748.2 |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu76952 | |
Clone ID Related Accession (Same CDS sequence) | XM_017313748.2 , XM_017313748.1 | |
Accession Version | XM_017313748.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | cyclic nucleotide-gated cation channel alpha-3 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169237.1 |
CDS | 349..2241 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017313748.1 |
1 | ATGGCAAAGG TGAACACCCA GTGTTCACAG CCCTCCCCGA CCCAACTTTC AATAAAGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Rods progressively escape saturation to drive visual responses in daylight conditions. |
Long-term retinal cone rescue using a capsid mutant AAV8 vector in a mouse model of CNGA3-achromatopsia. |