Gene Symbol | Fgf3 |
Entrez Gene ID | 14174 |
Full Name | fibroblast growth factor 3 |
Synonyms | Fgf-3,Int-2,Int-P |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Fgf3 cDNA ORF clone
Gene Symbol | Fgf3 |
Entrez Gene ID | 14174 |
Full Name | fibroblast growth factor 3 |
Synonyms | Fgf-3,Int-2,Int-P |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008007.2 | NP_032033.2 | fibroblast growth factor 3 precursor |
XM_011241980.2 | XP_011240282.1 | fibroblast growth factor 3 isoform X1 |
Homo sapiens (human) | FGF3 | NP_005238.1 |
FGF3 | XP_001100658.1 | |
Rattus norvegicus (Norway rat) | Fgf3 | NP_570830.1 |
Xenopus tropicalis (tropical clawed frog) | fgf3 | NP_001008154.1 |
Bos taurus (cattle) | FGF3 | XP_002699485.1 |
Mus musculus (house mouse) | Fgf3 | NP_032033.2 |
Pan troglodytes (chimpanzee) | FGF3 | XP_522092.2 |
Gallus gallus (chicken) | FGF3 | NP_990658.1 |
Danio rerio (zebrafish) | fgf3 | NP_571366.1 |
Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome.
Whittaker DE, Kasah S, Donovan APA, Ellegood J, Riegman KLH, Volk HA, McGonnell I, Lerch JP, Basson MA
American journal of medical genetics. Part C, Seminars in medical genetics175(4)(2017 Dec)
An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.
Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH
eLife6(2017 Nov)
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J
Nature communications8(1)1819(2017 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results indicate that Fgf3 hypomethylation and gene overexpression, but not protein expression, occurred in the early stage of oral carcinogenesis induced by DBP
Title: Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene.
We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist.
Title: An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.
FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing beta-catenin signaling.
Title: FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing ?-catenin signaling.
Data suggest that Fgf3/Fgfr3 signaling is required for maintenance of Gnrh (gonadotropin-releasing hormone) neurons in aging hypothalamus; postnatal Gnrh system is plastic/resilient, able to override preexisting defects and respond to external cues.
Title: Opposite-sex housing reactivates the declining GnRH system in aged transgenic male mice with FGF signaling deficiency.
Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos.
Title: Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos.
The following Fgf3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu01213 | |
Clone ID Related Accession (Same CDS sequence) | NM_008007.2 , XM_011241980.2 | |
Accession Version | NM_008007.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | fibroblast growth factor 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU923457.1, BC117059.1 and BM942045.1. On Oct 20, 2007 this sequence version replaced NM_008007.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU923457.1, AK133901.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032033.2 |
CDS | 97..834 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008007.2 |
1 | ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu01213 | |
Clone ID Related Accession (Same CDS sequence) | NM_008007.2 , XM_011241980.2 | |
Accession Version | XM_011241980.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | fibroblast growth factor 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011241980.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011240282.1 |
CDS | 257..994 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011241980.2 |
1 | ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome. |
An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. |
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma. |