Gene Symbol | Comt |
Entrez Gene ID | 12846 |
Full Name | catechol-O-methyltransferase |
Synonyms | Comt1,D16Wsu103e,D330014B15Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Comt cDNA ORF clone
gRNAs
Gene Symbol | Comt |
Entrez Gene ID | 12846 |
Full Name | catechol-O-methyltransferase |
Synonyms | Comt1,D16Wsu103e,D330014B15Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001111063.1 | NP_001104533.1 | catechol O-methyltransferase |
NM_007744.3 | NP_031770.2 | catechol O-methyltransferase |
NM_001111062.1 | NP_001104532.1 | catechol O-methyltransferase |
Bos taurus (cattle) | COMT | NP_001095787.1 |
Schizosaccharomyces pombe (fission yeast) | SPBC119.03 | NP_595284.1 |
Neurospora crassa | NCU07919 | XP_962435.2 |
Xenopus tropicalis (tropical clawed frog) | comt | NP_001016357.1 |
Xenopus tropicalis (tropical clawed frog) | comt.2 | NP_001017157.1 |
Homo sapiens (human) | COMT | NP_001128633.1 |
Mus musculus (house mouse) | Comt | NP_001104532.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00015 | XP_003719132.1 |
Gallus gallus (chicken) | COMT | XP_001233014.1 |
Pan troglodytes (chimpanzee) | COMT | XP_514984.2 |
Canis lupus familiaris (dog) | COMT | NP_001004074.1 |
Rattus norvegicus (Norway rat) | Comt | NP_036663.1 |
Schizosaccharomyces pombe (fission yeast) | SPBPB21E7.04c | NP_001018770.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100135405 | NP_001107540.1 |
COMT | XP_001105683.1 |
Attentional Control in Adolescent Mice Assessed with a Modified Five Choice Serial Reaction Time Task.
Ciampoli M, Contarini G, Mereu M, Papaleo F
Scientific reports7(1)9936(2017 Aug)
Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice.
Kanasaki M, Srivastava SP, Yang F, Xu L, Kudoh S, Kitada M, Ueki N, Kim H, Li J, Takeda S, Kanasaki K, Koya D
Scientific reports7(1)7927(2017 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
Title: Regulation of cancer-related genes - Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt - expression in ?-naphthoflavone-treated mice by miroestrol.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of male, but not female adult mice.
Title: COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
Title: Estradiol replacement enhances fear memory formation, impairs extinction and reduces COMT expression levels in the hippocampus of ovariectomized female mice.
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1.
Title: Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
Title: Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum.
The following Comt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Comt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17896 | |
Clone ID Related Accession (Same CDS sequence) | NM_001111063.1 , NM_007744.3 , NM_001111062.1 | |
Accession Version | NM_001111063.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-19 | |
Organism | Mus musculus(house mouse) | |
Product | catechol O-methyltransferase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC133487.14, AK148311.1, GU324998.1, AA250343.1 and AW908224.1. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1660813.66120.1, SRR1660811.207080.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGTTGG CTGCTGTCTC ATTGGGTCTC CTGTTGCTGG CCTTCCTCCT GCTCCTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001104533.1 |
CDS | 230..1027 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGTTGG CTGCTGTCTC ATTGGGTCTC CTGTTGCTGG CCTTCCTCCT GCTCCTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17896 | |
Clone ID Related Accession (Same CDS sequence) | NM_001111063.1 , NM_007744.3 , NM_001111062.1 | |
Accession Version | NM_007744.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | catechol O-methyltransferase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX237493.1, AK148311.1, AC133487.14 and AW908224.1. On Dec 1, 2007 this sequence version replaced NM_007744.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.372510.1, BC010402.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGTTGG CTGCTGTCTC ATTGGGTCTC CTGTTGCTGG CCTTCCTCCT GCTCCTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031770.2 |
CDS | 362..1159 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGTTGG CTGCTGTCTC ATTGGGTCTC CTGTTGCTGG CCTTCCTCCT GCTCCTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17896 | |
Clone ID Related Accession (Same CDS sequence) | NM_001111063.1 , NM_007744.3 , NM_001111062.1 | |
Accession Version | NM_001111062.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | catechol O-methyltransferase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX237493.1, AK148311.1, AC133487.14 and AW908224.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148311.1, DV051152.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGTTGG CTGCTGTCTC ATTGGGTCTC CTGTTGCTGG CCTTCCTCCT GCTCCTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001104532.1 |
CDS | 419..1216 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGTTGG CTGCTGTCTC ATTGGGTCTC CTGTTGCTGG CCTTCCTCCT GCTCCTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Attentional Control in Adolescent Mice Assessed with a Modified Five Choice Serial Reaction Time Task. |
Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice. |