Gene Symbol | Hmgcs2 |
Entrez Gene ID | 15360 |
Full Name | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 |
Synonyms | 1300002P16,mHS |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Hmgcs2 cDNA ORF clone
gRNAs
Gene Symbol | Hmgcs2 |
Entrez Gene ID | 15360 |
Full Name | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 |
Synonyms | 1300002P16,mHS |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008256.4 | NP_032282.2 | hydroxymethylglutaryl-CoA synthase, mitochondrial precursor |
Canis lupus familiaris (dog) | HMGCS2 | XP_849878.1 |
Mus musculus (house mouse) | Hmgcs2 | NP_032282.2 |
Rattus norvegicus (Norway rat) | Hmgcs2 | NP_775117.2 |
Pan troglodytes (chimpanzee) | HMGCS2 | XP_513693.1 |
HMGCS2 | XP_001114146.1 | |
Homo sapiens (human) | HMGCS2 | NP_005509.1 |
Bos taurus (cattle) | HMGCS2 | NP_001039348.1 |
Gallus gallus (chicken) | HMGCS2 | XP_422225.3 |
Early interleukin-6 enhances hepatic ketogenesis in APP
Shi L, Zhao D, Hou C, Peng Y, Liu J, Zhang S, Liu J, Long J
Neurobiology of aging56115-126(2017 Aug)
Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
Kang DY, S P N, Darvin P, Joung YH, Byun HJ, Do CH, Park KD, Park MN, Cho KH, Yang YM
Animal biotechnology28(3)189-197(2017 Jul)
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology216(3)675-693(2017 Mar)
Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction.
Cleaton MA, Dent CL, Howard M, Corish JA, Gutteridge I, Sovio U, Gaccioli F, Takahashi N, Bauer SR, Charnock-Jones DS, Powell TL, Smith GC, Ferguson-Smith AC, Charalambous M
Nature genetics48(12)1473-1480(2016 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 enhances ketogenesis through HMGCS2 signaling activation by p38/NF-kB p65.
Title: Early interleukin-6 enhances hepatic ketogenesis in APP
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b.
Title: Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8-/- mice.
Title: Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism.
The following Hmgcs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmgcs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu15606 | |
Clone ID Related Accession (Same CDS sequence) | NM_008256.4 | |
Accession Version | NM_008256.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-09 | |
Organism | Mus musculus(house mouse) | |
Product | hydroxymethylglutaryl-CoA synthase, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121771.3, AK004865.1 and AC147476.3. On Jun 16, 2009 this sequence version replaced NM_008256.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004865.1, BC014714.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## |
1 | ATGCAGCGGC TTTTGGCTCC AGCGAGGCGG GTCCTGCAAG TGAAGAGAGC GATGCAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032282.2 |
CDS | 54..1580 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCAGCGGC TTTTGGCTCC AGCGAGGCGG GTCCTGCAAG TGAAGAGAGC GATGCAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Early interleukin-6 enhances hepatic ketogenesis in APP |
Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2. |
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. |
Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction. |