Gene Symbol | Atp6v0a4 |
Entrez Gene ID | 140494 |
Full Name | ATPase, H+ transporting, lysosomal V0 subunit A4 |
Synonyms | Atp6n1b,a4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Atp6v0a4 cDNA ORF clone
Gene Symbol | Atp6v0a4 |
Entrez Gene ID | 140494 |
Full Name | ATPase, H+ transporting, lysosomal V0 subunit A4 |
Synonyms | Atp6n1b,a4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_080467.3 | NP_536715.3 | V-type proton ATPase 116 kDa subunit a isoform 4 |
Canis lupus familiaris (dog) | ATP6V0A4 | XP_539895.2 |
Rattus norvegicus (Norway rat) | Atp6v0a4 | NP_001100061.1 |
Pan troglodytes (chimpanzee) | ATP6V0A4 | XP_003318871.1 |
Bos taurus (cattle) | ATP6V0A4 | NP_001192780.1 |
Mus musculus (house mouse) | Atp6v0a4 | NP_536715.3 |
Xenopus tropicalis (tropical clawed frog) | atp6v0a4 | NP_001107162.1 |
Gallus gallus (chicken) | ATP6V0A4 | NP_001073571.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001587 | XP_321521.2 |
Arabidopsis thaliana (thale cress) | VHA-A3 | NP_568051.1 |
Arabidopsis thaliana (thale cress) | VHA-A2 | NP_179736.1 |
Homo sapiens (human) | ATP6V0A4 | NP_570856.2 |
ATP6V0A4 | XP_002803521.1 | |
Drosophila melanogaster (fruit fly) | Vha100-2 | NP_650722.1 |
Oryza sativa (rice) | Os03g0251500 | NP_001049572.1 |
Molecular architecture underlying fluid absorption by the developing inner ear.
Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa M, Kelley MW, Wangemann P, Morell RJ, Griffith AJ
eLife6(2017 Oct)
Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Rutledge EA, Benazet JD, McMahon AP
Development (Cambridge, England)144(17)3177-3188(2017 09)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
Extra-renal locations of the a4 subunit of H(+)ATPase.
Golder ZJ, Karet Frankl FE
BMC cell biology17(1)27(2016 07)
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The identification of novel locations for the a4 subunit and other tissue-restricted subunits increases the range of unique subunit combinations making up the proton pump.
Title: Extra-renal locations of the a4 subunit of H(+)ATPase.
The first detailed analysis of the structure and function of the auditory system in Atp6v0a4(-/-) knockout mice, is reported.
Title: Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear.
V-ATPase a4 knockout mice suffer not only from severe acidosis but also from proximal tubule dysfunction with defective endocytic trafficking, proteinuria, phosphaturia and accumulation of lysosomal material.
Title: A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype
Title: Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype.
Data suggestthat Foxi1 is necessary for expression of at least four subunits in three different epithelia and most likely is a major determinant for proper assembly of a functional vacuolar H(+)-ATPase complex at these locations.
Title: The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis.
The following Atp6v0a4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp6v0a4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu09686 | |
Clone ID Related Accession (Same CDS sequence) | NM_080467.3 | |
Accession Version | NM_080467.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2502bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-01-20 | |
Organism | Mus musculus(house mouse) | |
Product | V-type proton ATPase 116 kDa subunit a isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK143790.1 and BC046979.1. On Apr 1, 2008 this sequence version replaced NM_080467.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF435090.1, AF326316.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCATCTG TGTTTCGAAG TGAGGAGATG TGTTTATCCC AAGTGTTTCT CCAGGTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_536715.3 |
CDS | 277..2778 |
Translation |
Target ORF information:
Target ORF information:
|
NM_080467.3 |
1 | ATGGCATCTG TGTTTCGAAG TGAGGAGATG TGTTTATCCC AAGTGTTTCT CCAGGTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Molecular architecture underlying fluid absorption by the developing inner ear. |
Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. |
High-throughput discovery of novel developmental phenotypes. |
Extra-renal locations of the a4 subunit of H(+)ATPase. |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |