Gene Symbol | Cyp17a1 |
Entrez Gene ID | 13074 |
Full Name | cytochrome P450, family 17, subfamily a, polypeptide 1 |
Synonyms | Cyp17,p450c17 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cyp17a1 cDNA ORF clone
gRNAs
Gene Symbol | Cyp17a1 |
Entrez Gene ID | 13074 |
Full Name | cytochrome P450, family 17, subfamily a, polypeptide 1 |
Synonyms | Cyp17,p450c17 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_007809.3 | NP_031835.3 | steroid 17-alpha-hydroxylase/17,20 lyase precursor |
CYP17A1 | NP_001035322.1 | |
Arabidopsis thaliana (thale cress) | CYP706A3 | NP_199275.1 |
Canis lupus familiaris (dog) | CYP17A1 | XP_535000.3 |
Arabidopsis thaliana (thale cress) | CYP706A4 | NP_192967.1 |
Arabidopsis thaliana (thale cress) | CYP706A2 | NP_194002.1 |
Homo sapiens (human) | CYP17A1 | NP_000093.1 |
Bos taurus (cattle) | CYP17A1 | NP_776729.1 |
Arabidopsis thaliana (thale cress) | CYP706A6 | NP_192969.4 |
Arabidopsis thaliana (thale cress) | CYP706A5 | NP_192968.3 |
Arabidopsis thaliana (thale cress) | CYP706A1 | NP_567665.2 |
Mus musculus (house mouse) | Cyp17a1 | NP_031835.3 |
Oryza sativa (rice) | Os08g0547900 | NP_001062431.2 |
Pan troglodytes (chimpanzee) | CYP17A1 | NP_001009052.1 |
Rattus norvegicus (Norway rat) | Cyp17a1 | NP_036885.1 |
Arabidopsis thaliana (thale cress) | CYP706A7 | NP_192970.1 |
Oryza sativa (rice) | Os01g0700500 | NP_001043985.2 |
MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Shawki HH, Oishi H, Usui T, Kitadate Y, Basha WA, Abdellatif AM, Hasegawa K, Okada R, Mochida K, El-Shemy HA, Muratani M, Ogura A, Yoshida S, Takahashi S
PloS one13(1)e0190800(2018)
Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2.
Bagheri-Fam S, Bird AD, Zhao L, Ryan JM, Yong M, Wilhelm D, Koopman P, Eswarakumar VP, Harley VR
Endocrinology158(11)3832-3843(2017 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
through mouse-to-human search and validation, we found that CYP17A1 is overexpressed in hepatocellular carcinomas and it has great potentiality as a noninvasive marker for hepatocellular carcinoma detection
Title: Transcriptome Analysis of WHV/c-myc Transgenic Mice Implicates Cytochrome P450 Enzyme 17A1 as a Promising Biomarker for Hepatocellular Carcinoma.
Demonstration of the physiologic importance of cytochrome b5 activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.
Title: Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.
TRalpha/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 transactivation on these promoters.
Title: Differential regulation of steroidogenic enzyme genes by TR? signaling in testicular Leydig cells.
ata indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Title: Androgen receptor binding sites identified in mouse testis.
Data suggest that immune-activation of testicular interstitial macrophages may cause inhibition of P450c17 gene expression in Leydig cells.
Title: The role of cytokines in the regulation of Leydig cell P450c17 gene expression.
The following Cyp17a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp17a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16756 | |
Clone ID Related Accession (Same CDS sequence) | NM_007809.3 | |
Accession Version | NM_007809.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | steroid 17-alpha-hydroxylase/17,20 lyase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD552634.1, M64863.1 and AK134376.1. On Nov 22, 2007 this sequence version replaced NM_007809.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132830.1, BC064793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTGGGAAC TTGTGGGTCT CTTGCTGCTC ATCCTGGCCT ATTTCTTTTG GCCCAAGTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031835.3 |
CDS | 158..1681 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTGGGAAC TTGTGGGTCT CTTGCTGCTC ATCCTGGCCT ATTTCTTTTG GCCCAAGTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice. |
Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2. |