Gene Symbol | Nr6a1 |
Entrez Gene ID | 14536 |
Full Name | nuclear receptor subfamily 6, group A, member 1 |
Synonyms | 1700113M01Rik,Gcnf,NCNF,RTR |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nr6a1 cDNA ORF clone
gRNAs
Gene Symbol | Nr6a1 |
Entrez Gene ID | 14536 |
Full Name | nuclear receptor subfamily 6, group A, member 1 |
Synonyms | 1700113M01Rik,Gcnf,NCNF,RTR |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001159549.1 | NP_001153021.1 | nuclear receptor subfamily 6 group A member 1 isoform 3 |
NM_001159548.1 | NP_001153020.1 | nuclear receptor subfamily 6 group A member 1 isoform 2 |
XM_011239025.3 | XP_011237327.1 | nuclear receptor subfamily 6 group A member 1 isoform X1 |
XM_011239025.2 | XP_011237327.1 | nuclear receptor subfamily 6 group A member 1 isoform X1 |
NM_010264.4 | NP_034394.1 | nuclear receptor subfamily 6 group A member 1 isoform 1 |
Pan troglodytes (chimpanzee) | NR6A1 | XP_003951571.1 |
NR6A1 | XP_001082832.2 | |
Mus musculus (house mouse) | Nr6a1 | NP_034394.1 |
Homo sapiens (human) | NR6A1 | NP_201591.2 |
Xenopus tropicalis (tropical clawed frog) | nr6a1 | NP_001008005.1 |
Bos taurus (cattle) | NR6A1 | XP_002691647.2 |
Gallus gallus (chicken) | NR6A1 | XP_004946091.1 |
Rattus norvegicus (Norway rat) | Nr6a1 | XP_006234192.1 |
Danio rerio (zebrafish) | nr6a1a | NP_571331.2 |
A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
Weikum ER, Tuntland ML, Murphy MN, Ortlund EA
Journal of molecular biology428(24 Pt B)4981-4992(2016 Dec)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
Abnormal labyrinthine zone in the Hectd1-null placenta.
Sarkar AA, Sabatino JA, Sugrue KF, Zohn IE
Placenta3816-23(2016 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Here, the authors present the first structure of mouse GCNF DNA-binding domain in complex with the Oct4 DR0. The overall structure revealed two molecules bound in a head-to-tail fashion on opposite sides of the DNA at a DR0 motif located within the Oct4 promoter.
Title: A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
These results reveal that GCNF plays a key role in regulating activation of cyclin D1 expression via inhibition of Mir302a.
Title: GCNF-dependent activation of cyclin D1 expression via repression of Mir302a during ESC differentiation.
Inactivation of the Gcnf gene in vivo leads to loss of repression of Oct4 expression in both male and female gonads.
Title: Germ cell nuclear factor regulates gametogenesis in developing gonads.
characterize the let-7 target Nr6a1, an embryonic transcriptional repressor that regulates gene expression in adult fibroblasts following miRNA loss
Title: Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.
Gcnf is expressed in fetal ovarian germ cells.
Title: The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells.
The following Nr6a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nr6a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu07542 | |
Clone ID Related Accession (Same CDS sequence) | NM_001159548.1 | |
Accession Version | NM_001159548.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-14 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor subfamily 6 group A member 1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN537407.1, CK638822.1, CN532747.1 and AL844842.29. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGACAT GGGAAGTTTC CGTCCCAGAT GATCGAGCTG AACAACGAAC CTGTCTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001153020.1 |
CDS | 108..1424 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGACAT GGGAAGTTTC CGTCCCAGAT GATCGAGCTG AACAACGAAC CTGTCTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu07544 | |
Clone ID Related Accession (Same CDS sequence) | NM_001159549.1 | |
Accession Version | NM_001159549.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-14 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor subfamily 6 group A member 1 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN537407.1, CN537360.1, CK638822.1, CN532747.1 and AL844842.29. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGACAT GGGAAGTTTC CGTCCCAGAT GATCGAGCTG AACAACGAAC CTGTCTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001153021.1 |
CDS | 108..1421 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGACAT GGGAAGTTTC CGTCCCAGAT GATCGAGCTG AACAACGAAC CTGTCTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67814 | |
Clone ID Related Accession (Same CDS sequence) | XM_011239025.3 , XM_011239025.2 | |
Accession Version | XM_011239025.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor subfamily 6 group A member 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011239025.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCGGG ACGAACGGCC ACCTAGCGGA GGGGGAGGCG GCGGGGGCTC GGCGGGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011237327.1 |
CDS | 236..1720 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGCGGG ACGAACGGCC ACCTAGCGGA GGGGGAGGCG GCGGGGGCTC GGCGGGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu05853 | |
Clone ID Related Accession (Same CDS sequence) | NM_010264.4 | |
Accession Version | NM_010264.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor subfamily 6 group A member 1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL935155.13, CN538225.1, CK638822.1, CN532747.1 and AL844842.29. On Apr 21, 2009 this sequence version replaced NM_010264.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U09563.1, U14666.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCGGG ACGAACGGCC ACCTAGCGGA GGGGGAGGCG GCGGGGGCTC GGCGGGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034394.1 |
CDS | 245..1732 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGCGGG ACGAACGGCC ACCTAGCGGA GGGGGAGGCG GCGGGGGCTC GGCGGGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67814 | |
Clone ID Related Accession (Same CDS sequence) | XM_011239025.3 , XM_011239025.2 | |
Accession Version | XM_011239025.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor subfamily 6 group A member 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011239025.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCGGG ACGAACGGCC ACCTAGCGGA GGGGGAGGCG GCGGGGGCTC GGCGGGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011237327.1 |
CDS | 250..1734 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGCGGG ACGAACGGCC ACCTAGCGGA GGGGGAGGCG GCGGGGGCTC GGCGGGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1). |
High-throughput discovery of novel developmental phenotypes. |
Abnormal labyrinthine zone in the Hectd1-null placenta. |