Gene Symbol | Hsd11b1 |
Entrez Gene ID | 15483 |
Full Name | hydroxysteroid 11-beta dehydrogenase 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Hsd11b1 cDNA ORF clone
gRNAs
Gene Symbol | Hsd11b1 |
Entrez Gene ID | 15483 |
Full Name | hydroxysteroid 11-beta dehydrogenase 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001044751.1 | NP_001038216.1 | corticosteroid 11-beta-dehydrogenase isozyme 1 |
XM_006497228.2 | XP_006497291.1 | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2 |
XM_006497228.3 | XP_006497291.1 | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2 |
XM_006497227.1 | XP_006497290.1 | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1 |
NM_008288.2 | NP_032314.2 | corticosteroid 11-beta-dehydrogenase isozyme 1 |
XM_030249832.1 | XP_030105692.1 | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X3 |
Pan troglodytes (chimpanzee) | HSD11B1 | XP_003308773.1 |
HSD11B1 | XP_002801983.1 | |
Mus musculus (house mouse) | Hsd11b1 | NP_001038216.1 |
Gallus gallus (chicken) | HSD11B1 | XP_417988.2 |
Xenopus tropicalis (tropical clawed frog) | hsd11b1 | XP_002933552.2 |
Gallus gallus (chicken) | LOC771930 | XP_004935041.1 |
Homo sapiens (human) | HSD11B1 | NP_001193670.1 |
Canis lupus familiaris (dog) | HSD11B1 | NP_001005756.1 |
Bos taurus (cattle) | HSD11B1 | NP_001116504.1 |
Rattus norvegicus (Norway rat) | Hsd11b1 | NP_058776.2 |
11?-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.
Verma M, Kipari TMJ, Zhang Z, Man TY, Forster T, Homer NZM, Seckl JR, Holmes MC, Chapman KE
Brain, behavior, and immunity(2017 Nov)
11?-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner.
Vandermosten L, De Geest C, Knoops S, Thijs G, Chapman KE, De Bosscher K, Opdenakker G, Van den Steen PE
Scientific reports7(1)13835(2017 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
11beta-HSD1 protein expression after caloric restriction was significantly up-regulated, while no difference was detected after re-feeding. Interestingly, upregulation of protein after CR (1.4-fold) was lower than the increase in enzymatic activity (2.6-fold).
Title: Regulation of 11?-hydroxysteroid dehydrogenase type 1 following caloric restriction and re-feeding is species dependent.
11beta-HSD1 deficiency in myeloid phagocytes promotes angiogenesis.
Title: Macrophage 11?-HSD-1 deficiency promotes inflammatory angiogenesis.
We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad.
Title: Cellular and genetic models of H6PDH and 11?-HSD1 function in skeletal muscle.
These data identify suppression of CXCL2 and CXCL5 chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury.
Title: 11?-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI.
Brown adipose tissue (BAT) from aged 11beta-HSD1 KO mice showed elevated UCP1 protein and mitochondrial content, and a favorable profile of BAT function.
Title: 11?-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice.
The following Hsd11b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsd11b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu29002 | |
Clone ID Related Accession (Same CDS sequence) | XM_006497227.1 | |
Accession Version | XM_006497227.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGACAGA AGGATAGAGA GGAGGAGAGA GAGAGAAGAG AAGCAACCAG AGATAGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006497290.1 |
CDS | 6..1007 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGACAGA AGGATAGAGA GGAGGAGAGA GAGAGAAGAG AAGCAACCAG AGATAGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu29003 | |
Clone ID Related Accession (Same CDS sequence) | XM_006497228.2 , XM_006497228.3 | |
Accession Version | XM_006497228.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006497228.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAACAG GGCGCCCTGA GCCAGGTCCC TGTTTGATGG CAGTTATGAA AAATTACCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006497291.1 |
CDS | 92..1006 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAACAG GGCGCCCTGA GCCAGGTCCC TGTTTGATGG CAGTTATGAA AAATTACCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21942 | |
Clone ID Related Accession (Same CDS sequence) | NM_001044751.1 , NM_008288.2 , XM_030249832.1 | |
Accession Version | NM_001044751.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | corticosteroid 11-beta-dehydrogenase isozyme 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI099306.1, AK149518.1 and AI132676.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. An in-frame AUG is located 41 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149518.1, AK165212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGTTA TGAAAAATTA CCTCCTCCCG ATCCTGGTGC TCTTCCTGGC CTACTACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001038216.1 |
CDS | 99..977 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGTTA TGAAAAATTA CCTCCTCCCG ATCCTGGTGC TCTTCCTGGC CTACTACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21942 | |
Clone ID Related Accession (Same CDS sequence) | NM_001044751.1 , NM_008288.2 , XM_030249832.1 | |
Accession Version | NM_008288.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | corticosteroid 11-beta-dehydrogenase isozyme 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI182353.1, DQ089001.1 and AI132676.1. On Aug 31, 2006 this sequence version replaced NM_008288.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. An in-frame AUG is located 41 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC132364.1, BI145088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGTTA TGAAAAATTA CCTCCTCCCG ATCCTGGTGC TCTTCCTGGC CTACTACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032314.2 |
CDS | 125..1003 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGTTA TGAAAAATTA CCTCCTCCCG ATCCTGGTGC TCTTCCTGGC CTACTACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21942 | |
Clone ID Related Accession (Same CDS sequence) | NM_001044751.1 , NM_008288.2 , XM_030249832.1 | |
Accession Version | XM_030249832.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGTTA TGAAAAATTA CCTCCTCCCG ATCCTGGTGC TCTTCCTGGC CTACTACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030105692.1 |
CDS | 277..1155 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGTTA TGAAAAATTA CCTCCTCCCG ATCCTGGTGC TCTTCCTGGC CTACTACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu29003 | |
Clone ID Related Accession (Same CDS sequence) | XM_006497228.2 , XM_006497228.3 | |
Accession Version | XM_006497228.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497228.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAACAG GGCGCCCTGA GCCAGGTCCC TGTTTGATGG CAGTTATGAA AAATTACCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006497291.1 |
CDS | 92..1006 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAACAG GGCGCCCTGA GCCAGGTCCC TGTTTGATGG CAGTTATGAA AAATTACCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
11?-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation. |
11?-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner. |