Gene Symbol | Fdft1 |
Entrez Gene ID | 14137 |
Full Name | farnesyl diphosphate farnesyl transferase 1 |
Synonyms | SQS,SS |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Fdft1 cDNA ORF clone
gRNAs
Gene Symbol | Fdft1 |
Entrez Gene ID | 14137 |
Full Name | farnesyl diphosphate farnesyl transferase 1 |
Synonyms | SQS,SS |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_010191.3 | NP_034321.2 | squalene synthase |
NM_001360211.1 | NP_001347140.1 | squalene synthase |
XM_006518547.3 | XP_006518610.1 | squalene synthase isoform X2 |
XM_017315844.1 | XP_017171333.1 | squalene synthase isoform X1 |
XM_006518547.4 | XP_006518610.1 | squalene synthase isoform X2 |
Canis lupus familiaris (dog) | FDFT1 | XP_534557.2 |
Neurospora crassa | NCU06054 | XP_959817.1 |
Oryza sativa (rice) | Os07g0200700 | NP_001059129.1 |
Danio rerio (zebrafish) | si:ch73-107c13.2 | NP_001189454.1 |
Eremothecium gossypii | AGOS_AFR444C | NP_985991.1 |
Homo sapiens (human) | FDFT1 | NP_001274671.1 |
Mus musculus (house mouse) | Fdft1 | NP_034321.2 |
Rattus norvegicus (Norway rat) | Fdft1 | NP_062111.1 |
Gallus gallus (chicken) | FDFT1 | NP_001034383.1 |
Schizosaccharomyces pombe (fission yeast) | erg9 | NP_595363.1 |
Arabidopsis thaliana (thale cress) | SQS2 | NP_195191.2 |
Oryza sativa (rice) | Os03g0805100 | NP_001051625.1 |
Pan troglodytes (chimpanzee) | FDFT1 | XP_001141492.1 |
FDFT1 | XP_001086419.1 | |
Bos taurus (cattle) | FDFT1 | NP_001013022.1 |
Saccharomyces cerevisiae (baker's yeast) | ERG9 | NP_012060.1 |
Kluyveromyces lactis | KLLA0D08866g | XP_453457.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_09239 | XP_003709863.1 |
Arabidopsis thaliana (thale cress) | SQS1 | NP_195190.1 |
Xenopus tropicalis (tropical clawed frog) | fdft1 | NP_001135642.2 |
Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.
Shin SW, John Vogt E, Jimenez-Movilla M, Baibakov B, Dean J
Nature communications8(1)1643(2017 Nov)
Mfsd2a Is a Transporter for the Essential ?-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL
The Journal of biological chemistry291(20)10501-14(2016 May)
A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
?i?ecio?lu M, Budak H, Geffers L, ?ankaya M, ?iftci M, Thaller C, Eichele G, K?frevio?lu ??, ?zdemir H
Journal of lipid research56(8)1551-9(2015 Aug)
Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.
Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S
Journal of lipid research56(5)998-1005(2015 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study demonistrated that fdft1 is regulate the neuronal cholesterol synthesis during neurite outgrowth.
Title: Critical time window of neuronal cholesterol synthesis during neurite outgrowth.
VEGF expression, APOPTOSIS, AND ANGIOGENESIS in squalene synthase -ablated neural stem cells wERE strongly upregulated
Title: Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.
Result provides the first in vivo evidence that SS plays a regulatory role in cholesterol metabolism through modulation of HMG-CoA reductase activity and cholesterol biosynthesis.
Title: Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
The following Fdft1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fdft1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu49660 | |
Clone ID Related Accession (Same CDS sequence) | XM_006518547.3 , XM_006518547.4 | |
Accession Version | XM_006518547.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | squalene synthase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006518547.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGTG GGATGGCAGA ATTTGTAGAC AAGGATGTGA CCTCCAAACA GGACTGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006518610.1 |
CDS | 2480..3283 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGGTGTG GGATGGCAGA ATTTGTAGAC AAGGATGTGA CCTCCAAACA GGACTGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu05703 | |
Clone ID Related Accession (Same CDS sequence) | NM_010191.3 , NM_001360211.1 , XM_017315844.1 | |
Accession Version | NM_010191.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | squalene synthase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK136159.1 and BC054722.1. On or before Feb 15, 2015 this sequence version replaced XM_006518546.2, NM_010191.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136159.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGTTCG TCAAGTGTCT AGGCCACCCG GAGGAGTTCT ATAACCTGCT GCGATTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034321.2 |
CDS | 848..2098 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGTTCG TCAAGTGTCT AGGCCACCCG GAGGAGTTCT ATAACCTGCT GCGATTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu05703 | |
Clone ID Related Accession (Same CDS sequence) | NM_010191.3 , NM_001360211.1 , XM_017315844.1 | |
Accession Version | NM_001360211.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | squalene synthase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY293142.1, AK169317.1 and BC054722.1. Transcript Variant: This variant (1) represents transcription from a major CAGE transcription cluster, and represents the shorter transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054722.1, BC138302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGTTCG TCAAGTGTCT AGGCCACCCG GAGGAGTTCT ATAACCTGCT GCGATTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001347140.1 |
CDS | 107..1357 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGTTCG TCAAGTGTCT AGGCCACCCG GAGGAGTTCT ATAACCTGCT GCGATTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu05703 | |
Clone ID Related Accession (Same CDS sequence) | NM_010191.3 , NM_001360211.1 , XM_017315844.1 | |
Accession Version | XM_017315844.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | squalene synthase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGTTCG TCAAGTGTCT AGGCCACCCG GAGGAGTTCT ATAACCTGCT GCGATTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017171333.1 |
CDS | 3506..4756 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGTTCG TCAAGTGTCT AGGCCACCCG GAGGAGTTCT ATAACCTGCT GCGATTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu49660 | |
Clone ID Related Accession (Same CDS sequence) | XM_006518547.3 , XM_006518547.4 | |
Accession Version | XM_006518547.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | squalene synthase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006518547.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTGTG GGATGGCAGA ATTTGTAGAC AAGGATGTGA CCTCCAAACA GGACTGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006518610.1 |
CDS | 4042..4845 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGGTGTG GGATGGCAGA ATTTGTAGAC AAGGATGTGA CCTCCAAACA GGACTGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. |
Mfsd2a Is a Transporter for the Essential ?-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. |
A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. |
Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver. |