Gene Symbol | Bloc1s1 |
Entrez Gene ID | 14533 |
Full Name | biogenesis of lysosomal organelles complex-1, subunit 1 |
Synonyms | AI839753,BLOS1,Gcn5l1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Bloc1s1 cDNA ORF clone
Gene Symbol | Bloc1s1 |
Entrez Gene ID | 14533 |
Full Name | biogenesis of lysosomal organelles complex-1, subunit 1 |
Synonyms | AI839753,BLOS1,Gcn5l1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006513229.2 | XP_006513292.1 | biogenesis of lysosome-related organelles complex 1 subunit 1 isoform X1 |
XM_006513229.3 | XP_006513292.1 | biogenesis of lysosome-related organelles complex 1 subunit 1 isoform X1 |
NM_015740.3 | NP_056555.2 | biogenesis of lysosome-related organelles complex 1 subunit 1 |
Mus musculus (house mouse) | Bloc1s1 | NP_056555.2 |
Xenopus tropicalis (tropical clawed frog) | bloc1s1 | NP_001072249.1 |
Danio rerio (zebrafish) | LOC556597 | NP_001037815.1 |
Drosophila melanogaster (fruit fly) | blos1 | NP_725401.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001887 | XP_321175.4 |
BLOC1S1 | XP_001095809.2 | |
Homo sapiens (human) | BLOC1S1 | NP_001478.2 |
Pan troglodytes (chimpanzee) | BLOC1S1 | XP_509120.1 |
Bos taurus (cattle) | BLOC1S1 | NP_001069830.1 |
Rattus norvegicus (Norway rat) | Bloc1s1 | NP_001099411.2 |
Caenorhabditis elegans (roundworm) | CELE_T20G5.10 | NP_499262.1 |
GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis.
Wang L, Scott I, Zhu L, Wu K, Han K, Chen Y, Gucek M, Sack MN
Nature communications8(1)523(2017 09)
Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.
Thapa D, Zhang M, Manning JR, Guimar?es DA, Stoner MW, O'Doherty RM, Shiva S, Scott I
American journal of physiology. Heart and circulatory physiology313(2)H265-H274(2017 Aug)
The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem?cells.
Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, Florens L, Washburn MP, Stadtfeld M, Pinton P, Pagano M
Nature cell biology19(4)341-351(2017 Apr)
BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.
Zhou W, He Q, Zhang C, He X, Cui Z, Liu F, Li W
eLife5(2016 10)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that the mitochondrial enriched GCN5-like 1 protein (GCN5L1) controls hepatic glucose production by regulating FoxO1 protein levels.
Title: GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis.
Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice.
Title: Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.
TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem?cells.
BLOS1 interacts with sorting nexin 2 and the ESCRT-I component TSG101 to mediate the sorting of EGFR into endosomal compartments
Title: Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
Here we show that genetic deletion of GCN5L1 has a direct positive effect on the expression and activity of Transcriptional Factor EB (TFEB), which acts as a master regulator of autophagy.
Title: GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy.
The following Bloc1s1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bloc1s1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17703 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513229.2 , XM_006513229.3 , NM_015740.3 | |
Accession Version | NM_015740.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-28 | |
Organism | Mus musculus(house mouse) | |
Product | biogenesis of lysosome-related organelles complex 1 subunit 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK003035.1. On Apr 6, 2007 this sequence version replaced NM_015740.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK003035.1, CD769731.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGTCCC GCCTGCTCAA AGAACACCAA GCCAAGCAGA ACGAACGCAA GGAGCTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_056555.2 |
CDS | 90..467 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015740.3 |
1 | ATGCTGTCCC GCCTGCTCAA AGAACACCAA GCCAAGCAGA ACGAACGCAA GGAGCTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17703 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513229.2 , XM_006513229.3 , NM_015740.3 | |
Accession Version | XM_006513229.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-08 | |
Organism | Mus musculus(House mouse) | |
Product | biogenesis of lysosome-related organelles complex 1 subunit 1 isoform X1 | |
Comment |
1 | ATGCTGTCCC GCCTGCTCAA AGAACACCAA GCCAAGCAGA ACGAACGCAA GGAGCTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006513292.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006513229.2 |
1 | ATGCTGTCCC GCCTGCTCAA AGAACACCAA GCCAAGCAGA ACGAACGCAA GGAGCTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17703 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513229.2 , XM_006513229.3 , NM_015740.3 | |
Accession Version | XM_006513229.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | biogenesis of lysosome-related organelles complex 1 subunit 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513229.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGTCCC GCCTGCTCAA AGAACACCAA GCCAAGCAGA ACGAACGCAA GGAGCTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006513292.1 |
CDS | 116..493 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006513229.3 |
1 | ATGCTGTCCC GCCTGCTCAA AGAACACCAA GCCAAGCAGA ACGAACGCAA GGAGCTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis. |
Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart. |
The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem?cells. |
BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. |