Fbl cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fbl
Entrez Gene ID	14113
Full Name	fibrillarin
Synonyms	AL022665,FIB,FLRN,RNU3IP1
General protein information	Preferred Names fibrillarin Names rRNA 2'-O-methyltransferase fibrillarin histone-glutamine methyltransferase nucleolar protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_007991.3	NP_032017.2	rRNA 2'-O-methyltransferase fibrillarin
XM_030242131.1	XP_030097991.1	rRNA 2'-O-methyltransferase fibrillarin isoform X1

Pathways from BioSystems

Homologies

	FBL	XP_001088664.2
Danio rerio (zebrafish)	fbl	NP_998167.1
Saccharomyces cerevisiae (baker's yeast)	NOP1	NP_010270.1
Arabidopsis thaliana (thale cress)	FIB2	NP_567724.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011244	XP_309401.4
Homo sapiens (human)	FBL	NP_001427.2
Bos taurus (cattle)	FBL	NP_001192329.1
Rattus norvegicus (Norway rat)	Fbl	NP_001020814.1
Eremothecium gossypii	AGOS_AER214C	NP_985071.1
Magnaporthe oryzae (rice blast fungus)	MGG_09195	XP_003709808.1
Oryza sativa (rice)	Os02g0821800	NP_001048553.1
Xenopus tropicalis (tropical clawed frog)	fbl	NP_989101.1
Pan troglodytes (chimpanzee)	FBL	XP_512658.2
Mus musculus (house mouse)	Fbl	NP_032017.2
Drosophila melanogaster (fruit fly)	Fib	NP_523817.1
Caenorhabditis elegans (roundworm)	fib-1	NP_506691.1
Neurospora crassa	NCU03702	XP_961478.1
Canis lupus familiaris (dog)	FBL	XP_533671.3
Kluyveromyces lactis	KLLA0C04389g	XP_452393.1
Schizosaccharomyces pombe (fission yeast)	fib1	NP_596229.1
Arabidopsis thaliana (thale cress)	FIB1	NP_568772.3

Gene Ontology
Bibliography

Related articles in PubMed

Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies.
Hamdane N, Tremblay MG, Dillinger S, Stefanovsky VY, N?meth A, Moss T
Gene6125-11(2017 May)

Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli.
Krej?? J, Legartov? S, B?rtov? E
Stem cells international20171021240(2017)

[Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K].
Shishova KV, Khodarovich YM, Lavrentyeva EA, Zatsepina OV
Ontogenez46(3)162-73(2015 May-Jun)

Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking.
Brandis KA, Gale S, Jinn S, Langmade SJ, Dudley-Rucker N, Jiang H, Sidhu R, Ren A, Goldberg A, Schaffer JE, Ory DS
The Journal of biological chemistry288(50)35703-13(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K
Title: [Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K].

SUV39h1 associated with HP1 beta in fibrillarin-positive nucleolar regions.
Title: SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions.

massive apoptosis was observed in early Fibrillarin(-/-) embryos, showing that fibrillarin is essential for development
Title: Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse.

Results suggest that proteasome-dependent processing of fibrillarin occurs upon mercury induction.
Title: Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen.

This splicing factor was more abundant in hepatocyte nuclei of mice fed genetically-modified soybeans than in control mice.
Title: Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean.

The following Fbl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01189	NM_007991.3 Latest version!	Mus musculus fibrillarin (Fbl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu01189	XM_030242131.1 Latest version!	Mus musculus fibrillarin (Fbl), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fbl ( NM_007991.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032017.2 Mus musculus fibrillarin (Fbl), mRNA.

Price & Availability↑

CloneID	OMu01189
Clone ID Related Accession (Same CDS sequence)	NM_007991.3 , XM_030242131.1
Accession Version	NM_007991.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	rRNA 2'-O-methyltransferase fibrillarin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU511282.1 and AV486126.1. On Oct 20, 2007 this sequence version replaced NM_007991.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003813.1, Z22593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCAG GTTTCAGCCC CCGTGGGGGT GGCTTTGGTG GCAGAGGCGG CTTTGGTGAC 
AGAGGCGGTA GAGGAGGTGG AAGAGGAGGC CGAGGAGGCT TTGGCGGTGG ACGAGGAGGC 
TTTGGCGGTG GAGGTCGAGG TCGAGGCGGA GGGGGTGGTG GCTTCAGGGG ACGAGGAGGT 
GGCGGTGGCC GAGGTGGGGG CTTCCAGTCT GGGGGCAACC GGGGTCGAGG TGGTGGCCGG 
GGAGGCAAGA GAGGAAACCA GTCAGGGAAG AATGTGATGG TGGAGCCGCA TCGTCATGAA 
GGTGTCTTTA TCTGTCGCGG AAAGGAGGAT GCCCTTGTCA CAAAGAATCT GGTCCCTGGA 
GAGTCTGTGT ATGGAGAGAA GAGAGTCTCT ATTTCAGAAG GAGATGACAA AATTGAGTAC 
AGAGCCTGGA ACCCCTTCCG CTCCAAGCTG GCAGCAGCTA TCCTGGGCGG CGTAGACCAG 
ATCCACATCA AGCCAGGAGC CAAGGTGCTC TACCTTGGGG CAGCCTCAGG CACCACCGTC 
TCCCACGTCT CTGATATTGT CGGCCCGGAT GGTCTGGTCT ACGCAGTTGA GTTCTCCCAC 
CGCTCTGGCC GTGACCTCAT CAACTTGGCC AAGAAGAGGA CTAACATTAT TCCTGTAATT 
GAAGATGCTC GACACCCACA CAAATACCGC ATGCTTATCG CAATGGTGGA TGTCATCTTT 
GCCGATGTGG CCCAGCCAGA CCAAACCCGA ATTGTGGCCC TGAACGCCCA CACCTTCCTG 
CGGAATGGAG GACACTTTGT GATTTCCATT AAGGCCAACT GCATTGACTC CACTGCGTCA 
GCAGAGGCTG TGTTTGCATC TGAAGTGAAG AAGATGCAGC AGGAGAACAT GAAGCCGCAG 
GAGCAGCTGA CGCTAGAGCC TTATGAGCGA GACCACGCCG TGGTTGTCGG TGTGTACAGG 
CCACCTCCCA AGGTGAAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032017.2
CDS	62..1045
Translation	MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGGGRGRGGGGGGFRGRGGGGGRGGGFQSGGNRGRGGGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Target ORF information:

RefSeq Version	NM_007991.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibrillarin (Fbl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007991.3

ORF Insert Sequence:

ATGAAGCCAG GTTTCAGCCC CCGTGGGGGT GGCTTTGGTG GCAGAGGCGG CTTTGGTGAC 
AGAGGCGGTA GAGGAGGTGG AAGAGGAGGC CGAGGAGGCT TTGGCGGTGG ACGAGGAGGC 
TTTGGCGGTG GAGGTCGAGG TCGAGGCGGA GGGGGTGGTG GCTTCAGGGG ACGAGGAGGT 
GGCGGTGGCC GAGGTGGGGG CTTCCAGTCT GGGGGCAACC GGGGTCGAGG TGGTGGCCGG 
GGAGGCAAGA GAGGAAACCA GTCAGGGAAG AATGTGATGG TGGAGCCGCA TCGTCATGAA 
GGTGTCTTTA TCTGTCGCGG AAAGGAGGAT GCCCTTGTCA CAAAGAATCT GGTCCCTGGA 
GAGTCTGTGT ATGGAGAGAA GAGAGTCTCT ATTTCAGAAG GAGATGACAA AATTGAGTAC 
AGAGCCTGGA ACCCCTTCCG CTCCAAGCTG GCAGCAGCTA TCCTGGGCGG CGTAGACCAG 
ATCCACATCA AGCCAGGAGC CAAGGTGCTC TACCTTGGGG CAGCCTCAGG CACCACCGTC 
TCCCACGTCT CTGATATTGT CGGCCCGGAT GGTCTGGTCT ACGCAGTTGA GTTCTCCCAC 
CGCTCTGGCC GTGACCTCAT CAACTTGGCC AAGAAGAGGA CTAACATTAT TCCTGTAATT 
GAAGATGCTC GACACCCACA CAAATACCGC ATGCTTATCG CAATGGTGGA TGTCATCTTT 
GCCGATGTGG CCCAGCCAGA CCAAACCCGA ATTGTGGCCC TGAACGCCCA CACCTTCCTG 
CGGAATGGAG GACACTTTGT GATTTCCATT AAGGCCAACT GCATTGACTC CACTGCGTCA 
GCAGAGGCTG TGTTTGCATC TGAAGTGAAG AAGATGCAGC AGGAGAACAT GAAGCCGCAG 
GAGCAGCTGA CGCTAGAGCC TTATGAGCGA GACCACGCCG TGGTTGTCGG TGTGTACAGG 
CCACCTCCCA AGGTGAAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fbl ( XM_030242131.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030097991.1 Mus musculus fibrillarin (Fbl), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01189
Clone ID Related Accession (Same CDS sequence)	NM_007991.3 , XM_030242131.1
Accession Version	XM_030242131.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	rRNA 2'-O-methyltransferase fibrillarin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCAG GTTTCAGCCC CCGTGGGGGT GGCTTTGGTG GCAGAGGCGG CTTTGGTGAC 
AGAGGCGGTA GAGGAGGTGG AAGAGGAGGC CGAGGAGGCT TTGGCGGTGG ACGAGGAGGC 
TTTGGCGGTG GAGGTCGAGG TCGAGGCGGA GGGGGTGGTG GCTTCAGGGG ACGAGGAGGT 
GGCGGTGGCC GAGGTGGGGG CTTCCAGTCT GGGGGCAACC GGGGTCGAGG TGGTGGCCGG 
GGAGGCAAGA GAGGAAACCA GTCAGGGAAG AATGTGATGG TGGAGCCGCA TCGTCATGAA 
GGTGTCTTTA TCTGTCGCGG AAAGGAGGAT GCCCTTGTCA CAAAGAATCT GGTCCCTGGA 
GAGTCTGTGT ATGGAGAGAA GAGAGTCTCT ATTTCAGAAG GAGATGACAA AATTGAGTAC 
AGAGCCTGGA ACCCCTTCCG CTCCAAGCTG GCAGCAGCTA TCCTGGGCGG CGTAGACCAG 
ATCCACATCA AGCCAGGAGC CAAGGTGCTC TACCTTGGGG CAGCCTCAGG CACCACCGTC 
TCCCACGTCT CTGATATTGT CGGCCCGGAT GGTCTGGTCT ACGCAGTTGA GTTCTCCCAC 
CGCTCTGGCC GTGACCTCAT CAACTTGGCC AAGAAGAGGA CTAACATTAT TCCTGTAATT 
GAAGATGCTC GACACCCACA CAAATACCGC ATGCTTATCG CAATGGTGGA TGTCATCTTT 
GCCGATGTGG CCCAGCCAGA CCAAACCCGA ATTGTGGCCC TGAACGCCCA CACCTTCCTG 
CGGAATGGAG GACACTTTGT GATTTCCATT AAGGCCAACT GCATTGACTC CACTGCGTCA 
GCAGAGGCTG TGTTTGCATC TGAAGTGAAG AAGATGCAGC AGGAGAACAT GAAGCCGCAG 
GAGCAGCTGA CGCTAGAGCC TTATGAGCGA GACCACGCCG TGGTTGTCGG TGTGTACAGG 
CCACCTCCCA AGGTGAAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030097991.1
CDS	359..1342
Translation	MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGGGRGRGGGGGGFRGRGGGGGRGGGFQSGGNRGRGGGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Target ORF information:

RefSeq Version	XM_030242131.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibrillarin (Fbl), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030242131.1

ORF Insert Sequence:

ATGAAGCCAG GTTTCAGCCC CCGTGGGGGT GGCTTTGGTG GCAGAGGCGG CTTTGGTGAC 
AGAGGCGGTA GAGGAGGTGG AAGAGGAGGC CGAGGAGGCT TTGGCGGTGG ACGAGGAGGC 
TTTGGCGGTG GAGGTCGAGG TCGAGGCGGA GGGGGTGGTG GCTTCAGGGG ACGAGGAGGT 
GGCGGTGGCC GAGGTGGGGG CTTCCAGTCT GGGGGCAACC GGGGTCGAGG TGGTGGCCGG 
GGAGGCAAGA GAGGAAACCA GTCAGGGAAG AATGTGATGG TGGAGCCGCA TCGTCATGAA 
GGTGTCTTTA TCTGTCGCGG AAAGGAGGAT GCCCTTGTCA CAAAGAATCT GGTCCCTGGA 
GAGTCTGTGT ATGGAGAGAA GAGAGTCTCT ATTTCAGAAG GAGATGACAA AATTGAGTAC 
AGAGCCTGGA ACCCCTTCCG CTCCAAGCTG GCAGCAGCTA TCCTGGGCGG CGTAGACCAG 
ATCCACATCA AGCCAGGAGC CAAGGTGCTC TACCTTGGGG CAGCCTCAGG CACCACCGTC 
TCCCACGTCT CTGATATTGT CGGCCCGGAT GGTCTGGTCT ACGCAGTTGA GTTCTCCCAC 
CGCTCTGGCC GTGACCTCAT CAACTTGGCC AAGAAGAGGA CTAACATTAT TCCTGTAATT 
GAAGATGCTC GACACCCACA CAAATACCGC ATGCTTATCG CAATGGTGGA TGTCATCTTT 
GCCGATGTGG CCCAGCCAGA CCAAACCCGA ATTGTGGCCC TGAACGCCCA CACCTTCCTG 
CGGAATGGAG GACACTTTGT GATTTCCATT AAGGCCAACT GCATTGACTC CACTGCGTCA 
GCAGAGGCTG TGTTTGCATC TGAAGTGAAG AAGATGCAGC AGGAGAACAT GAAGCCGCAG 
GAGCAGCTGA CGCTAGAGCC TTATGAGCGA GACCACGCCG TGGTTGTCGG TGTGTACAGG 
CCACCTCCCA AGGTGAAGAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies.
Gene6125-11(2017 May)
Hamdane N,Tremblay MG,Dillinger S,Stefanovsky VY,N?meth A,Moss T

Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli.
Stem cells international20171021240(2017)
Krej?? J,Legartov? S,B?rtov? E

[Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K].
Ontogenez46(3)162-73(2015 May-Jun)
Shishova KV,Khodarovich YM,Lavrentyeva EA,Zatsepina OV

Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking.
The Journal of biological chemistry288(50)35703-13(2013 Dec)
Brandis KA,Gale S,Jinn S,Langmade SJ,Dudley-Rucker N,Jiang H,Sidhu R,Ren A,Goldberg A,Schaffer JE,Ory DS

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Fbl cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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