Gene Symbol | Cnn1 |
Entrez Gene ID | 12797 |
Full Name | calponin 1 |
Synonyms | CN,CnnI |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cnn1 cDNA ORF clone
Gene Symbol | Cnn1 |
Entrez Gene ID | 12797 |
Full Name | calponin 1 |
Synonyms | CN,CnnI |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_009922.4 | NP_034052.3 | calponin-1 |
XM_011242388.2 | XP_011240690.1 | calponin-1 isoform X1 |
XM_006509969.3 | XP_006510032.1 | calponin-1 isoform X2 |
Rattus norvegicus (Norway rat) | Cnn1 | NP_113935.1 |
Homo sapiens (human) | CNN1 | NP_001290.2 |
Canis lupus familiaris (dog) | CNN1 | XP_542053.1 |
Bos taurus (cattle) | CNN1 | NP_001039844.1 |
Mus musculus (house mouse) | Cnn1 | NP_034052.3 |
Pan troglodytes (chimpanzee) | CNN1 | XP_001168396.2 |
Danio rerio (zebrafish) | LOC572250 | XP_701038.5 |
Xenopus tropicalis (tropical clawed frog) | cnn2 | NP_001015796.1 |
Drosophila melanogaster (fruit fly) | CG5023 | NP_650867.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000749 | XP_311284.5 |
A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree.
Losa M, Latorre V, Andrabi M, Ladam F, Sagerstr?m C, Novoa A, Zarrineh P, Bridoux L, Hanley NA, Mallo M, Bobola N
eLife6(2017 Sep)
Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
Xu H, Wu F, Zhang H, Yang C, Li K, Wang H, Yang H, Liu Y, Ding B, Tan Y, Yuan M, Li Y, Dai Z
Biochimie138184-193(2017 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity.
Title: Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.
These findings reveal a novel function of CNN1 in maintaining bone homeostasis by coupling bone formation to bone resorption
Title: Overexpression of H1 calponin in osteoblast lineage cells leads to a decrease in bone mass by disrupting osteoblast function and promoting osteoclast formation.
data suggest that in mice myometrium, phosphorylation of h1 calponin induced by the PKC-epsilon might facilitate the contraction of uterine in labor and regulate pregnant myometrial contractility.
Title: Phosphorylation of h1 calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and labor.
A single intronic CArG element is necessary but insufficient for proper CNN1 expression in vivo. CNN1 overexpression antagonizes arterial injury-induced neointimal formation.
Title: Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation.
The structure of this functionally important region of calponin and its interaction with actin and calmodulin at amino-acid resolution, was mapped.
Title: The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR spectroscopy.
The following Cnn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17653 | |
Clone ID Related Accession (Same CDS sequence) | NM_009922.4 | |
Accession Version | NM_009922.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-16 | |
Organism | Mus musculus(house mouse) | |
Product | calponin-1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY326336.1 and AK035548.1. On Apr 7, 2009 this sequence version replaced NM_009922.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK035548.1, Z19542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCTTCTG CACATTTTAA CCGAGGTCCT GCCTACGGCT TGTCTGCTGA AGTAAAGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034052.3 |
CDS | 104..997 |
Translation |
Target ORF information:
Target ORF information:
|
NM_009922.4 |
1 | ATGTCTTCTG CACATTTTAA CCGAGGTCCT GCCTACGGCT TGTCTGCTGA AGTAAAGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu41972 | |
Clone ID Related Accession (Same CDS sequence) | XM_006509969.3 | |
Accession Version | XM_006509969.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | calponin-1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006509969.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGGCC TCAAAGACGG GATCATTCTT TGCGAATTTA TCAACAAGCT GCAGCCGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006510032.1 |
CDS | 170..913 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006509969.3 |
1 | ATGGATGGCC TCAAAGACGG GATCATTCTT TGCGAATTTA TCAACAAGCT GCAGCCGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67398 | |
Clone ID Related Accession (Same CDS sequence) | XM_011242388.2 | |
Accession Version | XM_011242388.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | calponin-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011242388.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTTCTG CACATTTTAA CCGAGGTCCT GCCTACGGCT TGTCTGCTGA AGTAAAGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011240690.1 |
CDS | 136..909 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011242388.2 |
1 | ATGTCTTCTG CACATTTTAA CCGAGGTCCT GCCTACGGCT TGTCTGCTGA AGTAAAGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree. |
Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity. |