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Pcdha4 cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Pcdha4
Entrez Gene ID 12936
Full Name protocadherin alpha 4
Synonyms Cnr1,Crnr1,R75250
General protein information
Preferred Names

protocadherin alpha 4

Names

protocadherin alpha-4
PCDH-alpha-4
cadherin-related neuronal receptor 1
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

18

18|18 B2-B3

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_007766.2 NP_031792.1 protocadherin alpha-4 precursor

Pathways from BioSystems


Homologies


Homo sapiens (human) PCDHA4 NP_061730.1
PCDHA4 XP_001088407.1
Mus musculus (house mouse) Pcdha4 NP_031792.1
Rattus norvegicus (Norway rat) Pcdha4 NP_446385.1
Xenopus tropicalis (tropical clawed frog) LOC101734840 XP_004913207.1
Bos taurus (cattle) LOC787538 XP_005209574.1

Gene Ontology


Bibliography

Related articles in PubMed

Structural Basis of Diverse Homophilic Recognition by Clustered ?- and ?-Protocadherins.
Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahls?n G, Rittenhouse C, Maniatis T, Honig B, Shapiro L
Neuron90(4)709-23(2016 05)

Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.
Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M, Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T, Hirabayashi T, Yagi T
Neuron82(1)94-108(2014 Apr)

Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.
Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM, Heard E, Brockdorff N
Molecular and cellular biology33(16)3150-65(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Shedding of the Pcdhalpha extracellular domain and subsequent processing by gamma-secretase require endocytosis.
Title: Proteolytic processing of protocadherin proteins requires endocytosis.

show that protocadherins (Pcdhs) form a heteromeric signaling complex(es), consisting of multiple Pcdh isoforms, receptor tyrosine kinases, phosphatases, and cell adhesion molecules.
Title: Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret.

This pattern of Pcdha4 expression suggests its involvement in the development of neocortical connectivity.
Title: CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.

CNR1 has a heterophilic, calcium-dependent cell adhesion activity with the beta1 integrin subfamily, suggesting the possibility of CNR-beta1 integrin association in synaptogenesis.
Title: Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with beta1 integrin mediated through the RGD site of CNR1.

The following Pcdha4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pcdha4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu00765 NM_007766.2
Latest version!		 Mus musculus protocadherin alpha 4 (Pcdha4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $559.30
$799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu00765
Clone ID Related Accession (Same CDS sequence) NM_007766.2
Accession Version NM_007766.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 2844bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-19
Organism Mus musculus(house mouse)
Product protocadherin alpha-4 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC020968.3, AC020972.3 and AC020973.3. On Mar 21, 2007 this sequence version replaced NM_007766.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D86916.1, SRR1660813.235044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGGAATTTT CCTGGGGAAG TGGCCAGGAA TCCCAGCGCT TGCTTCTTTC TTTTCTGCTT 
CTTGCAATCT GGGAGGCAGG GAACAGCCAG ATCCACTACT CCATCCCTGA GGAGGCCAAA 
CACGGCACCT TCGTGGGCCG CATCGCGCAG GACCTGGGGC TGGAGCTGAC GGAGCTGGTG 
CCCCGCCTGT TCAGAGTGGC GTCCAAGGAC CGCGGAGACC TTCTGGAGGT AAATCTGCAG 
AATGGCATTT TGTTTGTGAA TTCTCGGATC GACCGGGAGG AGCTGTGCGG GCGGAGCGCG 
GAGTGCAGCA TCCACCTGGA GGTGATCGTG GACAGGCCGT TGCAGGTTTT CCACGTGGAG 
GTGGAGGTGA GGGACATTAA CGACAACCCT CCCAGGTTCC CAACAACACA AAAGAATCTG 
TTCATTGCAG AATCAAGGCC ACTTGACACT TGGTTTCCAC TAGAGGGCGC TTCAGACGCA 
GATATCGGAA TCAATGCTGT ACTGACTTAC AGACTGAGTC CAAATGATTA CTTTTCTTTG 
GAAAAACCAT CCAACGACGA ACGGGTAAAA GGTCTTGGAC TTGTATTACG GAAATCTTTA 
GACCGGGAGG AAACTCCAGA GATAATTTTA GTGCTTACTG TCACGGACGG AGGAAAGCCA 
GAGCTGACCG GCAGTGTTCA GTTACTCATC ACTGTGCTGG ATGCCAATGA TAATGCTCCA 
GTTTTTGACA GATCTCTGTA TACCGTGAAA TTACCAGAAA ACGTTCCAAA TGGGACATTG 
GTAGTCAAAG TCAATGCCTC AGATTTAGAC GAAGGGGTAA ATGGGGATAT TATGTACTCA 
TTTTCTACAG ATATTTCACC AAATGTGAAA TACAAATTCC ACATAGACCC TGTTAGCGGA 
GAGATTATTG TAAAGGGATA CATTGATTTT GAAGAATGCA AATCCTATGA AATTCTCATA 
GAGGGAATTG ACAAGGGACA ACTTCCACTC TCTGGGCACT GTAAAGTCAT TGTACAAGTT 
GAAGACATCA ACGATAATGT TCCAGAATTG GAATTCAAAT CTCTATCACT TCCAATACGA 
GAGAATTCTC CAGTGGGCAC TGTCATCGCA CTCATTAGTG TGTCTGATCG GGACACGGGT 
GTCAACGGGC AGGTGACCTG CTCCCTGACA AGTCATGTCC CCTTCAAGTT GGTGTCCACA 
TTCAAGAATT ACTATTCGCT CGTGCTGGAC AGCGCCCTGG ACAGAGAGAC AACAGCGGAC 
TATAAGGTGG TGGTGACAGC GCGGGATGGG GGCTCTCCCT CGCTGTGGGC CACGGCTAGC 
GTGTCTGTTG AGGTTGCTGA CGTGAACGAC AATGCACCTG TGTTCGCGCA GCCCGAATAC 
ACGGTGTTCG TGAAGGAGAA CAACCCGCCT GGTGCGCACA TCTTCACGGT GTCAGCGATG 
GATGCGGACG CACAGGAGAA CGCGCTGGTG TCCTACTCGC TGGTGGAGCG GAGGGTGGGC 
GAGCGCTTGC TGTCGAGCTA TGTGTCTGTG CACGCGGAGA GCGGCAAGGT GTTCGCGCTG 
CAGCCTCTGG ACCATGAGGA GCTGGAGCTG CTGCGGTTCC AGGTGAGCGC GCGGGATGCT 
GGTGTACCTG CCCTGGGCAG CAATGTGACT CTGCAGGTGT TTGTGCTGGA CGAGAATGAC 
AACGCGCCCA CACTGCTGGA ACCTGAGGCA GGAGTCTCTG GTGGAATCGT GAGCCGGTTG 
GTGTCCAGAT CAGTGGGTGC AGGCCATGTG GTGGCTAAGG TGCGCGCGGT GGATGCAGAC 
TCTGGCTATA ATGCATGGCT CTCTTATGAG CTGCAATCGT CAGAAGGCAA TTCCCGTAGC 
CTTTTCCGCG TAGGTTTGTA TACGGGCGAG ATTAGTACTA CGCGCATACT GGATGAAGCA 
GATTCGCCAC GTCAGCGCCT TCTGGTGCTG GTGAAGGACC ATGGTGACCC AGCAATGATT 
GTTACCGCCA CAGTGTTGGT GTCTCTGGTA GAGAATGGCC CGGTACCAAA GGCTCCATCG 
CGAGTATCCA CGAGTGTCAC ACACTCTGAG GCGTCACTGG TGGATGTCAA CGTGTACCTG 
ATCATTGCCA TCTGTGCAGT GTCCAGCCTG CTAGTGCTCA CGCTGCTGCT GTACACAGCG 
CTGCGCTGTT CCACTGTCCC CAGTGAGAGC GTGTGCGGGC CTCCAAAACC GGTAATGGTG 
TGCTCCAGTG CAGTGGGGAG CTGGTCATAC TCCCAACAAA GGAGGCAAAG GGTGTGCTCT 
GGGGAGTACC CACCTAAGAC CGACCTCATG GCCTTCAGCC CCAGTTTATC TGATTCAAGG 
GACAGAGAGG ATCAATTGCA GTCTGCAGAG GATTCCTCTG GAAAGCCCCG GCAGCCCAAC 
CCTGACTGGC GCTACTCTGC CTCGCTAAGA GCAGGCATGC ACAGCTCTGT GCACCTGGAG 
GAGGCTGGCA TTCTACGGGC TGGTCCAGGA GGGCCTGATC AGCAGTGGCC AACAGTATCC 
AGTGCAACAC CAGAACCTGA GGCAGGAGAG GTGTCCCCTC CGGTGGGCGC CGGTGTCAAC 
AGCAACAGCT GGACCTTTAA ATACGGACCA GGCAACCCCA AACAGTCCGG TCCCGGTGAG 
TTGCCAGACA AATTCATTAT CCCAGGATCT CCTGCAATCA TCTCCATCCG GCAGGAGCCT 
GCTAACAACC AAATTGACAA AAGCGATTTT ATAACCTTCG GCAAAAAGGA GGAGACCAAG 
AAAAAGAAGA AAAAGAAGAA GGGTAACAAG ACCCAGGAGA AAAAAGAGAA AGGGAACAGC 
ACGACGGACA ACAGTGACCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_031792.1
CDS78..2921
Translation

Target ORF information:

RefSeq Version NM_007766.2
Organism Mus musculus(house mouse)
Definition Mus musculus protocadherin alpha 4 (Pcdha4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_007766.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGGAATTTT CCTGGGGAAG TGGCCAGGAA TCCCAGCGCT TGCTTCTTTC TTTTCTGCTT 
CTTGCAATCT GGGAGGCAGG GAACAGCCAG ATCCACTACT CCATCCCTGA GGAGGCCAAA 
CACGGCACCT TCGTGGGCCG CATCGCGCAG GACCTGGGGC TGGAGCTGAC GGAGCTGGTG 
CCCCGCCTGT TCAGAGTGGC GTCCAAGGAC CGCGGAGACC TTCTGGAGGT AAATCTGCAG 
AATGGCATTT TGTTTGTGAA TTCTCGGATC GACCGGGAGG AGCTGTGCGG GCGGAGCGCG 
GAGTGCAGCA TCCACCTGGA GGTGATCGTG GACAGGCCGT TGCAGGTTTT CCACGTGGAG 
GTGGAGGTGA GGGACATTAA CGACAACCCT CCCAGGTTCC CAACAACACA AAAGAATCTG 
TTCATTGCAG AATCAAGGCC ACTTGACACT TGGTTTCCAC TAGAGGGCGC TTCAGACGCA 
GATATCGGAA TCAATGCTGT ACTGACTTAC AGACTGAGTC CAAATGATTA CTTTTCTTTG 
GAAAAACCAT CCAACGACGA ACGGGTAAAA GGTCTTGGAC TTGTATTACG GAAATCTTTA 
GACCGGGAGG AAACTCCAGA GATAATTTTA GTGCTTACTG TCACGGACGG AGGAAAGCCA 
GAGCTGACCG GCAGTGTTCA GTTACTCATC ACTGTGCTGG ATGCCAATGA TAATGCTCCA 
GTTTTTGACA GATCTCTGTA TACCGTGAAA TTACCAGAAA ACGTTCCAAA TGGGACATTG 
GTAGTCAAAG TCAATGCCTC AGATTTAGAC GAAGGGGTAA ATGGGGATAT TATGTACTCA 
TTTTCTACAG ATATTTCACC AAATGTGAAA TACAAATTCC ACATAGACCC TGTTAGCGGA 
GAGATTATTG TAAAGGGATA CATTGATTTT GAAGAATGCA AATCCTATGA AATTCTCATA 
GAGGGAATTG ACAAGGGACA ACTTCCACTC TCTGGGCACT GTAAAGTCAT TGTACAAGTT 
GAAGACATCA ACGATAATGT TCCAGAATTG GAATTCAAAT CTCTATCACT TCCAATACGA 
GAGAATTCTC CAGTGGGCAC TGTCATCGCA CTCATTAGTG TGTCTGATCG GGACACGGGT 
GTCAACGGGC AGGTGACCTG CTCCCTGACA AGTCATGTCC CCTTCAAGTT GGTGTCCACA 
TTCAAGAATT ACTATTCGCT CGTGCTGGAC AGCGCCCTGG ACAGAGAGAC AACAGCGGAC 
TATAAGGTGG TGGTGACAGC GCGGGATGGG GGCTCTCCCT CGCTGTGGGC CACGGCTAGC 
GTGTCTGTTG AGGTTGCTGA CGTGAACGAC AATGCACCTG TGTTCGCGCA GCCCGAATAC 
ACGGTGTTCG TGAAGGAGAA CAACCCGCCT GGTGCGCACA TCTTCACGGT GTCAGCGATG 
GATGCGGACG CACAGGAGAA CGCGCTGGTG TCCTACTCGC TGGTGGAGCG GAGGGTGGGC 
GAGCGCTTGC TGTCGAGCTA TGTGTCTGTG CACGCGGAGA GCGGCAAGGT GTTCGCGCTG 
CAGCCTCTGG ACCATGAGGA GCTGGAGCTG CTGCGGTTCC AGGTGAGCGC GCGGGATGCT 
GGTGTACCTG CCCTGGGCAG CAATGTGACT CTGCAGGTGT TTGTGCTGGA CGAGAATGAC 
AACGCGCCCA CACTGCTGGA ACCTGAGGCA GGAGTCTCTG GTGGAATCGT GAGCCGGTTG 
GTGTCCAGAT CAGTGGGTGC AGGCCATGTG GTGGCTAAGG TGCGCGCGGT GGATGCAGAC 
TCTGGCTATA ATGCATGGCT CTCTTATGAG CTGCAATCGT CAGAAGGCAA TTCCCGTAGC 
CTTTTCCGCG TAGGTTTGTA TACGGGCGAG ATTAGTACTA CGCGCATACT GGATGAAGCA 
GATTCGCCAC GTCAGCGCCT TCTGGTGCTG GTGAAGGACC ATGGTGACCC AGCAATGATT 
GTTACCGCCA CAGTGTTGGT GTCTCTGGTA GAGAATGGCC CGGTACCAAA GGCTCCATCG 
CGAGTATCCA CGAGTGTCAC ACACTCTGAG GCGTCACTGG TGGATGTCAA CGTGTACCTG 
ATCATTGCCA TCTGTGCAGT GTCCAGCCTG CTAGTGCTCA CGCTGCTGCT GTACACAGCG 
CTGCGCTGTT CCACTGTCCC CAGTGAGAGC GTGTGCGGGC CTCCAAAACC GGTAATGGTG 
TGCTCCAGTG CAGTGGGGAG CTGGTCATAC TCCCAACAAA GGAGGCAAAG GGTGTGCTCT 
GGGGAGTACC CACCTAAGAC CGACCTCATG GCCTTCAGCC CCAGTTTATC TGATTCAAGG 
GACAGAGAGG ATCAATTGCA GTCTGCAGAG GATTCCTCTG GAAAGCCCCG GCAGCCCAAC 
CCTGACTGGC GCTACTCTGC CTCGCTAAGA GCAGGCATGC ACAGCTCTGT GCACCTGGAG 
GAGGCTGGCA TTCTACGGGC TGGTCCAGGA GGGCCTGATC AGCAGTGGCC AACAGTATCC 
AGTGCAACAC CAGAACCTGA GGCAGGAGAG GTGTCCCCTC CGGTGGGCGC CGGTGTCAAC 
AGCAACAGCT GGACCTTTAA ATACGGACCA GGCAACCCCA AACAGTCCGG TCCCGGTGAG 
TTGCCAGACA AATTCATTAT CCCAGGATCT CCTGCAATCA TCTCCATCCG GCAGGAGCCT 
GCTAACAACC AAATTGACAA AAGCGATTTT ATAACCTTCG GCAAAAAGGA GGAGACCAAG 
AAAAAGAAGA AAAAGAAGAA GGGTAACAAG ACCCAGGAGA AAAAAGAGAA AGGGAACAGC 
ACGACGGACA ACAGTGACCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Structural Basis of Diverse Homophilic Recognition by Clustered ?- and ?-Protocadherins.
Neuron90(4)709-23(2016 05)
Goodman KM,Rubinstein R,Thu CA,Bahna F,Mannepalli S,Ahls?n G,Rittenhouse C,Maniatis T,Honig B,Shapiro L


book

Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.
Neuron82(1)94-108(2014 Apr)
Toyoda S,Kawaguchi M,Kobayashi T,Tarusawa E,Toyama T,Okano M,Oda M,Nakauchi H,Yoshimura Y,Sanbo M,Hirabayashi M,Hirayama T,Hirabayashi T,Yagi T


book

Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.
Molecular and cellular biology33(16)3150-65(2013 Aug)
Gendrel AV,Tang YA,Suzuki M,Godwin J,Nesterova TB,Greally JM,Heard E,Brockdorff N