Gene Symbol | Dbh |
Entrez Gene ID | 13166 |
Full Name | dopamine beta hydroxylase |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dbh cDNA ORF clone
Gene Symbol | Dbh |
Entrez Gene ID | 13166 |
Full Name | dopamine beta hydroxylase |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_138942.3 | NP_620392.2 | dopamine beta-hydroxylase |
Xenopus tropicalis (tropical clawed frog) | dbh | XP_002942324.2 |
Canis lupus familiaris (dog) | DBH | NP_001005263.1 |
Bos taurus (cattle) | DBH | NP_851338.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010485 | XP_307804.4 |
Pan troglodytes (chimpanzee) | DBH | XP_520341.2 |
Danio rerio (zebrafish) | dbh | NP_001103164.1 |
Homo sapiens (human) | DBH | NP_000778.3 |
DBH | XP_001100196.2 | |
Mus musculus (house mouse) | Dbh | NP_620392.2 |
Drosophila melanogaster (fruit fly) | Tbh | NP_788884.1 |
Rattus norvegicus (Norway rat) | Dbh | NP_037290.2 |
Gallus gallus (chicken) | DBH | XP_415429.4 |
Caenorhabditis elegans (roundworm) | tbh-1 | NP_001257264.1 |
Intact calcium signaling in adrenergic-deficient embryonic mouse hearts.
Peoples JN, Taylor DG, Katchman AN, Ebert SN
Biochemical and biophysical research communications495(4)2547-2552(2018 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In mice, hepatic Dbh mRNA levels correlated with cardiovascular risk phenotypes.
Title: Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.
Dbh-deficient mice exhibit shorter latencies to loss of righting reflex and longer durations of hypersensitivity to general anesthesia.
Title: Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine ?-hydroxylase knockout mice.
our results suggest that DBH knockout mice have normal levels of dopamine 2 receptors in the high-affinity state and that additional mechanisms contribute to their behavioral sensitivity to psychostimulants
Title: Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding.
These results strongly suggest that the norepinephrine defect in Mecp2(-/Y) mice is likely to result from deficient expression of not only tyrosine hydroxylase but also DBH without significant loss of catecholaminergic neurons in the locus coeruleus.
Title: Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neurons.
Data show how deficiency of dopamine-beta-hydroxylase (DBH) and CRH affects tyrosine hydroxylase, DBH, and phenylethanolamine N-methyltransferase gene expression and protein levels in the adrenal medulla and stellate ganglia of control and stressed mice.
Title: Regulation of gene expression of catecholamine biosynthetic enzymes in dopamine-beta-hydroxylase- and CRH-knockout mice exposed to stress.
The following Dbh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dbh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16591 | |
Clone ID Related Accession (Same CDS sequence) | NM_138942.3 | |
Accession Version | NM_138942.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1869bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | dopamine beta-hydroxylase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132245.1 and BB109310.1. On Jul 28, 2006 this sequence version replaced NM_138942.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132245.1, S50200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCAAGCTC ATCTCAGCCA CCAGCCTTGT TGGAGCAGCC TCCCAAGCCC CAGTGTCCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_620392.2 |
CDS | 10..1878 |
Translation |
Target ORF information:
Target ORF information:
|
NM_138942.3 |
1 | ATGCAAGCTC ATCTCAGCCA CCAGCCTTGT TGGAGCAGCC TCCCAAGCCC CAGTGTCCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Intact calcium signaling in adrenergic-deficient embryonic mouse hearts. |