Gene Symbol | Hspa2 |
Entrez Gene ID | 15512 |
Full Name | heat shock protein 2 |
Synonyms | 70kDa,HSP70.2,HSP70A2,Hsp70-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Hspa2 cDNA ORF clone
gRNAs
Gene Symbol | Hspa2 |
Entrez Gene ID | 15512 |
Full Name | heat shock protein 2 |
Synonyms | 70kDa,HSP70.2,HSP70A2,Hsp70-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006515484.2 | XP_006515547.1 | heat shock-related 70 kDa protein 2 isoform X1 |
NM_008301.4 | NP_032327.2 | heat shock-related 70 kDa protein 2 |
XM_006515484.3 | XP_006515547.1 | heat shock-related 70 kDa protein 2 isoform X1 |
XM_006515484.4 | XP_006515547.1 | heat shock-related 70 kDa protein 2 isoform X1 |
NM_001002012.1 | NP_001002012.1 | heat shock-related 70 kDa protein 2 |
Pan troglodytes (chimpanzee) | HSPA2 | XP_510002.3 |
Mus musculus (house mouse) | Hspa2 | NP_032327.2 |
Arabidopsis thaliana (thale cress) | ERD2 | NP_176036.1 |
Rattus norvegicus (Norway rat) | Hspa2 | NP_068635.1 |
Xenopus tropicalis (tropical clawed frog) | hspa2 | XP_004917261.1 |
Homo sapiens (human) | HSPA2 | NP_068814.2 |
Canis lupus familiaris (dog) | HSPA2 | XP_537479.1 |
Bos taurus (cattle) | HSPA2 | NP_776769.1 |
Gallus gallus (chicken) | HSPA2 | NP_001006686.1 |
Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse.
Bromfield EG, Aitken RJ, McLaughlin EA, Nixon B
Molecular human reproduction23(2)91-105(2017 Feb)
Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
Borowiec AS, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, J?gou B, Prevarskaya N, Bidaux G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(9)3155-70(2016 09)
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osborne G, Bates GP, Glickman MH, Trost M, Knebel A, Marchesi F, Kurz T
Cell166(4)935-949(2016 Aug)
SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis.
Liu M, Shi X, Bi Y, Qi L, Guo X, Wang L, Zhou Z, Sha J
Molecular human reproduction20(6)463-75(2014 Jun)
A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice.
Akiyama K, Noguchi J, Hirose M, Kajita S, Katayama K, Khalaj M, Tsuji T, Fairfield H, Byers C, Reinholdt L, Ogura A, Kunieda T
The Journal of biological chemistry288(44)31830-41(2013 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
a candidate gene approach revealed that HSPA2 is a prominent molecular target of ELAVL1
Title: The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages.
Data show that Parp2 interacts significantly with both the transition protein TP2 and the transition chaperone HSPA2, whereas Parp1 binds weakly to HSPA2.
Title: Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.
NASP controls the ability of HSPA2 to activate CDC2 for CDC2/cyclin B1 complex formation.
Title: Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse.
Hspa2 was detected in central and peripheral nervous system: in neuron's bodies and fiber tracts, in the subventricular zone of the lateral ventricles, in the dentate gyrus of the hippocampus, in enteric ganglia of the gastrointestinal tract
Title: The expression pattern of the 70-kDa heat shock protein Hspa2 in mouse tissues.
Bat3 is identified as a critical regulator of Hsp70-2 in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility.
Title: Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis.
The following Hspa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22010 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515484.2 , NM_008301.4 , XM_006515484.3 , XM_006515484.4 , NM_001002012.1 | |
Accession Version | NM_008301.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-01 | |
Organism | Mus musculus(house mouse) | |
Product | heat shock-related 70 kDa protein 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY282370.1, AK132261.1 and BC052350.1. On Apr 20, 2006 this sequence version replaced NM_008301.3. Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032327.2 |
CDS | 165..2066 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22010 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515484.2 , NM_008301.4 , XM_006515484.3 , XM_006515484.4 , NM_001002012.1 | |
Accession Version | NM_001002012.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-02 | |
Organism | Mus musculus(house mouse) | |
Product | heat shock-related 70 kDa protein 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052350.1. Transcript Variant: This variant (2) has an alternate 5' sequence and encodes the same protein, as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052350.1, CA464921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001002012.1 |
CDS | 120..2021 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22010 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515484.2 , NM_008301.4 , XM_006515484.3 , XM_006515484.4 , NM_001002012.1 | |
Accession Version | XM_006515484.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-08 | |
Organism | Mus musculus(House mouse) | |
Product | heat shock-related 70 kDa protein 2 isoform X1 | |
Comment |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006515547.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22010 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515484.2 , NM_008301.4 , XM_006515484.3 , XM_006515484.4 , NM_001002012.1 | |
Accession Version | XM_006515484.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | heat shock-related 70 kDa protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006515484.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006515547.1 |
CDS | 95..1996 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22010 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515484.2 , NM_008301.4 , XM_006515484.3 , XM_006515484.4 , NM_001002012.1 | |
Accession Version | XM_006515484.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | heat shock-related 70 kDa protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006515484.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006515547.1 |
CDS | 137..2038 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTGCCC GCGGCCCGGC TATCGGCATC GACCTGGGCA CCACTTACTC GTGCGTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse. |
Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. |
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome. |
SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. |
A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice. |