Cycs cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Cycs
Entrez Gene ID	13063
Full Name	cytochrome c, somatic
General protein information	Preferred Names cytochrome c, somatic Names cytochrome c, somatic
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 B2.3\|6 24.32 cM

mRNA and Protein(s)

mRNA Protein Name

NM_007808.5 NP_031834.1 cytochrome c, somatic

NM_007808.4 NP_031834.1 cytochrome c, somatic
Pathways from BioSystems

mRNA	Protein	Name
NM_007808.5	NP_031834.1	cytochrome c, somatic
NM_007808.4	NP_031834.1	cytochrome c, somatic

Homologies

Bos taurus (cattle)	CYCS	NP_001039526.1
Rattus norvegicus (Norway rat)	Cycs	NP_036971.1
Drosophila melanogaster (fruit fly)	Cyt-c-p	NP_477176.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009537	XP_310154.1
Eremothecium gossypii	AGOS_AFR360W	NP_985907.1
Rattus norvegicus (Norway rat)	LOC100363502	XP_003751847.1
Gallus gallus (chicken)	CYCS	NP_001072946.1
Homo sapiens (human)	CYCS	NP_061820.1
Caenorhabditis elegans (roundworm)	cyc-2.2	NP_506156.1
Kluyveromyces lactis	KLLA0F16929g	XP_455841.1
Xenopus tropicalis (tropical clawed frog)	cycs	NP_988895.1
	LOC694977	XP_001085135.1
Canis lupus familiaris (dog)	CYCS	NP_001183974.1
Mus musculus (house mouse)	Cycs	NP_031834.1
Caenorhabditis elegans (roundworm)	cyc-2.1	NP_500629.1
Saccharomyces cerevisiae (baker's yeast)	CYC1	NP_012582.1

Gene Ontology
Bibliography

Related articles in PubMed

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD
Journal of molecular and cellular cardiology971-14(2016 Aug)

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.
G?mez-Del Arco P, Perdiguero E, Yunes-Leites PS, Ac?n-P?rez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jim?nez-Alc?zar M, Segal?s J, L?pez-Maderuelo D, Orn?s B, Jim?nez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Mu?oz-C?noves P, Redondo JM
Cell metabolism23(5)881-92(2016 May)

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM
PLoS genetics12(3)e1005916(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the amount of cytochrome c in lymphomyeloid cells does not affect their development and normal functioning
Title: Mouse lymphomyeloid cells can function with significantly decreased expression levels of cytochrome C.

Data suggest that peroxidase activation of cytochrome c may induce apoptosis and contribute to anti-cancer properties of alpha-tocopherol succinate.
Title: Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate.

Abeta oligomers bind to BAK on the membrane and induce apoptotic BAK pores and cytochrome c release
Title: Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release.

Data indicate that mitochondrial alpha 7 nicotinic acetylcholine receptors (alpha7 nAChRs) regulate cytochrome c (cyt c) release by engaging intramitochondrial protein kinases.
Title: ?7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways.

proposed that mutation of residue 41, and interaction with cardiolipin, increase peroxidase activity by altering the 40-57 Omega loop and its hydrogen bond network with the propionate of haem ring A; these changes enhance access of hydrogen peroxide and substrate to the haem
Title: Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release.

The following Cycs gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cycs cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18141	NM_007808.5 Latest version!	Mus musculus cytochrome c, somatic (Cycs), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu18141	NM_007808.4	Mus musculus cytochrome c, somatic (Cycs), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cycs ( NM_007808.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031834.1 Mus musculus cytochrome c, somatic (Cycs), mRNA.

Price & Availability↑

CloneID	OMu18141
Clone ID Related Accession (Same CDS sequence)	NM_007808.5 , NM_007808.4
Accession Version	NM_007808.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	cytochrome c, somatic
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153386.3, BY311395.1 and AK143887.1. On May 29, 2018 this sequence version replaced NM_007808.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143887.1, SRR1660815.252952.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAGA AGTGTGCCCA GTGCCACACT 
GTGGAAAAGG GAGGCAAGCA TAAGACTGGA CCAAATCTCC ACGGTCTGTT CGGGCGGAAG 
ACAGGCCAGG CTGCTGGATT CTCTTACACA GATGCCAACA AGAACAAAGG CATCACCTGG 
GGAGAGGATA CCCTGATGGA GTATTTGGAG AATCCCAAAA AGTACATCCC TGGAACAAAA 
ATGATCTTCG CTGGAATTAA GAAGAAGGGA GAAAGGGCAG ACCTAATAGC TTATCTTAAA 
AAGGCTACTA ATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031834.1
CDS	163..480
Translation	MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE

Target ORF information:

RefSeq Version	NM_007808.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c, somatic (Cycs), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007808.5

ORF Insert Sequence:

ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAGA AGTGTGCCCA GTGCCACACT 
GTGGAAAAGG GAGGCAAGCA TAAGACTGGA CCAAATCTCC ACGGTCTGTT CGGGCGGAAG 
ACAGGCCAGG CTGCTGGATT CTCTTACACA GATGCCAACA AGAACAAAGG CATCACCTGG 
GGAGAGGATA CCCTGATGGA GTATTTGGAG AATCCCAAAA AGTACATCCC TGGAACAAAA 
ATGATCTTCG CTGGAATTAA GAAGAAGGGA GAAAGGGCAG ACCTAATAGC TTATCTTAAA 
AAGGCTACTA ATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cycs ( NM_007808.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031834.1 Mus musculus cytochrome c, somatic (Cycs), mRNA.

Price & Availability↑

CloneID	OMu18141
Clone ID Related Accession (Same CDS sequence)	NM_007808.5 , NM_007808.4
Accession Version	NM_007808.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Mus musculus(house mouse)
Product	cytochrome c, somatic
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK143887.1. On Apr 6, 2007 this sequence version replaced NM_007808.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143887.1, SRR1660815.252952.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAGA AGTGTGCCCA GTGCCACACT 
GTGGAAAAGG GAGGCAAGCA TAAGACTGGA CCAAATCTCC ACGGTCTGTT CGGGCGGAAG 
ACAGGCCAGG CTGCTGGATT CTCTTACACA GATGCCAACA AGAACAAAGG CATCACCTGG 
GGAGAGGATA CCCTGATGGA GTATTTGGAG AATCCCAAAA AGTACATCCC TGGAACAAAA 
ATGATCTTCG CTGGAATTAA GAAGAAGGGA GAAAGGGCAG ACCTAATAGC TTATCTTAAA 
AAGGCTACTA ATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031834.1
CDS	68..385
Translation	MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE

Target ORF information:

RefSeq Version	NM_007808.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c, somatic (Cycs), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007808.4

ORF Insert Sequence:

ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAGA AGTGTGCCCA GTGCCACACT 
GTGGAAAAGG GAGGCAAGCA TAAGACTGGA CCAAATCTCC ACGGTCTGTT CGGGCGGAAG 
ACAGGCCAGG CTGCTGGATT CTCTTACACA GATGCCAACA AGAACAAAGG CATCACCTGG 
GGAGAGGATA CCCTGATGGA GTATTTGGAG AATCCCAAAA AGTACATCCC TGGAACAAAA 
ATGATCTTCG CTGGAATTAA GAAGAAGGGA GAAAGGGCAG ACCTAATAGC TTATCTTAAA 
AAGGCTACTA ATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Journal of molecular and cellular cardiology971-14(2016 Aug)
Magarin M,Pohl T,Lill A,Schulz H,Blaschke F,Heuser A,Thierfelder L,Donath S,Drenckhahn JD

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.
Cell metabolism23(5)881-92(2016 May)
G?mez-Del Arco P,Perdiguero E,Yunes-Leites PS,Ac?n-P?rez R,Zeini M,Garcia-Gomez A,Sreenivasan K,Jim?nez-Alc?zar M,Segal?s J,L?pez-Maderuelo D,Orn?s B,Jim?nez-Borreguero LJ,D'Amato G,Enshell-Seijffers D,Morgan B,Georgopoulos K,Islam AB,Braun T,de la Pompa JL,Kim J,Enriquez JA,Ballestar E,Mu?oz-C?noves P,Redondo JM

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
PLoS genetics12(3)e1005916(2016 Mar)
Van De Pette M,Tunster SJ,McNamara GI,Shelkovnikova T,Millership S,Benson L,Peirson S,Christian M,Vidal-Puig A,John RM

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Cycs cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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