Gene Symbol | Dnase2a |
Entrez Gene ID | 13423 |
Full Name | deoxyribonuclease II alpha |
Synonyms | Dnase2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dnase2a cDNA ORF clone
Gene Symbol | Dnase2a |
Entrez Gene ID | 13423 |
Full Name | deoxyribonuclease II alpha |
Synonyms | Dnase2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001368296.1 | NP_001355225.1 | deoxyribonuclease-2-alpha isoform 2 |
NM_010062.3 | NP_034192.1 | deoxyribonuclease-2-alpha precursor |
NM_001368295.1 | NP_001355224.1 | deoxyribonuclease-2-alpha isoform 3 precursor |
NM_010062.4 | NP_034192.1 | deoxyribonuclease-2-alpha isoform 1 precursor |
Danio rerio (zebrafish) | dnase2 | NP_001108210.1 |
Pan troglodytes (chimpanzee) | DNASE2 | XP_001170388.1 |
Bos taurus (cattle) | DNASE2 | NP_001068595.1 |
Rattus norvegicus (Norway rat) | Dnase2 | NP_612548.1 |
Homo sapiens (human) | DNASE2 | NP_001366.1 |
Xenopus tropicalis (tropical clawed frog) | dnase2 | NP_001039073.1 |
Mus musculus (house mouse) | Dnase2a | NP_034192.1 |
Caenorhabditis elegans (roundworm) | crn-7 | NP_498817.1 |
Canis lupus familiaris (dog) | DNASE2 | XP_533902.2 |
Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.
Fischer H, Buchberger M, Napirei M, Tschachler E, Eckhart L
Scientific reports7(1)6433(2017 Jul)
Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death.
Fischer H, Fumicz J, Rossiter H, Napirei M, Buchberger M, Tschachler E, Eckhart L
The Journal of investigative dermatology137(3)587-594(2017 Mar)
STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.
Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM
Arthritis & rheumatology (Hoboken, N.J.)69(2)460-471(2017 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
holocrine secretion is a DNase2-mediated form of programmed cell death and suggest that autophagy-dependent metabolism, DNA degradation
Title: Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death.
Data show that Klf1 is expressed in central macrophagse of erythroblastic islands and that it binds and activates the promoter of Dnase2a.
Title: Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.
The following Dnase2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnase2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu05449 | |
Clone ID Related Accession (Same CDS sequence) | NM_010062.3 , NM_010062.4 | |
Accession Version | NM_010062.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-10-19 | |
Organism | Mus musculus(house mouse) | |
Product | deoxyribonuclease-2-alpha precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK145192.1, BQ829838.1 and BY757082.1. On Feb 16, 2006 this sequence version replaced NM_010062.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145192.1, BC058609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAACAC TGAGATCGCT GCTGCTGGCT GCGCTGCTGT GGGTCCCTGC CGAAGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034192.1 |
CDS | 153..1214 |
Translation |
Target ORF information:
Target ORF information:
|
NM_010062.3 |
1 | ATGGCAACAC TGAGATCGCT GCTGCTGGCT GCGCTGCTGT GGGTCCCTGC CGAAGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu05449 | |
Clone ID Related Accession (Same CDS sequence) | NM_010062.3 , NM_010062.4 | |
Accession Version | NM_010062.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-26 | |
Organism | Mus musculus(house mouse) | |
Product | deoxyribonuclease-2-alpha isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5. On Feb 5, 2019 this sequence version replaced NM_010062.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.1289753.1, SRR7345562.266316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAACAC TGAGATCGCT GCTGCTGGCT GCGCTGCTGT GGGTCCCTGC CGAAGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034192.1 |
CDS | 22..1083 |
Translation |
Target ORF information:
Target ORF information:
|
NM_010062.4 |
1 | ATGGCAACAC TGAGATCGCT GCTGCTGGCT GCGCTGCTGT GGGTCCCTGC CGAAGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu84610 | |
Clone ID Related Accession (Same CDS sequence) | NM_001368296.1 | |
Accession Version | NM_001368296.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-24 | |
Organism | Mus musculus(house mouse) | |
Product | deoxyribonuclease-2-alpha isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK167277.1, SRR6238555.2259132.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGGACTC CGGGCAGCCT GTGGATTGGT GAGTTCGTGG TATACAAGCT GCCGGCTCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001355225.1 |
CDS | 89..1087 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001368296.1 |
1 | ATGGGGACTC CGGGCAGCCT GTGGATTGGT GAGTTCGTGG TATACAAGCT GCCGGCTCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu84611 | |
Clone ID Related Accession (Same CDS sequence) | NM_001368295.1 | |
Accession Version | NM_001368295.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-26 | |
Organism | Mus musculus(house mouse) | |
Product | deoxyribonuclease-2-alpha isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5314774.160083.3, SRR5314774.160083.11 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAACAC TGAGATCGCT GCTGCTGGCT GCGCTGCTGT GGGTCCCTGC CGAAGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001355224.1 |
CDS | 22..918 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001368295.1 |
1 | ATGGCAACAC TGAGATCGCT GCTGCTGGCT GCGCTGCTGT GGGTCCCTGC CGAAGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis. |
Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death. |
STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice. |